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Unreviewed, UniProtKB/TrEMBL Q573B4 (Q573B4_HUMAN)

Last modified February 9, 2010. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

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Names and origin

Protein namesSubmitted name:
    Proto-oncogene tyrosine-protein kinase LCK EMBL CAI23831.1
Gene names
Name: LCK EMBL CAI23831.1
OrganismHomo sapiens (Human) EMBL CAI23831.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length516 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. Spearmint SPM000980

Sequence similarities

Contains 1 SH2 domain.

Contains 1 SH3 domain.

Contains 1 protein kinase domain.

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Sequences

Sequence LengthMass (Da)Tools
Q573B4-1 [UniParc].

Last modified May 10, 2005. Version 1.
Checksum: EB9A52D4EBDF14D2

FASTA51658,333
        10         20         30         40         50         60 
MGCGCSSHPE DDWMENIDVC ENCHYPIVPL DGKGTLLIRN GSEVRDPLVT YEGSNPPASP 

        70         80         90        100        110        120 
LQGDPRQQGL KDKACGSLAV GFHLSPTYFL PGLAFLVPHP VTPGFLPIPA RFSLMPLVFT 

       130        140        150        160        170        180 
DNLVIALHSY EPSHDGDLGF EKGEQLRILE QSGEWWKAQS LTTGQEGFIP FNFVAKANSL 

       190        200        210        220        230        240 
EPEPWFFKNL SRKDAERQLL APGNTHGSFL IRESESTAGS FSLSVRDFDQ NQGEVVKHYK 

       250        260        270        280        290        300 
IRNLDNGGFY ISPRITFPGL HELVRHYTRY YNGHTKVAVK SLKQGSMSPD AFLAEANLMK 

       310        320        330        340        350        360 
QLQHQRLVRL YAVVTQEPIY IITEYMENGS LVDFLKTPSG IKLTINKLLD MAAQIAEGMA 

       370        380        390        400        410        420 
FIEERNYIHR DLRAANILVS DTLSCKIADF GLARLIEDNE YTAREGAKFP IKWTAPEAIN 

       430        440        450        460        470        480 
YGTFTIKSDV WSFGILLTEI VTHGRIPYPG MTNPEVIQNL ERGYRMVRPD NCPEELYQLM 

       490        500        510 
RLCWKERPED RPTFDYLRSV LEDFFTATEG QYQPQP

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References

[1]"A rare mRNA variant of the human lymphocyte-specific protein tyrosine kinase LCK gene with intron B retention and exon 7 skipping encodes a putative protein with altered SH3-dependent molecular interactions."
Nervi S., Guinamard R., Delaval B., Lecine P., Vialettes B., Naquet P., Imbert J.
Gene 359:18-25(2005) [PubMed: 16107303] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Blood EMBL CAI23831.1.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ865079 mRNA. Translation: CAI23831.1.
IPIIPI00555672.
UniGeneHs.470627

3D structure databases

SMRQ573B4. Positions 7-35, 121-178, 123-516.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ573B4.

Proteomic databases

PRIDEQ573B4.

Genome annotation databases

EnsemblENST00000373564; ENSP00000362665; ENSG00000182866; Homo sapiens. [Genome view]
UCSCuc001bva.1. human.

Organism-specific databases

HGNCHGNC:6524. LCK.
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ573B4.

Gene expression databases

ArrayExpressQ573B4.
BgeeQ573B4.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR020473. SH3_region.
IPR020749. Tyr_kinase_non-rcpt_Lck.
IPR020635. Tyr_Pkinase_cat_dom.
IPR020685. Tyr_prot_kinase.
IPR008266. Tyr_prot_kinase_AS.
[Graphical view]
Gene3DG3DSA:3.30.505.10. SH2. 1 hit.
PANTHERPTHR23256:SF260. Tyr_kinase_non-rcpt_Lck. 1 hit.
PTHR23256. Tyr_prot_kinase. 1 hit.
PfamPF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameQ573B4_HUMAN
AccessionPrimary (citable) accession number: Q573B4
Entry history
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: February 9, 2010
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information