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Q57265

- Q57265_NEIME

UniProt

Q57265 - Q57265_NEIME

Protein
Submitted name:

Capsule biosynthesis protein

Gene

synC

Organism
Neisseria meningitidis
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi186 – 1861ManganeseImported
    Metal bindingi215 – 2151Manganese; via tele nitrogenImported
    Metal bindingi236 – 2361Manganese; via tele nitrogenImported

    GO - Molecular functioni

    1. catalytic activity Source: InterPro
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro

    Keywords - Ligandi

    ManganeseImported, Metal-bindingImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Capsule biosynthesis proteinImported
    Submitted name:
    SiaCImported
    Gene namesi
    Name:synCImported
    Synonyms:siaCImported
    OrganismiNeisseria meningitidisImported
    Taxonomic identifieri487 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1XUUX-ray1.90A1-349[»]
    1XUZX-ray2.20A1-349[»]
    2ZDRX-ray1.85A1-349[»]
    3CM4X-ray1.85A1-349[»]
    4IPIX-ray1.75A1-349[»]
    4IPJX-ray2.15A1-349[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ57265.

    Family & Domainsi

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    3.90.1210.10. 1 hit.
    InterProiIPR006190. AFP_Neu5c_C.
    IPR013785. Aldolase_TIM.
    IPR013132. Neu5Ac_N.
    IPR013974. SAF.
    [Graphical view]
    PfamiPF03102. NeuB. 1 hit.
    PF08666. SAF. 1 hit.
    [Graphical view]
    SMARTiSM00858. SAF. 1 hit.
    [Graphical view]
    SUPFAMiSSF51269. SSF51269. 1 hit.
    PROSITEiPS50844. AFP_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q57265-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQNNNEFKIG NRSVGYNHEP LIICEIGINH EGSLKTAFEM VDAAYNAGAE    50
    VVKHQTHIVE DEMSDEAKQV IPGNADVSIY EIMERCALNE EDEIKLKEYV 100
    ESKGMIFIST PFSRAAALRL QRMDIPAYKI GSGECNNYPL IKLVASFGKP 150
    IILSTGMNSI ESIKKSVEII REAGVPYALL HCTNIYPTPY EDVRLGGMND 200
    LSEAFPDAII GLSDHTLDNY ACLGAVALGG SILERHFTDR MDRPGPDIVC 250
    SMNPDTFKEL KQGAHALKLA RGGKKDTIIA GEKPTKDFAF ASVVADKDIK 300
    KGELLSGDNL WVKRPGNGDF SVNEYETLFG KVAACNIRKG AQIKKTDIE 349
    Length:349
    Mass (Da):38,348
    Last modified:November 1, 1996 - v1
    Checksum:i1C7C13EE5847E71A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M95053 Genomic DNA. Translation: AAA20477.1.
    U40740 Genomic DNA. Translation: AAB17455.1.
    HM037270 Genomic DNA. Translation: ADK90955.1.
    PIRiS60760.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M95053 Genomic DNA. Translation: AAA20477.1 .
    U40740 Genomic DNA. Translation: AAB17455.1 .
    HM037270 Genomic DNA. Translation: ADK90955.1 .
    PIRi S60760.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1XUU X-ray 1.90 A 1-349 [» ]
    1XUZ X-ray 2.20 A 1-349 [» ]
    2ZDR X-ray 1.85 A 1-349 [» ]
    3CM4 X-ray 1.85 A 1-349 [» ]
    4IPI X-ray 1.75 A 1-349 [» ]
    4IPJ X-ray 2.15 A 1-349 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei Q57265.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    3.90.1210.10. 1 hit.
    InterProi IPR006190. AFP_Neu5c_C.
    IPR013785. Aldolase_TIM.
    IPR013132. Neu5Ac_N.
    IPR013974. SAF.
    [Graphical view ]
    Pfami PF03102. NeuB. 1 hit.
    PF08666. SAF. 1 hit.
    [Graphical view ]
    SMARTi SM00858. SAF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51269. SSF51269. 1 hit.
    PROSITEi PS50844. AFP_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evidence for a common molecular origin of the capsule gene loci in Gram-negative bacteria expressing group II capsular polysaccharides."
      Frosch M., Edwards U., Bousset K., Krausse B., Weisgerber C.
      Mol. Microbiol. 5:1251-1263(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: B1940Imported.
    2. "Molecular analysis of the biosynthesis pathway of the alpha 2,8 polysialic acid capsule by Neisseria meningitidis serogroup B."
      Edwards U., Muller A., Hammerschmidt S., Frosch M.
      Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: B1940Imported.
    3. "Expression of sialic acid and polysialic acid in serogroup B Neisseria meningitidis: divergent transcription of biosynthesis and transport operons through a common promoter region."
      Swartley J.S., Ahn J.H., Liu L.J., Kahler C.M., Stephens D.S.
      J. Bacteriol. 178:4052-4059(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NMBImported.
    4. "Structural and mechanistic analysis of sialic acid synthase NeuB from Neisseria meningitidis in complex with Mn2+, phosphoenolpyruvate, and N-acetylmannosaminitol."
      Gunawan J., Simard D., Gilbert M., Lovering A.L., Wakarchuk W.W., Tanner M.E., Strynadka N.C.
      J. Biol. Chem. 280:3555-3563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH MANGANESE.
    5. "Crystal structure of sialic acid synthase (NeuB) from neisseria meningitidis in complex with Mg2+ and (4S)-2-methyl-2,4-pentanediol."
      Morrison E., Rosanally A., Junop M.S., Berti P.
      Submitted (NOV-2007) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).
    6. "Crystal structure of metal-free sialic acid synthase (NeuB) from neisseria meningitidis in complex with malate."
      Morrison E., Rosanally A., Junop M.S., Berti P.
      Submitted (MAR-2008) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).
    7. "Genetic study of capsular switching between Neisseria meningitidis sequence type 7 serogroup A and C strains."
      Wang Q., Shao Z., Wang X., Gao Y., Li M., Xu L., Xu J., Wang L.
      Infect. Immun. 78:3883-3888(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 510602Imported.
    8. "Arg314 is essential for catalysis by N-acetyl neuraminic acid synthase from Neisseria meningitidis."
      Joseph D.D., Jiao W., Parker E.J.
      Biochemistry 52:2609-2619(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) IN COMPLEX WITH MANGANESE.

    Entry informationi

    Entry nameiQ57265_NEIME
    AccessioniPrimary (citable) accession number: Q57265
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1996
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3