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Q57233 (THIM_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:HI_0415
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 265265Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_0000156936

Sites

Binding site431Substrate; via amide nitrogen By similarity
Binding site1191ATP By similarity
Binding site1651ATP By similarity
Binding site1921Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q57233 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: C43B7ABED91A8BD6

FASTA26527,733
        10         20         30         40         50         60 
MLMQSIYLSK IREQNPLIHN ITNIVAANFS ANGLLALGAS PLMSANVEEM QEVPKISQAL 

        70         80         90        100        110        120 
VINIGTLIGK DREAMLQAGK TANEVGIPVV LDPVGVGATS YRRETIRELL AEVKFALIRG 

       130        140        150        160        170        180 
NAGELAAIAG ETWQAKGVDA GQGEVDLKAV AEKVAQRYGC TVLISGAVDI VSDGTQTATV 

       190        200        210        220        230        240 
HNGTSLFPKV TASGCLLSAV CAAFLAVSEG NYFSATLEAC VAYTIAGECA AQGLTTQVGQ 

       250        260 
FQIRLLDELA ALSPETIGQR GRINE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC22073.1.
PIRH64151.
RefSeqNP_438577.1. NC_000907.1.

3D structure databases

ProteinModelPortalQ57233.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI0415.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC22073; AAC22073; HI_0415.
GeneID949516.
KEGGhin:HI0415.
PATRIC20189383. VBIHaeInf48452_0435.

Phylogenomic databases

eggNOGCOG2145.
KOK00878.
OMASPVMAHA.
OrthoDBEOG628F8M.
ProtClustDBPRK09355.

Enzyme and pathway databases

UniPathwayUPA00060; UER00139.

Family and domain databases

HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
TIGRFAMsTIGR00694. thiM. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIM_HAEIN
AccessionPrimary (citable) accession number: Q57233
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names