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Protein
Submitted name:

Streptokinase

Gene

ska

Organism
Streptococcus pyogenes
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
StreptokinaseImported
Gene namesi
Name:skaImported
OrganismiStreptococcus pyogenesImported
Taxonomic identifieri1314 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 440414Sequence analysisPRO_5007704495Add
BLAST

Family & Domainsi

Keywords - Domaini

SignalSequence analysis

Family and domain databases

InterProiIPR004093. SAK/SK.
IPR008124. SK.
[Graphical view]
PfamiPF02821. Staphylokinase. 3 hits.
[Graphical view]
PRINTSiPR01753. STREPKINASE.
SUPFAMiSSF54328. SSF54328. 3 hits.

Sequencei

Sequence statusi: Complete.

Q57391-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNYLSFGMF ALLFALTFGT VKPVQAIAGY EWLLDRPSVN NSQLVVSVAG
60 70 80 90 100
TVEGTNQEIS LKFFEIDLTS RPAHGGKTEQ GLSPKSKPFA TDKGAMSHKL
110 120 130 140 150
EKADLLKAIQ EQLIANVHSN DGYFEVIDFA SDATITDRNG KVYFADKDDS
160 170 180 190 200
VTLPTQPVQE FLLSGHVRVK PYQPKAVHNS AERVNVNYEV SFVSETGDLD
210 220 230 240 250
FTPLLRNQYH LTTLAVGDSL SSQELAAIAQ FILSKKHPDY IITKRDSSIV
260 270 280 290 300
THDNDIFRTI LPMDQEFTYH IKDREQAYKA NSKTGIEEKT NNTDLISEKY
310 320 330 340 350
YVLKKGEKPY DPFDRSHLKL FTINYVDVNT NKLLKSEQLL TASERNLDFR
360 370 380 390 400
DLYDPRDKAK LLYNNLDAFG IMDYTLTGKV EDNHDDTNRI ITVYMGKRPE
410 420 430 440
GENASYHLAY DKDRYTEEER EVYSYLRYTG TPIPDNPKDK
Length:440
Mass (Da):50,084
Last modified:November 1, 1996 - v1
Checksum:iCD95775139E3F883
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19347 Genomic DNA. Translation: AAA26973.1.
AY234135 Genomic DNA. Translation: AAP39955.1.
PIRiA43867. JU0292.
S04168.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19347 Genomic DNA. Translation: AAA26973.1.
AY234135 Genomic DNA. Translation: AAP39955.1.
PIRiA43867. JU0292.
S04168.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR004093. SAK/SK.
IPR008124. SK.
[Graphical view]
PfamiPF02821. Staphylokinase. 3 hits.
[Graphical view]
PRINTSiPR01753. STREPKINASE.
SUPFAMiSSF54328. SSF54328. 3 hits.
ProtoNetiSearch...

Publicationsi

  1. "The streptokinase gene of group A streptococci: cloning, expression in Escherichia coli, and sequence analysis."
    Huang T.T., Malke H., Ferretti J.J.
    Mol. Microbiol. 3:197-205(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: N2131Imported.
  2. "Immunochemical studies and complete amino acid sequence of the streptokinase from Streptococcus pyogenes (group A) M type 12 strain A374."
    Ohkuni H., Todome Y., Suzuki H., Mizuse M., Kotani N., Horiuchi K., Shikama N., Tsugita A., Johnston K.H.
    Infect. Immun. 60:278-283(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
  3. "Natural selection and evolution of streptococcal virulence genes involved in tissue-specific adaptations."
    Kalia A., Bessen D.E.
    J. Bacteriol. 186:110-121(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: B737Imported.

Entry informationi

Entry nameiQ57391_STRPY
AccessioniPrimary (citable) accession number: Q57391
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.