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Q571I4 (SG223_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase SgK223

EC=2.7.10.2
Alternative name(s):
Sugen kinase 223
Gene names
Name:Sgk223
Synonyms:D8Ertd82e
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1179 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Sequence similarities

Belongs to the protein kinase superfamily.

Contains 1 protein kinase domain.

Sequence caution

The sequence BAD90130.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11791179Tyrosine-protein kinase SgK223
PRO_0000263009

Regions

Domain751 – 1102352Protein kinase
Nucleotide binding757 – 7659ATP By similarity
Compositional bias422 – 4265Poly-Glu
Compositional bias494 – 4996Poly-Pro
Compositional bias701 – 73131Ser-rich

Sites

Active site9301Proton acceptor By similarity
Binding site8081ATP By similarity

Amino acid modifications

Modified residue1961Phosphotyrosine Ref.4
Modified residue4771Phosphoserine By similarity
Modified residue5261Phosphoserine Ref.5
Modified residue6081Phosphoserine By similarity

Experimental info

Sequence conflict481D → Y in BAD90130. Ref.2
Sequence conflict661R → C in BAD90130. Ref.2
Sequence conflict2981G → S in BAD90130. Ref.2
Sequence conflict3091T → I in BAD90130. Ref.2
Sequence conflict3181V → M in BAD90130. Ref.2
Sequence conflict3471Missing in BAC29528. Ref.1
Sequence conflict3471Missing in AAH89024. Ref.3
Sequence conflict5921A → V in BAD90130. Ref.2
Sequence conflict6671G → E in BAD90130. Ref.2
Sequence conflict9451S → I in BAD90130. Ref.2
Sequence conflict9661A → V in BAD90130. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q571I4 [UniParc].

Last modified November 28, 2006. Version 2.
Checksum: 9A6A6872251F7F77

FASTA1,179126,640
        10         20         30         40         50         60 
MTSSCPKGPR PCTSPQPLRE SLPSEDDSDQ RCSPSGDSEG GEYCSILDCC PESKDAVHST 

        70         80         90        100        110        120 
EGSGRRGGDC SPTCREQGPR TRPTEEEKQG LSFPRECCGQ GSTANPPRLG PKKPSLNSEA 

       130        140        150        160        170        180 
ASSSDGLSCG SSRSGASSPF APHLENDYCS LVKEPASGKQ QDLSGHFLTS GKCVGQAAEL 

       190        200        210        220        230        240 
QPASLLRDPV QPEPIYAESA KRKKAAPGPP RPEPKKEQVP AGHSQGQVWT GDTWIQKTPP 

       250        260        270        280        290        300 
SWSQDREGAN PAPQVATTIT VIAAHPEEDH RTIYLSSPDS AVGVQWPRGP SNQDLQAGEE 

       310        320        330        340        350        360 
EPLVAQGLTS RESHPHNVTE NTAKEKPAIP PKLSKSSPGG SPVSPAAPPL TDHSDGNTGG 

       370        380        390        400        410        420 
SSVGPQLLSR VPANLTSSCH TNGVATAGDS AKCPPPATSS SVLDQRRPRY QTGAWSRQCR 

       430        440        450        460        470        480 
IEEEEEVGQE LSQSWGRELE NGTADHSNSS TWHRLHPIDG TSGQNSKTNS GMSKSASFAF 

       490        500        510        520        530        540 
EFPKDRGRLE AFSPPPPPPK SRHLLKMNKS SSDLEKVSQS SAESLSPSFR GAHVSFTTGS 

       550        560        570        580        590        600 
TDSLASDSRP CSDGGPSYEP THSPTISGKK LFAPVPFPSG STEDVSPGGG PAQPPPLPQK 

       610        620        630        640        650        660 
KIVSRAASSP DGFFWTQGSP KPRTASPKLN LSHSETNVCA HDEPPFNCSL NSGNRSHHVF 

       670        680        690        700        710        720 
SSSEPLGKAF KGNAPWAPAL GLANSKGGCG SPSLQCRAAT STSSSQLSVS SQASSSSTQL 

       730        740        750        760        770        780 
QLHSLLSSIS SKEGTYAKLG GLYTQSLARL VTKCEDLFMG GQKKELRFNE NYWSLFKLTC 

       790        800        810        820        830        840 
NKPCCDSGDA IYYCATCSED PGSIYAVKIC KTPEPKSASY CSPSVPVHFN IQQDCGHFVA 

       850        860        870        880        890        900 
SVPSSMLASP DTSSKDTAPA VSPQPPAQEQ DCVVVITREV PHQTASDFVR DSMASHRAEP 

       910        920        930        940        950        960 
EVYERRVCFL LLQLCNGLEH LKEHGIIHRD LCLENLLLAH CNPQSSPGPS ATPTVPTTTS 

       970        980        990       1000       1010       1020 
RCPSAAPAAT TACQGGPGEK QLPRLIISNF LKAKQKPGGT TNLQQKKSQA RLAPEIVSAS 

      1030       1040       1050       1060       1070       1080 
QYRKFDEFQT GILIYELLHQ PNPFEVRAQL RERDYRREDL PPLPTLSLYS PGLQQLAHLL 

      1090       1100       1110       1120       1130       1140 
LEADPIKRIR IGEAKRVLQC LLWGPRRELV EQPCTSEEVL CNTLHNWIDM KRALMMMKFA 

      1150       1160       1170 
EKAVDRRRGV ELEDWLCCQY LASAEPGALL QSLKLLQLL 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Bone.
[2]"Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Spleen.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Eye.
[4]"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-196, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[5]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-526, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK036672 mRNA. Translation: BAC29528.1.
AK220205 mRNA. Translation: BAD90130.1. Different initiation.
BC089024 mRNA. Translation: AAH89024.1.
RefSeqNP_766499.2. NM_172911.3.
UniGeneMm.244971.

3D structure databases

ProteinModelPortalQ571I4.
SMRQ571I4. Positions 911-939.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid232647. 3 interactions.
IntActQ571I4. 1 interaction.
STRING10090.ENSMUSP00000106118.

PTM databases

PhosphoSiteQ571I4.

Proteomic databases

PaxDbQ571I4.
PRIDEQ571I4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID244418.
KEGGmmu:244418.

Organism-specific databases

CTD244418.
MGIMGI:1196223. D8Ertd82e.

Phylogenomic databases

eggNOGNOG115841.
HOGENOMHOG000168455.
HOVERGENHBG055817.
InParanoidQ571I4.
KOK17537.
PhylomeDBQ571I4.

Gene expression databases

CleanExMM_D8ERTD82E.
GenevestigatorQ571I4.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 2 hits.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio386268.
PROQ571I4.
SOURCESearch...

Entry information

Entry nameSG223_MOUSE
AccessionPrimary (citable) accession number: Q571I4
Secondary accession number(s): Q8CB68
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: June 11, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot