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Protein

Tyrosine-protein kinase PRAG1

Gene

PRAG1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei808ATPPROSITE-ProRule annotation1
Active sitei930Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi757 – 765ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase PRAG1Imported (EC:2.7.10.2)
Alternative name(s):
PEAK1-related kinase-activating pseudokinase 1Imported
Sugen kinase 223
Tyrosine-protein kinase SgK223
Gene namesi
Name:PRAG1Imported
Synonyms:D8Ertd82eImported, Sgk223
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1196223 Prag1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002630091 – 1179Tyrosine-protein kinase PRAG1Add BLAST1179

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei196PhosphotyrosineCombined sources1
Modified residuei477PhosphoserineBy similarity1
Modified residuei526PhosphoserineCombined sources1
Modified residuei563PhosphoserineBy similarity1
Modified residuei608PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ571I4
MaxQBiQ571I4
PaxDbiQ571I4
PeptideAtlasiQ571I4
PRIDEiQ571I4

PTM databases

iPTMnetiQ571I4

Expressioni

Gene expression databases

CleanExiMM_D8ERTD82E

Interactioni

Protein-protein interaction databases

BioGridi232647, 5 interactors
IntActiQ571I4, 2 interactors
STRINGi10090.ENSMUSP00000106118

Structurei

3D structure databases

ProteinModelPortaliQ571I4
SMRiQ571I4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini751 – 1102Protein kinasePROSITE-ProRule annotationAdd BLAST352

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi494 – 499Poly-Pro6
Compositional biasi701 – 731Ser-richAdd BLAST31

Sequence similaritiesi

Belongs to the protein kinase superfamily.Curated

Phylogenomic databases

eggNOGiENOG410IJMD Eukaryota
ENOG4110SRP LUCA
HOGENOMiHOG000168455
HOVERGENiHBG055817
InParanoidiQ571I4
KOiK17537
PhylomeDBiQ571I4

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008266 Tyr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequencei

Sequence statusi: Complete.

Q571I4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSSCPKGPR PCTSPQPLRE SLPSEDDSDQ RCSPSGDSEG GEYCSILDCC
60 70 80 90 100
PESKDAVHST EGSGRRGGDC SPTCREQGPR TRPTEEEKQG LSFPRECCGQ
110 120 130 140 150
GSTANPPRLG PKKPSLNSEA ASSSDGLSCG SSRSGASSPF APHLENDYCS
160 170 180 190 200
LVKEPASGKQ QDLSGHFLTS GKCVGQAAEL QPASLLRDPV QPEPIYAESA
210 220 230 240 250
KRKKAAPGPP RPEPKKEQVP AGHSQGQVWT GDTWIQKTPP SWSQDREGAN
260 270 280 290 300
PAPQVATTIT VIAAHPEEDH RTIYLSSPDS AVGVQWPRGP SNQDLQAGEE
310 320 330 340 350
EPLVAQGLTS RESHPHNVTE NTAKEKPAIP PKLSKSSPGG SPVSPAAPPL
360 370 380 390 400
TDHSDGNTGG SSVGPQLLSR VPANLTSSCH TNGVATAGDS AKCPPPATSS
410 420 430 440 450
SVLDQRRPRY QTGAWSRQCR IEEEEEVGQE LSQSWGRELE NGTADHSNSS
460 470 480 490 500
TWHRLHPIDG TSGQNSKTNS GMSKSASFAF EFPKDRGRLE AFSPPPPPPK
510 520 530 540 550
SRHLLKMNKS SSDLEKVSQS SAESLSPSFR GAHVSFTTGS TDSLASDSRP
560 570 580 590 600
CSDGGPSYEP THSPTISGKK LFAPVPFPSG STEDVSPGGG PAQPPPLPQK
610 620 630 640 650
KIVSRAASSP DGFFWTQGSP KPRTASPKLN LSHSETNVCA HDEPPFNCSL
660 670 680 690 700
NSGNRSHHVF SSSEPLGKAF KGNAPWAPAL GLANSKGGCG SPSLQCRAAT
710 720 730 740 750
STSSSQLSVS SQASSSSTQL QLHSLLSSIS SKEGTYAKLG GLYTQSLARL
760 770 780 790 800
VTKCEDLFMG GQKKELRFNE NYWSLFKLTC NKPCCDSGDA IYYCATCSED
810 820 830 840 850
PGSIYAVKIC KTPEPKSASY CSPSVPVHFN IQQDCGHFVA SVPSSMLASP
860 870 880 890 900
DTSSKDTAPA VSPQPPAQEQ DCVVVITREV PHQTASDFVR DSMASHRAEP
910 920 930 940 950
EVYERRVCFL LLQLCNGLEH LKEHGIIHRD LCLENLLLAH CNPQSSPGPS
960 970 980 990 1000
ATPTVPTTTS RCPSAAPAAT TACQGGPGEK QLPRLIISNF LKAKQKPGGT
1010 1020 1030 1040 1050
TNLQQKKSQA RLAPEIVSAS QYRKFDEFQT GILIYELLHQ PNPFEVRAQL
1060 1070 1080 1090 1100
RERDYRREDL PPLPTLSLYS PGLQQLAHLL LEADPIKRIR IGEAKRVLQC
1110 1120 1130 1140 1150
LLWGPRRELV EQPCTSEEVL CNTLHNWIDM KRALMMMKFA EKAVDRRRGV
1160 1170
ELEDWLCCQY LASAEPGALL QSLKLLQLL
Length:1,179
Mass (Da):126,640
Last modified:November 28, 2006 - v2
Checksum:i9A6A6872251F7F77
GO

Sequence cautioni

The sequence BAD90130 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48D → Y in BAD90130 (Ref. 2) Curated1
Sequence conflicti66R → C in BAD90130 (Ref. 2) Curated1
Sequence conflicti298G → S in BAD90130 (Ref. 2) Curated1
Sequence conflicti309T → I in BAD90130 (Ref. 2) Curated1
Sequence conflicti318V → M in BAD90130 (Ref. 2) Curated1
Sequence conflicti347Missing in BAC29528 (PubMed:16141072).Curated1
Sequence conflicti347Missing in AAH89024 (PubMed:15489334).Curated1
Sequence conflicti592A → V in BAD90130 (Ref. 2) Curated1
Sequence conflicti667G → E in BAD90130 (Ref. 2) Curated1
Sequence conflicti945S → I in BAD90130 (Ref. 2) Curated1
Sequence conflicti966A → V in BAD90130 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036672 mRNA Translation: BAC29528.1
AK220205 mRNA Translation: BAD90130.1 Different initiation.
BC089024 mRNA Translation: AAH89024.1
RefSeqiNP_766499.2, NM_172911.3
UniGeneiMm.244971

Genome annotation databases

GeneIDi244418
KEGGimmu:244418

Similar proteinsi

Entry informationi

Entry nameiPRAG1_MOUSE
AccessioniPrimary (citable) accession number: Q571I4
Secondary accession number(s): Q8CB68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: May 23, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families
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