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Q571I4

- SG223_MOUSE

UniProt

Q571I4 - SG223_MOUSE

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Protein
Tyrosine-protein kinase SgK223
Gene
Sgk223, D8Ertd82e
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei808 – 8081ATP By similarity
Active sitei930 – 9301Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi757 – 7659ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase SgK223 (EC:2.7.10.2)
Alternative name(s):
Sugen kinase 223
Gene namesi
Name:Sgk223
Synonyms:D8Ertd82e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1196223. D8Ertd82e.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11791179Tyrosine-protein kinase SgK223
PRO_0000263009Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei196 – 1961Phosphotyrosine1 Publication
Modified residuei477 – 4771Phosphoserine By similarity
Modified residuei526 – 5261Phosphoserine1 Publication
Modified residuei608 – 6081Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ571I4.
PRIDEiQ571I4.

PTM databases

PhosphoSiteiQ571I4.

Expressioni

Gene expression databases

CleanExiMM_D8ERTD82E.
GenevestigatoriQ571I4.

Interactioni

Protein-protein interaction databases

BioGridi232647. 3 interactions.
IntActiQ571I4. 1 interaction.
STRINGi10090.ENSMUSP00000106118.

Structurei

3D structure databases

ProteinModelPortaliQ571I4.
SMRiQ571I4. Positions 911-939.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini751 – 1102352Protein kinase
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi422 – 4265Poly-Glu
Compositional biasi494 – 4996Poly-Pro
Compositional biasi701 – 73131Ser-rich
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG115841.
HOGENOMiHOG000168455.
HOVERGENiHBG055817.
InParanoidiQ571I4.
KOiK17537.
PhylomeDBiQ571I4.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q571I4-1 [UniParc]FASTAAdd to Basket

« Hide

MTSSCPKGPR PCTSPQPLRE SLPSEDDSDQ RCSPSGDSEG GEYCSILDCC     50
PESKDAVHST EGSGRRGGDC SPTCREQGPR TRPTEEEKQG LSFPRECCGQ 100
GSTANPPRLG PKKPSLNSEA ASSSDGLSCG SSRSGASSPF APHLENDYCS 150
LVKEPASGKQ QDLSGHFLTS GKCVGQAAEL QPASLLRDPV QPEPIYAESA 200
KRKKAAPGPP RPEPKKEQVP AGHSQGQVWT GDTWIQKTPP SWSQDREGAN 250
PAPQVATTIT VIAAHPEEDH RTIYLSSPDS AVGVQWPRGP SNQDLQAGEE 300
EPLVAQGLTS RESHPHNVTE NTAKEKPAIP PKLSKSSPGG SPVSPAAPPL 350
TDHSDGNTGG SSVGPQLLSR VPANLTSSCH TNGVATAGDS AKCPPPATSS 400
SVLDQRRPRY QTGAWSRQCR IEEEEEVGQE LSQSWGRELE NGTADHSNSS 450
TWHRLHPIDG TSGQNSKTNS GMSKSASFAF EFPKDRGRLE AFSPPPPPPK 500
SRHLLKMNKS SSDLEKVSQS SAESLSPSFR GAHVSFTTGS TDSLASDSRP 550
CSDGGPSYEP THSPTISGKK LFAPVPFPSG STEDVSPGGG PAQPPPLPQK 600
KIVSRAASSP DGFFWTQGSP KPRTASPKLN LSHSETNVCA HDEPPFNCSL 650
NSGNRSHHVF SSSEPLGKAF KGNAPWAPAL GLANSKGGCG SPSLQCRAAT 700
STSSSQLSVS SQASSSSTQL QLHSLLSSIS SKEGTYAKLG GLYTQSLARL 750
VTKCEDLFMG GQKKELRFNE NYWSLFKLTC NKPCCDSGDA IYYCATCSED 800
PGSIYAVKIC KTPEPKSASY CSPSVPVHFN IQQDCGHFVA SVPSSMLASP 850
DTSSKDTAPA VSPQPPAQEQ DCVVVITREV PHQTASDFVR DSMASHRAEP 900
EVYERRVCFL LLQLCNGLEH LKEHGIIHRD LCLENLLLAH CNPQSSPGPS 950
ATPTVPTTTS RCPSAAPAAT TACQGGPGEK QLPRLIISNF LKAKQKPGGT 1000
TNLQQKKSQA RLAPEIVSAS QYRKFDEFQT GILIYELLHQ PNPFEVRAQL 1050
RERDYRREDL PPLPTLSLYS PGLQQLAHLL LEADPIKRIR IGEAKRVLQC 1100
LLWGPRRELV EQPCTSEEVL CNTLHNWIDM KRALMMMKFA EKAVDRRRGV 1150
ELEDWLCCQY LASAEPGALL QSLKLLQLL 1179
Length:1,179
Mass (Da):126,640
Last modified:November 28, 2006 - v2
Checksum:i9A6A6872251F7F77
GO

Sequence cautioni

The sequence BAD90130.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti48 – 481D → Y in BAD90130. 1 Publication
Sequence conflicti66 – 661R → C in BAD90130. 1 Publication
Sequence conflicti298 – 2981G → S in BAD90130. 1 Publication
Sequence conflicti309 – 3091T → I in BAD90130. 1 Publication
Sequence conflicti318 – 3181V → M in BAD90130. 1 Publication
Sequence conflicti347 – 3471Missing in BAC29528. 1 Publication
Sequence conflicti347 – 3471Missing in AAH89024. 1 Publication
Sequence conflicti592 – 5921A → V in BAD90130. 1 Publication
Sequence conflicti667 – 6671G → E in BAD90130. 1 Publication
Sequence conflicti945 – 9451S → I in BAD90130. 1 Publication
Sequence conflicti966 – 9661A → V in BAD90130. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK036672 mRNA. Translation: BAC29528.1.
AK220205 mRNA. Translation: BAD90130.1. Different initiation.
BC089024 mRNA. Translation: AAH89024.1.
RefSeqiNP_766499.2. NM_172911.3.
UniGeneiMm.244971.

Genome annotation databases

GeneIDi244418.
KEGGimmu:244418.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK036672 mRNA. Translation: BAC29528.1 .
AK220205 mRNA. Translation: BAD90130.1 . Different initiation.
BC089024 mRNA. Translation: AAH89024.1 .
RefSeqi NP_766499.2. NM_172911.3.
UniGenei Mm.244971.

3D structure databases

ProteinModelPortali Q571I4.
SMRi Q571I4. Positions 911-939.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 232647. 3 interactions.
IntActi Q571I4. 1 interaction.
STRINGi 10090.ENSMUSP00000106118.

PTM databases

PhosphoSitei Q571I4.

Proteomic databases

PaxDbi Q571I4.
PRIDEi Q571I4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 244418.
KEGGi mmu:244418.

Organism-specific databases

CTDi 244418.
MGIi MGI:1196223. D8Ertd82e.

Phylogenomic databases

eggNOGi NOG115841.
HOGENOMi HOG000168455.
HOVERGENi HBG055817.
InParanoidi Q571I4.
KOi K17537.
PhylomeDBi Q571I4.

Miscellaneous databases

NextBioi 386268.
PROi Q571I4.
SOURCEi Search...

Gene expression databases

CleanExi MM_D8ERTD82E.
Genevestigatori Q571I4.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 2 hits.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Eye.
  4. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-196, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-526, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSG223_MOUSE
AccessioniPrimary (citable) accession number: Q571I4
Secondary accession number(s): Q8CB68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: June 11, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi