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Protein

Tyrosine-protein kinase

Gene

LCK

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:LCKImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:6524. LCK.

PTM / Processingi

Proteomic databases

PeptideAtlasiQ573B4.

Expressioni

Gene expression databases

BgeeiENSG00000182866.

Structurei

3D structure databases

SMRiQ573B4. Positions 7-35, 121-516.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini119 – 17961SH3InterPro annotationAdd
BLAST
Domaini185 – 286102SH2InterPro annotationAdd
BLAST
Domaini238 – 505268Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotationSAAS annotation
Contains 1 SH2 domain.UniRule annotation
Contains 1 SH3 domain.UniRule annotation
Contains 1 protein kinase domain.UniRule annotation

Keywords - Domaini

SH3 domainUniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118938.
HOGENOMiHOG000233858.
HOVERGENiHBG008761.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q573B4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCGCSSHPE DDWMENIDVC ENCHYPIVPL DGKGTLLIRN GSEVRDPLVT
60 70 80 90 100
YEGSNPPASP LQGDPRQQGL KDKACGSLAV GFHLSPTYFL PGLAFLVPHP
110 120 130 140 150
VTPGFLPIPA RFSLMPLVFT DNLVIALHSY EPSHDGDLGF EKGEQLRILE
160 170 180 190 200
QSGEWWKAQS LTTGQEGFIP FNFVAKANSL EPEPWFFKNL SRKDAERQLL
210 220 230 240 250
APGNTHGSFL IRESESTAGS FSLSVRDFDQ NQGEVVKHYK IRNLDNGGFY
260 270 280 290 300
ISPRITFPGL HELVRHYTRY YNGHTKVAVK SLKQGSMSPD AFLAEANLMK
310 320 330 340 350
QLQHQRLVRL YAVVTQEPIY IITEYMENGS LVDFLKTPSG IKLTINKLLD
360 370 380 390 400
MAAQIAEGMA FIEERNYIHR DLRAANILVS DTLSCKIADF GLARLIEDNE
410 420 430 440 450
YTAREGAKFP IKWTAPEAIN YGTFTIKSDV WSFGILLTEI VTHGRIPYPG
460 470 480 490 500
MTNPEVIQNL ERGYRMVRPD NCPEELYQLM RLCWKERPED RPTFDYLRSV
510
LEDFFTATEG QYQPQP
Length:516
Mass (Da):58,333
Last modified:May 10, 2005 - v1
Checksum:iEB9A52D4EBDF14D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL109945 Genomic DNA. No translation available.
AL121991 Genomic DNA. No translation available.
AJ865079 mRNA. Translation: CAI23831.1.
RefSeqiXP_011539755.1. XM_011541453.2.
XP_011539756.1. XM_011541454.2.
UniGeneiHs.470627.

Genome annotation databases

EnsembliENST00000373564; ENSP00000362665; ENSG00000182866.
GeneIDi3932.
UCSCiuc057ejm.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL109945 Genomic DNA. No translation available.
AL121991 Genomic DNA. No translation available.
AJ865079 mRNA. Translation: CAI23831.1.
RefSeqiXP_011539755.1. XM_011541453.2.
XP_011539756.1. XM_011541454.2.
UniGeneiHs.470627.

3D structure databases

SMRiQ573B4. Positions 7-35, 121-516.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiQ573B4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373564; ENSP00000362665; ENSG00000182866.
GeneIDi3932.
UCSCiuc057ejm.1. human.

Organism-specific databases

CTDi3932.
HGNCiHGNC:6524. LCK.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118938.
HOGENOMiHOG000233858.
HOVERGENiHBG008761.

Miscellaneous databases

ChiTaRSiLCK. human.
GenomeRNAii3932.

Gene expression databases

BgeeiENSG00000182866.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ573B4_HUMAN
AccessioniPrimary (citable) accession number: Q573B4
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: September 7, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.