ID   HGP4_HAEIN              Reviewed;         999 AA.
AC   Q57408; O86244; P96344;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   29-AUG-2001, sequence version 3.
DT   27-MAR-2024, entry version 125.
DE   RecName: Full=Probable hemoglobin and hemoglobin-haptoglobin-binding protein 4;
DE   Flags: Precursor;
GN   OrderedLocusNames=HI_1565/HI_1567;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
RN   [2]
RP   SEQUENCE REVISION.
RA   White O., Clayton R.A., Kerlavage A.R., Fleischmann R.D., Peterson J.,
RA   Hickey E., Dodson R., Gwinn M.;
RL   Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a receptor for hemoglobin or the
CC       hemoglobin/haptoglobin complex of the human host and is required for
CC       heme uptake. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|PROSITE-
CC       ProRule:PRU01360}; Multi-pass membrane protein {ECO:0000255|PROSITE-
CC       ProRule:PRU01360}.
CC   -!- MISCELLANEOUS: This protein is subject to phase-variable expression
CC       associated with alteration in the length of the CCAA repeat region.
CC       This mechanism is called slipped-strand mispairing. Addition or loss of
CC       CCAA repeat units would change the reading frame and result in
CC       introduction of stop codons downstream of the repeat region. This may
CC       be a mechanism of regulation and a way to avoid the immunological
CC       response of the host (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TonB-dependent receptor family.
CC       Hemoglobin/haptoglobin binding protein subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC23213.1; Type=Frameshift; Note=The first frameshift is found in the repeats region.; Evidence={ECO:0000305};
CC       Sequence=AAC23214.1; Type=Frameshift; Note=The first frameshift is found in the repeats region.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L42023; AAC23213.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; L42023; AAC23214.1; ALT_SEQ; Genomic_DNA.
DR   PIR; A64130; A64130.
DR   AlphaFoldDB; Q57408; -.
DR   SMR; Q57408; -.
DR   STRING; 71421.HI_1567; -.
DR   EnsemblBacteria; AAC23213; AAC23213; HI_1565.
DR   EnsemblBacteria; AAC23214; AAC23214; HI_1567.
DR   KEGG; hin:HI_1565; -.
DR   KEGG; hin:HI_1567; -.
DR   eggNOG; COG1629; Bacteria.
DR   eggNOG; COG4771; Bacteria.
DR   HOGENOM; CLU_078218_0_0_6; -.
DR   PhylomeDB; Q57408; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015344; F:siderophore uptake transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0044718; P:siderophore transmembrane transport; IBA:GO_Central.
DR   CDD; cd01347; ligand_gated_channel; 1.
DR   Gene3D; 2.40.170.20; TonB-dependent receptor, beta-barrel domain; 2.
DR   Gene3D; 2.170.130.10; TonB-dependent receptor, plug domain; 1.
DR   InterPro; IPR012910; Plug_dom.
DR   InterPro; IPR037066; Plug_dom_sf.
DR   InterPro; IPR006970; PT.
DR   InterPro; IPR039426; TonB-dep_rcpt-like.
DR   InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR   InterPro; IPR010949; TonB_Hb/transfer/lactofer_rcpt.
DR   InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR   InterPro; IPR010917; TonB_rcpt_CS.
DR   NCBIfam; TIGR01786; TonB-hemlactrns; 1.
DR   PANTHER; PTHR30069:SF58; HEMOGLOBIN AND HEMOGLOBIN-HAPTOGLOBIN-BINDING PROTEIN 1-RELATED; 1.
DR   PANTHER; PTHR30069; TONB-DEPENDENT OUTER MEMBRANE RECEPTOR; 1.
DR   Pfam; PF07715; Plug; 1.
DR   Pfam; PF04886; PT; 1.
DR   Pfam; PF00593; TonB_dep_Rec; 1.
DR   SUPFAM; SSF56935; Porins; 1.
