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Q57265

- Q57265_NEIME

UniProt

Q57265 - Q57265_NEIME

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Protein
Submitted name:

Capsule biosynthesis protein

Gene
synC, siaC
Organism
Neisseria meningitidis
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi186 – 1861ManganeseImported
Metal bindingi215 – 2151Manganese; via tele nitrogenImported
Metal bindingi236 – 2361Manganese; via tele nitrogenImported

GO - Molecular functioni

  1. catalytic activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Ligandi

ManganeseImported, Metal-bindingImported

Names & Taxonomyi

Protein namesi
Submitted name:
Capsule biosynthesis proteinImported
Submitted name:
SiaCImported
Gene namesi
Name:synCImported
Synonyms:siaCImported
OrganismiNeisseria meningitidisImported
Taxonomic identifieri487 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XUUX-ray1.90A1-349[»]
1XUZX-ray2.20A1-349[»]
2ZDRX-ray1.85A1-349[»]
3CM4X-ray1.85A1-349[»]
4IPIX-ray1.75A1-349[»]
4IPJX-ray2.15A1-349[»]

Miscellaneous databases

EvolutionaryTraceiQ57265.

Family & Domainsi

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
3.90.1210.10. 1 hit.
InterProiIPR006190. AFP_Neu5c_C.
IPR013785. Aldolase_TIM.
IPR013132. Neu5Ac_N.
IPR013974. SAF.
[Graphical view]
PfamiPF03102. NeuB. 1 hit.
PF08666. SAF. 1 hit.
[Graphical view]
SMARTiSM00858. SAF. 1 hit.
[Graphical view]
SUPFAMiSSF51269. SSF51269. 1 hit.
PROSITEiPS50844. AFP_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57265-1 [UniParc]FASTAAdd to Basket

« Hide

MQNNNEFKIG NRSVGYNHEP LIICEIGINH EGSLKTAFEM VDAAYNAGAE    50
VVKHQTHIVE DEMSDEAKQV IPGNADVSIY EIMERCALNE EDEIKLKEYV 100
ESKGMIFIST PFSRAAALRL QRMDIPAYKI GSGECNNYPL IKLVASFGKP 150
IILSTGMNSI ESIKKSVEII REAGVPYALL HCTNIYPTPY EDVRLGGMND 200
LSEAFPDAII GLSDHTLDNY ACLGAVALGG SILERHFTDR MDRPGPDIVC 250
SMNPDTFKEL KQGAHALKLA RGGKKDTIIA GEKPTKDFAF ASVVADKDIK 300
KGELLSGDNL WVKRPGNGDF SVNEYETLFG KVAACNIRKG AQIKKTDIE 349
Length:349
Mass (Da):38,348
Last modified:November 1, 1996 - v1
Checksum:i1C7C13EE5847E71A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M95053 Genomic DNA. Translation: AAA20477.1.
U40740 Genomic DNA. Translation: AAB17455.1.
HM037270 Genomic DNA. Translation: ADK90955.1.
PIRiS60760.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M95053 Genomic DNA. Translation: AAA20477.1 .
U40740 Genomic DNA. Translation: AAB17455.1 .
HM037270 Genomic DNA. Translation: ADK90955.1 .
PIRi S60760.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1XUU X-ray 1.90 A 1-349 [» ]
1XUZ X-ray 2.20 A 1-349 [» ]
2ZDR X-ray 1.85 A 1-349 [» ]
3CM4 X-ray 1.85 A 1-349 [» ]
4IPI X-ray 1.75 A 1-349 [» ]
4IPJ X-ray 2.15 A 1-349 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q57265.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
3.90.1210.10. 1 hit.
InterProi IPR006190. AFP_Neu5c_C.
IPR013785. Aldolase_TIM.
IPR013132. Neu5Ac_N.
IPR013974. SAF.
[Graphical view ]
Pfami PF03102. NeuB. 1 hit.
PF08666. SAF. 1 hit.
[Graphical view ]
SMARTi SM00858. SAF. 1 hit.
[Graphical view ]
SUPFAMi SSF51269. SSF51269. 1 hit.
PROSITEi PS50844. AFP_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evidence for a common molecular origin of the capsule gene loci in Gram-negative bacteria expressing group II capsular polysaccharides."
    Frosch M., Edwards U., Bousset K., Krausse B., Weisgerber C.
    Mol. Microbiol. 5:1251-1263(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: B1940Imported.
  2. "Molecular analysis of the biosynthesis pathway of the alpha 2,8 polysialic acid capsule by Neisseria meningitidis serogroup B."
    Edwards U., Muller A., Hammerschmidt S., Frosch M.
    Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: B1940Imported.
  3. "Expression of sialic acid and polysialic acid in serogroup B Neisseria meningitidis: divergent transcription of biosynthesis and transport operons through a common promoter region."
    Swartley J.S., Ahn J.H., Liu L.J., Kahler C.M., Stephens D.S.
    J. Bacteriol. 178:4052-4059(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NMBImported.
  4. "Structural and mechanistic analysis of sialic acid synthase NeuB from Neisseria meningitidis in complex with Mn2+, phosphoenolpyruvate, and N-acetylmannosaminitol."
    Gunawan J., Simard D., Gilbert M., Lovering A.L., Wakarchuk W.W., Tanner M.E., Strynadka N.C.
    J. Biol. Chem. 280:3555-3563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH MANGANESE.
  5. "Crystal structure of sialic acid synthase (NeuB) from neisseria meningitidis in complex with Mg2+ and (4S)-2-methyl-2,4-pentanediol."
    Morrison E., Rosanally A., Junop M.S., Berti P.
    Submitted (NOV-2007) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).
  6. "Crystal structure of metal-free sialic acid synthase (NeuB) from neisseria meningitidis in complex with malate."
    Morrison E., Rosanally A., Junop M.S., Berti P.
    Submitted (MAR-2008) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).
  7. "Genetic study of capsular switching between Neisseria meningitidis sequence type 7 serogroup A and C strains."
    Wang Q., Shao Z., Wang X., Gao Y., Li M., Xu L., Xu J., Wang L.
    Infect. Immun. 78:3883-3888(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 510602Imported.
  8. "Arg314 is essential for catalysis by N-acetyl neuraminic acid synthase from Neisseria meningitidis."
    Joseph D.D., Jiao W., Parker E.J.
    Biochemistry 52:2609-2619(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) IN COMPLEX WITH MANGANESE.

Entry informationi

Entry nameiQ57265_NEIME
AccessioniPrimary (citable) accession number: Q57265
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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