Q57265 (Q57265_NEIME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Capsule biosynthesis protein EMBL AAB17455.1

Submitted name:
SiaC EMBL AAA20477.1

Gene names

Name:	synC EMBL AAB17455.1
Synonyms:	siaC EMBL AAA20477.1

Organism

Neisseria meningitidis EMBL AAB17455.1

Taxonomic identifier

487 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length	349 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Ligand	Manganese PDB 1XUZ PDB 1XUU Metal-binding PDB 1XUZ PDB 1XUU PDB 2ZDR
Technical term	3D-structure PDB 1XUZ PDB 1XUU PDB 3CM4 PDB 2ZDR
Gene Ontology (GO)
Biological_process	carbohydrate biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular_function	catalytic activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	186	1	Manganese PDB 1XUU
	Metal binding	215	1	Manganese; via tele nitrogen PDB 1XUU
	Metal binding	236	1	Manganese; via tele nitrogen PDB 1XUU

Sequences

	Sequence		Length	Mass (Da)
	Q57265 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 1C7C13EE5847E71A	FASTA	349	38,348
	10 20 30 40 50 60 MQNNNEFKIG NRSVGYNHEP LIICEIGINH EGSLKTAFEM VDAAYNAGAE VVKHQTHIVE 70 80 90 100 110 120 DEMSDEAKQV IPGNADVSIY EIMERCALNE EDEIKLKEYV ESKGMIFIST PFSRAAALRL 130 140 150 160 170 180 QRMDIPAYKI GSGECNNYPL IKLVASFGKP IILSTGMNSI ESIKKSVEII REAGVPYALL 190 200 210 220 230 240 HCTNIYPTPY EDVRLGGMND LSEAFPDAII GLSDHTLDNY ACLGAVALGG SILERHFTDR 250 260 270 280 290 300 MDRPGPDIVC SMNPDTFKEL KQGAHALKLA RGGKKDTIIA GEKPTKDFAF ASVVADKDIK 310 320 330 340 KGELLSGDNL WVKRPGNGDF SVNEYETLFG KVAACNIRKG AQIKKTDIE

References

[1]	"Evidence for a common molecular origin of the capsule gene loci in gram-negative bacteria expressing group II capsular polysaccharides." Frosch M., Edwards U., Bousset K., Krausse B., Weisgerber C. Mol. Microbiol. 5:1251-1263(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: B1940 EMBL AAA20477.1.
[2]	"Molecular analysis of the biosynthesis pathway of the alpha 2,8 polysialic acid capsule by Neisseria meningitidis serogroup B." Edwards U., Muller A., Hammerschmidt S., Frosch M. Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: B1940 EMBL AAA20477.1.
[3]	"Expression of sialic acid and polysialic acid in serogroup B Neisseria meningitidis: divergent transcription of biosynthesis and transport operons through a common promoter region." Swartley J.S., Ahn J.H., Liu L.J., Kahler C.M., Stephens D.S. J. Bacteriol. 178:4052-4059(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: NMB EMBL AAB17455.1.
[4]	"Structural and mechanistic analysis of sialic acid synthase NeuB from Neisseria meningitidis in complex with Mn2+, phosphoenolpyruvate, and N-acetylmannosaminitol." Gunawan J., Simard D., Gilbert M., Lovering A.L., Wakarchuk W.W., Tanner M.E., Strynadka N.C. J. Biol. Chem. 280:3555-3563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH MANGANESE.
[5]	"Crystal structure of sialic acid synthase (NeuB) from neisseria meningitidis in complex with Mg2+ and (4S)-2-methyl-2,4-pentanediol." Morrison E., Rosanally A., Junop M.S., Berti P. Submitted (NOV-2007) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).
[6]	"Crystal structure of metal-free sialic acid synthase (NeuB) from neisseria meningitidis in complex with malate." Morrison E., Rosanally A., Junop M.S., Berti P. Submitted (MAR-2008) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).
[7]	"Genetic study of capsular switching between Neisseria meningitidis sequence type 7 serogroup A and C strains." Wang Q., Shao Z., Wang X., Gao Y., Li M., Xu L., Xu J., Wang L. Infect. Immun. 78:3883-3888(2010) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: 510602 EMBL ADK90955.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M95053 Genomic DNA. Translation: AAA20477.1.
U40740 Genomic DNA. Translation: AAB17455.1.
HM037270 Genomic DNA. Translation: ADK90955.1.

PIR

S60760.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1XUU	X-ray	1.90	A	1-349	[»]
1XUZ	X-ray	2.20	A	1-349	[»]
2ZDR	X-ray	1.85	A	1-349	[»]
3CM4	X-ray	1.85	A	1-349	[»]

SMR

Q57265. Positions 2-349.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

Gene3D

3.20.20.70. 1 hit.
3.90.1210.10. 1 hit.

InterPro

IPR006190. AFP_Neu5c_C.
IPR013785. Aldolase_TIM.
IPR013132. Neu5Ac_N.
IPR013974. SAF.
[Graphical view]

Pfam

PF03102. NeuB. 1 hit.
PF08666. SAF. 1 hit.
[Graphical view]

SMART

SM00858. SAF. 1 hit.
[Graphical view]

SUPFAM

SSF51269. AFP_Neu5c_C. 1 hit.

PROSITE

PS50844. AFP_LIKE. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q57265.

Entry information

Entry name

Q57265_NEIME

Accession

Primary (citable) accession number: Q57265

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	May 29, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)