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Q57346 (UDG_STREE) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-glucose 6-dehydrogenase

Short name=UDP-Glc dehydrogenase
Short name=UDP-GlcDH
Short name=UDPGDH
EC=1.1.1.22
Gene names
Name:cap3A
Synonyms:cps3D
OrganismStreptococcus pneumoniae
Taxonomic identifier1313 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length394 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of UDP-glucuronic acid which is required for capsular hyaluronic acid synthesis. Directly responsible for the transformation of some unencapsulated serotype-3 SP mutants to the encapsulated phenotype.

Catalytic activity

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.

Pathway

Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.

Sequence similarities

Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

Ontologies

Keywords
   Biological processCapsule biogenesis/degradation
   LigandNAD
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processUDP-glucuronate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

polysaccharide biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

UDP-glucose 6-dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 394394UDP-glucose 6-dehydrogenase
PRO_0000074053

Regions

Nucleotide binding2 – 1918NAD Potential

Sites

Active site2591 By similarity

Experimental info

Sequence conflict2151R → A in AAC43311. Ref.4
Sequence conflict2471Y → D in AAC43311. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q57346 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: C68671ED88140FC3

FASTA39444,697
        10         20         30         40         50         60 
MKIAIAGSGY VGLSLAVLLA QHHEVKVIDV IKDKVESINN RKSPIKDEAI EKYLVEKELN 

        70         80         90        100        110        120 
LEASLDPAHV YKDVEYAIIA TPTNYDVDLN QFDTSSVEAA IKTCMEYNDT CTIVIKSTIP 

       130        140        150        160        170        180 
EGYTKEVREK FNTDRIIFSP EFLRESKALY DNLYPSRIVV GTDLDDSELT KRAWQFADLL 

       190        200        210        220        230        240 
KGGAIKEEVP ILVVAFNEAE VAKLFSNTYL ATRVRYFNEI DTYSEVKGLN PKTIIDIVCY 

       250        260        270        280        290        300 
DPRIGSYYNN PSFGYGGYCL PKDTKQLKAS FRDVPENLIT AVVQSNKTRK DYIAGAILAK 

       310        320        330        340        350        360 
QPSVVGIYRL IMKSDSDNFR SSAVKGVMER LDNYGKEIVI YEPTIECDTF MGYRVIKSLD 

       370        380        390 
EFKNISDIVV ANRMNDDLRD IQEKLYTRDL FGRE 

« Hide

References

[1]"Molecular characterization of cap3A, a gene from the operon required for the synthesis of the capsule of Streptococcus pneumoniae type 3: sequencing of mutations responsible for the unencapsulated phenotype and localization of the capsular cluster on the pneumococcal chromosome."
Arrecubieta C., Lopez R., Garcia E.
J. Bacteriol. 176:6375-6383(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 406 / Type 3.
[2]"Sequence and transcriptional analysis of a DNA region involved in the production of capsular polysaccharide in Streptococcus pneumoniae type 3."
Arrecubieta C., Garcia E., Lopez R.
Gene 167:1-7(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 406 / Type 3.
[3]Garcia E., Arrecubieta C., Munoz R., Mollerach M., Lopez R.
Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO 129 AND 228.
[4]"Characterization of the cassette containing genes for type 3 capsular polysaccharide biosynthesis in Streptococcus pneumoniae."
Dillard J.P., Vandersea M.W., Yother J.
J. Exp. Med. 181:973-983(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: WU2 / Serotype 3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z47210 Genomic DNA. Translation: CAA87403.1.
Z12159 Genomic DNA. Translation: CAA78147.1.
U15171 Genomic DNA. Translation: AAC43311.1.

3D structure databases

ProteinModelPortalQ57346.
SMRQ57346. Positions 1-394.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-18145.
UniPathwayUPA00038; UER00491.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 2 hits.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028357. UDPglc_DH_bac.
[Graphical view]
PANTHERPTHR11374. PTHR11374. 1 hit.
PfamPF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view]
PIRSFPIRSF500134. UDPglc_DH_bac. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTSM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view]
SUPFAMSSF48179. SSF48179. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsTIGR03026. NDP-sugDHase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUDG_STREE
AccessionPrimary (citable) accession number: Q57346
Secondary accession number(s): P72519, Q54610
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: December 11, 2013
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways