Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q57265 (Q57265_NEIME) Unreviewed, UniProtKB/TrEMBL

Last modified March 19, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names

SiaC EMBL AAA20477.1
Gene names
Name:synC EMBL AAB17455.1
Synonyms:siaC EMBL AAA20477.1
OrganismNeisseria meningitidis EMBL AAB17455.1
Taxonomic identifier487 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

Protein attributes

Sequence length349 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding1861Manganese PDB 4IPJ PDB 4IPI PDB 1XUU
Metal binding2151Manganese; via tele nitrogen PDB 4IPJ PDB 4IPI PDB 1XUU
Metal binding2361Manganese; via tele nitrogen PDB 4IPJ PDB 4IPI PDB 1XUU

Sequences

Sequence LengthMass (Da)Tools
Q57265 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 1C7C13EE5847E71A

FASTA34938,348
        10         20         30         40         50         60 
MQNNNEFKIG NRSVGYNHEP LIICEIGINH EGSLKTAFEM VDAAYNAGAE VVKHQTHIVE 

        70         80         90        100        110        120 
DEMSDEAKQV IPGNADVSIY EIMERCALNE EDEIKLKEYV ESKGMIFIST PFSRAAALRL 

       130        140        150        160        170        180 
QRMDIPAYKI GSGECNNYPL IKLVASFGKP IILSTGMNSI ESIKKSVEII REAGVPYALL 

       190        200        210        220        230        240 
HCTNIYPTPY EDVRLGGMND LSEAFPDAII GLSDHTLDNY ACLGAVALGG SILERHFTDR 

       250        260        270        280        290        300 
MDRPGPDIVC SMNPDTFKEL KQGAHALKLA RGGKKDTIIA GEKPTKDFAF ASVVADKDIK 

       310        320        330        340 
KGELLSGDNL WVKRPGNGDF SVNEYETLFG KVAACNIRKG AQIKKTDIE 

« Hide

References

[1]"Evidence for a common molecular origin of the capsule gene loci in Gram-negative bacteria expressing group II capsular polysaccharides."
Frosch M., Edwards U., Bousset K., Krausse B., Weisgerber C.
Mol. Microbiol. 5:1251-1263(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: B1940 EMBL AAA20477.1.
[2]"Molecular analysis of the biosynthesis pathway of the alpha 2,8 polysialic acid capsule by Neisseria meningitidis serogroup B."
Edwards U., Muller A., Hammerschmidt S., Frosch M.
Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: B1940 EMBL AAA20477.1.
[3]"Expression of sialic acid and polysialic acid in serogroup B Neisseria meningitidis: divergent transcription of biosynthesis and transport operons through a common promoter region."
Swartley J.S., Ahn J.H., Liu L.J., Kahler C.M., Stephens D.S.
J. Bacteriol. 178:4052-4059(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NMB EMBL AAB17455.1.
[4]"Structural and mechanistic analysis of sialic acid synthase NeuB from Neisseria meningitidis in complex with Mn2+, phosphoenolpyruvate, and N-acetylmannosaminitol."
Gunawan J., Simard D., Gilbert M., Lovering A.L., Wakarchuk W.W., Tanner M.E., Strynadka N.C.
J. Biol. Chem. 280:3555-3563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH MANGANESE.
[5]"Crystal structure of sialic acid synthase (NeuB) from neisseria meningitidis in complex with Mg2+ and (4S)-2-methyl-2,4-pentanediol."
Morrison E., Rosanally A., Junop M.S., Berti P.
Submitted (NOV-2007) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).
[6]"Crystal structure of metal-free sialic acid synthase (NeuB) from neisseria meningitidis in complex with malate."
Morrison E., Rosanally A., Junop M.S., Berti P.
Submitted (MAR-2008) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).
[7]"Genetic study of capsular switching between Neisseria meningitidis sequence type 7 serogroup A and C strains."
Wang Q., Shao Z., Wang X., Gao Y., Li M., Xu L., Xu J., Wang L.
Infect. Immun. 78:3883-3888(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 510602 EMBL ADK90955.1.
[8]"Arg314 is essential for catalysis by N-acetyl neuraminic acid synthase from Neisseria meningitidis."
Joseph D.D., Jiao W., Parker E.J.
Biochemistry 52:2609-2619(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) IN COMPLEX WITH MANGANESE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M95053 Genomic DNA. Translation: AAA20477.1.
U40740 Genomic DNA. Translation: AAB17455.1.
HM037270 Genomic DNA. Translation: ADK90955.1.
PIRS60760.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1XUUX-ray1.90A1-349[»]
1XUZX-ray2.20A1-349[»]
2ZDRX-ray1.85A1-349[»]
3CM4X-ray1.85A1-349[»]
4IPIX-ray1.75A1-349[»]
4IPJX-ray2.15A1-349[»]
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.20.20.70. 1 hit.
3.90.1210.10. 1 hit.
InterProIPR006190. AFP_Neu5c_C.
IPR013785. Aldolase_TIM.
IPR013132. Neu5Ac_N.
IPR013974. SAF.
[Graphical view]
PfamPF03102. NeuB. 1 hit.
PF08666. SAF. 1 hit.
[Graphical view]
SMARTSM00858. SAF. 1 hit.
[Graphical view]
SUPFAMSSF51269. SSF51269. 1 hit.
PROSITEPS50844. AFP_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ57265.

Entry information

Entry nameQ57265_NEIME
AccessionPrimary (citable) accession number: Q57265
Entry history
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: March 19, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)