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Q571I4

- SG223_MOUSE

UniProt

Q571I4 - SG223_MOUSE

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Protein

Tyrosine-protein kinase SgK223

Gene

Sgk223

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei808 – 8081ATPPROSITE-ProRule annotation
Active sitei930 – 9301Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi757 – 7659ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase SgK223 (EC:2.7.10.2)
Alternative name(s):
Sugen kinase 223
Gene namesi
Name:Sgk223
Synonyms:D8Ertd82e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1196223. D8Ertd82e.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11791179Tyrosine-protein kinase SgK223PRO_0000263009Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei196 – 1961Phosphotyrosine1 Publication
Modified residuei477 – 4771PhosphoserineBy similarity
Modified residuei526 – 5261Phosphoserine1 Publication
Modified residuei608 – 6081PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ571I4.
PaxDbiQ571I4.
PRIDEiQ571I4.

PTM databases

PhosphoSiteiQ571I4.

Expressioni

Gene expression databases

CleanExiMM_D8ERTD82E.
GenevestigatoriQ571I4.

Interactioni

Protein-protein interaction databases

BioGridi232647. 3 interactions.
IntActiQ571I4. 1 interaction.
STRINGi10090.ENSMUSP00000106118.

Structurei

3D structure databases

ProteinModelPortaliQ571I4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini751 – 1102352Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi494 – 4996Poly-Pro
Compositional biasi701 – 73131Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG115841.
HOGENOMiHOG000168455.
HOVERGENiHBG055817.
InParanoidiQ571I4.
KOiK17537.
PhylomeDBiQ571I4.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q571I4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSSCPKGPR PCTSPQPLRE SLPSEDDSDQ RCSPSGDSEG GEYCSILDCC
60 70 80 90 100
PESKDAVHST EGSGRRGGDC SPTCREQGPR TRPTEEEKQG LSFPRECCGQ
110 120 130 140 150
GSTANPPRLG PKKPSLNSEA ASSSDGLSCG SSRSGASSPF APHLENDYCS
160 170 180 190 200
LVKEPASGKQ QDLSGHFLTS GKCVGQAAEL QPASLLRDPV QPEPIYAESA
210 220 230 240 250
KRKKAAPGPP RPEPKKEQVP AGHSQGQVWT GDTWIQKTPP SWSQDREGAN
260 270 280 290 300
PAPQVATTIT VIAAHPEEDH RTIYLSSPDS AVGVQWPRGP SNQDLQAGEE
310 320 330 340 350
EPLVAQGLTS RESHPHNVTE NTAKEKPAIP PKLSKSSPGG SPVSPAAPPL
360 370 380 390 400
TDHSDGNTGG SSVGPQLLSR VPANLTSSCH TNGVATAGDS AKCPPPATSS
410 420 430 440 450
SVLDQRRPRY QTGAWSRQCR IEEEEEVGQE LSQSWGRELE NGTADHSNSS
460 470 480 490 500
TWHRLHPIDG TSGQNSKTNS GMSKSASFAF EFPKDRGRLE AFSPPPPPPK
510 520 530 540 550
SRHLLKMNKS SSDLEKVSQS SAESLSPSFR GAHVSFTTGS TDSLASDSRP
560 570 580 590 600
CSDGGPSYEP THSPTISGKK LFAPVPFPSG STEDVSPGGG PAQPPPLPQK
610 620 630 640 650
KIVSRAASSP DGFFWTQGSP KPRTASPKLN LSHSETNVCA HDEPPFNCSL
660 670 680 690 700
NSGNRSHHVF SSSEPLGKAF KGNAPWAPAL GLANSKGGCG SPSLQCRAAT
710 720 730 740 750
STSSSQLSVS SQASSSSTQL QLHSLLSSIS SKEGTYAKLG GLYTQSLARL
760 770 780 790 800
VTKCEDLFMG GQKKELRFNE NYWSLFKLTC NKPCCDSGDA IYYCATCSED
810 820 830 840 850
PGSIYAVKIC KTPEPKSASY CSPSVPVHFN IQQDCGHFVA SVPSSMLASP
860 870 880 890 900
DTSSKDTAPA VSPQPPAQEQ DCVVVITREV PHQTASDFVR DSMASHRAEP
910 920 930 940 950
EVYERRVCFL LLQLCNGLEH LKEHGIIHRD LCLENLLLAH CNPQSSPGPS
960 970 980 990 1000
ATPTVPTTTS RCPSAAPAAT TACQGGPGEK QLPRLIISNF LKAKQKPGGT
1010 1020 1030 1040 1050
TNLQQKKSQA RLAPEIVSAS QYRKFDEFQT GILIYELLHQ PNPFEVRAQL
1060 1070 1080 1090 1100
RERDYRREDL PPLPTLSLYS PGLQQLAHLL LEADPIKRIR IGEAKRVLQC
1110 1120 1130 1140 1150
LLWGPRRELV EQPCTSEEVL CNTLHNWIDM KRALMMMKFA EKAVDRRRGV
1160 1170
ELEDWLCCQY LASAEPGALL QSLKLLQLL
Length:1,179
Mass (Da):126,640
Last modified:November 28, 2006 - v2
Checksum:i9A6A6872251F7F77
GO

