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Protein

Transcription factor TFIIIB component B'' homolog

Gene

Bdp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
R-MMU-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
R-MMU-76071. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor TFIIIB component B'' homolog
Alternative name(s):
Transcription factor IIIB 150
Short name:
TFIIIB150
Transcription factor-like nuclear regulator
Gene namesi
Name:Bdp1
Synonyms:Kiaa1241, Tfnr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1347077. Bdp1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003338641 – 2467Transcription factor TFIIIB component B'' homologAdd BLAST2467

Post-translational modificationi

Phosphorylated by CSNK2A1 during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription.By similarity

Proteomic databases

PaxDbiQ571C7.
PeptideAtlasiQ571C7.
PRIDEiQ571C7.

PTM databases

iPTMnetiQ571C7.
PhosphoSitePlusiQ571C7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000049658.
ExpressionAtlasiQ571C7. baseline and differential.
GenevisibleiQ571C7. MM.

Interactioni

Subunit structurei

Component of TFIIIB complex. The TFIIIB complex has two activities, alpha and beta. The TFIIIB-alpha and TFIIIB-beta activities are required for transcription of genes with TFIIIC-bound internal promoters and PSE transcription factor-bound external promoters, respectively. The TFIIIB-alpha activity complex is composed of TBP, BDP1, and a complex containing both BRF2 and at least four stably associated proteins; YY1 facilitates the formation of TFIIIB-alpha activity complex. The TFIIIB-beta activity complex is composed of TBP, BDP1, and BRF1. Interacts with BRF1; this interaction diminishes during mitosis resulting in the release of BDP1 from chromosomal templates. Component of TFIIIC complex. The TFIIIC complex has two activities, C1 and C2. The TFIIIC2 activity complex is only required for transcription of the 'classical' pol III genes whereas the TFIIIC1 activity complex is required for transcription of all pol III genes. The TFIIIC1 activity complex is composed at least of BDP1. Interacts with ZBTB43 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038321.

Structurei

3D structure databases

ProteinModelPortaliQ571C7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini297 – 347Myb-likeAdd BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 301Interaction with ZBTB43By similarityAdd BLAST301
Regioni357 – 472Required for phosphorylation by CSNK2A1By similarityAdd BLAST116

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili144 – 177Sequence analysisAdd BLAST34
Coiled coili458 – 487Sequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi892 – 1168Glu-richAdd BLAST277

Sequence similaritiesi

Contains 1 Myb-like domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2009. Eukaryota.
COG5118. LUCA.
GeneTreeiENSGT00390000012762.
HOGENOMiHOG000169168.
HOVERGENiHBG107497.
InParanoidiQ571C7.
KOiK15198.
OMAiEDKSHAP.
OrthoDBiEOG091G0GQF.
PhylomeDBiQ571C7.
TreeFamiTF328878.

