ID   LPXB_SYNY3              Reviewed;         394 AA.
AC   Q57310;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   27-MAR-2024, entry version 127.
DE   RecName: Full=Lipid-A-disaccharide synthase;
DE            EC=2.4.1.182;
GN   Name=lpxB; OrderedLocusNames=slr0015;
OS   Synechocystis sp. (strain PCC 6803 / Kazusa).
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales; Merismopediaceae;
OC   Synechocystis.
OX   NCBI_TaxID=1111708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Cassier-Chauvat C., Poncelet M., Villoing S., Chauvat F.;
RL   Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27184 / PCC 6803 / N-1;
RX   PubMed=8590279; DOI=10.1093/dnares/2.4.153;
RA   Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N.,
RA   Sugiura M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region
RT   from map positions 64% to 92% of the genome.";
RL   DNA Res. 2:153-166(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 6803 / Kazusa;
RX   PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA   Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA   Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT   genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
CC   -!- FUNCTION: Condensation of UDP-2,3-diacylglucosamine and 2,3-
CC       diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor
CC       of lipid A, a phosphorylated glycolipid that anchors the
CC       lipopolysaccharide to the outer membrane of the cell. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-
CC         glucosamine = a lipid A disaccharide + H(+) + UDP;
CC         Xref=Rhea:RHEA:67828, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223,
CC         ChEBI:CHEBI:137748, ChEBI:CHEBI:176338, ChEBI:CHEBI:176343;
CC         EC=2.4.1.182;
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.
CC   -!- SIMILARITY: Belongs to the LpxB family. {ECO:0000305}.
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DR   EMBL; U38802; AAB72026.1; -; Genomic_DNA.
DR   EMBL; BA000022; BAA10196.1; -; Genomic_DNA.
DR   PIR; S76344; S76344.
DR   AlphaFoldDB; Q57310; -.
DR   SMR; Q57310; -.
DR   IntAct; Q57310; 1.
DR   STRING; 1148.gene:10499693; -.
DR   CAZy; GT19; Glycosyltransferase Family 19.
DR   PaxDb; 1148-1001569; -.
DR   EnsemblBacteria; BAA10196; BAA10196; BAA10196.
DR   KEGG; syn:slr0015; -.
DR   eggNOG; COG0763; Bacteria.
DR   InParanoid; Q57310; -.
DR   PhylomeDB; Q57310; -.
DR   UniPathway; UPA00973; -.
DR   Proteomes; UP000001425; Chromosome.
DR   GO; GO:0008915; F:lipid-A-disaccharide synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005543; F:phospholipid binding; IBA:GO_Central.
DR   GO; GO:0009245; P:lipid A biosynthetic process; IBA:GO_Central.
DR   HAMAP; MF_00392; LpxB; 1.
DR   InterPro; IPR003835; Glyco_trans_19.
DR   NCBIfam; TIGR00215; lpxB; 1.
DR   PANTHER; PTHR30372; LIPID-A-DISACCHARIDE SYNTHASE; 1.
DR   PANTHER; PTHR30372:SF7; LIPID-A-DISACCHARIDE SYNTHASE; 1.
DR   Pfam; PF02684; LpxB; 1.
DR   SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase; Lipid A biosynthesis; Lipid biosynthesis;
KW   Lipid metabolism; Reference proteome; Transferase.
FT   CHAIN           1..394
FT                   /note="Lipid-A-disaccharide synthase"
FT                   /id="PRO_0000190187"
SQ   SEQUENCE   394 AA;  43468 MW;  DCD5FD0F49F95ACF CRC64;
     MRIFISTGEV SGDLQGSLLV GALRQQAEEQ NLELELVGLG GEKMAAAGLT LLANTAAIGS
     VGLTESLRFI IPTWQIQQRV KRYLKTNPID LLVLIDYMGP NLTIANYLRK TYPNLPILYY
     IAPQAWVWSP TKRETAQIMA VTDRLLAIFP GEAEFFQKQG LDVTWVGHPL LDRITKEAPS
     RGSAREKLGI DHNETVITLL PASRIQELRY LLPSICGAAQ QLQSQLPNVK LLLPVSLKDY
     QPQIEQTLKE FNLTVQLLEG KETLTAIAAA DLAITKSGTV NLEIALLNVP QVILYRVSPL
     TMAIARRIFK FNLPFVSPTN IVLNRGIMPE LLQEQATASN IAQAGLELLL NGDRQAKIAQ
     DYQELREALG EPGVCERAAQ AVLEFANGQQ KSRA
//