Aldh16a1

Functionⁱ

GO - Molecular functionⁱ

aldehyde dehydrogenase (NAD) activity Source: GO_Central

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Aldehyde dehydrogenase family 16 member A1
Gene namesⁱ	Name:Aldh16a1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Unplaced

Organism-specific databases

MGIⁱ	MGI:1916998. Aldh16a1.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000312987	1 – 802	Aldehyde dehydrogenase family 16 member A1Add BLAST		802

Proteomic databases

EPDⁱ	Q571I9.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q571I9.
PaxDbⁱ	Q571I9.
PRIDEⁱ	Q571I9.

PTM databases

iPTMnetⁱ	Q571I9.
PhosphoSitePlusⁱ	Q571I9.

Expressionⁱ

Gene expression databases

CleanExⁱ	MM_ALDH16A1.

CleanExⁱ

MM_ALDH16A1.

Interactionⁱ

Subunit structureⁱ

Interacts with SPG21.By similarity

Protein-protein interaction databases

IntActⁱ	Q571I9. 4 interactors.
Molecular INTeraction database More...MINTⁱ	Q571I9.
STRINGⁱ	10090.ENSMUSP00000007977.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q571I9.
SMRⁱ	Q571I9.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2450. Eukaryota. COG1012. LUCA.
HOGENOMⁱ	HOG000112558.
HOVERGENⁱ	HBG069396.
InParanoidⁱ	Q571I9.
PhylomeDBⁱ	Q571I9.
TreeFamⁱ	TF329461.

Family and domain databases

Gene3Dⁱ	3.40.309.10. 1 hit. 3.40.605.10. 3 hits.
InterProⁱ	View protein in InterPro IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016162. Ald_DH_N. IPR011408. Aldehyde_DH. IPR015590. Aldehyde_DH_dom.
PANTHERⁱ	PTHR11699:SF98. PTHR11699:SF98. 2 hits.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00171. Aldedh. 2 hits.
PIRSFⁱ	PIRSF036490. Aldedh_dupl. 1 hit.
SUPFAMⁱ	SSF53720. SSF53720. 2 hits.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q571I9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAATRVQPST REIFTTLEYG PVPESHACAL AWLDTHNRLL GHHVNGMWLK 
        60         70         80         90        100
PEHRNPAPCQ DPITGENLAS CLQAEAEDIA AAVEAAKIAF KAWSQLPGAA 
       110        120        130        140        150
RGQHLTRLAK VVQKHQRLLW TLESLVTGRA VREVRDGDVP LAQQLLQYHA 
       160        170        180        190        200
VQAHAQGDAL ADWQPVGVIG LILPTPFSFL DMMWRVCPAL AMGCTVVALV 
       210        220        230        240        250
PPAFPTPLLL AQLAGELGSF PGILNVVCGP ASLGPVLASQ PGVQKVAFCG 
       260        270        280        290        300
AVEEGRVLRR TLAGRGAELG LALGTESLLL LTDSADVDSA VEGVVDAVWS 
       310        320        330        340        350
DRSLGGLRLL IQESVWDEAM RRLQARMAQI RSGRGLDGAV DMGARGAAAR 
       360        370        380        390        400
DLAQSFVDEA QSQGGQVFQA GDVPSSSPFF SPALVSGLPP AAPCAQAEVP 
       410        420        430        440        450
WPVVMASPFR TVKEALALAN GTPRGGSASV WSERLGQALE LGYGLQVGTV 
       460        470        480        490        500
WINAHGLRDP AVPTGGCKES GSSWHGGPDG LYEYLQPLGT PSQESFLCEN 
       510        520        530        540        550
INYDTFGLAA SSILPSGPET GPSPAPPYGL FVGGRFQSPG TQSSRPIQDS 
       560        570        580        590        600
SGKVSSYVAE GGAKDIRGAV EAAHQAAPGW GAQSPRARAG LLWALAAALE 
       610        620        630        640        650
RRKPVLTSQL ERHGAAPTVA KTEVELSVRR LQTWGTRVQD QGQTLQVTGL 
       660        670        680        690        700
RGPVLRLREP LGVLAVVCPD EWPLLAFVSL LAPALAHGNA VVLVPSGACP 
       710        720        730        740        750
LLALEVCQDI APLFPAGLVS VVTGDRDHLT RCLALHQDVQ ALWYFGSAQG 
       760        770        780        790        800
SQFVEWASAG NLKSVWVNRG FPRAWDVEVQ GAGQELSLHA ARTKALWLPM 

