Reviewed, UniProtKB/Swiss-Prot Q57190 (THIL_HAEIN)

Names and origin

Protein names

Recommended name:
    Thiamine-monophosphate kinase
      Short name=Thiamine-phosphate kinase
    EC=2.7.4.16

Gene names

Name:	thiL
Ordered Locus Names:	HI1305

Organism

Haemophilus influenzae [Complete proteome] [HAMAP]

Taxonomic identifier

727 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	328 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + thiamine phosphate = ADP + thiamine diphosphate.
Pathway	Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.
Sequence similarities	Belongs to the thiamine-monophosphate kinase family.

Ontologies

Keywords
Biological process	Thiamine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	thiamin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW thiamin phosphate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 328	328	Thiamine-monophosphate kinase		PRO_0000096197

Sequences

	Sequence		Length	Mass (Da)
	Q57190-1 [UniParc]. Last modified May 30, 2000. Version 2. Checksum: DD0F666BD73A6056	FASTA	328	36,016
	10 20 30 40 50 60 MAMGEFDLIK RYFQQQILVD DSVQLSIGDD CALVSVPENY QLAITTDTMV ENTHFLPTIS 70 80 90 100 110 120 PEDLAYKAVA TNLSDLAAMG AQPKWVSLAL TLPNVDENWI STFSQSLLHT LKQYNVTLIG 130 140 150 160 170 180 GDTTKGNLSI TITAQGFVEK NKGICRHKAQ IGDLIYVSST LGDSAAGLTQ ILLGKSAVDS 190 200 210 220 230 240 DDVFLQQRHL RPTPRIELGQ ALIGIAHVAI DLSDGLISDL GHILERSQCS AEVELTALPL 250 260 270 280 290 300 SSSILNKYDR TQAEQFALSG GEDYELCFTI PPEYKDELEL RLKKLNVPCT CIGKINEKCG 310 320 DFSPRFLRDG KPVNITFSSG FDHFKESK

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC22952.1. Different initiation.
PIR	E64115.
RefSeq	NP_439456.1.
3D structure databases
SMR	Q57190. Positions 1-313.
ModBase	Search...
Genome annotation databases
GeneID	950230.
GenomeReviews	Gene locus HI1305 in contig L42023_GR.
KEGG	hin:HI1305.
NMPDR	fig|71421.1.peg.1243.
TIGR	HI1305.
Phylogenomic databases
HOGENOM	HBG577902.
OMA	MGAEPAW.
Enzyme and pathway databases
BioCyc	HINF71421:HI_1305-MONOMER.
BRENDA	2.7.4.16. 109.
Family and domain databases
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR016188. PurM_N-like. IPR006283. ThiL. [Graphical view]
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
PIRSF	PIRSF005303. Thiam_monoph_kin. 1 hit.
TIGRFAMs	TIGR01379. thiL. 1 hit.
ProtoNet	Search...

Entry information

Entry name

THIL_HAEIN

Accession

Primary (citable) accession number: Q57190

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 30, 2000
Last modified:	February 9, 2010
This is version 57 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)