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Protein

TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Gene

Tab3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL-1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri686 – 716RanBP2-typePROSITE-ProRule annotationAdd BLAST31

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-168638. NOD1/2 Signaling Pathway.
R-MMU-2871837. FCERI mediated NF-kB activation.
R-MMU-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-MMU-446652. Interleukin-1 family signaling.
R-MMU-450302. activated TAK1 mediates p38 MAPK activation.
R-MMU-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
R-MMU-5357956. TNFR1-induced NFkappaB signaling pathway.
R-MMU-5607764. CLEC7A (Dectin-1) signaling.
R-MMU-937042. IRAK2 mediated activation of TAK1 complex.
R-MMU-975163. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.

Names & Taxonomyi

Protein namesi
Recommended name:
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
Alternative name(s):
Mitogen-activated protein kinase kinase kinase 7-interacting protein 3
TAK1-binding protein 3
Short name:
TAB-3
TGF-beta-activated kinase 1-binding protein 3
Gene namesi
Name:Tab3
Synonyms:Kiaa4135, Map3k7ip3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1913974. Tab3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002269732 – 716TGF-beta-activated kinase 1 and MAP3K7-binding protein 3Add BLAST715

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei60PhosphoserineBy similarity1
Modified residuei101PhosphoserineBy similarity1
Modified residuei103PhosphoserineBy similarity1
Modified residuei389PhosphoserineBy similarity1
Modified residuei408PhosphothreonineBy similarity1
Modified residuei413PhosphoserineBy similarity1
Modified residuei496PhosphoserineBy similarity1
Modified residuei510Phosphoserine; by MAPKAPK2 and MAPKAPK3By similarity1

Post-translational modificationi

Phosphorylated at Ser-510 by MAPKAPK2 and MAPKAPK3 following IL1 treatment.
Ubiquitinated; following IL1 stimulation or TRAF6 overexpression.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ571K4.
MaxQBiQ571K4.
PaxDbiQ571K4.
PRIDEiQ571K4.

PTM databases

iPTMnetiQ571K4.
PhosphoSitePlusiQ571K4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000035476.
ExpressionAtlasiQ571K4. baseline and differential.
GenevisibleiQ571K4. MM.

Interactioni

Subunit structurei

Interacts with TAB1, TAB2, MAP3K7, TRAF2 and TRAF6. The minimal TAB3-containing complex (TAB1-MAP3K7-TAB3) appears not to contain TAB2. However, it seems sensible to consider that TAB2 may also join this complex and may act in a cooperative manner with TAB3. Interacts with WDR34 (via the WD domains). Binds 'Lys-63'-linked polyubiquitin chains. Interacts with RBCK1 (By similarity). Interacts with TRIM5 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
UbcP629912EBI-7606337,EBI-413074

Protein-protein interaction databases

BioGridi211673. 5 interactors.
IntActiQ571K4. 1 interactor.
STRINGi10090.ENSMUSP00000039668.

Structurei

Secondary structure

1716
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni694 – 696Combined sources3
Turni708 – 710Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3A9KX-ray1.40C688-716[»]
ProteinModelPortaliQ571K4.
SMRiQ571K4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ571K4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 51CUEPROSITE-ProRule annotationAdd BLAST44

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili521 – 564Sequence analysisAdd BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi152 – 455Pro-richAdd BLAST304
Compositional biasi508 – 513Poly-Ser6
Compositional biasi661 – 666Poly-Ala6

Domaini

The RanBP2-type zinc finger (NZF) mediates binding to two consecutive 'Lys-63'-linked ubiquitins.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri686 – 716RanBP2-typePROSITE-ProRule annotationAdd BLAST31

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IG4E. Eukaryota.
ENOG410XPAC. LUCA.
GeneTreeiENSGT00530000063642.
HOGENOMiHOG000261646.
HOVERGENiHBG056952.
InParanoidiQ571K4.
KOiK12793.
OMAiNENCHQR.
OrthoDBiEOG091G0AYA.
PhylomeDBiQ571K4.
TreeFamiTF332021.

Family and domain databases

InterProiView protein in InterPro
IPR003892. CUE.
IPR001876. Znf_RanBP2.
PfamiView protein in Pfam
PF02845. CUE. 1 hit.
SMARTiView protein in SMART
SM00546. CUE. 1 hit.
SM00547. ZnF_RBZ. 1 hit.
SUPFAMiSSF90209. SSF90209. 1 hit.
PROSITEiView protein in PROSITE
PS51140. CUE. 1 hit.
PS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q571K4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQNSPQLDI QVLHDLRQRF PEIPEGVVSQ CMLQNNNNLE ACCRALSQES
60 70 80 90 100
SKYLYMEYHS PEDNRMNRNR LLHINLGIHS PSSYHPGDGA HLNGGRTLVH
110 120 130 140 150
SSSDGHIDPQ HTAGKQLICL VQEPHSAPAV VAATPNYNPF FMNEQNRSAA
160 170 180 190 200
TPPSQPPQQP SSMQTGMNPS AMQGPSPPPP PPSYMHIPRY STNPITVTVS
210 220 230 240 250
QNLPSGQTVP RALQILPQIP SNLYGSPGSI FIRQTSQSSS GRQTPQNAPW
260 270 280 290 300
QSSPQGPVPH YSQRPLPVYP HQQNYQPSQY SPKQQQIPQS VYHSPPPSQC
310 320 330 340 350
PSPFSSPQHQ VQPPQLGHPS SHVFMPPSPS TTPPHLYQQG PPSYQKPGSH
360 370 380 390 400
SVAYLPYTAS SLPKGSMKKI EITVEPSQRP GTAITRSPSP ISNQPSPRNQ
410 420 430 440 450
HSLYTATTPP SSSPSRGISS QPKPPFSVNP VYITYTQPTG PSCAPSPSPR
460 470 480 490 500
VIPNPTTVFK ITVGRATTEN LLNLVDQEER SAAPEPIQPI SVIPGSGGEK
510 520 530 540 550
GNHKYQRSSS SGSDDYAYTQ ALLLHQRARM ERLAKQLKLE KEELERLKAE
560 570 580 590 600
VNSMEHDLMQ RRLRRVSCTT AIPTPEEMTR LRSTNRQLQI NVDCTLKEVD
610 620 630 640 650
LLQSRGNFDP KAINNFYDHI EPGPVVPPKP SKKDSSDSCA IERKARRISV
660 670 680 690 700
TSKAPVDIHD AQAAAADEHL SICKQSARTQ PRDEDYEGAP WNCDSCTFLN
710
HPALNRCEQC EMPRYT
Length:716
Mass (Da):79,029
Last modified:March 7, 2006 - v2
Checksum:i65B3FCC60C4A1CB1
GO

Sequence cautioni

The sequence BAD90370 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220185 mRNA. Translation: BAD90370.1. Different initiation.
CCDSiCCDS41049.1.
RefSeqiNP_080005.2. NM_025729.4.
XP_006528301.1. XM_006528238.3.
XP_006528302.1. XM_006528239.2.
XP_017174093.1. XM_017318604.1.
UniGeneiMm.119646.
Mm.403286.

Genome annotation databases

EnsembliENSMUST00000048250; ENSMUSP00000039668; ENSMUSG00000035476.
GeneIDi66724.
KEGGimmu:66724.
UCSCiuc009trt.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiTAB3_MOUSE
AccessioniPrimary (citable) accession number: Q571K4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 7, 2006
Last modified: September 27, 2017
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references