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Protein

Zinc finger protein 354C

Gene

Znf354c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May function as a transcription repressor. Binds to 5'-CCACA-3' core sequence. Suppresses osteogenic effects of RUNX2. May be involved in osteoblastic differentiation (By similarity). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (PubMed:27446912).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri218 – 240C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri246 – 268C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri274 – 296C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri302 – 324C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri330 – 352C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 380C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 464C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri470 – 492C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri498 – 520C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 354C
Alternative name(s):
Kidney, ischemia, and developmentally-regulated protein 3
Gene namesi
Name:Znf354c
Synonyms:Kiaa4218, Kid3, Zfp354c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1353621. Zfp354c.

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

  • cytosol Source: MGI
  • nuclear membrane Source: MGI
  • nucleus Source: MGI

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002804091 – 560Zinc finger protein 354CAdd BLAST560

Proteomic databases

MaxQBiQ571J5.
PaxDbiQ571J5.
PeptideAtlasiQ571J5.
PRIDEiQ571J5.

PTM databases

iPTMnetiQ571J5.
PhosphoSitePlusiQ571J5.

Expressioni

Tissue specificityi

Expressed in brain. Lower levels in kidney, heart, lung, spleen and eye. Down-regulated during kidney maturation. Expressed in embronic myogenic progenitor cells, not expressded in adult and aged satellite cells (PubMed:27446912).2 Publications

Developmental stagei

In myogenic progenitor cells, expressed during early myogenic development (E11.5) to be gradually down-regulated during the fetal stages (from E14.5 to adulthood).1 Publication

Gene expression databases

BgeeiENSMUSG00000044807.
CleanExiMM_ZFP354C.
GenevisibleiQ571J5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000632.

Structurei

3D structure databases

ProteinModelPortaliQ571J5.
SMRiQ571J5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 84KRABPROSITE-ProRule annotationAdd BLAST71

Domaini

KRAB domain is not required for nuclear targeting or for DNA binding.By similarity
Zinc finger region is involved in nuclear targeting and DNA-binding.By similarity

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri218 – 240C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri246 – 268C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri274 – 296C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri302 – 324C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri330 – 352C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 380C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 464C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri470 – 492C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri498 – 520C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00880000137872.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ571J5.
KOiK09228.
OMAiCFQIYPG.
OrthoDBiEOG091G02KC.
PhylomeDBiQ571J5.
TreeFamiTF350822.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 6 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.

Sequencei

Sequence statusi: Complete.

Q571J5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVDLLAARG TEPVTFRDVA VSFSQDEWLH LDPAQRSLYR EVMLENYSNL
60 70 80 90 100
ASLGFQASIP PVIGKLQKGQ DPCMEREAPE DTCLDFEIWP EIEALPPKQD
110 120 130 140 150
VLTKETSHGL IKNGSTKCVY WKISFGELVK TECRDIAQEQ EKKVHGPGAE
160 170 180 190 200
SPKETTSEDG TPTGFEPEKP LFISKALVSQ EGDPTESVPA TYHTSEKDLP
210 220 230 240 250
QDFDLMRSFQ MYPGQKPHVC SECGKGFTQS LHLLEHKRLH TGEKPYKCSE
260 270 280 290 300
CGKSFSHRSS LLAHQRTHTG EKPYKCSECE KAFGSSSTLI KHLRVHTGEK
310 320 330 340 350
PYRCRQCGKA FSQCSTLTVH QRIHTGEKLY KCAECDKAFN CRAKLHRHQR
360 370 380 390 400
IHTGEKPYKC AECGKGYSQF PSLAEHQRLH TGEQLCQCLQ CGRTFTRVST
410 420 430 440 450
LIEHQRIHTG QKPYQCNECG KTFNQYSSFN EHRKIHTGEK LYTCEECGKA
460 470 480 490 500
FGCKSNLYRH QRIHTGEKPY QCNQCGKAFS QYSFLTEHER IHTGEKLYKC
510 520 530 540 550
MECGKAYSYR SNLCRHKKVH LKERLYKWKE YGTPFIYGSS LTPYQKFLKG
560
DKPENFNSSL
Length:560
Mass (Da):64,065
Last modified:March 20, 2007 - v2
Checksum:iA348B1C5C9392A22
GO

Sequence cautioni

The sequence BAD90379 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti77E → K in BAC39738 (PubMed:16141072).Curated1
Sequence conflicti87E → K in BAE26722 (PubMed:16141072).Curated1
Sequence conflicti284G → D in BAE26722 (PubMed:16141072).Curated1
Sequence conflicti287S → P in BAE26722 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192804 mRNA. Translation: AAF35173.1.
AK086760 mRNA. Translation: BAC39738.1.
AK145882 mRNA. Translation: BAE26722.1.
AK220194 mRNA. Translation: BAD90379.1. Different initiation.
AL627215 Genomic DNA. Translation: CAI35293.1.
BC079908 mRNA. Translation: AAH79908.1.
CCDSiCCDS24637.1.
RefSeqiNP_038950.3. NM_013922.4.
UniGeneiMm.103674.

Genome annotation databases

EnsembliENSMUST00000000632; ENSMUSP00000000632; ENSMUSG00000044807.
ENSMUST00000109135; ENSMUSP00000104763; ENSMUSG00000044807.
GeneIDi30944.
KEGGimmu:30944.
UCSCiuc007isq.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiZ354C_MOUSE
AccessioniPrimary (citable) accession number: Q571J5
Secondary accession number(s): Q3UKS9, Q8C365, Q9JLD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: June 7, 2017
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families