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UniProtKB - Q571I9 (A16A1_MOUSE)

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Protein

Aldehyde dehydrogenase family 16 member A1

Gene

Aldh16a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase family 16 member A1
Gene namesi
Name:Aldh16a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1916998. Aldh16a1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003129871 – 802Aldehyde dehydrogenase family 16 member A1Add BLAST802

Proteomic databases

EPDiQ571I9.
MaxQBiQ571I9.
PaxDbiQ571I9.
PRIDEiQ571I9.

PTM databases

iPTMnetiQ571I9.
PhosphoSitePlusiQ571I9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000007833.
CleanExiMM_ALDH16A1.

Interactioni

Subunit structurei

Interacts with SPG21.By similarity

Protein-protein interaction databases

IntActiQ571I9. 4 interactors.
MINTiMINT-4113910.
STRINGi10090.ENSMUSP00000007977.

Structurei

3D structure databases

ProteinModelPortaliQ571I9.
SMRiQ571I9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiKOG2450. Eukaryota.
COG1012. LUCA.
HOGENOMiHOG000112558.
HOVERGENiHBG069396.
InParanoidiQ571I9.
PhylomeDBiQ571I9.
TreeFamiTF329461.

Family and domain databases

Gene3Di3.40.605.10. 2 hits.
InterProiView protein in InterPro
IPR016161. Ald_DH/histidinol_DH.
IPR016162. Ald_DH_N.
IPR011408. Aldehyde_DH.
IPR015590. Aldehyde_DH_dom.
PfamiView protein in Pfam
PF00171. Aldedh. 2 hits.
PIRSFiPIRSF036490. Aldedh_dupl. 1 hit.
SUPFAMiSSF53720. SSF53720. 2 hits.

Sequencei

Sequence statusi: Complete.

Q571I9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATRVQPST REIFTTLEYG PVPESHACAL AWLDTHNRLL GHHVNGMWLK 
        60         70         80         90        100
PEHRNPAPCQ DPITGENLAS CLQAEAEDIA AAVEAAKIAF KAWSQLPGAA 
       110        120        130        140        150
RGQHLTRLAK VVQKHQRLLW TLESLVTGRA VREVRDGDVP LAQQLLQYHA 
       160        170        180        190        200
VQAHAQGDAL ADWQPVGVIG LILPTPFSFL DMMWRVCPAL AMGCTVVALV 
       210        220        230        240        250
PPAFPTPLLL AQLAGELGSF PGILNVVCGP ASLGPVLASQ PGVQKVAFCG 
       260        270        280        290        300
AVEEGRVLRR TLAGRGAELG LALGTESLLL LTDSADVDSA VEGVVDAVWS 
       310        320        330        340        350
DRSLGGLRLL IQESVWDEAM RRLQARMAQI RSGRGLDGAV DMGARGAAAR 
       360        370        380        390        400
DLAQSFVDEA QSQGGQVFQA GDVPSSSPFF SPALVSGLPP AAPCAQAEVP 
       410        420        430        440        450
WPVVMASPFR TVKEALALAN GTPRGGSASV WSERLGQALE LGYGLQVGTV 
       460        470        480        490        500
WINAHGLRDP AVPTGGCKES GSSWHGGPDG LYEYLQPLGT PSQESFLCEN 
       510        520        530        540        550
INYDTFGLAA SSILPSGPET GPSPAPPYGL FVGGRFQSPG TQSSRPIQDS 
       560        570        580        590        600
SGKVSSYVAE GGAKDIRGAV EAAHQAAPGW GAQSPRARAG LLWALAAALE 
       610        620        630        640        650
RRKPVLTSQL ERHGAAPTVA KTEVELSVRR LQTWGTRVQD QGQTLQVTGL 
       660        670        680        690        700
RGPVLRLREP LGVLAVVCPD EWPLLAFVSL LAPALAHGNA VVLVPSGACP 
       710        720        730        740        750
LLALEVCQDI APLFPAGLVS VVTGDRDHLT RCLALHQDVQ ALWYFGSAQG 
       760        770        780        790        800
SQFVEWASAG NLKSVWVNRG FPRAWDVEVQ GAGQELSLHA ARTKALWLPM 

GD
Length:802
Mass (Da):84,756
Last modified:January 15, 2008 - v2
Checksum:i4853B80CAC29B9AE
GO

Sequence cautioni

The sequence BAD90125 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27A → T in BAE26175 (PubMed:16141072).Curated1
Sequence conflicti166V → M in BAD90125 (Ref. 1) Curated1
Sequence conflicti186V → I in BAD90125 (Ref. 1) Curated1
Sequence conflicti282T → M in BAC27074 (PubMed:16141072).Curated1
Sequence conflicti282T → M in BAE30615 (PubMed:16141072).Curated1
Sequence conflicti282T → M in BAE36234 (PubMed:16141072).Curated1
Sequence conflicti282T → M in BAE41680 (PubMed:16141072).Curated1
Sequence conflicti282T → M in AAH13548 (PubMed:15489334).Curated1
Sequence conflicti359E → V in BAE31742 (PubMed:16141072).Curated1
Sequence conflicti405M → K in BAE31742 (PubMed:16141072).Curated1
Sequence conflicti622T → I in BAD90125 (Ref. 1) Curated1
Sequence conflicti622T → I in BAC27074 (PubMed:16141072).Curated1
Sequence conflicti622T → I in BAE30615 (PubMed:16141072).Curated1
Sequence conflicti622T → I in BAE31742 (PubMed:16141072).Curated1
Sequence conflicti622T → I in BAE36234 (PubMed:16141072).Curated1
Sequence conflicti622T → I in BAE41680 (PubMed:16141072).Curated1
Sequence conflicti622T → I in AAH13548 (PubMed:15489334).Curated1
Sequence conflicti773R → K in BAC27074 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220200 mRNA. Translation: BAD90125.1. Different initiation.
AK030673 mRNA. Translation: BAC27074.1.
AK144995 mRNA. Translation: BAE26175.1.
AK151691 mRNA. Translation: BAE30615.1.
AK153129 mRNA. Translation: BAE31742.1.
AK161198 mRNA. Translation: BAE36234.1.
AK170276 mRNA. Translation: BAE41680.1.
BC013548 mRNA. Translation: AAH13548.2.
CCDSiCCDS21231.1.
RefSeqiNP_666066.1. NM_145954.1.
UniGeneiMm.82139.

Genome annotation databases

GeneIDi69748.
KEGGimmu:69748.
UCSCiuc009gtr.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiA16A1_MOUSE
AccessioniPrimary (citable) accession number: Q571I9
Secondary accession number(s): Q3U6I2
, Q3UMC3, Q8C0L4, Q8VD78
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: May 10, 2017
This is version 91 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

The active site cysteine and glutamate residues are not conserved in this protein. Its activity is therefore unsure.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families