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Protein

Probable thiol peroxidase

Gene

tpx

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Has antioxidant activity. Could remove peroxides or H2O2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase, Peroxidase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable thiol peroxidase (EC:1.11.1.-)
Gene namesi
Name:tpx
Ordered Locus Names:HI_0751
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001878801 – 165Probable thiol peroxidaseAdd BLAST165

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0751.

Structurei

Secondary structure

1165
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 5Combined sources3
Beta strandi8 – 10Combined sources3
Beta strandi12 – 14Combined sources3
Beta strandi27 – 29Combined sources3
Beta strandi35 – 37Combined sources3
Helixi38 – 41Combined sources4
Beta strandi44 – 50Combined sources7
Helixi61 – 72Combined sources12
Beta strandi76 – 84Combined sources9
Helixi86 – 89Combined sources4
Turni93 – 97Combined sources5
Beta strandi101 – 105Combined sources5
Helixi111 – 115Combined sources5
Turni124 – 127Combined sources4
Beta strandi132 – 136Combined sources5
Beta strandi140 – 147Combined sources8
Helixi157 – 162Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q98X-ray1.90A/B1-165[»]
ProteinModelPortaliQ57549.
SMRiQ57549.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ57549.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 165ThioredoxinAdd BLAST149

Sequence similaritiesi

Belongs to the AhpC/TSA family. Tpx subfamily.Curated
Contains 1 thioredoxin domain.Curated

Phylogenomic databases

eggNOGiENOG4108V1J. Bacteria.
COG2077. LUCA.
KOiK11065.
OMAiKFNAQAN.
PhylomeDBiQ57549.

Family and domain databases

CDDicd03014. PRX_Atyp2cys. 1 hit.
Gene3Di3.40.30.10. 1 hit.
HAMAPiMF_00269. Tpx. 1 hit.
InterProiIPR002065. Put_TPX.
IPR013740. Redoxin.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
IPR018219. Tpx_CS.
[Graphical view]
PfamiPF08534. Redoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
PS01265. TPX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57549-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVTLAGNPI EVGGHFPQVG EIVENFILVG NDLADVALND FASKRKVLNI
60 70 80 90 100
FPSIDTGVCA TSVRKFNQQA AKLSNTIVLC ISADLPFAQA RFCGAEGIEN
110 120 130 140 150
AKTVSTFRNH ALHSQLGVDI QTGPLAGLTS RAVIVLDEQN NVLHSQLVEE
160
IKEEPNYEAA LAVLA
Length:165
Mass (Da):17,626
Last modified:November 1, 1996 - v1
Checksum:i221DA969C76106CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22410.1.
PIRiG64090.
RefSeqiNP_438910.1. NC_000907.1.
WP_005693150.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22410; AAC22410; HI_0751.
GeneIDi949774.
KEGGihin:HI0751.
PATRICi20190145. VBIHaeInf48452_0788.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22410.1.
PIRiG64090.
RefSeqiNP_438910.1. NC_000907.1.
WP_005693150.1. NC_000907.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q98X-ray1.90A/B1-165[»]
ProteinModelPortaliQ57549.
SMRiQ57549.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0751.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22410; AAC22410; HI_0751.
GeneIDi949774.
KEGGihin:HI0751.
PATRICi20190145. VBIHaeInf48452_0788.

Phylogenomic databases

eggNOGiENOG4108V1J. Bacteria.
COG2077. LUCA.
KOiK11065.
OMAiKFNAQAN.
PhylomeDBiQ57549.

Miscellaneous databases

EvolutionaryTraceiQ57549.

Family and domain databases

CDDicd03014. PRX_Atyp2cys. 1 hit.
Gene3Di3.40.30.10. 1 hit.
HAMAPiMF_00269. Tpx. 1 hit.
InterProiIPR002065. Put_TPX.
IPR013740. Redoxin.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
IPR018219. Tpx_CS.
[Graphical view]
PfamiPF08534. Redoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
PS01265. TPX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTPX_HAEIN
AccessioniPrimary (citable) accession number: Q57549
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.