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Protein
Submitted name:

BoNT/F

Gene

bont

Organism
Clostridium botulinum
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1195GalactoseCombined sources1
Binding sitei1195N-acetyl-D-galactosamineCombined sources1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNeurotoxinImported, Toxin

Enzyme and pathway databases

BRENDAi3.4.24.69 1462

Protein family/group databases

MEROPSiM27.002

Names & Taxonomyi

Protein namesi
Submitted name:
BoNT/FImported
Submitted name:
Botulinum neurotoxin type FImported
Submitted name:
Neurotoxin type FImported
Gene namesi
Name:bontImported
Synonyms:bonTImported, FImported, fImported
OrganismiClostridium botulinumImported
Taxonomic identifieri1491 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Subcellular locationi

GO - Cellular componenti

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
VAMP2P630273EBI-15790260,EBI-520113From Homo sapiens.

Protein-protein interaction databases

DIPiDIP-48535N
IntActiQ57236, 1 interactor

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FUQX-ray2.10A862-1278[»]
3RSJX-ray2.00A/B/C/D866-1278[»]
SMRiQ57236
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 409Peptidase_M27InterPro annotationAdd BLAST406
Domaini538 – 856Toxin_transInterPro annotationAdd BLAST319
Domaini878 – 1072Toxin_R_bind_NInterPro annotationAdd BLAST195
Domaini1085 – 1277Toxin_R_bind_CInterPro annotationAdd BLAST193

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1240 – 1241Galactose bindingCombined sources2
Regioni1248 – 1250Galactose bindingCombined sources3

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili717 – 737Sequence analysisAdd BLAST21
Coiled coili763 – 783Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Gene3Di1.20.1120.10, 1 hit
InterProiView protein in InterPro
IPR000395 Bot/tetX_LC
IPR036248 Clostridium_toxin_transloc
IPR013320 ConA-like_dom_sf
IPR011065 Kunitz_inhibitor_STI-like_sf
IPR013104 Toxin_rcpt-bd_C
IPR012928 Toxin_rcpt-bd_N
IPR012500 Toxin_trans
PfamiView protein in Pfam
PF01742 Peptidase_M27, 1 hit
PF07951 Toxin_R_bind_C, 1 hit
PF07953 Toxin_R_bind_N, 1 hit
PF07952 Toxin_trans, 1 hit
PRINTSiPR00760 BONTOXILYSIN
SUPFAMiSSF49899 SSF49899, 1 hit
SSF50386 SSF50386, 1 hit
SSF58091 SSF58091, 1 hit

Sequencei

Sequence statusi: Complete.

Q57236-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVVINSFNY NDPVNDDTIL YMQIPYEEKS KKYYKAFEIM RNVWIIPERN
60 70 80 90 100
TIGTDPSDFD PPASLENGSS AYYDPNYLTT DAEKDRYLKT TIKLFKRINS
110 120 130 140 150
NPAGEVLLQE ISYAKPYLGN EHTPINEFHP VTRTTSVNIK SSTNVKSSII
160 170 180 190 200
LNLLVLGAGP DIFENSSYPV RKLMDSGGVY DPSNDGFGSI NIVTFSPEYE
210 220 230 240 250
YTFNDISGGY NSSTESFIAD PAISLAHELI HALHGLYGAR GVTYKETIKV
260 270 280 290 300
KQAPLMIAEK PIRLEEFLTF GGQDLNIITS AMKEKIYNNL LANYEKIATR
310 320 330 340 350
LSRVNSAPPE YDINEYKDYF QWKYGLDKNA DGSYTVNENK FNEIYKKLYS
360 370 380 390 400
FTEIDLANKF KVKCRNTYFI KYGFLKVPNL LDDDIYTVSE GFNIGNLAVN
410 420 430 440 450
NRGQNIKLNP KIIDSIPDKG LVEKIVKFCK SVIPRKGTKA PPRLCIRVNN
460 470 480 490 500
RELFFVASES SYNENDINTP KEIDDTTNLN NNYRNNLDEV ILDYNSETIP
510 520 530 540 550
QISNQTLNTL VQDDSYVPRY DSNGTSEIEE HNVVDLNVFF YLHAQKVPEG
560 570 580 590 600
ETNISLTSSI DTALSEESQV YTFFSSEFIN TINKPVHAAL FISWINQVIR
610 620 630 640 650
DFTTEATQKS TFDKIADISL VVPYVGLALN IGNEVQKENF KEAFELLGAG
660 670 680 690 700
ILLEFVPELL IPTILVFTIK SFIGSSENKN KIIKAINNSL MERETKWKEI
710 720 730 740 750
YSWIVSNWLT RINTQFNKRK EQMYQALQNQ VDAIKTVIEY KYNNYTSDER
760 770 780 790 800
NRLESEYNIN NIREELNKKV SLAMENIERF ITESSIFYLM KLINEAKVSK
810 820 830 840 850
LREYDEGVKE YLLDYISEHR SILGNSVQEL NDLVTSTLNN SIPFELSSYT
860 870 880 890 900
NDKILILYFN KLYKKIKDNS ILDMRYENNK FIDISGYGSN ISINGDVYIY
910 920 930 940 950
STNRNQFGIY SSKPSEVNIA QNNDIIYNGR YQNFSISFWV RIPKYFNKVN
960 970 980 990 1000
LNNEYTIIDC IRNNNSGWKI SLNYNKIIWT LQDTAGNNQK LVFNYTQMIS
1010 1020 1030 1040 1050
ISDYINKWIF VTITNNRLGN SRIYINGNLI DEKSISNLGD IHVSDNILFK
1060 1070 1080 1090 1100
IVGCNDTRYV GIRYFKVFDT ELGKTEIETL YSDEPDPSIL KDFWGNYLLY
1110 1120 1130 1140 1150
NKRYYLLNLL RTDKSITQNS NFLNINQQRG VYQKPNIFSN TRLYTGVEVI
1160 1170 1180 1190 1200
IRKNGSTDIS NTDNFVRKND LAYINVVDRD VEYRLYADIS IAKPEKIIKL
1210 1220 1230 1240 1250
IRTSNSNNSL GQIIVMDSIG NNCTMNFQNN NGGNIGLLGF HSNNLVASSW
1260 1270
YYNNIRKNTS SNGCFWSFIS KEHGWQEN
Length:1,278
Mass (Da):147,075
Last modified:November 1, 1996 - v1
Checksum:iA1BE1318431D6918
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35496 Genomic DNA Translation: AAA23210.1
GU213204 Genomic DNA Translation: ADA79552.1
GU213205 Genomic DNA Translation: ADA79553.1
GU213206 Genomic DNA Translation: ADA79554.1
GU213207 Genomic DNA Translation: ADA79555.1
GU213208 Genomic DNA Translation: ADA79556.1
X81714 Genomic DNA Translation: CAA57358.1
PIRiS48110
RefSeqiWP_011987710.1, NZ_LFPF01000007.1

Genome annotation databases

PATRICifig|1491.420.peg.3551

Similar proteinsi

Entry informationi

Entry nameiQ57236_CLOBO
AccessioniPrimary (citable) accession number: Q57236
Secondary accession number(s): Q45863
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

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