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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.By similarity

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:slr0015
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Lipid-A-disaccharide synthasePRO_0000190187Add
BLAST

Proteomic databases

PaxDbiQ57310.

Interactioni

Protein-protein interaction databases

IntActiQ57310. 1 interaction.
STRINGi1148.slr0015.

Structurei

3D structure databases

ProteinModelPortaliQ57310.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.Curated

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
InParanoidiQ57310.
KOiK00748.
OMAiAPQEWAW.
OrthoDBiEOG6FBWZR.
PhylomeDBiQ57310.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q57310-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIFISTGEV SGDLQGSLLV GALRQQAEEQ NLELELVGLG GEKMAAAGLT
60 70 80 90 100
LLANTAAIGS VGLTESLRFI IPTWQIQQRV KRYLKTNPID LLVLIDYMGP
110 120 130 140 150
NLTIANYLRK TYPNLPILYY IAPQAWVWSP TKRETAQIMA VTDRLLAIFP
160 170 180 190 200
GEAEFFQKQG LDVTWVGHPL LDRITKEAPS RGSAREKLGI DHNETVITLL
210 220 230 240 250
PASRIQELRY LLPSICGAAQ QLQSQLPNVK LLLPVSLKDY QPQIEQTLKE
260 270 280 290 300
FNLTVQLLEG KETLTAIAAA DLAITKSGTV NLEIALLNVP QVILYRVSPL
310 320 330 340 350
TMAIARRIFK FNLPFVSPTN IVLNRGIMPE LLQEQATASN IAQAGLELLL
360 370 380 390
NGDRQAKIAQ DYQELREALG EPGVCERAAQ AVLEFANGQQ KSRA
Length:394
Mass (Da):43,468
Last modified:October 31, 1996 - v1
Checksum:iDCD5FD0F49F95ACF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38802 Genomic DNA. Translation: AAB72026.1.
BA000022 Genomic DNA. Translation: BAA10196.1.
PIRiS76344.
RefSeqiNP_442126.1. NC_000911.1.
YP_005652184.1. NC_017277.1.
YP_007452003.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA10196; BAA10196; BAA10196.
KEGGisyn:slr0015.
PATRICi23841856. VBISynSp132158_2472.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38802 Genomic DNA. Translation: AAB72026.1.
BA000022 Genomic DNA. Translation: BAA10196.1.
PIRiS76344.
RefSeqiNP_442126.1. NC_000911.1.
YP_005652184.1. NC_017277.1.
YP_007452003.1. NC_020286.1.

3D structure databases

ProteinModelPortaliQ57310.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ57310. 1 interaction.
STRINGi1148.slr0015.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Proteomic databases

PaxDbiQ57310.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA10196; BAA10196; BAA10196.
KEGGisyn:slr0015.
PATRICi23841856. VBISynSp132158_2472.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
InParanoidiQ57310.
KOiK00748.
OMAiAPQEWAW.
OrthoDBiEOG6FBWZR.
PhylomeDBiQ57310.

Enzyme and pathway databases

UniPathwayiUPA00359; UER00481.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cassier-Chauvat C., Poncelet M., Villoing S., Chauvat F.
    Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome."
    Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S.
    DNA Res. 2:153-166(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27184 / PCC 6803 / N-1.
  3. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiLPXB_SYNY3
AccessioniPrimary (citable) accession number: Q57310
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 31, 2001
Last sequence update: October 31, 1996
Last modified: March 31, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.