Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q571I4

- SG223_MOUSE

UniProt

Q571I4 - SG223_MOUSE

Protein

Tyrosine-protein kinase SgK223

Gene

Sgk223

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 2 (28 Nov 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei808 – 8081ATPPROSITE-ProRule annotation
    Active sitei930 – 9301Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi757 – 7659ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinase SgK223 (EC:2.7.10.2)
    Alternative name(s):
    Sugen kinase 223
    Gene namesi
    Name:Sgk223
    Synonyms:D8Ertd82e
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1196223. D8Ertd82e.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11791179Tyrosine-protein kinase SgK223PRO_0000263009Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei196 – 1961Phosphotyrosine1 Publication
    Modified residuei477 – 4771PhosphoserineBy similarity
    Modified residuei526 – 5261Phosphoserine1 Publication
    Modified residuei608 – 6081PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ571I4.
    PRIDEiQ571I4.

    PTM databases

    PhosphoSiteiQ571I4.

    Expressioni

    Gene expression databases

    CleanExiMM_D8ERTD82E.
    GenevestigatoriQ571I4.

    Interactioni

    Protein-protein interaction databases

    BioGridi232647. 3 interactions.
    IntActiQ571I4. 1 interaction.
    STRINGi10090.ENSMUSP00000106118.

    Structurei

    3D structure databases

    ProteinModelPortaliQ571I4.
    SMRiQ571I4. Positions 911-939.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini751 – 1102352Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi494 – 4996Poly-Pro
    Compositional biasi701 – 73131Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily.Curated
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG115841.
    HOGENOMiHOG000168455.
    HOVERGENiHBG055817.
    InParanoidiQ571I4.
    KOiK17537.
    PhylomeDBiQ571I4.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008266. Tyr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 2 hits.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q571I4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSSCPKGPR PCTSPQPLRE SLPSEDDSDQ RCSPSGDSEG GEYCSILDCC     50
    PESKDAVHST EGSGRRGGDC SPTCREQGPR TRPTEEEKQG LSFPRECCGQ 100
    GSTANPPRLG PKKPSLNSEA ASSSDGLSCG SSRSGASSPF APHLENDYCS 150
    LVKEPASGKQ QDLSGHFLTS GKCVGQAAEL QPASLLRDPV QPEPIYAESA 200
    KRKKAAPGPP RPEPKKEQVP AGHSQGQVWT GDTWIQKTPP SWSQDREGAN 250
    PAPQVATTIT VIAAHPEEDH RTIYLSSPDS AVGVQWPRGP SNQDLQAGEE 300
    EPLVAQGLTS RESHPHNVTE NTAKEKPAIP PKLSKSSPGG SPVSPAAPPL 350
    TDHSDGNTGG SSVGPQLLSR VPANLTSSCH TNGVATAGDS AKCPPPATSS 400
    SVLDQRRPRY QTGAWSRQCR IEEEEEVGQE LSQSWGRELE NGTADHSNSS 450
    TWHRLHPIDG TSGQNSKTNS GMSKSASFAF EFPKDRGRLE AFSPPPPPPK 500
    SRHLLKMNKS SSDLEKVSQS SAESLSPSFR GAHVSFTTGS TDSLASDSRP 550
    CSDGGPSYEP THSPTISGKK LFAPVPFPSG STEDVSPGGG PAQPPPLPQK 600
    KIVSRAASSP DGFFWTQGSP KPRTASPKLN LSHSETNVCA HDEPPFNCSL 650
    NSGNRSHHVF SSSEPLGKAF KGNAPWAPAL GLANSKGGCG SPSLQCRAAT 700
    STSSSQLSVS SQASSSSTQL QLHSLLSSIS SKEGTYAKLG GLYTQSLARL 750
    VTKCEDLFMG GQKKELRFNE NYWSLFKLTC NKPCCDSGDA IYYCATCSED 800
    PGSIYAVKIC KTPEPKSASY CSPSVPVHFN IQQDCGHFVA SVPSSMLASP 850
    DTSSKDTAPA VSPQPPAQEQ DCVVVITREV PHQTASDFVR DSMASHRAEP 900
    EVYERRVCFL LLQLCNGLEH LKEHGIIHRD LCLENLLLAH CNPQSSPGPS 950
    ATPTVPTTTS RCPSAAPAAT TACQGGPGEK QLPRLIISNF LKAKQKPGGT 1000
    TNLQQKKSQA RLAPEIVSAS QYRKFDEFQT GILIYELLHQ PNPFEVRAQL 1050
    RERDYRREDL PPLPTLSLYS PGLQQLAHLL LEADPIKRIR IGEAKRVLQC 1100
    LLWGPRRELV EQPCTSEEVL CNTLHNWIDM KRALMMMKFA EKAVDRRRGV 1150
    ELEDWLCCQY LASAEPGALL QSLKLLQLL 1179
    Length:1,179
    Mass (Da):126,640
    Last modified:November 28, 2006 - v2
    Checksum:i9A6A6872251F7F77
    GO

