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Protein

Nucleolar pre-ribosomal-associated protein 1

Gene

Urb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar pre-ribosomal-associated protein 1
Alternative name(s):
URB1 ribosome biogenesis 1 homolog
Gene namesi
Name:Urb1
Synonyms:Kiaa0539, Npa1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2146468. Urb1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 22742274Nucleolar pre-ribosomal-associated protein 1PRO_0000307935Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei17 – 171PhosphoserineCombined sources
Modified residuei1141 – 11411PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ571H0.
MaxQBiQ571H0.
PaxDbiQ571H0.
PRIDEiQ571H0.

PTM databases

iPTMnetiQ571H0.
PhosphoSiteiQ571H0.

Expressioni

Gene expression databases

BgeeiQ571H0.

Interactioni

Protein-protein interaction databases

BioGridi228935. 1 interaction.
STRINGi10090.ENSMUSP00000114717.

Family & Domainsi

Phylogenomic databases

eggNOGiKOG1791. Eukaryota.
ENOG410XR9W. LUCA.
HOGENOMiHOG000113835.
HOVERGENiHBG108197.
InParanoidiQ571H0.
KOiK14861.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR032436. NopRA1_C.
IPR021714. Npa1_N.
[Graphical view]
PfamiPF16201. NopRA1. 1 hit.
PF11707. Npa1. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q571H0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGVPKRKASE GPSSAASPAG TVKRTRAEEF TGVRFKTLLK DAQGPGPALE
60 70 80 90 100
AFVSAAKKLP QEDMCDVVEG YIKISMECAE IFQLLSGEKR PESEMLLIFQ
110 120 130 140 150
AFEAILLRTA SDLTHFHVVG ANIVKKLLYN HMKLLCESLY ASGYRMARAC
160 170 180 190 200
LDLMTAMVTQ GPEAARDVCS SLDLNKKALF ALVTKRDSKG VHDVRLAYIQ
210 220 230 240 250
FALSFLIAGD DNTIGQVLEI KEFIPCIFSS GIKEDKISTI NILLSTLKTK
260 270 280 290 300
VIHNKNITKT QKVRFFTGQF LNHIAALYNW NGITDVTPEK PEISAEEAGK
310 320 330 340 350
AMVRDLVHNF LMDLCCSRKH GISFYDASLG TSGRGGNLTL LHFLLSLKTA
360 370 380 390 400
AGDDLVASLV VSILKVCPDL LTKYFKEVTF SFLPRVKSTW LNNVKLLNKI
410 420 430 440 450
YEAQPEISPA FWTREFIPLP RLLAMVMVTT VPLVCNKIMF TQALNLDSIP
460 470 480 490 500
VKHSALSLIS DILKRALKTV DHCLDKETWQ DSDVYTAEMM EEFVQLFREA
510 520 530 540 550
LGKILPDLNT VIWVWQSFKK QEIKEDHEKG KKSSSKTPAV SKAAQHDVAE
560 570 580 590 600
TILLKSVLLQ VICLYQQVVP HVIMQYNFDF SKLLKGIISE QGPSQEVPPI
610 620 630 640 650
LQHHMLKVAL ELPANKFLWL KAQEGPEAEI IGGERSVFYL LMKMFVNSNH
660 670 680 690 700
LQLKSSTKLL IMKILRDTGV FEHTWRELEL WLEHLDSTAE ERKEAVIQFL
710 720 730 740 750
ERILLTLVMN PYSYTDKASE FVQEASTLQA SMGKQDADDV SIPISHIDDV
760 770 780 790 800
LDMVDVLVEG SEGLDEDIGF LLNEDMILLT FPFSALVPAA LEARNKLLLG
810 820 830 840 850
TDCEAGESIM AYMTAVLTDL LHTQRDPLAL CLLLQSYDKF EPVSLLCGQQ
860 870 880 890 900
LAQFHRYYSL WIPAQAQEAL PLQVSSSSGP CTLPPSSCFS TLLQTAYESQ
910 920 930 940 950
TLGDKSVQAQ LLAAVPSLAL QHMLRSAKQV LLYLKSTVEN FSQLGRSVGP
960 970 980 990 1000
ALLQSLLGLL KQLVIHAERL DAQNQQKLEA ARAESDLFLD MESVASLELA
1010 1020 1030 1040 1050
TDKTIEELLL AILKHPTLET WFLALEQKAL PPHTLSPILV KLLAAHFSAG
1060 1070 1080 1090 1100
VLQLLVASSP ILHKLGQLGL LAKYSEAITQ SVLIELRTRT LNSTSTPKTL
1110 1120 1130 1140 1150
PQLEALRELH PYMEGVQIRE VTLALLALPE AHLLTQQGTQ SLGKERHLSS
1160 1170 1180 1190 1200
LGKTLVQLLA SSHQDQLQSS ELLWCAEYVR GLGALLPTLA EHELDTVFLQ
1210 1220 1230 1240 1250
TLQKDPVLAP VVPEGVLEYC LARRTQTALG IASLLLQYSG THLVKFELWC
1260 1270 1280 1290 1300
GQPGVGPTLQ EHLDDFFPLI HVYLQHRAQG SFMRPTGVSS AVTPVLKALW
1310 1320 1330 1340 1350
RQVRDRFFHI TGPSKDALHL EALAQLIPFA RTKDLHVLMD HLPNTLRTLS
1360 1370 1380 1390 1400
NHKSWTLADS VSAALAESAE ELGSWRKTLL RSCIQWLAVS FSGREPEDEN
1410 1420 1430 1440 1450
TQEHEKAMLV RLSELLHAVK EVDPGDWQQF VKTGLKFRYH DLTFLKTLLS
1460 1470 1480 1490 1500
ATKLLYGPES SGRTKLVQLS VVHMMLTQHS LFLPTMLSSE EEETPDSGVK
1510 1520 1530 1540 1550
ETLLDLMSTV VRLCPSVCQS SHFAVLLGTY SATLSVLDQK ILLLLRAYEQ
1560 1570 1580 1590 1600
NNLSLISFRV LLWGPAAVEH HKTCRSLGKS LWQQPSVGDI LRLLDPDRMM
1610 1620 1630 1640 1650
QTILHFPQYR KLLPTEDTGE PLVFKDKTAR VDLDSLYDPC FLLHLFGELT
1660 1670 1680 1690 1700
RPEFVVDCRK FLDSNALGLT VAALSSYDPQ MRAAAYYVLA AYYSHLEGAR
1710 1720 1730 1740 1750
FREQSQVLYL LDVVRNGIRT PNLRLPFTVA LFIAKAAVQI LKPEEHMYWK
1760 1770 1780 1790 1800
ISKFLLSHEN LNMDKLPGFY QFFYSSDFQQ KTEQEWVLEI LRQGIRDKHC
1810 1820 1830 1840 1850
YELCSRRGVF HIILSFFNSP LCDEVAQNWI LEILQNVAHI TRSAYEVIRD
1860 1870 1880 1890 1900
YSLLTWVLHI LESRFVETQL LSNVISLLHT LWVTNLGNKA PEERSQPPGQ
1910 1920 1930 1940 1950
VGSQESEKML ALHMVSEFLY VLIALTKHLR PTLASAQLMN FFWTLESVLS
1960 1970 1980 1990 2000
YRATIIKLFK DMGRFTVNKV ALSTKDVLIL LHKWSLIERD TKLQGELKAV
2010 2020 2030 2040 2050
IEQHQAKDLM KMLKDKSRPV VAAQARGPRG RKRRHGGLEE TAEPQLEASC
2060 2070 2080 2090 2100
LEKCKDLLRA TLTHWGPGDP LPGPTQGSVG QTIPKSKTLS SAHAAVSLVA
2110 2120 2130 2140 2150
SWVLRSLAER PVSRAEVTRL LDWLKSHILP QPMVVADLLG DSAVKTGIFK
2160 2170 2180 2190 2200
LYNHHCSAQG LVGPAQDVAC KFSTVMLQLL VAQGRKESPF HSVAEALCLD
2210 2220 2230 2240 2250
SLNEKEEAKR APAAFLVSLY VKDMWLGAQQ PDTFLAHIRM VCEAAKDVPL
2260 2270
DEPEAIVVLC RNVDSSAQCL TRSR
Length:2,274
Mass (Da):254,614
Last modified:October 23, 2007 - v2
Checksum:iB1966E35F3697484
GO
Isoform 2 (identifier: Q571H0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     222-231: EFIPCIFSSG → GGSALSLGDV
     232-2274: Missing.

