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Protein

Tyrosine-protein kinase

Gene

LCK

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:LCKImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000182866.16
HGNCiHGNC:6524 LCK

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000182866

PTM / Processingi

Proteomic databases

MaxQBiQ573B4
PeptideAtlasiQ573B4

Expressioni

Gene expression databases

BgeeiENSG00000182866

Interactioni

Protein-protein interaction databases

IntActiQ573B4, 7 interactors

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini119 – 179SH3InterPro annotationAdd BLAST61
Domaini185 – 286SH2InterPro annotationAdd BLAST102
Domaini238 – 505Protein kinaseInterPro annotationAdd BLAST268

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotationSAAS annotation

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118938
HOGENOMiHOG000233858
HOVERGENiHBG008761

Family and domain databases

CDDicd10362 SH2_Src_Lck, 1 hit
cd12005 SH3_Lck, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR035850 Lck_SH2
IPR035749 Lck_SH3
IPR000719 Prot_kinase_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PF00017 SH2, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00452 SH3DOMAIN
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00326 SH3, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF55550 SSF55550, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50001 SH2, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Q573B4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCGCSSHPE DDWMENIDVC ENCHYPIVPL DGKGTLLIRN GSEVRDPLVT
60 70 80 90 100
YEGSNPPASP LQGDPRQQGL KDKACGSLAV GFHLSPTYFL PGLAFLVPHP
110 120 130 140 150
VTPGFLPIPA RFSLMPLVFT DNLVIALHSY EPSHDGDLGF EKGEQLRILE
160 170 180 190 200
QSGEWWKAQS LTTGQEGFIP FNFVAKANSL EPEPWFFKNL SRKDAERQLL
210 220 230 240 250
APGNTHGSFL IRESESTAGS FSLSVRDFDQ NQGEVVKHYK IRNLDNGGFY
260 270 280 290 300
ISPRITFPGL HELVRHYTRY YNGHTKVAVK SLKQGSMSPD AFLAEANLMK
310 320 330 340 350
QLQHQRLVRL YAVVTQEPIY IITEYMENGS LVDFLKTPSG IKLTINKLLD
360 370 380 390 400
MAAQIAEGMA FIEERNYIHR DLRAANILVS DTLSCKIADF GLARLIEDNE
410 420 430 440 450
YTAREGAKFP IKWTAPEAIN YGTFTIKSDV WSFGILLTEI VTHGRIPYPG
460 470 480 490 500
MTNPEVIQNL ERGYRMVRPD NCPEELYQLM RLCWKERPED RPTFDYLRSV
510
LEDFFTATEG QYQPQP
Length:516
Mass (Da):58,333
Last modified:May 10, 2005 - v1
Checksum:iEB9A52D4EBDF14D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL109945 Genomic DNA No translation available.
AL121991 Genomic DNA No translation available.
AJ865079 mRNA Translation: CAI23831.1
RefSeqiXP_011539755.1, XM_011541453.2
XP_011539756.1, XM_011541454.2
UniGeneiHs.470627

Genome annotation databases

EnsembliENST00000373564; ENSP00000362665; ENSG00000182866
GeneIDi3932
UCSCiuc057ejm.1 human

Similar proteinsi

Entry informationi

Entry nameiQ573B4_HUMAN
AccessioniPrimary (citable) accession number: Q573B4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: April 25, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health