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Protein

Probable hemoglobin and hemoglobin-haptoglobin-binding protein 4

Gene

HI_1565/HI_1567

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Acts as a receptor for hemoglobin or the hemoglobin/haptoglobin complex of the human host and is required for heme uptake.By similarity

GO - Molecular functioni

  1. receptor activity Source: InterPro
  2. transporter activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Probable hemoglobin and hemoglobin-haptoglobin-binding protein 4
Gene namesi
Ordered Locus Names:HI_1565/HI_1567
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cell outer membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 999975Probable hemoglobin and hemoglobin-haptoglobin-binding protein 4PRO_0000034788Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ57408.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati26 – 2941
Repeati30 – 3342
Repeati34 – 3743
Repeati38 – 4144
Repeati42 – 4545
Repeati46 – 4946

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni26 – 49246 X 4 AA tandem repeats of P-T-N-QAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi58 – 658TonB box
Motifi982 – 99918TonB C-terminal boxAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, TonB box, Transmembrane, Transmembrane beta strand

Family and domain databases

Gene3Di2.170.130.10. 1 hit.
2.40.170.20. 3 hits.
InterProiIPR012910. Plug.
IPR006970. PT.
IPR000531. TonB-dep_rcpt_b-brl.
IPR010949. TonB_Hb/transfer/lactofer_rcpt.
IPR010917. TonB_rcpt_CS.
[Graphical view]
PfamiPF07715. Plug. 1 hit.
PF04886. PT. 1 hit.
PF00593. TonB_dep_Rec. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01786. TonB-hemlactrns. 1 hit.
PROSITEiPS01156. TONB_DEPENDENT_REC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q57408-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNFRLNVLA YSVMLGLTAS VAYAEPTNQP TNQPTNQPTN QPTNQPTNQN
60 70 80 90 100
SNASEQLEQI NVLGSDNNND NTPPKIAETV KTASQLKRQQ VQDSRDLVRY
110 120 130 140 150
ETGVTVVEAG RFGSSGYAIR GVDENRVAIT VDGLHQAETL SSQGFKELFE
160 170 180 190 200
GYGNFNNTRN SVEIETLKVA KIAKGADSVK VGSGSLGGAV LFETKDARDF
210 220 230 240 250
LTEKDWHIGY KAGYSTADNQ GLNAVTLAGR YQMFDALIMH SKRHGHELEN
260 270 280 290 300
YDYKNGRDIQ GKEREKADPY TITKESTLVK FSFSPTENHR FTVASDTYLQ
310 320 330 340 350
HSRGHDFSYN LVKTTYINKD EEELRHTNDL TKRKNVSFTY ENYTVTPFWD
360 370 380 390 400
TLKLSYSQQR ITTRARTEDY CDGNEKCDSY KNPLGLQLKE GKVVDRNGDP
410 420 430 440 450
VELKLVEDEQ GQKRHQVVDK YNNPFSVASG TNNDAFVGKQ LSPSEFWLDC
460 470 480 490 500
SIFNCDKPVR VYKYQYSNQE PESKEVELNR TMEINGKKFA TYESNNYRDR
510 520 530 540 550
YHMILPNSKG YLPLDYKERD LNTKTKQINL DLTKAFTLFE IENELSYGGV
560 570 580 590 600
YAKTTKEMVN KAGYYGRNPT WWAERTLGKS LLNGLRTCKE DSSYNGLLCP
610 620 630 640 650
RHEPKTSFLI PVETTTKSLY FADNIKLHNM LSVDLGYRYD DIKYQPEYIP
660 670 680 690 700
GVTPKIADDM VRELFVPLPP ANGKDWQGNP VYTPEQIRKN AEENIAYIAQ
710 720 730 740 750
EKRFKKHSYS LGATFDPLNF LRVQVKYSKG FRTPTSDELY FTFKHPDFTI
760 770 780 790 800
LPNPNMKPEE AKNQEIALTF HHDWGFFSTN VFQTKYRQFI DLAYLGSRNL
810 820 830 840 850
SNSVGGQAQA RDFQVYQNVN VDRAKVKGVE INSRLNIGYF FEKLDGFNVS
860 870 880 890 900
YKFTYQRGRL DGNRPMNAIQ PKTSVIGLGY DHKEQRFGAD LYVTHVSAKK
910 920 930 940 950
AKDTYNMFYK EQGYKDSAVR WRSDDYTLVD FVTYIKPVKN VTLQFGVYNL
960 970 980 990
TDRKYLTWES ARSIKPFGTS NLINQGTGAG INRFYSPGRN YKLSAEITF
Length:999
Mass (Da):114,315
Last modified:August 29, 2001 - v3
Checksum:iDAFCD4EB7000A876
GO

Sequence cautioni

The sequence AAC23213.1 differs from that shown. Reason: Frameshift at positions 49 and 289. The first frameshift is found in the repeats region.Curated
The sequence AAC23214.1 differs from that shown. Reason: Frameshift at positions 49 and 289. The first frameshift is found in the repeats region.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC23213.1. Sequence problems.
L42023 Genomic DNA. Translation: AAC23214.1. Sequence problems.
PIRiA64130.

Genome annotation databases

EnsemblBacteriaiAAC23213; AAC23213; HI_1565.
AAC23214; AAC23214; HI_1567.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC23213.1. Sequence problems.
L42023 Genomic DNA. Translation: AAC23214.1. Sequence problems.
PIRiA64130.

3D structure databases

ProteinModelPortaliQ57408.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC23213; AAC23213; HI_1565.
AAC23214; AAC23214; HI_1567.

Family and domain databases

Gene3Di2.170.130.10. 1 hit.
2.40.170.20. 3 hits.
InterProiIPR012910. Plug.
IPR006970. PT.
IPR000531. TonB-dep_rcpt_b-brl.
IPR010949. TonB_Hb/transfer/lactofer_rcpt.
IPR010917. TonB_rcpt_CS.
[Graphical view]
PfamiPF07715. Plug. 1 hit.
PF04886. PT. 1 hit.
PF00593. TonB_dep_Rec. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01786. TonB-hemlactrns. 1 hit.
PROSITEiPS01156. TONB_DEPENDENT_REC_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
  2. White O., Clayton R.A., Kerlavage A.R., Fleischmann R.D., Peterson J., Hickey E., Dodson R., Gwinn M.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.

Entry informationi

Entry nameiHGP4_HAEIN
AccessioniPrimary (citable) accession number: Q57408
Secondary accession number(s): O86244, P96344
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 29, 2001
Last modified: January 7, 2015
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is subject to phase-variable expression associated with alteration in the length of the CCAA repeat region. This mechanism is called slipped-strand mispairing. Addition or loss of CCAA repeat units would change the reading frame and result in introduction of stop codons downstream of the repeat region. This may be a mechanism of regulation and a way to avoid the immunological response of the host (By similarity).By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.