Note: No experimental confirmation available.
Show »
Length:231
Mass (Da):25,031
Checksum:iAEFEF983EB8F3559
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261R → Q in BAB30774 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei222 – 23110EFIPCIFSSG → GGSALSLGDV in isoform 2. 1 PublicationVSP_028877
Alternative sequencei232 – 22742043Missing in isoform 2. 1 PublicationVSP_028878Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017495 mRNA. Translation: BAB30774.1.
AC126671 Genomic DNA. No translation available.
AC134560 Genomic DNA. No translation available.
AK220219 mRNA. Translation: BAD90144.1.
RefSeqiNP_083773.1. NM_029497.1.
UniGeneiMm.328688.
Mm.473093.

Genome annotation databases

GeneIDi207932.
KEGGimmu:207932.
UCSCiuc007zwo.2. mouse. [Q571H0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017495 mRNA. Translation: BAB30774.1.
AC126671 Genomic DNA. No translation available.
AC134560 Genomic DNA. No translation available.
AK220219 mRNA. Translation: BAD90144.1.
RefSeqiNP_083773.1. NM_029497.1.
UniGeneiMm.328688.
Mm.473093.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228935. 1 interaction.
STRINGi10090.ENSMUSP00000114717.

PTM databases

iPTMnetiQ571H0.
PhosphoSiteiQ571H0.

Proteomic databases

EPDiQ571H0.
MaxQBiQ571H0.
PaxDbiQ571H0.
PRIDEiQ571H0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi207932.
KEGGimmu:207932.
UCSCiuc007zwo.2. mouse. [Q571H0-2]

Organism-specific databases

CTDi9875.
MGIiMGI:2146468. Urb1.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1791. Eukaryota.
ENOG410XR9W. LUCA.
HOGENOMiHOG000113835.
HOVERGENiHBG108197.
InParanoidiQ571H0.
KOiK14861.

Miscellaneous databases

NextBioi372093.
PROiQ571H0.
SOURCEiSearch...

Gene expression databases

BgeeiQ571H0.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR032436. NopRA1_C.
IPR021714. Npa1_N.
[Graphical view]
PfamiPF16201. NopRA1. 1 hit.
PF11707. Npa1. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Embryo.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1148-2274 (ISOFORM 1).
    Tissue: Spleen.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Testis.

Entry informationi

Entry nameiNPA1P_MOUSE
AccessioniPrimary (citable) accession number: Q571H0
Secondary accession number(s): Q9CYN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: March 16, 2016
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.