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Protein

Zinc finger protein 354C

Gene

Znf354c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May function as a transcription repressor. Suppresses osteogenic effects of RUNX2. Binds to 5'-CCACA-3' core sequence. May be involved in osteoblastic differentiation (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri218 – 24023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri246 – 26823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri274 – 29623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri302 – 32423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri330 – 35223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri358 – 38023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri386 – 40823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri414 – 43623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri442 – 46423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri470 – 49223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri498 – 52023C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 354C
Alternative name(s):
Kidney, ischemia, and developmentally-regulated protein 3
Gene namesi
Name:Znf354c
Synonyms:Kiaa4218, Kid3, Zfp354c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1353621. Zfp354c.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nuclear membrane Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 560560Zinc finger protein 354CPRO_0000280409Add
BLAST

Proteomic databases

MaxQBiQ571J5.
PaxDbiQ571J5.
PRIDEiQ571J5.

PTM databases

iPTMnetiQ571J5.
PhosphoSiteiQ571J5.

Expressioni

Tissue specificityi

Expressed in brain. Lower levels in kidney, heart, lung, spleen and eye. Down-regulated during kidney maturation.1 Publication

Developmental stagei

During E14.5 highly expressed in kidneys, expression decreases in late embryonic and new born. In E16.5, highly expressed in brain, with lower levels in the lung, gut and heart.1 Publication

Gene expression databases

BgeeiQ571J5.
CleanExiMM_ZFP354C.
GenevisibleiQ571J5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000632.

Structurei

3D structure databases

ProteinModelPortaliQ571J5.
SMRiQ571J5. Positions 7-55, 184-546.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 8471KRABPROSITE-ProRule annotationAdd
BLAST

Domaini

KRAB domain is not required for nuclear targeting or for DNA binding.By similarity
Zinc finger region is involved in nuclear targeting and DNA-binding.By similarity

Sequence similaritiesi

Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri218 – 24023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri246 – 26823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri274 – 29623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri302 – 32423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri330 – 35223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri358 – 38023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri386 – 40823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri414 – 43623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri442 – 46423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri470 – 49223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri498 – 52023C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129726.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ571J5.
KOiK09228.
OMAiGIPFSMP.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ571J5.
TreeFamiTF350822.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q571J5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVDLLAARG TEPVTFRDVA VSFSQDEWLH LDPAQRSLYR EVMLENYSNL
60 70 80 90 100
ASLGFQASIP PVIGKLQKGQ DPCMEREAPE DTCLDFEIWP EIEALPPKQD
110 120 130 140 150
VLTKETSHGL IKNGSTKCVY WKISFGELVK TECRDIAQEQ EKKVHGPGAE
160 170 180 190 200
SPKETTSEDG TPTGFEPEKP LFISKALVSQ EGDPTESVPA TYHTSEKDLP
210 220 230 240 250
QDFDLMRSFQ MYPGQKPHVC SECGKGFTQS LHLLEHKRLH TGEKPYKCSE
260 270 280 290 300
CGKSFSHRSS LLAHQRTHTG EKPYKCSECE KAFGSSSTLI KHLRVHTGEK
310 320 330 340 350
PYRCRQCGKA FSQCSTLTVH QRIHTGEKLY KCAECDKAFN CRAKLHRHQR
360 370 380 390 400
IHTGEKPYKC AECGKGYSQF PSLAEHQRLH TGEQLCQCLQ CGRTFTRVST
410 420 430 440 450
LIEHQRIHTG QKPYQCNECG KTFNQYSSFN EHRKIHTGEK LYTCEECGKA
460 470 480 490 500
FGCKSNLYRH QRIHTGEKPY QCNQCGKAFS QYSFLTEHER IHTGEKLYKC
510 520 530 540 550
MECGKAYSYR SNLCRHKKVH LKERLYKWKE YGTPFIYGSS LTPYQKFLKG
560
DKPENFNSSL
Length:560
Mass (Da):64,065
Last modified:March 20, 2007 - v2
Checksum:iA348B1C5C9392A22
GO

Sequence cautioni

The sequence BAD90379.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti77 – 771E → K in BAC39738 (PubMed:16141072).Curated
Sequence conflicti87 – 871E → K in BAE26722 (PubMed:16141072).Curated
Sequence conflicti284 – 2841G → D in BAE26722 (PubMed:16141072).Curated
Sequence conflicti287 – 2871S → P in BAE26722 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192804 mRNA. Translation: AAF35173.1.
AK086760 mRNA. Translation: BAC39738.1.
AK145882 mRNA. Translation: BAE26722.1.
AK220194 mRNA. Translation: BAD90379.1. Different initiation.
AL627215 Genomic DNA. Translation: CAI35293.1.
BC079908 mRNA. Translation: AAH79908.1.
CCDSiCCDS24637.1.
RefSeqiNP_038950.3. NM_013922.4.
UniGeneiMm.103674.

Genome annotation databases

EnsembliENSMUST00000000632; ENSMUSP00000000632; ENSMUSG00000044807.
ENSMUST00000109135; ENSMUSP00000104763; ENSMUSG00000044807.
GeneIDi30944.
KEGGimmu:30944.
UCSCiuc007isq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192804 mRNA. Translation: AAF35173.1.
AK086760 mRNA. Translation: BAC39738.1.
AK145882 mRNA. Translation: BAE26722.1.
AK220194 mRNA. Translation: BAD90379.1. Different initiation.
AL627215 Genomic DNA. Translation: CAI35293.1.
BC079908 mRNA. Translation: AAH79908.1.
CCDSiCCDS24637.1.
RefSeqiNP_038950.3. NM_013922.4.
UniGeneiMm.103674.

3D structure databases

ProteinModelPortaliQ571J5.
SMRiQ571J5. Positions 7-55, 184-546.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000632.

PTM databases

iPTMnetiQ571J5.
PhosphoSiteiQ571J5.

Proteomic databases

MaxQBiQ571J5.
PaxDbiQ571J5.
PRIDEiQ571J5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000632; ENSMUSP00000000632; ENSMUSG00000044807.
ENSMUST00000109135; ENSMUSP00000104763; ENSMUSG00000044807.
GeneIDi30944.
KEGGimmu:30944.
UCSCiuc007isq.1. mouse.

Organism-specific databases

CTDi30944.
MGIiMGI:1353621. Zfp354c.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129726.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ571J5.
KOiK09228.
OMAiGIPFSMP.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ571J5.
TreeFamiTF350822.

Miscellaneous databases

PROiQ571J5.
SOURCEiSearch...

Gene expression databases

BgeeiQ571J5.
CleanExiMM_ZFP354C.
GenevisibleiQ571J5. MM.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterisation, chromosomal localisation and expression of the mouse Kid3 gene."
    Watson R.P., Tekki-Kessaris N., Boulter C.A.
    Biochim. Biophys. Acta 1490:153-158(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head and Placenta.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryonic tail.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.

Entry informationi

Entry nameiZ354C_MOUSE
AccessioniPrimary (citable) accession number: Q571J5
Secondary accession number(s): Q3UKS9, Q8C365, Q9JLD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: June 8, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.