Q57265 (Q57265_NEIME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Capsule biosynthesis protein EMBL AAB17455.1

Submitted name:
SiaC EMBL AAA20477.1

Gene names

Name:	synC EMBL AAB17455.1
Synonyms:	siaC EMBL AAA20477.1

Organism

Neisseria meningitidis EMBL AAB17455.1

Taxonomic identifier

487 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length	349 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Technical term	3D-structure PDB 1XUZ PDB 3CM4 PDB 2ZDR PDB 1XUU
Gene Ontology (GO)
Biological process	carbohydrate biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	catalytic activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q57265 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 1C7C13EE5847E71A	FASTA	349	38,348
	10 20 30 40 50 60 MQNNNEFKIG NRSVGYNHEP LIICEIGINH EGSLKTAFEM VDAAYNAGAE VVKHQTHIVE 70 80 90 100 110 120 DEMSDEAKQV IPGNADVSIY EIMERCALNE EDEIKLKEYV ESKGMIFIST PFSRAAALRL 130 140 150 160 170 180 QRMDIPAYKI GSGECNNYPL IKLVASFGKP IILSTGMNSI ESIKKSVEII REAGVPYALL 190 200 210 220 230 240 HCTNIYPTPY EDVRLGGMND LSEAFPDAII GLSDHTLDNY ACLGAVALGG SILERHFTDR 250 260 270 280 290 300 MDRPGPDIVC SMNPDTFKEL KQGAHALKLA RGGKKDTIIA GEKPTKDFAF ASVVADKDIK 310 320 330 340 KGELLSGDNL WVKRPGNGDF SVNEYETLFG KVAACNIRKG AQIKKTDIE

References

[1]	"Genetic study of capsular switching between Neisseria meningitidis sequence type 7 serogroup A and C strains." Wang Q., Shao Z., Wang X., Gao Y., Li M., Xu L., Xu J., Wang L. Infect. Immun. 78:3883-3888(2010) [PubMed: 20624905] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: 510602 EMBL ADK90955.1.
[2]	"Evidence for a common molecular origin of the capsule gene loci in Gram-negative bacteria expressing group II capsular polysaccharides." Frosch M., Edwards U., Bousset K., Krausse B., Weisgerber C. Mol. Microbiol. 5:1251-1263(1991) [PubMed: 1659649] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 288-349. Strain: B1940 EMBL AAA20477.1.
[3]	"Structural and mechanistic analysis of sialic acid synthase NeuB from Neisseria meningitidis in complex with Mn2+, phosphoenolpyruvate, and N-acetylmannosaminitol." Gunawan J., Simard D., Gilbert M., Lovering A.L., Wakarchuk W.W., Tanner M.E., Strynadka N.C. J. Biol. Chem. 280:3555-3563(2005) [PubMed: 15516336] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS).
[4]	"Expression of sialic acid and polysialic acid in serogroup B Neisseria meningitidis: divergent transcription of biosynthesis and transport operons through a common promoter region." Swartley J.S., Ahn J.H., Liu L.J., Kahler C.M., Stephens D.S. J. Bacteriol. 178:4052-4059(1996) [PubMed: 8763931] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: NMB EMBL AAB17455.1.
[5]	"Crystal structure of metal-free sialic acid synthase (NeuB) from neisseria meningitidis in complex with malate." Morrison E., Rosanally A., Junop M.S., Berti P. Submitted (MAR-2008) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).
[6]	"Crystal structure of sialic acid synthase (NeuB) from neisseria meningitidis in complex with Mg2+ and (4S)-2-methyl-2,4-pentanediol." Morrison E., Rosanally A., Junop M.S., Berti P. Submitted (NOV-2007) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).
[7]	"Molecular analysis of the biosynthesis pathway of the alpha 2,8 polysialic acid capsule by Neisseria meningitidis serogroup B." Edwards U., Muller A., Hammerschmidt S., Frosch M. Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: B1940 EMBL AAA20477.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M95053 Genomic DNA. Translation: AAA20477.1.
U40740 Genomic DNA. Translation: AAB17455.1.
HM037270 Genomic DNA. Translation: ADK90955.1.

PIR

S60760.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1XUU	X-ray	1.90	A	1-349	[»]
1XUZ	X-ray	2.20	A	1-349	[»]
2ZDR	X-ray	1.85	A	1-349	[»]
3CM4	X-ray	1.85	A	1-349	[»]

ProteinModelPortal

Q57265.

SMR

Q57265. Positions 2-349.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

InterPro

IPR006190. AFP_Neu5c_C.
IPR013785. Aldolase_TIM.
IPR013132. Neu5Ac_N.
IPR013974. SAF.
[Graphical view]

Gene3D

G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
G3DSA:3.90.1210.10. G3DSA:3.90.1210.10. 1 hit.

Pfam

PF03102. NeuB. 1 hit.
PF08666. SAF. 1 hit.
[Graphical view]

SMART

SM00858. SAF. 1 hit.
[Graphical view]

SUPFAM

SSF51269. AFP_Neu5c_C. 1 hit.

PROSITE

PS50844. AFP_LIKE. 1 hit.
[Graphical view]

ProtoNet

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Entry information

Entry name

Q57265_NEIME

Accession

Primary (citable) accession number: Q57265

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	July 27, 2011
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)