Aldh16a1

Functionⁱ

GO - Molecular functionⁱ

4-trimethylammoniobutyraldehyde dehydrogenase activity Source: GO_Central
aminobutyraldehyde dehydrogenase activity Source: GO_Central

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Aldehyde dehydrogenase family 16 member A1
Gene namesⁱ	Name:Aldh16a1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Unplaced

Organism-specific databases

MGIⁱ	MGI:1916998. Aldh16a1.

Subcellular locationⁱ

GO - Cellular componentⁱ

extracellular exosome Source: MGI
membrane Source: MGI

Complete GO annotation...

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Chainⁱ	1 – 802	802	Aldehyde dehydrogenase family 16 member A1		PRO_0000312987	Add BLAST

Proteomic databases

EPDⁱ	Q571I9.
MaxQBⁱ	Q571I9.
PaxDbⁱ	Q571I9.
PRIDEⁱ	Q571I9.

PTM databases

iPTMnetⁱ	Q571I9.
PhosphoSiteⁱ	Q571I9.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000007833.
CleanExⁱ	MM_ALDH16A1.

Interactionⁱ

Subunit structureⁱ

Interacts with SPG21.By similarity

Protein-protein interaction databases

IntActⁱ	Q571I9. 4 interactions.
MINTⁱ	MINT-4113910.
STRINGⁱ	10090.ENSMUSP00000007977.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q571I9.
SMRⁱ	Q571I9. Positions 44-486, 530-790.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2450. Eukaryota. COG1012. LUCA.
HOGENOMⁱ	HOG000112558.
HOVERGENⁱ	HBG069396.
InParanoidⁱ	Q571I9.
PhylomeDBⁱ	Q571I9.
TreeFamⁱ	TF329461.

Family and domain databases

Gene3Dⁱ	3.40.309.10. 1 hit. 3.40.605.10. 2 hits.
InterProⁱ	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016162. Ald_DH_N. IPR011408. Aldehyde_DH. IPR015590. Aldehyde_DH_dom. [Graphical view]
Pfamⁱ	PF00171. Aldedh. 2 hits. [Graphical view]
PIRSFⁱ	PIRSF036490. Aldedh_dupl. 1 hit.
SUPFAMⁱ	SSF53720. SSF53720. 2 hits.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q571I9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAATRVQPST REIFTTLEYG PVPESHACAL AWLDTHNRLL GHHVNGMWLK 
        60         70         80         90        100
PEHRNPAPCQ DPITGENLAS CLQAEAEDIA AAVEAAKIAF KAWSQLPGAA 
       110        120        130        140        150
RGQHLTRLAK VVQKHQRLLW TLESLVTGRA VREVRDGDVP LAQQLLQYHA 
       160        170        180        190        200
VQAHAQGDAL ADWQPVGVIG LILPTPFSFL DMMWRVCPAL AMGCTVVALV 
       210        220        230        240        250
PPAFPTPLLL AQLAGELGSF PGILNVVCGP ASLGPVLASQ PGVQKVAFCG 
       260        270        280        290        300
AVEEGRVLRR TLAGRGAELG LALGTESLLL LTDSADVDSA VEGVVDAVWS 
       310        320        330        340        350
DRSLGGLRLL IQESVWDEAM RRLQARMAQI RSGRGLDGAV DMGARGAAAR 
       360        370        380        390        400
DLAQSFVDEA QSQGGQVFQA GDVPSSSPFF SPALVSGLPP AAPCAQAEVP 
       410        420        430        440        450
WPVVMASPFR TVKEALALAN GTPRGGSASV WSERLGQALE LGYGLQVGTV 
       460        470        480        490        500
WINAHGLRDP AVPTGGCKES GSSWHGGPDG LYEYLQPLGT PSQESFLCEN 
       510        520        530        540        550
INYDTFGLAA SSILPSGPET GPSPAPPYGL FVGGRFQSPG TQSSRPIQDS 
       560        570        580        590        600
SGKVSSYVAE GGAKDIRGAV EAAHQAAPGW GAQSPRARAG LLWALAAALE 
       610        620        630        640        650
RRKPVLTSQL ERHGAAPTVA KTEVELSVRR LQTWGTRVQD QGQTLQVTGL 
       660        670        680        690        700
RGPVLRLREP LGVLAVVCPD EWPLLAFVSL LAPALAHGNA VVLVPSGACP 
       710        720        730        740        750
LLALEVCQDI APLFPAGLVS VVTGDRDHLT RCLALHQDVQ ALWYFGSAQG 
       760        770        780        790        800
SQFVEWASAG NLKSVWVNRG FPRAWDVEVQ GAGQELSLHA ARTKALWLPM 