Family and domain databases

InterProiIPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR030701. TFIIIB_B''.
[Graphical view]
PANTHERiPTHR22929. PTHR22929. 4 hits.
SMARTiSM00717. SANT. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q571C7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFRRARLSVK PNVRPGVGTR GSAAPNPQRG PEAPRPPEPA TESAPKPAEP
60 70 80 90 100
TDVPAVDSGG AEPQEQAPGS SDEKTGDKNN AAESSTLSSA SSQRRKRVSS
110 120 130 140 150
TSSLVQPSGS APSQSRPLST VDHDAPQPNP TPAKEKQPCS DRYRIYKARK
160 170 180 190 200
LREMLKEELR KEKKQWKNKF STNESQRPPD RSKMTMRDFI YYLPDNNPMT
210 220 230 240 250
SSVEQEKKPE KSLAPTPTRD RQENQSTQDA NDNEDVEEEV DDGPLLVPRV
260 270 280 290 300
KVAEDGSIIL DEESLTVEVL RTKGPCVVEE NDPIFERGST TTYSSFRKNY
310 320 330 340 350
YSKPWSNKET DMFFLAISMV GTDFSMIGQL FPHRARIEIK NKFKREEKTN
360 370 380 390 400
GWRIDKAFQE KRPFDFDFFA HLLQKVLAEE EKRKQKSTKC QSLKEKASKP
410 420 430 440 450
RKNLKAKTVT SEEVNDDPDE SVNSNISDPE RSQNDAETVN EEESPSSSGQ
460 470 480 490 500
HLEQAMLEQD QNQEKKRRRN QGEANKQEAT NLLERVLVHS SPPAAEIHKN
510 520 530 540 550
TCPSEENESE CNKEQIPSLT QNIDDIAGLA PSEETEMRMD PIPSTCNQQD
560 570 580 590 600
IMPLARESSE SCAVALPVWE PGNTASADMA HAESSCSEGR GADLKTAAPE
610 620 630 640 650
TEQTENVKPK SRSRLQRPKP NLARAVGKKS AVSQDRQDER NKNSPSETAA
660 670 680 690 700
EKNHMEKETM NESETSVAKN TDGESPGAKT VSDLSEKSCV QQDSQAKVLR
710 720 730 740 750
PTRLMRSRMQ RPKPNVVKAA ERKEILTSQE KFGAHVEKSE DESCVVIPPQ
760 770 780 790 800
TENESHKNLQ CEDTVSEPGR KDPFENIQPD QPQVLSDCPS IHEGNKENKR
810 820 830 840 850
KQVPVLRTRF QKPKPNTGRR RRRISSKEGI PEETPISGEI PATWEEIPSL
860 870 880 890 900
DTSLREEVLS VPLAPLTATA STKDSESDVK DSGRNDTASN AEMSEMTDVT
910 920 930 940 950
MEMETGLETI GRDTCPGEMG AEMIDIPMET EAGLKASLNE TSCMEKVPEL
960 970 980 990 1000
IDTTGEICTN LGETGRKEVF LQENGPKEVG PVSEPETGLQ ETGKDLAMKE
1010 1020 1030 1040 1050
STPDTTDSTE EREAYSEETE RQEKISALIK DAEEAKARGE METPLEEIGG
1060 1070 1080 1090 1100
GTSQRGKAAG APVEQSASEE EPQGSACREE VAVESSTAEG KELNLRETGE
1110 1120 1130 1140 1150
DDVSSMVVVL GEKTDIEETN GDPKETERES SVSWERGSGE IQVGEEMVED
1160 1170 1180 1190 1200
LGKPEKIDVA PREREPEEHS SGQPEADVIL SSSDGSTGSP QDKVNISSKI
1210 1220 1230 1240 1250
SVMPTLVEEK ETTDKDISSH LGHVESCSQN LGRHETDQGM PLPDALERFS
1260 1270 1280 1290 1300
DTNLSKPLPQ EQQPLQVKPA PFLRSRFKKP KPNLSRAALK RATIEAEHCV
1310 1320 1330 1340 1350
PGKKSEACKV EAAMLQQDSD QAALSPQHNV PSLMASREND KSGHEEEEEA
1360 1370 1380 1390 1400
AILPCTQTEK DASPPNSSEP KEGSQLTPNQ ENGLLVPIGT PMMNTVTQET
1410 1420 1430 1440 1450
RQNVVQTTLP VRGRLQRPRP NVQKARQRQI VEKGEARDIA KNEGPELQKD
1460 1470 1480 1490 1500
ETRTCLTVAN SSHIESGVAV DMSSRVSECQ VSESQGHADP VENLSVNKAS
1510 1520 1530 1540 1550
VVHEQMRHEN KPYVPSPALL IRRRFQKAKP NLGGARRKDE QPGVEKGRTD
1560 1570 1580 1590 1600
ESTALTAEDH LLQKEDCDTQ LSLQAREKAD MPLEVSVRKE CIHSEESGSD
1610 1620 1630 1640 1650
RNDAQPNAGP SEGSRDETAK EQPTSLGLEE QSLSKQIRSS CPQLWKESSY
1660 1670 1680 1690 1700
PKTVSSRRTP LSSASECEIE HSWKRTQRKT KPNLTKGRGS KRIRGKTAKK
1710 1720 1730 1740 1750
EPRASKSVLV TLRASQKEDE DDAEDFDSDY EEETYHLAPE ELSKAPVFVP
1760 1770 1780 1790 1800
VGLRSPEPVS AQIEETMEEL EITMDVADMT VVEHQLSHMD TTAQAVQAEK
1810 1820 1830 1840 1850
AVYPPSFEMD VGEQTQEEPG PSDGSTEAAI TLLTMGDIVL QSEIIPGQGD
1860 1870 1880 1890 1900
VGVCVFPDVH SEDKSHAPFS PDNVNQKVVH DYPEVCSPVI STSHASFEEN
1910 1920 1930 1940 1950
RIVSKEQSNR DAAVEEEAVE ETLPTRNTTS TMSTHLRMES MVVTPELNSE
1960 1970 1980 1990 2000
KTLEISESHG HQEVASFCIT KETEVEIQRE TEGDDSKAVE LEDKSHAPVT
2010 2020 2030 2040 2050
AAETKEEEQS QCVGDVEGAS VSQEAILPAR IEDHEETLQE VQESGTAVAS
2060 2070 2080 2090 2100
SEIGQQTLDS GQSFGESAAK EALKETPKGS DVPVLHGPES VPSHIPEAQQ
2110 2120 2130 2140 2150
ENTGPQAVTV NPFADGQQDG EDEQAFILTL VEIPTHATEG FTDAAMQLMP
2160 2170 2180 2190 2200
SSLLPAPILV RSGNAAERGD LSGSLQTSLV VQDAPSLSPS RSGSSEKPPA
2210 2220 2230 2240 2250
NLDLTSRKRF CCSPDESIHV PPAKKSSLVP GIDYQECTSE VCSEELNVFE
2260 2270 2280 2290 2300
KTAESCMGQG IFPTSESTHA TSKPQKEHSE PTDTGSSGSL DEIKDACVEN
2310 2320 2330 2340 2350
MAQLPQSEIV SDKEEKTEPA SNSEQRDIVT SSSKPPLTRP GRRPLGFLSL
2360 2370 2380 2390 2400
LCPKNSLESD EVTQTHSKKR LKPQIPVSRR NLRKPNLHNT SQKKNQDSSA
2410 2420 2430 2440 2450
PPPSPSVTAP LSGTAGSPES SAAQVSSDQP LLKEECKNGP KGAPEEEVTP
2460
VSEFVFSDIF IEVDETL
Length:2,467
Mass (Da):270,790
Last modified:May 20, 2008 - v2
Checksum:iC4B6BBCB266D47AA
GO
Isoform 2 (identifier: Q571C7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2426-2467: SSDQPLLKEE...DIFIEVDETL → CEHCCVLLCM...LLFPTKMHLI

