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Protein

Probable thiol peroxidase

Gene

tpx

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Has antioxidant activity. Could remove peroxides or H2O2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase, Peroxidase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable thiol peroxidase (EC:1.11.1.-)
Gene namesi
Name:tpx
Ordered Locus Names:HI_0751
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 165165Probable thiol peroxidasePRO_0000187880Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0751.

Structurei

Secondary structure

1
165
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 53Combined sources
Beta strandi8 – 103Combined sources
Beta strandi12 – 143Combined sources
Beta strandi27 – 293Combined sources
Beta strandi35 – 373Combined sources
Helixi38 – 414Combined sources
Beta strandi44 – 507Combined sources
Helixi61 – 7212Combined sources
Beta strandi76 – 849Combined sources
Helixi86 – 894Combined sources
Turni93 – 975Combined sources
Beta strandi101 – 1055Combined sources
Helixi111 – 1155Combined sources
Turni124 – 1274Combined sources
Beta strandi132 – 1365Combined sources
Beta strandi140 – 1478Combined sources
Helixi157 – 1626Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q98X-ray1.90A/B1-165[»]
ProteinModelPortaliQ57549.
SMRiQ57549. Positions 2-165.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ57549.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 165149ThioredoxinAdd
BLAST

Sequence similaritiesi

Belongs to the AhpC/TSA family. Tpx subfamily.Curated
Contains 1 thioredoxin domain.Curated

Phylogenomic databases

eggNOGiENOG4108V1J. Bacteria.
COG2077. LUCA.
KOiK11065.
OMAiKFNAQAN.
PhylomeDBiQ57549.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
HAMAPiMF_00269. Tpx. 1 hit.
InterProiIPR002065. Put_TPX.
IPR013740. Redoxin.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
IPR018219. Tpx_CS.
[Graphical view]
PfamiPF08534. Redoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
PS01265. TPX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57549-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVTLAGNPI EVGGHFPQVG EIVENFILVG NDLADVALND FASKRKVLNI
60 70 80 90 100
FPSIDTGVCA TSVRKFNQQA AKLSNTIVLC ISADLPFAQA RFCGAEGIEN
110 120 130 140 150
AKTVSTFRNH ALHSQLGVDI QTGPLAGLTS RAVIVLDEQN NVLHSQLVEE
160
IKEEPNYEAA LAVLA
Length:165
Mass (Da):17,626
Last modified:November 1, 1996 - v1
Checksum:i221DA969C76106CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22410.1.
PIRiG64090.
RefSeqiNP_438910.1. NC_000907.1.
WP_005693150.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22410; AAC22410; HI_0751.
GeneIDi949774.
KEGGihin:HI0751.
PATRICi20190145. VBIHaeInf48452_0788.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22410.1.
PIRiG64090.
RefSeqiNP_438910.1. NC_000907.1.
WP_005693150.1. NC_000907.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q98X-ray1.90A/B1-165[»]
ProteinModelPortaliQ57549.
SMRiQ57549. Positions 2-165.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0751.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22410; AAC22410; HI_0751.
GeneIDi949774.
KEGGihin:HI0751.
PATRICi20190145. VBIHaeInf48452_0788.

Phylogenomic databases

eggNOGiENOG4108V1J. Bacteria.
COG2077. LUCA.
KOiK11065.
OMAiKFNAQAN.
PhylomeDBiQ57549.

Miscellaneous databases

EvolutionaryTraceiQ57549.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
HAMAPiMF_00269. Tpx. 1 hit.
InterProiIPR002065. Put_TPX.
IPR013740. Redoxin.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
IPR018219. Tpx_CS.
[Graphical view]
PfamiPF08534. Redoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
PS01265. TPX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTPX_HAEIN
AccessioniPrimary (citable) accession number: Q57549
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.