GD

Length:802

Mass (Da):84,756

Last modified:January 15, 2008 - v2

Checksum:ⁱ4853B80CAC29B9AE

GO

Sequence cautionⁱ

The sequence BAD90125 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature key	Position(s)	Length	Description
Sequence conflictⁱ	27 – 27	1	A → T in BAE26175 (PubMed:16141072).Curated
Sequence conflictⁱ	166 – 166	1	V → M in BAD90125 (Ref. 1) Curated
Sequence conflictⁱ	186 – 186	1	V → I in BAD90125 (Ref. 1) Curated
Sequence conflictⁱ	282 – 282	1	T → M in BAC27074 (PubMed:16141072).Curated
Sequence conflictⁱ	282 – 282	1	T → M in BAE30615 (PubMed:16141072).Curated
Sequence conflictⁱ	282 – 282	1	T → M in BAE36234 (PubMed:16141072).Curated
Sequence conflictⁱ	282 – 282	1	T → M in BAE41680 (PubMed:16141072).Curated
Sequence conflictⁱ	282 – 282	1	T → M in AAH13548 (PubMed:15489334).Curated
Sequence conflictⁱ	359 – 359	1	E → V in BAE31742 (PubMed:16141072).Curated
Sequence conflictⁱ	405 – 405	1	M → K in BAE31742 (PubMed:16141072).Curated
Sequence conflictⁱ	622 – 622	1	T → I in BAD90125 (Ref. 1) Curated
Sequence conflictⁱ	622 – 622	1	T → I in BAC27074 (PubMed:16141072).Curated
Sequence conflictⁱ	622 – 622	1	T → I in BAE30615 (PubMed:16141072).Curated
Sequence conflictⁱ	622 – 622	1	T → I in BAE31742 (PubMed:16141072).Curated
Sequence conflictⁱ	622 – 622	1	T → I in BAE36234 (PubMed:16141072).Curated
Sequence conflictⁱ	622 – 622	1	T → I in BAE41680 (PubMed:16141072).Curated
Sequence conflictⁱ	622 – 622	1	T → I in AAH13548 (PubMed:15489334).Curated
Sequence conflictⁱ	773 – 773	1	R → K in BAC27074 (PubMed:16141072).Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK220200 mRNA. Translation: BAD90125.1. Different initiation. AK030673 mRNA. Translation: BAC27074.1. AK144995 mRNA. Translation: BAE26175.1. AK151691 mRNA. Translation: BAE30615.1. AK153129 mRNA. Translation: BAE31742.1. AK161198 mRNA. Translation: BAE36234.1. AK170276 mRNA. Translation: BAE41680.1. BC013548 mRNA. Translation: AAH13548.2.
CCDSⁱ	CCDS21231.1.
RefSeqⁱ	NP_666066.1. NM_145954.1.
UniGeneⁱ	Mm.82139.

Genome annotation databases

GeneIDⁱ	69748.
KEGGⁱ	mmu:69748.
UCSCⁱ	uc009gtr.1. mouse.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK220200 mRNA. Translation: BAD90125.1. Different initiation. AK030673 mRNA. Translation: BAC27074.1. AK144995 mRNA. Translation: BAE26175.1. AK151691 mRNA. Translation: BAE30615.1. AK153129 mRNA. Translation: BAE31742.1. AK161198 mRNA. Translation: BAE36234.1. AK170276 mRNA. Translation: BAE41680.1. BC013548 mRNA. Translation: AAH13548.2.
CCDSⁱ	CCDS21231.1.
RefSeqⁱ	NP_666066.1. NM_145954.1.
UniGeneⁱ	Mm.82139.

3D structure databases

ProteinModelPortalⁱ	Q571I9.
SMRⁱ	Q571I9. Positions 44-486, 530-790.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q571I9. 4 interactions.
MINTⁱ	MINT-4113910.
STRINGⁱ	10090.ENSMUSP00000007977.

PTM databases

iPTMnetⁱ	Q571I9.
PhosphoSiteⁱ	Q571I9.

Proteomic databases

EPDⁱ	Q571I9.
MaxQBⁱ	Q571I9.
PaxDbⁱ	Q571I9.
PRIDEⁱ	Q571I9.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	69748.
KEGGⁱ	mmu:69748.
UCSCⁱ	uc009gtr.1. mouse.

Organism-specific databases

CTDⁱ	126133.
MGIⁱ	MGI:1916998. Aldh16a1.

Phylogenomic databases

eggNOGⁱ	KOG2450. Eukaryota. COG1012. LUCA.
HOGENOMⁱ	HOG000112558.
HOVERGENⁱ	HBG069396.
InParanoidⁱ	Q571I9.
PhylomeDBⁱ	Q571I9.
TreeFamⁱ	TF329461.

Miscellaneous databases

ChiTaRSⁱ	Aldh16a1. mouse.
PROⁱ	Q571I9.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000007833.
CleanExⁱ	MM_ALDH16A1.

Family and domain databases

Gene3Dⁱ	3.40.309.10. 1 hit. 3.40.605.10. 2 hits.
InterProⁱ	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016162. Ald_DH_N. IPR011408. Aldehyde_DH. IPR015590. Aldehyde_DH_dom. [Graphical view]
Pfamⁱ	PF00171. Aldedh. 2 hits. [Graphical view]
PIRSFⁱ	PIRSF036490. Aldedh_dupl. 1 hit.
SUPFAMⁱ	SSF53720. SSF53720. 2 hits.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ

A16A1_MOUSE

Accessionⁱ

Primary (citable) accession number: Q571I9
Secondary accession number(s): Q3U6I2

Q8VD78

Entry historyⁱ

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 15, 2008
Last modified:	September 7, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]

Entry statusⁱ

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Miscellaneousⁱ

Caution

The active site cysteine and glutamate residues are not conserved in this protein. Its activity is therefore unsure.Curated

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q571I9 (A16A1_MOUSE)

UniProt

Q571I9 - A16A1_MOUSE

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Aldehyde dehydrogenase family 16 member A1

Select a section on the left to see content.

<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>Provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.</p><p><a href='../manual/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>Provides information on the tertiary and secondary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequencei

<p>Reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.</p><p><a href='../manual/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Documents

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