Q57179 (ILVC_CORGL) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 94.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Ketol-acid reductoisomerase EC=1.1.1.86 Alternative name(s): Acetohydroxy-acid isomeroreductase Alpha-keto-beta-hydroxylacyl reductoisomerase | ||||
| Gene names |
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| Organism | Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025) [Reference proteome] [HAMAP] | ||||
| Taxonomic identifier | 196627 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium › ![]() |
Protein attributes
| Sequence length | 338 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Catalytic activity | (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP-Rule MF_00435 (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP-Rule MF_00435 |
| Pathway | Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP-Rule MF_00435 Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP-Rule MF_00435 |
| Sequence similarities | Belongs to the ketol-acid reductoisomerase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Branched-chain amino acid biosynthesis |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | isoleucine biosynthetic process Inferred from electronic annotation. Source: HAMAP valine biosynthetic processInferred from electronic annotation. Source: HAMAP |
| Molecular_function | coenzyme binding Inferred from electronic annotation. Source: InterPro ketol-acid reductoisomerase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 338 | 338 | Ketol-acid reductoisomerase HAMAP-Rule MF_00435 | PRO_0000151306 | |||||
Sites | |||||||||
| Active site | 109 | 1 | Potential | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Isoleucine synthesis in Corynebacterium glutamicum: molecular analysis of the ilvB-ilvN-ilvC operon." Keilhauer C., Eggeling L., Sahm H. J. Bacteriol. 175:5595-5603(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025. |
| [2] | "Identification and sequence determination of the acetohydroxy acid isomeroreductase gene from Brevibacterium flavum MJ233." Inui M., Vertes A.A., Kobayashi M., Kurusu Y., Yukawa H. DNA Seq. 4:95-103(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: MJ233. |
| [3] | "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes." Ikeda M., Nakagawa S. Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025. |
| [4] | "The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins." Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M., Burkovski A., Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L., Goesmann A., Hartmann M., Huthmacher K., Kraemer R., Linke B., McHardy A.C., Meyer F., Moeckel B. Tauch A.J. Biotechnol. 104:5-25(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | L09232 Genomic DNA. Translation: AAA62431.1. D14551 Genomic DNA. Translation: BAA03414.1. BA000036 Genomic DNA. Translation: BAB98666.1. BX927151 Genomic DNA. Translation: CAF19976.1. |
| PIR | C48648. |
| RefSeq | NP_600495.1. NC_003450.3. YP_225562.1. NC_006958.1. |
3D structure databases | |
| ProteinModelPortal | Q57179. |
| SMR | Q57179. Positions 4-329. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 196627.cg1437. |
2D gel databases | |
| World-2DPAGE | 0001:Q57179. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | BAB98666; BAB98666; BAB98666. CAF19976; CAF19976; cg1437. |
| GeneID | 1019254. 3343961. |
| KEGG | cgb:cg1437. cgl:NCgl1224. |
| PATRIC | 21494588. VBICorGlu203724_1250. |
Phylogenomic databases | |
| eggNOG | COG0059. |
| HOGENOM | HOG000016230. |
| KO | K00053. |
| OMA | WDITLAY. |
| ProtClustDB | PRK05479. |
Enzyme and pathway databases | |
| BioCyc | CGLU196627:GJDM-1257-MONOMER. |
| UniPathway | UPA00047; UER00056. UPA00049; UER00060. |
Family and domain databases | |
| Gene3D | 1.10.1040.10. 1 hit. |
| HAMAP | MF_00435. IlvC. |
| InterPro | IPR008927. 6-PGluconate_DH_C-like. IPR013023. AcH_isomrdctse. IPR000506. AcH_isomrdctse_C. IPR013328. DH_multihelical. IPR013116. IlvN. [Graphical view] |
| PANTHER | PTHR21371. PTHR21371. 1 hit. |
| Pfam | PF01450. IlvC. 1 hit. PF07991. IlvN. 1 hit. [Graphical view] |
| SUPFAM | SSF48179. 6DGDH_C_like. 1 hit. |
| TIGRFAMs | TIGR00465. ilvC. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | ILVC_CORGL | ||||||||
| Accession | Primary (citable) accession number: Q57179 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with
