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Q57310

- LPXB_SYNY3

UniProt

Q57310 - LPXB_SYNY3

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.By similarity

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthase (EC:2.4.1.182)
    Gene namesi
    Name:lpxB
    Ordered Locus Names:slr0015
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 394394Lipid-A-disaccharide synthasePRO_0000190187Add
    BLAST

    Proteomic databases

    PaxDbiQ57310.

    Interactioni

    Protein-protein interaction databases

    IntActiQ57310. 1 interaction.
    STRINGi1148.slr0015.

    Structurei

    3D structure databases

    ProteinModelPortaliQ57310.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.Curated

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018004.
    KOiK00748.
    OMAiEWTINPP.
    OrthoDBiEOG6FBWZR.
    PhylomeDBiQ57310.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q57310-1 [UniParc]FASTAAdd to Basket

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    MRIFISTGEV SGDLQGSLLV GALRQQAEEQ NLELELVGLG GEKMAAAGLT    50
    LLANTAAIGS VGLTESLRFI IPTWQIQQRV KRYLKTNPID LLVLIDYMGP 100
    NLTIANYLRK TYPNLPILYY IAPQAWVWSP TKRETAQIMA VTDRLLAIFP 150
    GEAEFFQKQG LDVTWVGHPL LDRITKEAPS RGSAREKLGI DHNETVITLL 200
    PASRIQELRY LLPSICGAAQ QLQSQLPNVK LLLPVSLKDY QPQIEQTLKE 250
    FNLTVQLLEG KETLTAIAAA DLAITKSGTV NLEIALLNVP QVILYRVSPL 300
    TMAIARRIFK FNLPFVSPTN IVLNRGIMPE LLQEQATASN IAQAGLELLL 350
    NGDRQAKIAQ DYQELREALG EPGVCERAAQ AVLEFANGQQ KSRA 394
    Length:394
    Mass (Da):43,468
    Last modified:November 1, 1996 - v1
    Checksum:iDCD5FD0F49F95ACF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U38802 Genomic DNA. Translation: AAB72026.1.
    BA000022 Genomic DNA. Translation: BAA10196.1.
    PIRiS76344.
    RefSeqiNP_442126.1. NC_000911.1.
    YP_005652184.1. NC_017277.1.
    YP_007452003.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA10196; BAA10196; BAA10196.
    GeneIDi952658.
    KEGGisyn:slr0015.
    syy:SYNGTS_2231.
    syz:MYO_122550.
    PATRICi23841856. VBISynSp132158_2472.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U38802 Genomic DNA. Translation: AAB72026.1 .
    BA000022 Genomic DNA. Translation: BAA10196.1 .
    PIRi S76344.
    RefSeqi NP_442126.1. NC_000911.1.
    YP_005652184.1. NC_017277.1.
    YP_007452003.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali Q57310.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q57310. 1 interaction.
    STRINGi 1148.slr0015.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Proteomic databases

    PaxDbi Q57310.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA10196 ; BAA10196 ; BAA10196 .
    GeneIDi 952658.
    KEGGi syn:slr0015.
    syy:SYNGTS_2231.
    syz:MYO_122550.
    PATRICi 23841856. VBISynSp132158_2472.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018004.
    KOi K00748.
    OMAi EWTINPP.
    OrthoDBi EOG6FBWZR.
    PhylomeDBi Q57310.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cassier-Chauvat C., Poncelet M., Villoing S., Chauvat F.
      Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome."
      Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S.
      DNA Res. 2:153-166(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27184 / PCC 6803 / N-1.
    3. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiLPXB_SYNY3
    AccessioniPrimary (citable) accession number: Q57310
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3