ID   Q572P5_HUMAN            Unreviewed;       234 AA.
AC   Q572P5; E9PEJ2;
DT   10-MAY-2005, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2005, sequence version 1.
DT   27-MAR-2024, entry version 119.
DE   SubName: Full=Tyrosine-protein kinase BTK isoform 65 {ECO:0000313|EMBL:CAI59842.1};
DE   Flags: Fragment;
GN   Name=BTK {ECO:0000313|EMBL:CAI59842.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:CAI59842.1};
RN   [1] {ECO:0000313|EMBL:CAI59842.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=BCR-ABL1+ pre-B lymphoblastic leukemia
RC   {ECO:0000313|EMBL:CAI59842.1};
RX   PubMed=15939795; DOI=10.1084/jem.20042101;
RA   Feldhahn N., Klein F., Mooster J.L., Hadweh P., Sprangers M.,
RA   Wartenberg M., Bekhite M.M., Hofmann W.K., Herzog S., Jumaa H.,
RA   Rowley J.D., Muschen M.;
RT   "Mimicry of a constitutively active pre-B cell receptor: Aberrant splicing
RT   links Bruton's tyrosine kinase to BCR-ABL1 in pre-B lymphoblastic
RT   leukemia.";
RL   J. Exp. Med. 201:1837-1852(2005).
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DR   EMBL; AJ888376; CAI59842.1; -; mRNA.
DR   AlphaFoldDB; Q572P5; -.
DR   SMR; Q572P5; -.
DR   MaxQB; Q572P5; -.
DR   PeptideAtlas; Q572P5; -.
DR   ProteomicsDB; 62594; -.
DR   ChiTaRS; BTK; human.
DR   GO; GO:0005829; C:cytosol; IEA:UniProt.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   PANTHER; PTHR24418; TYROSINE-PROTEIN KINASE; 1.
DR   PANTHER; PTHR24418:SF92; TYROSINE-PROTEIN KINASE BTK; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 2.
DR   PRINTS; PR00109; TYRKINASE.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:CAI59842.1};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT   DOMAIN          1..230
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   DOMAIN          1..46
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   BINDING         99
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:CAI59842.1"
FT   NON_TER         234
FT                   /evidence="ECO:0000313|EMBL:CAI59842.1"
SQ   SEQUENCE   234 AA;  27048 MW;  B0C99DAB3A359157 CRC64;
     RHYVVCSTPQ SQYYLAEKHL FSTIPELINY HQHNSAGLIS RLKYPVSQQN KNAPSTAGLG
     YGSWEIDPKD LTFLKELGTG QFGVVKYGKW RGQYDVAIKM IKEGSMSEDE FIEEAKVMMY
     VLDDEYTSSV GSKFPVRWSP PEVLMYSKFS SKSDIWAFGV LMWEIYSLGK MPYERFTNSE
     TAEHIAQGLR LYRPHLASEK VYTIMYSCWH EKADERPTFK ILLSNILDVM DEES
//