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Q57408

- HGP4_HAEIN

UniProt

Q57408 - HGP4_HAEIN

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Protein

Probable hemoglobin and hemoglobin-haptoglobin-binding protein 4

Gene
HI_1565/HI_1567
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Acts as a receptor for hemoglobin or the hemoglobin/haptoglobin complex of the human host and is required for heme uptake By similarity.

GO - Molecular functioni

  1. receptor activity Source: InterPro
  2. transporter activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Probable hemoglobin and hemoglobin-haptoglobin-binding protein 4
Gene namesi
Ordered Locus Names:HI_1565/HI_1567
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cell outer membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed predictionAdd
BLAST
Chaini25 – 999975Probable hemoglobin and hemoglobin-haptoglobin-binding protein 4PRO_0000034788Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ57408.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati26 – 2941
Repeati30 – 3342
Repeati34 – 3743
Repeati38 – 4144
Repeati42 – 4545
Repeati46 – 4946

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni26 – 49246 X 4 AA tandem repeats of P-T-N-QAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi58 – 658TonB box
Motifi982 – 99918TonB C-terminal boxAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, TonB box, Transmembrane, Transmembrane beta strand

Family and domain databases

Gene3Di2.170.130.10. 1 hit.
2.40.170.20. 3 hits.
InterProiIPR012910. Plug.
IPR006970. PT.
IPR000531. TonB-dep_rcpt_b-brl.
IPR010949. TonB_Hb/transfer/lactofer_rcpt.
IPR010917. TonB_rcpt_CS.
[Graphical view]
PfamiPF07715. Plug. 1 hit.
PF04886. PT. 1 hit.
PF00593. TonB_dep_Rec. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01786. TonB-hemlactrns. 1 hit.
PROSITEiPS01156. TONB_DEPENDENT_REC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q57408-1 [UniParc]FASTAAdd to Basket

« Hide

MTNFRLNVLA YSVMLGLTAS VAYAEPTNQP TNQPTNQPTN QPTNQPTNQN    50
SNASEQLEQI NVLGSDNNND NTPPKIAETV KTASQLKRQQ VQDSRDLVRY 100
ETGVTVVEAG RFGSSGYAIR GVDENRVAIT VDGLHQAETL SSQGFKELFE 150
GYGNFNNTRN SVEIETLKVA KIAKGADSVK VGSGSLGGAV LFETKDARDF 200
LTEKDWHIGY KAGYSTADNQ GLNAVTLAGR YQMFDALIMH SKRHGHELEN 250
YDYKNGRDIQ GKEREKADPY TITKESTLVK FSFSPTENHR FTVASDTYLQ 300
HSRGHDFSYN LVKTTYINKD EEELRHTNDL TKRKNVSFTY ENYTVTPFWD 350
TLKLSYSQQR ITTRARTEDY CDGNEKCDSY KNPLGLQLKE GKVVDRNGDP 400
VELKLVEDEQ GQKRHQVVDK YNNPFSVASG TNNDAFVGKQ LSPSEFWLDC 450
SIFNCDKPVR VYKYQYSNQE PESKEVELNR TMEINGKKFA TYESNNYRDR 500
YHMILPNSKG YLPLDYKERD LNTKTKQINL DLTKAFTLFE IENELSYGGV 550
YAKTTKEMVN KAGYYGRNPT WWAERTLGKS LLNGLRTCKE DSSYNGLLCP 600
RHEPKTSFLI PVETTTKSLY FADNIKLHNM LSVDLGYRYD DIKYQPEYIP 650
GVTPKIADDM VRELFVPLPP ANGKDWQGNP VYTPEQIRKN AEENIAYIAQ 700
EKRFKKHSYS LGATFDPLNF LRVQVKYSKG FRTPTSDELY FTFKHPDFTI 750
LPNPNMKPEE AKNQEIALTF HHDWGFFSTN VFQTKYRQFI DLAYLGSRNL 800
SNSVGGQAQA RDFQVYQNVN VDRAKVKGVE INSRLNIGYF FEKLDGFNVS 850
YKFTYQRGRL DGNRPMNAIQ PKTSVIGLGY DHKEQRFGAD LYVTHVSAKK 900
AKDTYNMFYK EQGYKDSAVR WRSDDYTLVD FVTYIKPVKN VTLQFGVYNL 950
TDRKYLTWES ARSIKPFGTS NLINQGTGAG INRFYSPGRN YKLSAEITF 999
Length:999
Mass (Da):114,315
Last modified:August 29, 2001 - v3
Checksum:iDAFCD4EB7000A876
GO

Sequence cautioni

The sequence AAC23213.1 differs from that shown. Reason: Frameshift at positions 49 and 289. The first frameshift is found in the repeats region.
The sequence AAC23214.1 differs from that shown. Reason: Frameshift at positions 49 and 289. The first frameshift is found in the repeats region.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC23213.1. Sequence problems.
L42023 Genomic DNA. Translation: AAC23214.1. Sequence problems.
PIRiA64130.

Genome annotation databases

EnsemblBacteriaiAAC23213; AAC23213; HI_1565.
AAC23214; AAC23214; HI_1567.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC23213.1 . Sequence problems.
L42023 Genomic DNA. Translation: AAC23214.1 . Sequence problems.
PIRi A64130.

3D structure databases

ProteinModelPortali Q57408.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC23213 ; AAC23213 ; HI_1565 .
AAC23214 ; AAC23214 ; HI_1567 .

Family and domain databases

Gene3Di 2.170.130.10. 1 hit.
2.40.170.20. 3 hits.
InterProi IPR012910. Plug.
IPR006970. PT.
IPR000531. TonB-dep_rcpt_b-brl.
IPR010949. TonB_Hb/transfer/lactofer_rcpt.
IPR010917. TonB_rcpt_CS.
[Graphical view ]
Pfami PF07715. Plug. 1 hit.
PF04886. PT. 1 hit.
PF00593. TonB_dep_Rec. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01786. TonB-hemlactrns. 1 hit.
PROSITEi PS01156. TONB_DEPENDENT_REC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
  2. White O., Clayton R.A., Kerlavage A.R., Fleischmann R.D., Peterson J., Hickey E., Dodson R., Gwinn M.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.

Entry informationi

Entry nameiHGP4_HAEIN
AccessioniPrimary (citable) accession number: Q57408
Secondary accession number(s): O86244, P96344
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 29, 2001
Last modified: February 19, 2014
This is version 92 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is subject to phase-variable expression associated with alteration in the length of the CCAA repeat region. This mechanism is called slipped-strand mispairing. Addition or loss of CCAA repeat units would change the reading frame and result in introduction of stop codons downstream of the repeat region. This may be a mechanism of regulation and a way to avoid the immunological response of the host By similarity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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