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Q57408

- HGP4_HAEIN

UniProt

Q57408 - HGP4_HAEIN

Protein

Probable hemoglobin and hemoglobin-haptoglobin-binding protein 4

Gene

HI_1565/HI_1567

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 3 (29 Aug 2001)
      Previous versions | rss
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    Functioni

    Acts as a receptor for hemoglobin or the hemoglobin/haptoglobin complex of the human host and is required for heme uptake.By similarity

    GO - Molecular functioni

    1. receptor activity Source: InterPro
    2. transporter activity Source: InterPro

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable hemoglobin and hemoglobin-haptoglobin-binding protein 4
    Gene namesi
    Ordered Locus Names:HI_1565/HI_1567
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cell outer membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell outer membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 999975Probable hemoglobin and hemoglobin-haptoglobin-binding protein 4PRO_0000034788Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ57408.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati26 – 2941
    Repeati30 – 3342
    Repeati34 – 3743
    Repeati38 – 4144
    Repeati42 – 4545
    Repeati46 – 4946

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni26 – 49246 X 4 AA tandem repeats of P-T-N-QAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi58 – 658TonB box
    Motifi982 – 99918TonB C-terminal boxAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Repeat, Signal, TonB box, Transmembrane, Transmembrane beta strand

    Family and domain databases

    Gene3Di2.170.130.10. 1 hit.
    2.40.170.20. 3 hits.
    InterProiIPR012910. Plug.
    IPR006970. PT.
    IPR000531. TonB-dep_rcpt_b-brl.
    IPR010949. TonB_Hb/transfer/lactofer_rcpt.
    IPR010917. TonB_rcpt_CS.
    [Graphical view]
    PfamiPF07715. Plug. 1 hit.
    PF04886. PT. 1 hit.
    PF00593. TonB_dep_Rec. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01786. TonB-hemlactrns. 1 hit.
    PROSITEiPS01156. TONB_DEPENDENT_REC_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q57408-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTNFRLNVLA YSVMLGLTAS VAYAEPTNQP TNQPTNQPTN QPTNQPTNQN    50
    SNASEQLEQI NVLGSDNNND NTPPKIAETV KTASQLKRQQ VQDSRDLVRY 100
    ETGVTVVEAG RFGSSGYAIR GVDENRVAIT VDGLHQAETL SSQGFKELFE 150
    GYGNFNNTRN SVEIETLKVA KIAKGADSVK VGSGSLGGAV LFETKDARDF 200
    LTEKDWHIGY KAGYSTADNQ GLNAVTLAGR YQMFDALIMH SKRHGHELEN 250
    YDYKNGRDIQ GKEREKADPY TITKESTLVK FSFSPTENHR FTVASDTYLQ 300
    HSRGHDFSYN LVKTTYINKD EEELRHTNDL TKRKNVSFTY ENYTVTPFWD 350
    TLKLSYSQQR ITTRARTEDY CDGNEKCDSY KNPLGLQLKE GKVVDRNGDP 400
    VELKLVEDEQ GQKRHQVVDK YNNPFSVASG TNNDAFVGKQ LSPSEFWLDC 450
    SIFNCDKPVR VYKYQYSNQE PESKEVELNR TMEINGKKFA TYESNNYRDR 500
    YHMILPNSKG YLPLDYKERD LNTKTKQINL DLTKAFTLFE IENELSYGGV 550
    YAKTTKEMVN KAGYYGRNPT WWAERTLGKS LLNGLRTCKE DSSYNGLLCP 600
    RHEPKTSFLI PVETTTKSLY FADNIKLHNM LSVDLGYRYD DIKYQPEYIP 650
    GVTPKIADDM VRELFVPLPP ANGKDWQGNP VYTPEQIRKN AEENIAYIAQ 700
    EKRFKKHSYS LGATFDPLNF LRVQVKYSKG FRTPTSDELY FTFKHPDFTI 750
    LPNPNMKPEE AKNQEIALTF HHDWGFFSTN VFQTKYRQFI DLAYLGSRNL 800
    SNSVGGQAQA RDFQVYQNVN VDRAKVKGVE INSRLNIGYF FEKLDGFNVS 850
    YKFTYQRGRL DGNRPMNAIQ PKTSVIGLGY DHKEQRFGAD LYVTHVSAKK 900
    AKDTYNMFYK EQGYKDSAVR WRSDDYTLVD FVTYIKPVKN VTLQFGVYNL 950
    TDRKYLTWES ARSIKPFGTS NLINQGTGAG INRFYSPGRN YKLSAEITF 999
    Length:999
    Mass (Da):114,315
    Last modified:August 29, 2001 - v3
    Checksum:iDAFCD4EB7000A876
    GO

    Sequence cautioni

    The sequence AAC23213.1 differs from that shown. Reason: Frameshift at positions 49 and 289. The first frameshift is found in the repeats region.
    The sequence AAC23214.1 differs from that shown. Reason: Frameshift at positions 49 and 289. The first frameshift is found in the repeats region.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC23213.1. Sequence problems.
    L42023 Genomic DNA. Translation: AAC23214.1. Sequence problems.
    PIRiA64130.

    Genome annotation databases

    EnsemblBacteriaiAAC23213; AAC23213; HI_1565.
    AAC23214; AAC23214; HI_1567.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC23213.1 . Sequence problems.
    L42023 Genomic DNA. Translation: AAC23214.1 . Sequence problems.
    PIRi A64130.

    3D structure databases

    ProteinModelPortali Q57408.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC23213 ; AAC23213 ; HI_1565 .
    AAC23214 ; AAC23214 ; HI_1567 .

    Family and domain databases

    Gene3Di 2.170.130.10. 1 hit.
    2.40.170.20. 3 hits.
    InterProi IPR012910. Plug.
    IPR006970. PT.
    IPR000531. TonB-dep_rcpt_b-brl.
    IPR010949. TonB_Hb/transfer/lactofer_rcpt.
    IPR010917. TonB_rcpt_CS.
    [Graphical view ]
    Pfami PF07715. Plug. 1 hit.
    PF04886. PT. 1 hit.
    PF00593. TonB_dep_Rec. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01786. TonB-hemlactrns. 1 hit.
    PROSITEi PS01156. TONB_DEPENDENT_REC_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
    2. White O., Clayton R.A., Kerlavage A.R., Fleischmann R.D., Peterson J., Hickey E., Dodson R., Gwinn M.
      Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.

    Entry informationi

    Entry nameiHGP4_HAEIN
    AccessioniPrimary (citable) accession number: Q57408
    Secondary accession number(s): O86244, P96344
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: August 29, 2001
    Last modified: October 1, 2014
    This is version 93 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    This protein is subject to phase-variable expression associated with alteration in the length of the CCAA repeat region. This mechanism is called slipped-strand mispairing. Addition or loss of CCAA repeat units would change the reading frame and result in introduction of stop codons downstream of the repeat region. This may be a mechanism of regulation and a way to avoid the immunological response of the host By similarity.By similarity

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3