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Q57310 (LPXB_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lipid-A-disaccharide synthase

EC=2.4.1.182
Gene names
Name:lpxB
Ordered Locus Names:slr0015
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]
Taxonomic identifier1111708 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis

Protein attributes

Sequence length394 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392

Catalytic activity

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392

Sequence similarities

Belongs to the LpxB family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 394394Lipid-A-disaccharide synthase HAMAP-Rule MF_00392
PRO_0000190187

Sequences

Sequence LengthMass (Da)Tools
Q57310 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: DCD5FD0F49F95ACF

FASTA39443,468
        10         20         30         40         50         60 
MRIFISTGEV SGDLQGSLLV GALRQQAEEQ NLELELVGLG GEKMAAAGLT LLANTAAIGS 

        70         80         90        100        110        120 
VGLTESLRFI IPTWQIQQRV KRYLKTNPID LLVLIDYMGP NLTIANYLRK TYPNLPILYY 

       130        140        150        160        170        180 
IAPQAWVWSP TKRETAQIMA VTDRLLAIFP GEAEFFQKQG LDVTWVGHPL LDRITKEAPS 

       190        200        210        220        230        240 
RGSAREKLGI DHNETVITLL PASRIQELRY LLPSICGAAQ QLQSQLPNVK LLLPVSLKDY 

       250        260        270        280        290        300 
QPQIEQTLKE FNLTVQLLEG KETLTAIAAA DLAITKSGTV NLEIALLNVP QVILYRVSPL 

       310        320        330        340        350        360 
TMAIARRIFK FNLPFVSPTN IVLNRGIMPE LLQEQATASN IAQAGLELLL NGDRQAKIAQ 

       370        380        390 
DYQELREALG EPGVCERAAQ AVLEFANGQQ KSRA 

« Hide

References

« Hide 'large scale' references
[1]Cassier-Chauvat C., Poncelet M., Villoing S., Chauvat F.
Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome."
Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S.
DNA Res. 2:153-166(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 27184 / PCC 6803 / N-1.
[3]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U38802 Genomic DNA. Translation: AAB72026.1.
BA000022 Genomic DNA. Translation: BAA10196.1.
PIRS76344.
RefSeqNP_442126.1. NC_000911.1.
YP_005652184.1. NC_017277.1.
YP_007452003.1. NC_020286.1.

3D structure databases

ProteinModelPortalQ57310.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ57310. 1 interaction.
STRING1148.slr0015.

Protein family/group databases

CAZyGT19. Glycosyltransferase Family 19.

Proteomic databases

PaxDbQ57310.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA10196; BAA10196; BAA10196.
GeneID12253401.
14617677.
952658.
KEGGsyn:slr0015.
syy:SYNGTS_2231.
syz:MYO_122550.
PATRIC23841856. VBISynSp132158_2472.

Phylogenomic databases

eggNOGCOG0763.
HOGENOMHOG000018004.
KOK00748.
OMAYIAPQEW.
OrthoDBEOG6FBWZR.
PhylomeDBQ57310.
ProtClustDBPRK00025.

Enzyme and pathway databases

UniPathwayUPA00359; UER00481.

Family and domain databases

HAMAPMF_00392. LpxB.
InterProIPR003835. Glyco_trans_19.
[Graphical view]
PfamPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00215. lpxB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLPXB_SYNY3
AccessionPrimary (citable) accession number: Q57310
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways