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Q572P5

- Q572P5_HUMAN

UniProt

Q572P5 - Q572P5_HUMAN

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Protein
Submitted name:

Tyrosine-protein kinase BTK isoform 65

Gene

BTK

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein tyrosine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinaseSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Tyrosine-protein kinase BTK isoform 65Imported
Gene namesi
Name:BTKImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ572P5.
SMRiQ572P5. Positions 1-56, 64-233.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000233858.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 2 hits.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q572P5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
RHYVVCSTPQ SQYYLAEKHL FSTIPELINY HQHNSAGLIS RLKYPVSQQN
60 70 80 90 100
KNAPSTAGLG YGSWEIDPKD LTFLKELGTG QFGVVKYGKW RGQYDVAIKM
110 120 130 140 150
IKEGSMSEDE FIEEAKVMMY VLDDEYTSSV GSKFPVRWSP PEVLMYSKFS
160 170 180 190 200
SKSDIWAFGV LMWEIYSLGK MPYERFTNSE TAEHIAQGLR LYRPHLASEK
210 220 230
VYTIMYSCWH EKADERPTFK ILLSNILDVM DEES
Length:234
Mass (Da):27,048
Last modified:May 10, 2005 - v1
Checksum:iB0C99DAB3A359157
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei234 – 2341Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ888376 mRNA. Translation: CAI59842.1.
UniGeneiHs.159494.
Hs.733206.

Genome annotation databases

UCSCiuc010nnl.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ888376 mRNA. Translation: CAI59842.1 .
UniGenei Hs.159494.
Hs.733206.

3D structure databases

ProteinModelPortali Q572P5.
SMRi Q572P5. Positions 1-56, 64-233.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q572P5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi uc010nnl.2. human.

Phylogenomic databases

HOGENOMi HOG000233858.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 2 hits.
[Graphical view ]
PRINTSi PR00109. TYRKINASE.
SUPFAMi SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mimicry of a constitutively active pre-B cell receptor: Aberrant splicing links Bruton's tyrosine kinase to BCR-ABL1 in pre-B lymphoblastic leukemia."
    Feldhahn N., Klein F., Mooster J.L., Hadweh P., Sprangers M., Wartenberg M., Bekhite M.M., Hofmann W.K., Herzog S., Jumaa H., Rowley J.D., Muschen M.
    J. Exp. Med. 201:1837-1852(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BCR-ABL1+ pre-B lymphoblastic leukemiaImported.

Entry informationi

Entry nameiQ572P5_HUMAN
AccessioniPrimary (citable) accession number: Q572P5
Secondary accession number(s): E9PEJ2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.