Q57310 (LPXB_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lipid-A-disaccharide synthase
EC=2.4.1.182

Gene names

Name:	lpxB
Ordered Locus Names:	slr0015

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechocystis › Synechocystis sp. PCC 6803

Protein attributes

Sequence length	394 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392
Sequence similarities	Belongs to the LpxB family.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid biosynthesis Lipid metabolism
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 394	394	Lipid-A-disaccharide synthase HAMAP-Rule MF_00392		PRO_0000190187

Sequences

	Sequence		Length	Mass (Da)
	Q57310 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: DCD5FD0F49F95ACF	FASTA	394	43,468
	10 20 30 40 50 60 MRIFISTGEV SGDLQGSLLV GALRQQAEEQ NLELELVGLG GEKMAAAGLT LLANTAAIGS 70 80 90 100 110 120 VGLTESLRFI IPTWQIQQRV KRYLKTNPID LLVLIDYMGP NLTIANYLRK TYPNLPILYY 130 140 150 160 170 180 IAPQAWVWSP TKRETAQIMA VTDRLLAIFP GEAEFFQKQG LDVTWVGHPL LDRITKEAPS 190 200 210 220 230 240 RGSAREKLGI DHNETVITLL PASRIQELRY LLPSICGAAQ QLQSQLPNVK LLLPVSLKDY 250 260 270 280 290 300 QPQIEQTLKE FNLTVQLLEG KETLTAIAAA DLAITKSGTV NLEIALLNVP QVILYRVSPL 310 320 330 340 350 360 TMAIARRIFK FNLPFVSPTN IVLNRGIMPE LLQEQATASN IAQAGLELLL NGDRQAKIAQ 370 380 390 DYQELREALG EPGVCERAAQ AVLEFANGQQ KSRA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Cassier-Chauvat C., Poncelet M., Villoing S., Chauvat F. Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome." Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S. DNA Res. 2:153-166(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27184 / PCC 6803 / N-1.
[3]	"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U38802 Genomic DNA. Translation: AAB72026.1. BA000022 Genomic DNA. Translation: BAA10196.1.
PIR	S76344.
RefSeq	NP_442126.1. NC_000911.1. YP_005652184.1. NC_017277.1. YP_007452003.1. NC_020286.1.
3D structure databases
ProteinModelPortal	Q57310.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q57310. 1 interaction.
STRING	1148.slr0015.
Protein family/group databases
CAZy	GT19. Glycosyltransferase Family 19.
Proteomic databases
PaxDb	Q57310.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAA10196; BAA10196; BAA10196.
GeneID	12253401. 14617677. 952658.
KEGG	syn:slr0015. syy:SYNGTS_2231.
PATRIC	23841856. VBISynSp132158_2472.
Phylogenomic databases
eggNOG	COG0763.
HOGENOM	HOG000018004.
KO	K00748.
OMA	IPRILGI.
ProtClustDB	PRK00025.
Enzyme and pathway databases
UniPathway	UPA00359; UER00481.
Family and domain databases
HAMAP	MF_00392. LpxB.
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. lpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LPXB_SYNY3

Accession

Primary (citable) accession number: Q57310

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program