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Q57168

- T1MH_HAEIN

UniProt

Q57168 - T1MH_HAEIN

Protein

Putative type I restriction enzyme HindVIIP M protein

Gene

HI_1287

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Methylation of specific adenine residues; required for both restriction and modification activities.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei173 – 1731S-adenosyl-L-methionineBy similarity

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. N-methyltransferase activity Source: InterPro
    3. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA restriction-modification system Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Restriction system

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Protein family/group databases

    REBASEi3426. M.HindI.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative type I restriction enzyme HindVIIP M protein (EC:2.1.1.72)
    Short name:
    M.HindVIIP
    Gene namesi
    Ordered Locus Names:HI_1287
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 443443Putative type I restriction enzyme HindVIIP M proteinPRO_0000088027Add
    BLAST

    Interactioni

    Subunit structurei

    The type I restriction/modification system is composed of three polypeptides R, M and S.

    Protein-protein interaction databases

    STRINGi71421.HI1287.

    Structurei

    3D structure databases

    ProteinModelPortaliQ57168.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni117 – 1226S-adenosyl-L-methionine bindingBy similarity
    Regioni146 – 1483S-adenosyl-L-methionine bindingBy similarity

    Sequence similaritiesi

    Belongs to the N(4)/N(6)-methyltransferase family.Curated

    Phylogenomic databases

    eggNOGiCOG0286.
    KOiK03427.
    OMAiDIAGFCK.
    OrthoDBiEOG6VQPSK.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR003356. DNA_methylase_A-5.
    IPR002296. N12N6_MeTrfase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF02384. N6_Mtase. 1 hit.
    [Graphical view]
    PRINTSiPR00507. N12N6MTFRASE.
    SUPFAMiSSF53335. SSF53335. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q57168-1 [UniParc]FASTAAdd to Basket

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    MPASARWQAL QEVSILNTGA ELPWGGKFSG VAKLIDDAFD AIEKDNEKLK    50
    GVLQRISGYA VNEDTLRGLI ILFSDTHFTR PTYNGEPVHL GAKDILGHVY 100
    EYFLSRFAQA EGKRSGQYFT PKSIVSLIVE MLEPYSGRVY DPAMGSGGFF 150
    VQTERFITAH QGNINNVSIY GQEFNPTTWK LAAMNMAIRG IDYDFGKYNA 200
    DSFTQPQHID KKMDFIMANP HFNDKEWWNE SLADDPRWAY GTPPKGNANF 250
    AWLQHMIYHL SPNGKIALLL ANGSMSSQTN NEGEIRKAII NADLVECMVA 300
    LPGQLFTNTK IPACIWFLNR NKKRKGEVLF IDARQIGYMK DRVLRDFTAD 350
    DIAKIADTLH AWQTSDGYED QAAFCKSATL EEIKNNDFVL TPGRYVGTAE 400
    QEDDGVPFAE KMQNLTALLK EQFAKSAELE AEIKKNLGGL GYE 443
    Length:443
    Mass (Da):49,732
    Last modified:November 1, 1996 - v1
    Checksum:i70573FBFFA78594C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22936.1.
    PIRiG64114.
    RefSeqiNP_439439.2. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22936; AAC22936; HI_1287.
    GeneIDi950217.
    KEGGihin:HI1287.
    PATRICi20191257. VBIHaeInf48452_1339.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22936.1 .
    PIRi G64114.
    RefSeqi NP_439439.2. NC_000907.1.

    3D structure databases

    ProteinModelPortali Q57168.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI1287.

    Protein family/group databases

    REBASEi 3426. M.HindI.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22936 ; AAC22936 ; HI_1287 .
    GeneIDi 950217.
    KEGGi hin:HI1287.
    PATRICi 20191257. VBIHaeInf48452_1339.

    Phylogenomic databases

    eggNOGi COG0286.
    KOi K03427.
    OMAi DIAGFCK.
    OrthoDBi EOG6VQPSK.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR003356. DNA_methylase_A-5.
    IPR002296. N12N6_MeTrfase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF02384. N6_Mtase. 1 hit.
    [Graphical view ]
    PRINTSi PR00507. N12N6MTFRASE.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiT1MH_HAEIN
    AccessioniPrimary (citable) accession number: Q57168
    Secondary accession number(s): O05053
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3