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Protein
Submitted name:

Capsule biosynthesis protein

Gene

synC

Organism
Neisseria meningitidis
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi186 – 1861Manganese
Metal bindingi215 – 2151Manganese; via tele nitrogen
Metal bindingi236 – 2361Manganese; via tele nitrogen

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Manganese, Metal-bindingCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
Capsule biosynthesis proteinImported
Submitted name:
SiaCImported
Gene namesi
Name:synCImported
Synonyms:siaCImported
OrganismiNeisseria meningitidisImported
Taxonomic identifieri487 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XUUX-ray1.90A1-349[»]
1XUZX-ray2.20A1-349[»]
2ZDRX-ray1.85A1-349[»]
3CM4X-ray1.85A1-349[»]
4IPIX-ray1.75A1-349[»]
4IPJX-ray2.15A1-349[»]
ProteinModelPortaliQ57265.
SMRiQ57265. Positions 2-349.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ57265.

Family & Domainsi

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
3.90.1210.10. 1 hit.
InterProiIPR006190. AFP_Neu5c_C.
IPR013785. Aldolase_TIM.
IPR013132. Neu5Ac_N.
IPR013974. SAF.
[Graphical view]
PfamiPF03102. NeuB. 1 hit.
PF08666. SAF. 1 hit.
[Graphical view]
SMARTiSM00858. SAF. 1 hit.
[Graphical view]
SUPFAMiSSF51269. SSF51269. 1 hit.
PROSITEiPS50844. AFP_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57265-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNNNEFKIG NRSVGYNHEP LIICEIGINH EGSLKTAFEM VDAAYNAGAE
60 70 80 90 100
VVKHQTHIVE DEMSDEAKQV IPGNADVSIY EIMERCALNE EDEIKLKEYV
110 120 130 140 150
ESKGMIFIST PFSRAAALRL QRMDIPAYKI GSGECNNYPL IKLVASFGKP
160 170 180 190 200
IILSTGMNSI ESIKKSVEII REAGVPYALL HCTNIYPTPY EDVRLGGMND
210 220 230 240 250
LSEAFPDAII GLSDHTLDNY ACLGAVALGG SILERHFTDR MDRPGPDIVC
260 270 280 290 300
SMNPDTFKEL KQGAHALKLA RGGKKDTIIA GEKPTKDFAF ASVVADKDIK
310 320 330 340
KGELLSGDNL WVKRPGNGDF SVNEYETLFG KVAACNIRKG AQIKKTDIE
Length:349
Mass (Da):38,348
Last modified:November 1, 1996 - v1
Checksum:i1C7C13EE5847E71A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95053 Genomic DNA. Translation: AAA20477.1.
U40740 Genomic DNA. Translation: AAB17455.1.
HM037270 Genomic DNA. Translation: ADK90955.1.
PIRiS60760.

Genome annotation databases

EnsemblBacteriaiKGI97763; KGI97763; JH16_08925.
KHF23611; KHF23611; QP84_01390.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95053 Genomic DNA. Translation: AAA20477.1.
U40740 Genomic DNA. Translation: AAB17455.1.
HM037270 Genomic DNA. Translation: ADK90955.1.
PIRiS60760.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XUUX-ray1.90A1-349[»]
1XUZX-ray2.20A1-349[»]
2ZDRX-ray1.85A1-349[»]
3CM4X-ray1.85A1-349[»]
4IPIX-ray1.75A1-349[»]
4IPJX-ray2.15A1-349[»]
ProteinModelPortaliQ57265.
SMRiQ57265. Positions 2-349.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiKGI97763; KGI97763; JH16_08925.
KHF23611; KHF23611; QP84_01390.

Miscellaneous databases

EvolutionaryTraceiQ57265.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
3.90.1210.10. 1 hit.
InterProiIPR006190. AFP_Neu5c_C.
IPR013785. Aldolase_TIM.
IPR013132. Neu5Ac_N.
IPR013974. SAF.
[Graphical view]
PfamiPF03102. NeuB. 1 hit.
PF08666. SAF. 1 hit.
[Graphical view]
SMARTiSM00858. SAF. 1 hit.
[Graphical view]
SUPFAMiSSF51269. SSF51269. 1 hit.
PROSITEiPS50844. AFP_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evidence for a common molecular origin of the capsule gene loci in Gram-negative bacteria expressing group II capsular polysaccharides."
    Frosch M., Edwards U., Bousset K., Krausse B., Weisgerber C.
    Mol. Microbiol. 5:1251-1263(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: B1940Imported.
  2. "Molecular analysis of the biosynthesis pathway of the alpha 2,8 polysialic acid capsule by Neisseria meningitidis serogroup B."
    Edwards U., Muller A., Hammerschmidt S., Frosch M.
    Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: B1940Imported.
  3. "Expression of sialic acid and polysialic acid in serogroup B Neisseria meningitidis: divergent transcription of biosynthesis and transport operons through a common promoter region."
    Swartley J.S., Ahn J.H., Liu L.J., Kahler C.M., Stephens D.S.
    J. Bacteriol. 178:4052-4059(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NMBImported.
  4. "Structural and mechanistic analysis of sialic acid synthase NeuB from Neisseria meningitidis in complex with Mn2+, phosphoenolpyruvate, and N-acetylmannosaminitol."
    Gunawan J., Simard D., Gilbert M., Lovering A.L., Wakarchuk W.W., Tanner M.E., Strynadka N.C.
    J. Biol. Chem. 280:3555-3563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH MANGANESE.
  5. "Crystal structure of sialic acid synthase (NeuB) from neisseria meningitidis in complex with Mg2+ and (4S)-2-methyl-2,4-pentanediol."
    Morrison E., Rosanally A., Junop M.S., Berti P.
    Submitted (NOV-2007) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).
  6. "Crystal structure of metal-free sialic acid synthase (NeuB) from neisseria meningitidis in complex with malate."
    Morrison E., Rosanally A., Junop M.S., Berti P.
    Submitted (MAR-2008) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).
  7. "Genetic study of capsular switching between Neisseria meningitidis sequence type 7 serogroup A and C strains."
    Wang Q., Shao Z., Wang X., Gao Y., Li M., Xu L., Xu J., Wang L.
    Infect. Immun. 78:3883-3888(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 510602Imported.
  8. "Arg314 is essential for catalysis by N-acetyl neuraminic acid synthase from Neisseria meningitidis."
    Joseph D.D., Jiao W., Parker E.J.
    Biochemistry 52:2609-2619(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) IN COMPLEX WITH MANGANESE.

Entry informationi

Entry nameiQ57265_NEIME
AccessioniPrimary (citable) accession number: Q57265
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 27, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.