DR   PROSITE; PS01156; TONB_DEPENDENT_REC_2; 1.
DR   PROSITE; PS52016; TONB_DEPENDENT_REC_3; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Receptor; Reference proteome; Repeat;
KW   Signal; TonB box; Transmembrane; Transmembrane beta strand; Transport.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..999
FT                   /note="Probable hemoglobin and hemoglobin-haptoglobin-
FT                   binding protein 4"
FT                   /id="PRO_0000034788"
FT   REPEAT          26..29
FT                   /note="1"
FT   REPEAT          30..33
FT                   /note="2"
FT   REPEAT          34..37
FT                   /note="3"
FT   REPEAT          38..41
FT                   /note="4"
FT   REPEAT          42..45
FT                   /note="5"
FT   REPEAT          46..49
FT                   /note="6"
FT   DOMAIN          68..195
FT                   /note="TBDR plug"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01360"
FT   DOMAIN          203..999
FT                   /note="TBDR beta-barrel"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01360"
FT   REGION          25..52
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          26..49
FT                   /note="6 X 4 AA tandem repeats of P-T-N-Q"
FT   MOTIF           58..65
FT                   /note="TonB box"
FT   MOTIF           982..999
FT                   /note="TonB C-terminal box"
SQ   SEQUENCE   999 AA;  114315 MW;  DAFCD4EB7000A876 CRC64;
     MTNFRLNVLA YSVMLGLTAS VAYAEPTNQP TNQPTNQPTN QPTNQPTNQN SNASEQLEQI
     NVLGSDNNND NTPPKIAETV KTASQLKRQQ VQDSRDLVRY ETGVTVVEAG RFGSSGYAIR
     GVDENRVAIT VDGLHQAETL SSQGFKELFE GYGNFNNTRN SVEIETLKVA KIAKGADSVK
     VGSGSLGGAV LFETKDARDF LTEKDWHIGY KAGYSTADNQ GLNAVTLAGR YQMFDALIMH
     SKRHGHELEN YDYKNGRDIQ GKEREKADPY TITKESTLVK FSFSPTENHR FTVASDTYLQ
     HSRGHDFSYN LVKTTYINKD EEELRHTNDL TKRKNVSFTY ENYTVTPFWD TLKLSYSQQR
     ITTRARTEDY CDGNEKCDSY KNPLGLQLKE GKVVDRNGDP VELKLVEDEQ GQKRHQVVDK
     YNNPFSVASG TNNDAFVGKQ LSPSEFWLDC SIFNCDKPVR VYKYQYSNQE PESKEVELNR
     TMEINGKKFA TYESNNYRDR YHMILPNSKG YLPLDYKERD LNTKTKQINL DLTKAFTLFE
     IENELSYGGV YAKTTKEMVN KAGYYGRNPT WWAERTLGKS LLNGLRTCKE DSSYNGLLCP
     RHEPKTSFLI PVETTTKSLY FADNIKLHNM LSVDLGYRYD DIKYQPEYIP GVTPKIADDM
     VRELFVPLPP ANGKDWQGNP VYTPEQIRKN AEENIAYIAQ EKRFKKHSYS LGATFDPLNF
     LRVQVKYSKG FRTPTSDELY FTFKHPDFTI LPNPNMKPEE AKNQEIALTF HHDWGFFSTN
     VFQTKYRQFI DLAYLGSRNL SNSVGGQAQA RDFQVYQNVN VDRAKVKGVE INSRLNIGYF
     FEKLDGFNVS YKFTYQRGRL DGNRPMNAIQ PKTSVIGLGY DHKEQRFGAD LYVTHVSAKK
     AKDTYNMFYK EQGYKDSAVR WRSDDYTLVD FVTYIKPVKN VTLQFGVYNL TDRKYLTWES
     ARSIKPFGTS NLINQGTGAG INRFYSPGRN YKLSAEITF
//