GD

Length:802

Mass (Da):84,756

Last modified:January 15, 2008 - v2

Checksum:ⁱ4853B80CAC29B9AE

GO

Sequence cautionⁱ

The sequence BAD90125 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	27	A → T in BAE26175 (PubMed:16141072).Curated	1
Sequence conflictⁱ	166	V → M in BAD90125 (Ref. 1) Curated	1
Sequence conflictⁱ	186	V → I in BAD90125 (Ref. 1) Curated	1
Sequence conflictⁱ	282	T → M in BAC27074 (PubMed:16141072).Curated	1
Sequence conflictⁱ	282	T → M in BAE30615 (PubMed:16141072).Curated	1
Sequence conflictⁱ	282	T → M in BAE36234 (PubMed:16141072).Curated	1
Sequence conflictⁱ	282	T → M in BAE41680 (PubMed:16141072).Curated	1
Sequence conflictⁱ	282	T → M in AAH13548 (PubMed:15489334).Curated	1
Sequence conflictⁱ	359	E → V in BAE31742 (PubMed:16141072).Curated	1
Sequence conflictⁱ	405	M → K in BAE31742 (PubMed:16141072).Curated	1
Sequence conflictⁱ	622	T → I in BAD90125 (Ref. 1) Curated	1
Sequence conflictⁱ	622	T → I in BAC27074 (PubMed:16141072).Curated	1
Sequence conflictⁱ	622	T → I in BAE30615 (PubMed:16141072).Curated	1
Sequence conflictⁱ	622	T → I in BAE31742 (PubMed:16141072).Curated	1
Sequence conflictⁱ	622	T → I in BAE36234 (PubMed:16141072).Curated	1
Sequence conflictⁱ	622	T → I in BAE41680 (PubMed:16141072).Curated	1
Sequence conflictⁱ	622	T → I in AAH13548 (PubMed:15489334).Curated	1
Sequence conflictⁱ	773	R → K in BAC27074 (PubMed:16141072).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK220200 mRNA. Translation: BAD90125.1. Different initiation. AK030673 mRNA. Translation: BAC27074.1. AK144995 mRNA. Translation: BAE26175.1. AK151691 mRNA. Translation: BAE30615.1. AK153129 mRNA. Translation: BAE31742.1. AK161198 mRNA. Translation: BAE36234.1. AK170276 mRNA. Translation: BAE41680.1. BC013548 mRNA. Translation: AAH13548.2.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS21231.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_666066.1. NM_145954.1.
UniGeneⁱ	Mm.82139.

Genome annotation databases

GeneIDⁱ	69748.
KEGGⁱ	mmu:69748.
UCSC genome browser More...UCSCⁱ	uc009gtr.1. mouse.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q571I9	Q3T1L0 UPI0003D0C414 A0A1B0GSU0 Q9CWT9 G3I000 UPI000454227E UPI000A30E62F UPI000A318CAC UPI000B4E8701 UPI000A307565 +2	Rattus norvegicus (Rat) Mus musculus (Mouse) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) Mus pahari (Gairdner's shrew-mouse) (Coelomys pahari) Mus caroli (Ryukyu mouse) (Ricefield mouse) Meriones unguiculatus (Mongolian jird) (Mongolian gerbil)	802	UniRef90_Q3T1L0	Cluster: Aldehyde dehydrogenase family 16 member A1	13

