Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q572P5

- Q572P5_HUMAN

UniProt

Q572P5 - Q572P5_HUMAN

Protein
Submitted name:

Tyrosine-protein kinase BTK isoform 65

Gene

BTK

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein tyrosine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinaseSAAS annotation

    Keywords - Ligandi

    ATP-bindingSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Tyrosine-protein kinase BTK isoform 65Imported
    Gene namesi
    Name:BTKImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliQ572P5.
    SMRiQ572P5. Positions 1-56, 64-233.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000233858.

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 2 hits.
    [Graphical view]
    PRINTSiPR00109. TYRKINASE.
    SUPFAMiSSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS50001. SH2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q572P5-1 [UniParc]FASTAAdd to Basket

    « Hide

    RHYVVCSTPQ SQYYLAEKHL FSTIPELINY HQHNSAGLIS RLKYPVSQQN    50
    KNAPSTAGLG YGSWEIDPKD LTFLKELGTG QFGVVKYGKW RGQYDVAIKM 100
    IKEGSMSEDE FIEEAKVMMY VLDDEYTSSV GSKFPVRWSP PEVLMYSKFS 150
    SKSDIWAFGV LMWEIYSLGK MPYERFTNSE TAEHIAQGLR LYRPHLASEK 200
    VYTIMYSCWH EKADERPTFK ILLSNILDVM DEES 234
    Length:234
    Mass (Da):27,048
    Last modified:May 10, 2005 - v1
    Checksum:iB0C99DAB3A359157
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei234 – 2341Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ888376 mRNA. Translation: CAI59842.1.
    UniGeneiHs.159494.
    Hs.733206.

    Genome annotation databases

    UCSCiuc010nnl.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ888376 mRNA. Translation: CAI59842.1 .
    UniGenei Hs.159494.
    Hs.733206.

    3D structure databases

    ProteinModelPortali Q572P5.
    SMRi Q572P5. Positions 1-56, 64-233.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q572P5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi uc010nnl.2. human.

    Phylogenomic databases

    HOGENOMi HOG000233858.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 2 hits.
    [Graphical view ]
    PRINTSi PR00109. TYRKINASE.
    SUPFAMi SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mimicry of a constitutively active pre-B cell receptor: Aberrant splicing links Bruton's tyrosine kinase to BCR-ABL1 in pre-B lymphoblastic leukemia."
      Feldhahn N., Klein F., Mooster J.L., Hadweh P., Sprangers M., Wartenberg M., Bekhite M.M., Hofmann W.K., Herzog S., Jumaa H., Rowley J.D., Muschen M.
      J. Exp. Med. 201:1837-1852(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: BCR-ABL1+ pre-B lymphoblastic leukemiaImported.

    Entry informationi

    Entry nameiQ572P5_HUMAN
    AccessioniPrimary (citable) accession number: Q572P5
    Secondary accession number(s): E9PEJ2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 10, 2005
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.