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Protein

Aldehyde dehydrogenase family 16 member A1

Gene

Aldh16a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

The active site cysteine and glutamate residues are not conserved in this protein. Its activity is therefore unsure.Curated

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase family 16 member A1
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1916998 Aldh16a1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003129871 – 802Aldehyde dehydrogenase family 16 member A1Add BLAST802

Proteomic databases

EPDiQ571I9
MaxQBiQ571I9
PaxDbiQ571I9
PRIDEiQ571I9

PTM databases

iPTMnetiQ571I9
PhosphoSitePlusiQ571I9
SwissPalmiQ571I9

Expressioni

Gene expression databases

CleanExiMM_ALDH16A1

Interactioni

Subunit structurei

Interacts with SPG21.By similarity

Protein-protein interaction databases

IntActiQ571I9, 4 interactors
MINTiQ571I9
STRINGi10090.ENSMUSP00000007977

Structurei

3D structure databases

ProteinModelPortaliQ571I9
SMRiQ571I9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiKOG2450 Eukaryota
COG1012 LUCA
HOGENOMiHOG000112558
HOVERGENiHBG069396
InParanoidiQ571I9
PhylomeDBiQ571I9
TreeFamiTF329461

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 3 hits
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016162 Ald_DH_N
IPR011408 Aldehyde_DH
IPR015590 Aldehyde_DH_dom
PANTHERiPTHR11699:SF98 PTHR11699:SF98, 2 hits
PfamiView protein in Pfam
PF00171 Aldedh, 2 hits
PIRSFiPIRSF036490 Aldedh_dupl, 1 hit
SUPFAMiSSF53720 SSF53720, 2 hits

Sequencei

Sequence statusi: Complete.

Q571I9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATRVQPST REIFTTLEYG PVPESHACAL AWLDTHNRLL GHHVNGMWLK
60 70 80 90 100
PEHRNPAPCQ DPITGENLAS CLQAEAEDIA AAVEAAKIAF KAWSQLPGAA
110 120 130 140 150
RGQHLTRLAK VVQKHQRLLW TLESLVTGRA VREVRDGDVP LAQQLLQYHA
160 170 180 190 200
VQAHAQGDAL ADWQPVGVIG LILPTPFSFL DMMWRVCPAL AMGCTVVALV
210 220 230 240 250
PPAFPTPLLL AQLAGELGSF PGILNVVCGP ASLGPVLASQ PGVQKVAFCG
260 270 280 290 300
AVEEGRVLRR TLAGRGAELG LALGTESLLL LTDSADVDSA VEGVVDAVWS
310 320 330 340 350
DRSLGGLRLL IQESVWDEAM RRLQARMAQI RSGRGLDGAV DMGARGAAAR
360 370 380 390 400
DLAQSFVDEA QSQGGQVFQA GDVPSSSPFF SPALVSGLPP AAPCAQAEVP
410 420 430 440 450
WPVVMASPFR TVKEALALAN GTPRGGSASV WSERLGQALE LGYGLQVGTV
460 470 480 490 500
WINAHGLRDP AVPTGGCKES GSSWHGGPDG LYEYLQPLGT PSQESFLCEN
510 520 530 540 550
INYDTFGLAA SSILPSGPET GPSPAPPYGL FVGGRFQSPG TQSSRPIQDS
560 570 580 590 600
SGKVSSYVAE GGAKDIRGAV EAAHQAAPGW GAQSPRARAG LLWALAAALE
610 620 630 640 650
RRKPVLTSQL ERHGAAPTVA KTEVELSVRR LQTWGTRVQD QGQTLQVTGL
660 670 680 690 700
RGPVLRLREP LGVLAVVCPD EWPLLAFVSL LAPALAHGNA VVLVPSGACP
710 720 730 740 750
LLALEVCQDI APLFPAGLVS VVTGDRDHLT RCLALHQDVQ ALWYFGSAQG
760 770 780 790 800
SQFVEWASAG NLKSVWVNRG FPRAWDVEVQ GAGQELSLHA ARTKALWLPM

GD
Length:802
Mass (Da):84,756
Last modified:January 15, 2008 - v2
Checksum:i4853B80CAC29B9AE
GO

Sequence cautioni

The sequence BAD90125 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27A → T in BAE26175 (PubMed:16141072).Curated1
Sequence conflicti166V → M in BAD90125 (Ref. 1) Curated1
Sequence conflicti186V → I in BAD90125 (Ref. 1) Curated1
Sequence conflicti282T → M in BAC27074 (PubMed:16141072).Curated1
Sequence conflicti282T → M in BAE30615 (PubMed:16141072).Curated1
Sequence conflicti282T → M in BAE36234 (PubMed:16141072).Curated1
Sequence conflicti282T → M in BAE41680 (PubMed:16141072).Curated1
Sequence conflicti282T → M in AAH13548 (PubMed:15489334).Curated1
Sequence conflicti359E → V in BAE31742 (PubMed:16141072).Curated1
Sequence conflicti405M → K in BAE31742 (PubMed:16141072).Curated1
Sequence conflicti622T → I in BAD90125 (Ref. 1) Curated1
Sequence conflicti622T → I in BAC27074 (PubMed:16141072).Curated1
Sequence conflicti622T → I in BAE30615 (PubMed:16141072).Curated1
Sequence conflicti622T → I in BAE31742 (PubMed:16141072).Curated1
Sequence conflicti622T → I in BAE36234 (PubMed:16141072).Curated1
Sequence conflicti622T → I in BAE41680 (PubMed:16141072).Curated1
Sequence conflicti622T → I in AAH13548 (PubMed:15489334).Curated1
Sequence conflicti773R → K in BAC27074 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220200 mRNA Translation: BAD90125.1 Different initiation.
AK030673 mRNA Translation: BAC27074.1
AK144995 mRNA Translation: BAE26175.1
AK151691 mRNA Translation: BAE30615.1
AK153129 mRNA Translation: BAE31742.1
AK161198 mRNA Translation: BAE36234.1
AK170276 mRNA Translation: BAE41680.1
BC013548 mRNA Translation: AAH13548.2
CCDSiCCDS21231.1
RefSeqiNP_666066.1, NM_145954.1
UniGeneiMm.82139

Genome annotation databases

GeneIDi69748
KEGGimmu:69748
UCSCiuc009gtr.1 mouse

Similar proteinsi

Entry informationi

Entry nameiA16A1_MOUSE
AccessioniPrimary (citable) accession number: Q571I9
Secondary accession number(s): Q3U6I2
, Q3UMC3, Q8C0L4, Q8VD78
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: May 23, 2018
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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