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Protein

Protein lin-54 homolog

Gene

Lin54

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes. In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation. In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Cell cycle, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-1538133. G0 and Early G1.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lin-54 homolog
Gene namesi
Name:Lin54
Synonyms:Kiaa2037
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2140902. Lin54.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 749749Protein lin-54 homologPRO_0000341390Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei244 – 2441N6-acetyllysineBy similarity
Modified residuei249 – 2491N6-acetyllysineBy similarity
Modified residuei264 – 2641PhosphoserineBy similarity
Modified residuei282 – 2821PhosphoserineBy similarity
Modified residuei310 – 3101PhosphoserineBy similarity
Modified residuei314 – 3141PhosphoserineBy similarity
Modified residuei635 – 6351PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ571G4.
PaxDbiQ571G4.
PeptideAtlasiQ571G4.
PRIDEiQ571G4.

PTM databases

iPTMnetiQ571G4.
PhosphoSiteiQ571G4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000035310.
ExpressionAtlasiQ571G4. baseline and differential.
GenevisibleiQ571G4. MM.

Interactioni

Subunit structurei

Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, RBL2, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi231129. 10 interactions.
IntActiQ571G4. 10 interactions.
STRINGi10090.ENSMUSP00000041374.

Structurei

3D structure databases

ProteinModelPortaliQ571G4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini521 – 634114CRCPROSITE-ProRule annotationAdd
BLAST

Domaini

The CXC domains mediate DNA-binding.By similarity

Sequence similaritiesi

Belongs to the lin-54 family.Curated
Contains 1 CRC domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1171. Eukaryota.
ENOG4110UR5. LUCA.
GeneTreeiENSGT00390000013974.
HOGENOMiHOG000082518.
HOVERGENiHBG108088.
InParanoidiQ571G4.
OMAiTPGIQTQ.
OrthoDBiEOG091G09E2.
PhylomeDBiQ571G4.
TreeFamiTF313189.

Family and domain databases

InterProiIPR005172. CRC.
IPR028307. Lin-54_fam.
IPR033467. Tesmin/TSO1-like_CXC.
[Graphical view]
PANTHERiPTHR12446. PTHR12446. 1 hit.
PfamiPF03638. TCR. 2 hits.
[Graphical view]
SMARTiSM01114. CXC. 2 hits.
[Graphical view]
PROSITEiPS51634. CRC. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q571G4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVVPAEVNS LLPDDIMDTA ITLVDEDSIE AVIVSSPIPM ETELEEIVNI
60 70 80 90 100
NSTGDSTATP ISTEPITVYS NHTNQVAVNT TVSKADSNTT VKPAFPSGLQ
110 120 130 140 150
KLGAQTPVTI SANQIILNKV SQTSDLKLGN QTLKPDGQKL ILTTLGKSGS
160 170 180 190 200
PIVLALPHSQ LPQAQKVTAQ AQPGDAKLPP QQIKVVTIGG RPEVKPVIGV
210 220 230 240 250
SALTPGSQLI NTTTQPSVLQ TQQLKTVQIA KKPRTPTSGP VITKLIFAKP
260 270 280 290 300
INSKAVTGQT TQASPPVVTG RVLSQSTPGT PSKTITISES GVIGSTLNST
310 320 330 340 350
TQTPNKIAIS PLKSPNKTVK SAVQTITVGG MSTSQFKTII PLATAPNVQQ
360 370 380 390 400
IQVPGSKFHY VRLVTATTAS SSAQPVSQSP SVNTQPLQQA KPVVVNTTPV
410 420 430 440 450
RMSVPFVQAQ AVKQVVPKPI NSTSQIVTTS QPQQRLIMPA TPLPQIQPNL
460 470 480 490 500
TNLPPGTVLA PAPGTGNVGY AVLPAQYVTQ LQQSSYVSIA SNSNFTGTSG
510 520 530 540 550
IQTQARLPFN GIIPSESTSR PRKPCNCTKS LCLKLYCDCF ANGEFCNNCN
560 570 580 590 600
CTNCYNNLEH ENERQKAIKA CLDRNPEAFK PKIGKGKEGE SDRRHSKGCN
610 620 630 640 650
CKRSGCLKNY CECYEAKIMC SSICKCIGCK NFEESPERKT LMHLADAAEV
660 670 680 690 700
RVQQQTAAKT KLSSQISDLL TRPTPALNSA GGKLPFTFVT KEVAEATCNC
710 720 730 740
LLAQAEQADK KGKSKAAAER MILEEFGRCL MSVINSAGKA KSDPCAMHC
Length:749
Mass (Da):79,566
Last modified:June 10, 2008 - v2
Checksum:i9A547A07B7216394
GO
Isoform 2 (identifier: Q571G4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-330: Missing.

