Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

F component of leucocodin R

Gene

hlgB-like ORF

Organism
Staphylococcus aureus
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
F component of leucocodin RImported
Submitted name:
Gamma-hemolysin subunit BImported
Submitted name:
HlgB-like ORF proteinImported
Gene namesi
Name:hlgB-like ORFImported
Synonyms:luk F-RImported
ORF Names:AL077_06150Imported
OrganismiStaphylococcus aureusImported
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 325299Sequence analysisPRO_5007209788Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi93062.SACOL2422.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2QK7X-ray2.40B27-325[»]
SMRiQ57227. Positions 27-325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini60 – 310251LeukocidinInterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG4106XHW. Bacteria.
ENOG410YTX5. LUCA.

Family and domain databases

Gene3Di2.70.240.10. 1 hit.
InterProiIPR003963. Bi-component_toxin_staph.
IPR016183. Leukocidin/porin.
[Graphical view]
PfamiPF07968. Leukocidin. 1 hit.
[Graphical view]
PRINTSiPR01468. BICOMPNTOXIN.
SUPFAMiSSF56959. SSF56959. 1 hit.
TIGRFAMsiTIGR01002. hlyII. 1 hit.

Sequencei

Sequence statusi: Complete.

Q57227-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNMNKLVKSS VATSMALLLL SNTANAEGKI TPVSVKKVDD KVTLYKTTAT
60 70 80 90 100
ADSDKFKISQ ILTFNFIKDK SYDKDTLVLK AAGNINSGYE RPNPKDYDFS
110 120 130 140 150
KIYWGAKYNV SISSQSNDSV NVVDYAPKNQ NEEFQVQNTL GYTFGGDISI
160 170 180 190 200
SNGLSGGLNG NTAFSETINY KQESYRTTLS RNTNYKNVGW GVEAHKIMNN
210 220 230 240 250
GWGPYGRDSF HPTYGNELFL AGRQSSAYAG QNFIAQHQMP LLSRSNFNPE
260 270 280 290 300
FLSVLSHRQD GAKKSKITVT YQREMDLYQI RWNGFYWAGA NYKNFKTRTF
310 320
KSTYEIDWEN HKVKLLDTKE TENNK
Length:325
Mass (Da):36,812
Last modified:November 1, 1996 - v1
Checksum:i38A0066D8DBD8935
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64389 Genomic DNA. Translation: CAA45729.1.
X81586 Genomic DNA. Translation: CAA57278.1.
LIGV01000007 Genomic DNA. Translation: KQB70858.1.
PIRiB49234.
RefSeqiWP_001056917.1. NZ_LNTF01000013.1.

Genome annotation databases

EnsemblBacteriaiKLM34415; KLM34415; RK78_01415.
KLM84497; KLM84497; RK90_10260.
KLM87737; KLM87737; RK88_12965.
KLN25964; KLN25964; RL03_00895.
KQB70858; KQB70858; AL077_06150.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64389 Genomic DNA. Translation: CAA45729.1.
X81586 Genomic DNA. Translation: CAA57278.1.
LIGV01000007 Genomic DNA. Translation: KQB70858.1.
PIRiB49234.
RefSeqiWP_001056917.1. NZ_LNTF01000013.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2QK7X-ray2.40B27-325[»]
SMRiQ57227. Positions 27-325.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi93062.SACOL2422.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiKLM34415; KLM34415; RK78_01415.
KLM84497; KLM84497; RK90_10260.
KLM87737; KLM87737; RK88_12965.
KLN25964; KLN25964; RL03_00895.
KQB70858; KQB70858; AL077_06150.

Phylogenomic databases

eggNOGiENOG4106XHW. Bacteria.
ENOG410YTX5. LUCA.

Family and domain databases

Gene3Di2.70.240.10. 1 hit.
InterProiIPR003963. Bi-component_toxin_staph.
IPR016183. Leukocidin/porin.
[Graphical view]
PfamiPF07968. Leukocidin. 1 hit.
[Graphical view]
PRINTSiPR01468. BICOMPNTOXIN.
SUPFAMiSSF56959. SSF56959. 1 hit.
TIGRFAMsiTIGR01002. hlyII. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Sequencing of leucocidin R from Staphylococcus aureus P83 suggests that staphylococcal leucocidins and gamma-hemolysin are members of a single, two-component family of toxins."
    Supersac G., Prevost G., Piemont Y.
    Infect. Immun. 61:580-587(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 1-186.
    Strain: P83Imported.
  2. "The new family of leukotoxins from S.aureua: structural and biological properties."
    Prevost G., Supersac G., Piemont Y., Colin D., Sire S., Henslen T., Petiau P., Meunier O., Gibier B., Koenig W., Piermont Y.
    Zentralbl. Bakteriol. 24:284-293(1994)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: P83Imported.
  3. "Panton-Valentine leucocidin and gamma-hemolysin from Staphylococcus aureus ATCC 49775 are encoded by distinct genetic loci and have different biological activities."
    Prevost G., Cribier B., Couppie P., Petiau P., Supersac G., Finck-Barbancon V., Monteil H., Piemont Y.
    Infect. Immun. 63:4121-4129(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ATCC 49775Imported.
  4. "A covalent S-F heterodimer of leucotoxin reveals molecular plasticity of beta-barrel pore-forming toxins."
    Roblin P., Guillet V., Joubert O., Keller D., Erard M., Maveyraud L., Prevost G., Mourey L.
    Proteins 71:485-496(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 27-325.
  5. "Analysis of methicillin-resistant Staphylococcus aureus ST5 and ST30 strains colonizing healthy children in public daycare centers in Niteroi, Brazil."
    Stephens C.M., Cho P.J., Braga E.D., Cardoso C.A., Riley L.W., Alves F.A.
    Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CC175Imported.

Entry informationi

Entry nameiQ57227_STAAU
AccessioniPrimary (citable) accession number: Q57227
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.