    Sequence cautioni

    The sequence BAD90130.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti48 – 481D → Y in BAD90130. 1 PublicationCurated
    Sequence conflicti66 – 661R → C in BAD90130. 1 PublicationCurated
    Sequence conflicti298 – 2981G → S in BAD90130. 1 PublicationCurated
    Sequence conflicti309 – 3091T → I in BAD90130. 1 PublicationCurated
    Sequence conflicti318 – 3181V → M in BAD90130. 1 PublicationCurated
    Sequence conflicti347 – 3471Missing in BAC29528. (PubMed:16141072)Curated
    Sequence conflicti347 – 3471Missing in AAH89024. (PubMed:15489334)Curated
    Sequence conflicti592 – 5921A → V in BAD90130. 1 PublicationCurated
    Sequence conflicti667 – 6671G → E in BAD90130. 1 PublicationCurated
    Sequence conflicti945 – 9451S → I in BAD90130. 1 PublicationCurated
    Sequence conflicti966 – 9661A → V in BAD90130. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK036672 mRNA. Translation: BAC29528.1.
    AK220205 mRNA. Translation: BAD90130.1. Different initiation.
    BC089024 mRNA. Translation: AAH89024.1.
    RefSeqiNP_766499.2. NM_172911.3.
    UniGeneiMm.244971.

    Genome annotation databases

    GeneIDi244418.
    KEGGimmu:244418.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK036672 mRNA. Translation: BAC29528.1 .
    AK220205 mRNA. Translation: BAD90130.1 . Different initiation.
    BC089024 mRNA. Translation: AAH89024.1 .
    RefSeqi NP_766499.2. NM_172911.3.
    UniGenei Mm.244971.

    3D structure databases

    ProteinModelPortali Q571I4.
    SMRi Q571I4. Positions 911-939.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 232647. 3 interactions.
    IntActi Q571I4. 1 interaction.
    STRINGi 10090.ENSMUSP00000106118.

    PTM databases

    PhosphoSitei Q571I4.

    Proteomic databases

    PaxDbi Q571I4.
    PRIDEi Q571I4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 244418.
    KEGGi mmu:244418.

    Organism-specific databases

    CTDi 244418.
    MGIi MGI:1196223. D8Ertd82e.

    Phylogenomic databases

    eggNOGi NOG115841.
    HOGENOMi HOG000168455.
    HOVERGENi HBG055817.
    InParanoidi Q571I4.
    KOi K17537.
    PhylomeDBi Q571I4.

    Miscellaneous databases

    NextBioi 386268.
    PROi Q571I4.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_D8ERTD82E.
    Genevestigatori Q571I4.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008266. Tyr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 2 hits.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone.
    2. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
      Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Spleen.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Eye.
    4. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
      Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-196, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-526, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSG223_MOUSE
    AccessioniPrimary (citable) accession number: Q571I4
    Secondary accession number(s): Q8CB68
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: November 28, 2006
    Last modified: October 1, 2014
    This is version 77 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3