Note: No experimental confirmation available.
Show »
Length:419
Mass (Da):45,301
Checksum:i24E3D4D454217D5B
GO
Isoform 3 (identifier: Q571G4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     229-237: IAKKPRTPT → VKTKKGHIT
     238-749: Missing.

Note: No experimental confirmation available.
Show »
Length:237
Mass (Da):24,929
Checksum:i3218D2D0D2FF2E42
GO

Sequence cautioni

The sequence AAI06127 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAD90150 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 330330Missing in isoform 2. 1 PublicationVSP_034277Add
BLAST
Alternative sequencei229 – 2379IAKKPRTPT → VKTKKGHIT in isoform 3. 1 PublicationVSP_034278
Alternative sequencei238 – 749512Missing in isoform 3. 1 PublicationVSP_034279Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220225 mRNA. Translation: BAD90150.1. Different initiation.
AK028016 mRNA. Translation: BAC25700.1.
AK029288 mRNA. Translation: BAC26373.1.
AK134320 mRNA. Translation: BAE22096.1.
BC106126 mRNA. Translation: AAI06127.1. Sequence problems.
BC125580 mRNA. Translation: AAI25581.1.
CCDSiCCDS19462.2. [Q571G4-1]
RefSeqiNP_001108482.1. NM_001115010.1. [Q571G4-1]
NP_766302.2. NM_172714.4. [Q571G4-1]
XP_006534947.1. XM_006534884.2. [Q571G4-1]
XP_006534949.1. XM_006534886.2. [Q571G4-2]
UniGeneiMm.212568.

Genome annotation databases

EnsembliENSMUST00000046154; ENSMUSP00000041374; ENSMUSG00000035310. [Q571G4-1]
ENSMUST00000123572; ENSMUSP00000123425; ENSMUSG00000035310. [Q571G4-1]
GeneIDi231506.
KEGGimmu:231506.
UCSCiuc008yhn.3. mouse. [Q571G4-1]
uc008yhq.2. mouse. [Q571G4-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220225 mRNA. Translation: BAD90150.1. Different initiation.
AK028016 mRNA. Translation: BAC25700.1.
AK029288 mRNA. Translation: BAC26373.1.
AK134320 mRNA. Translation: BAE22096.1.
BC106126 mRNA. Translation: AAI06127.1. Sequence problems.
BC125580 mRNA. Translation: AAI25581.1.
CCDSiCCDS19462.2. [Q571G4-1]
RefSeqiNP_001108482.1. NM_001115010.1. [Q571G4-1]
NP_766302.2. NM_172714.4. [Q571G4-1]
XP_006534947.1. XM_006534884.2. [Q571G4-1]
XP_006534949.1. XM_006534886.2. [Q571G4-2]
UniGeneiMm.212568.

3D structure databases

ProteinModelPortaliQ571G4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231129. 10 interactions.
IntActiQ571G4. 10 interactions.
STRINGi10090.ENSMUSP00000041374.

PTM databases

iPTMnetiQ571G4.
PhosphoSiteiQ571G4.

Proteomic databases

MaxQBiQ571G4.
PaxDbiQ571G4.
PeptideAtlasiQ571G4.
PRIDEiQ571G4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046154; ENSMUSP00000041374; ENSMUSG00000035310. [Q571G4-1]
ENSMUST00000123572; ENSMUSP00000123425; ENSMUSG00000035310. [Q571G4-1]
GeneIDi231506.
KEGGimmu:231506.
UCSCiuc008yhn.3. mouse. [Q571G4-1]
uc008yhq.2. mouse. [Q571G4-3]

Organism-specific databases

CTDi132660.
MGIiMGI:2140902. Lin54.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1171. Eukaryota.
ENOG4110UR5. LUCA.
GeneTreeiENSGT00390000013974.
HOGENOMiHOG000082518.
HOVERGENiHBG108088.
InParanoidiQ571G4.
OMAiTPGIQTQ.
OrthoDBiEOG091G09E2.
PhylomeDBiQ571G4.
TreeFamiTF313189.

Enzyme and pathway databases

ReactomeiR-MMU-1538133. G0 and Early G1.

Miscellaneous databases

ChiTaRSiLin54. mouse.
PROiQ571G4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035310.
ExpressionAtlasiQ571G4. baseline and differential.
GenevisibleiQ571G4. MM.

Family and domain databases

InterProiIPR005172. CRC.
IPR028307. Lin-54_fam.
IPR033467. Tesmin/TSO1-like_CXC.
[Graphical view]
PANTHERiPTHR12446. PTHR12446. 1 hit.
PfamiPF03638. TCR. 2 hits.
[Graphical view]
SMARTiSM01114. CXC. 2 hits.
[Graphical view]
PROSITEiPS51634. CRC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIN54_MOUSE
AccessioniPrimary (citable) accession number: Q571G4
Secondary accession number(s): A0JLY2
, Q3KQN0, Q3UYW5, Q8BMU8, Q8C107
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: September 7, 2016
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.