Sequence cautioni

The sequence BAD90130.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti48 – 481D → Y in BAD90130. 1 PublicationCurated
Sequence conflicti66 – 661R → C in BAD90130. 1 PublicationCurated
Sequence conflicti298 – 2981G → S in BAD90130. 1 PublicationCurated
Sequence conflicti309 – 3091T → I in BAD90130. 1 PublicationCurated
Sequence conflicti318 – 3181V → M in BAD90130. 1 PublicationCurated
Sequence conflicti347 – 3471Missing in BAC29528. (PubMed:16141072)Curated
Sequence conflicti347 – 3471Missing in AAH89024. (PubMed:15489334)Curated
Sequence conflicti592 – 5921A → V in BAD90130. 1 PublicationCurated
Sequence conflicti667 – 6671G → E in BAD90130. 1 PublicationCurated
Sequence conflicti945 – 9451S → I in BAD90130. 1 PublicationCurated
Sequence conflicti966 – 9661A → V in BAD90130. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036672 mRNA. Translation: BAC29528.1.
AK220205 mRNA. Translation: BAD90130.1. Different initiation.
BC089024 mRNA. Translation: AAH89024.1.
RefSeqiNP_766499.2. NM_172911.3.
UniGeneiMm.244971.

Genome annotation databases

GeneIDi244418.
KEGGimmu:244418.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036672 mRNA. Translation: BAC29528.1 .
AK220205 mRNA. Translation: BAD90130.1 . Different initiation.
BC089024 mRNA. Translation: AAH89024.1 .
RefSeqi NP_766499.2. NM_172911.3.
UniGenei Mm.244971.

3D structure databases

ProteinModelPortali Q571I4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 232647. 3 interactions.
IntActi Q571I4. 1 interaction.
STRINGi 10090.ENSMUSP00000106118.

PTM databases

PhosphoSitei Q571I4.

Proteomic databases

MaxQBi Q571I4.
PaxDbi Q571I4.
PRIDEi Q571I4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 244418.
KEGGi mmu:244418.

Organism-specific databases

CTDi 244418.
MGIi MGI:1196223. D8Ertd82e.

Phylogenomic databases

eggNOGi NOG115841.
HOGENOMi HOG000168455.
HOVERGENi HBG055817.
InParanoidi Q571I4.
KOi K17537.
PhylomeDBi Q571I4.

Miscellaneous databases

NextBioi 386268.
PROi Q571I4.
SOURCEi Search...

Gene expression databases

CleanExi MM_D8ERTD82E.
Genevestigatori Q571I4.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 2 hits.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Eye.
  4. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-196, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-526, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSG223_MOUSE
AccessioniPrimary (citable) accession number: Q571I4
Secondary accession number(s): Q8CB68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: November 26, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3