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Protein

UDP-glucose 6-dehydrogenase

Gene

cap3A

Organism
Streptococcus pneumoniae
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of UDP-glucuronic acid which is required for capsular hyaluronic acid synthesis. Directly responsible for the transformation of some unencapsulated serotype-3 SP mutants to the encapsulated phenotype.

Catalytic activityi

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.

Pathwayi: UDP-alpha-D-glucuronate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes UDP-alpha-D-glucuronate from UDP-alpha-D-glucose.
Proteins known to be involved in this subpathway in this organism are:
  1. UDP-glucose 6-dehydrogenase (cap3A)
This subpathway is part of the pathway UDP-alpha-D-glucuronate biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UDP-alpha-D-glucuronate from UDP-alpha-D-glucose, the pathway UDP-alpha-D-glucuronate biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei259By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi2 – 19NADSequence analysisAdd BLAST18

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCapsule biogenesis/degradation
LigandNAD

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-18145.
UniPathwayiUPA00038; UER00491.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose 6-dehydrogenase (EC:1.1.1.22)
Short name:
UDP-Glc dehydrogenase
Short name:
UDP-GlcDH
Short name:
UDPGDH
Gene namesi
Name:cap3A
Synonyms:cps3D
OrganismiStreptococcus pneumoniae
Taxonomic identifieri1313 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000740531 – 394UDP-glucose 6-dehydrogenaseAdd BLAST394

Structurei

3D structure databases

ProteinModelPortaliQ57346.
SMRiQ57346.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
1.20.5.100. 1 hit.
InterProiView protein in InterPro
IPR008927. 6-PGluconate_DH-like_C_sf.
IPR013328. 6PGD_dom2.
IPR021157. Cyt_c1_TM_anchor_C.
IPR036291. NAD(P)-bd_dom_sf.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR036220. UDP-Glc/GDP-Man_DH_C_sf.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028357. UDPglc_DH_bac.
PfamiView protein in Pfam
PF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
PIRSFiPIRSF500134. UDPglc_DH_bac. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTiView protein in SMART
SM00984. UDPG_MGDP_dh_C. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q57346-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIAIAGSGY VGLSLAVLLA QHHEVKVIDV IKDKVESINN RKSPIKDEAI
60 70 80 90 100
EKYLVEKELN LEASLDPAHV YKDVEYAIIA TPTNYDVDLN QFDTSSVEAA
110 120 130 140 150
IKTCMEYNDT CTIVIKSTIP EGYTKEVREK FNTDRIIFSP EFLRESKALY
160 170 180 190 200
DNLYPSRIVV GTDLDDSELT KRAWQFADLL KGGAIKEEVP ILVVAFNEAE
210 220 230 240 250
VAKLFSNTYL ATRVRYFNEI DTYSEVKGLN PKTIIDIVCY DPRIGSYYNN
260 270 280 290 300
PSFGYGGYCL PKDTKQLKAS FRDVPENLIT AVVQSNKTRK DYIAGAILAK
310 320 330 340 350
QPSVVGIYRL IMKSDSDNFR SSAVKGVMER LDNYGKEIVI YEPTIECDTF
360 370 380 390
MGYRVIKSLD EFKNISDIVV ANRMNDDLRD IQEKLYTRDL FGRE
Length:394
Mass (Da):44,697
Last modified:May 30, 2000 - v2
Checksum:iC68671ED88140FC3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti215R → A in AAC43311 (PubMed:7869055).Curated1
Sequence conflicti247Y → D in AAC43311 (PubMed:7869055).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47210 Genomic DNA. Translation: CAA87403.1.
Z12159 Genomic DNA. Translation: CAA78147.1.
U15171 Genomic DNA. Translation: AAC43311.1.

Similar proteinsi

Entry informationi

Entry nameiUDG_STREE
AccessioniPrimary (citable) accession number: Q57346
Secondary accession number(s): P72519, Q54610
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: November 22, 2017
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families