Q57290 (Y740_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable phosphomannomutase
Short name=PMM
EC=5.4.2.8

Gene names

Ordered Locus Names:

HI_0740

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus › Haemophilus influenzae

Protein attributes

Sequence length	485 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Sequence similarities	Belongs to the phosphohexose mutase family.

Ontologies

Keywords
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	magnesium ion binding Inferred from electronic annotation. Source: InterPro phosphomannomutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 485	485	Probable phosphomannomutase		PRO_0000148021
Sites
	Active site	86	1	Phosphoserine intermediate By similarity
	Metal binding	86	1	Magnesium; via phosphate group By similarity
	Metal binding	236	1	Magnesium By similarity
	Metal binding	238	1	Magnesium By similarity
	Metal binding	240	1	Magnesium By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q57290 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: BBCF7D443623B34E	FASTA	485	52,568
	10 20 30 40 50 60 MGMNRVLVSQ AAGGLAEYLK GYDKEPSIVI GYDGRKNSDV FARDTAEIMA GAGVKAYLLP 70 80 90 100 110 120 RKLPTPVLAY AIQYFDTTAG VMVTASHNPP EDNGYKVYLG KANGGGQIVS PADKDIAALI 130 140 150 160 170 180 DKVAAGNIQD LPRSDNYVVL NDEVVDAYIT KTASLAKEPA CDINYVYTAM HGVGYEVLSK 190 200 210 220 230 240 TLAKAGLPQP HVVADQVWPD GTFPTVNFPN PEEKGALDLA IKVAKEKNAE FIIANDPDAD 250 260 270 280 290 300 RLAVAVPDAQ GNWKSLHGNV VGCFLGWYLA KQYQGKQGTL ACSLVSSPAL AEIAKKYSFQ 310 320 330 340 350 360 SEETLTGFKY IGKVSGLLFG FEEALGYLVD PDKVRDKDGI SAAIVFLDLV RNLKKQGKTL 370 380 390 400 410 420 ADYADEFTKE FGAYVSGQIS IRVSDLSEIG KLMTALRNNP PAEIAGVKVA QFIDHIKTDR 430 440 450 460 470 480 QSDILVFNLE NGGRLIARPS GTEPKIKFYL DARGKDPKDA DRVLAEFDEG VRHILRQDAY GKQDC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
[2]	"Two-dimensional map of the proteome of Haemophilus influenzae." Langen H., Takacs B., Evers S., Berndt P., Lahm H.W., Wipf B., Gray C., Fountoulakis M. Electrophoresis 21:411-429(2000) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC22400.1.
PIR	I64157.
RefSeq	NP_438900.2. NC_000907.1.
3D structure databases
ProteinModelPortal	Q57290.
ModBase	Search...
Protein-protein interaction databases
STRING	71421.HI0740.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC22400; AAC22400; HI_0740.
GeneID	949768.
KEGG	hin:HI0740.
PATRIC	20190123. VBIHaeInf48452_0777.
Phylogenomic databases
eggNOG	COG1109.
KO	K01840.
OMA	EPKVKAY.
ProtClustDB	CLSK870357.
Family and domain databases
Gene3D	3.40.120.10. 3 hits.
InterPro	IPR005844. A-D-PHexomutase_a/b/a-I. IPR016055. A-D-PHexomutase_a/b/a-I/II/III. IPR005845. A-D-PHexomutase_a/b/a-II. IPR005846. A-D-PHexomutase_a/b/a-III. IPR005843. A-D-PHexomutase_C. IPR016066. A-D-PHexomutase_CS. IPR005841. Alpha-D-phosphohexomutase_SF. [Graphical view]
Pfam	PF02878. PGM_PMM_I. 1 hit. PF02879. PGM_PMM_II. 1 hit. PF02880. PGM_PMM_III. 1 hit. PF00408. PGM_PMM_IV. 1 hit. [Graphical view]
PRINTS	PR00509. PGMPMM.
SUPFAM	SSF53738. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
PROSITE	PS00710. PGM_PMM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Y740_HAEIN

Accession

Primary (citable) accession number: Q57290
Secondary accession number(s): O05032

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program