Note: No experimental confirmation available.
Show »
Length:2,471
Mass (Da):271,724
Checksum:iFBEEB88E9B5E04AC
GO

Sequence cautioni

The sequence AAH30359 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti788C → F in BAD90187 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0335832426 – 2467SSDQP…VDETL → CEHCCVLLCMRYIYHLNEGR KSKFIFSWMSEIILVQLLFP TKMHLI in isoform 2. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT025569 Genomic DNA. No translation available.
CT030167 Genomic DNA. No translation available.
AK220262 mRNA. Translation: BAD90187.1.
BC030359 mRNA. Translation: AAH30359.1. Sequence problems.
AK090184 mRNA. Translation: BAC41127.1.
CCDSiCCDS49343.1. [Q571C7-1]
RefSeqiNP_001074530.1. NM_001081061.1. [Q571C7-1]
XP_006517788.1. XM_006517725.3. [Q571C7-2]
UniGeneiMm.288546.

Genome annotation databases

EnsembliENSMUST00000038104; ENSMUSP00000038321; ENSMUSG00000049658. [Q571C7-1]
ENSMUST00000109379; ENSMUSP00000105005; ENSMUSG00000049658. [Q571C7-2]
GeneIDi544971.
KEGGimmu:544971.
UCSCiuc007rqc.1. mouse. [Q571C7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT025569 Genomic DNA. No translation available.
CT030167 Genomic DNA. No translation available.
AK220262 mRNA. Translation: BAD90187.1.
BC030359 mRNA. Translation: AAH30359.1. Sequence problems.
AK090184 mRNA. Translation: BAC41127.1.
CCDSiCCDS49343.1. [Q571C7-1]
RefSeqiNP_001074530.1. NM_001081061.1. [Q571C7-1]
XP_006517788.1. XM_006517725.3. [Q571C7-2]
UniGeneiMm.288546.

3D structure databases

ProteinModelPortaliQ571C7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038321.

PTM databases

iPTMnetiQ571C7.
PhosphoSitePlusiQ571C7.

Proteomic databases

PaxDbiQ571C7.
PeptideAtlasiQ571C7.
PRIDEiQ571C7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038104; ENSMUSP00000038321; ENSMUSG00000049658. [Q571C7-1]
ENSMUST00000109379; ENSMUSP00000105005; ENSMUSG00000049658. [Q571C7-2]
GeneIDi544971.
KEGGimmu:544971.
UCSCiuc007rqc.1. mouse. [Q571C7-1]

Organism-specific databases

CTDi55814.
MGIiMGI:1347077. Bdp1.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2009. Eukaryota.
COG5118. LUCA.
GeneTreeiENSGT00390000012762.
HOGENOMiHOG000169168.
HOVERGENiHBG107497.
InParanoidiQ571C7.
KOiK15198.
OMAiEDKSHAP.
OrthoDBiEOG091G0GQF.
PhylomeDBiQ571C7.
TreeFamiTF328878.

Enzyme and pathway databases

ReactomeiR-MMU-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
R-MMU-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
R-MMU-76071. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Miscellaneous databases

ChiTaRSiBdp1. mouse.
PROiQ571C7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049658.
ExpressionAtlasiQ571C7. baseline and differential.
GenevisibleiQ571C7. MM.

Family and domain databases

InterProiIPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR030701. TFIIIB_B''.
[Graphical view]
PANTHERiPTHR22929. PTHR22929. 4 hits.
SMARTiSM00717. SANT. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBDP1_MOUSE
AccessioniPrimary (citable) accession number: Q571C7
Secondary accession number(s): Q8BTI4, Q8K0U7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: November 30, 2016
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.