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q571I9	Q8IZ83 A0A2I3S9Y2 A0A2I2YG60 A0A2I3RW52 A0A2I3NGD1 A0A0D9S3R2 A0A2K6RQR0 A0A2K5KS78 UPI00027447C6 A0A2K5YHI6 +135	Homo sapiens (Human) Pan troglodytes (Chimpanzee) Gorilla gorilla gorilla (Western lowland gorilla) Papio anubis (Olive baboon) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Pan paniscus (Pygmy chimpanzee) (Bonobo) Mandrillus leucophaeus (Drill) (Papio leucophaeus) Macaca nemestrina (Pig-tailed macaque) And more	802	UniRef50_Q8IZ83	Cluster: Aldehyde dehydrogenase family 16 member A1	146

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK220200 mRNA. Translation: BAD90125.1. Different initiation. AK030673 mRNA. Translation: BAC27074.1. AK144995 mRNA. Translation: BAE26175.1. AK151691 mRNA. Translation: BAE30615.1. AK153129 mRNA. Translation: BAE31742.1. AK161198 mRNA. Translation: BAE36234.1. AK170276 mRNA. Translation: BAE41680.1. BC013548 mRNA. Translation: AAH13548.2.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS21231.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_666066.1. NM_145954.1.
UniGeneⁱ	Mm.82139.

3D structure databases

ProteinModelPortalⁱ	Q571I9.
SMRⁱ	Q571I9.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q571I9. 4 interactors.
Molecular INTeraction database More...MINTⁱ	Q571I9.
STRINGⁱ	10090.ENSMUSP00000007977.

PTM databases

iPTMnetⁱ	Q571I9.
PhosphoSitePlusⁱ	Q571I9.

Proteomic databases

EPDⁱ	Q571I9.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q571I9.
PaxDbⁱ	Q571I9.
PRIDEⁱ	Q571I9.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	69748.
KEGGⁱ	mmu:69748.
UCSC genome browser More...UCSCⁱ	uc009gtr.1. mouse.

Organism-specific databases

CTDⁱ	126133.
MGIⁱ	MGI:1916998. Aldh16a1.

Phylogenomic databases

eggNOGⁱ	KOG2450. Eukaryota. COG1012. LUCA.
HOGENOMⁱ	HOG000112558.
HOVERGENⁱ	HBG069396.
InParanoidⁱ	Q571I9.
PhylomeDBⁱ	Q571I9.
TreeFamⁱ	TF329461.

Miscellaneous databases

ChiTaRSⁱ	Aldh16a1. mouse.
Protein Ontology More...PROⁱ	PR:Q571I9.
SOURCEⁱ	Search...

Gene expression databases

CleanExⁱ	MM_ALDH16A1.

CleanExⁱ

MM_ALDH16A1.

Family and domain databases

Gene3Dⁱ	3.40.309.10. 1 hit. 3.40.605.10. 3 hits.
InterProⁱ	View protein in InterPro IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016162. Ald_DH_N. IPR011408. Aldehyde_DH. IPR015590. Aldehyde_DH_dom.
PANTHERⁱ	PTHR11699:SF98. PTHR11699:SF98. 2 hits.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00171. Aldedh. 2 hits.
PIRSFⁱ	PIRSF036490. Aldedh_dupl. 1 hit.
SUPFAMⁱ	SSF53720. SSF53720. 2 hits.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A16A1_MOUSE
Accessionⁱ	Q571I9Primary (citable) accession number: Q571I9 Secondary accession number(s): Q3U6I2 , Q3UMC3, Q8C0L4, Q8VD78
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
	Last sequence update:	January 15, 2008
	Last modified:	February 28, 2018
	This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Caution

The active site cysteine and glutamate residues are not conserved in this protein. Its activity is therefore unsure.Curated

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q571I9 (A16A1_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Aldehyde dehydrogenase family 16 member A1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