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Protein

Putative type I restriction enzyme HindVIIP M protein

Gene

HI_1287

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Methylation of specific adenine residues; required for both restriction and modification activities.By similarity

Catalytic activityi

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei173 – 1731S-adenosyl-L-methionineBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Restriction system

Keywords - Ligandi

S-adenosyl-L-methionine

Protein family/group databases

REBASEi3426. M.HindI.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative type I restriction enzyme HindVIIP M protein (EC:2.1.1.72)
Short name:
M.HindVIIP
Gene namesi
Ordered Locus Names:HI_1287
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Putative type I restriction enzyme HindVIIP M proteinPRO_0000088027Add
BLAST

Interactioni

Subunit structurei

The type I restriction/modification system is composed of three polypeptides R, M and S.

Protein-protein interaction databases

STRINGi71421.HI1287.

Structurei

3D structure databases

ProteinModelPortaliQ57168.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni117 – 1226S-adenosyl-L-methionine bindingBy similarity
Regioni146 – 1483S-adenosyl-L-methionine bindingBy similarity

Sequence similaritiesi

Belongs to the N(4)/N(6)-methyltransferase family.Curated

Phylogenomic databases

eggNOGiCOG0286.
KOiK03427.
OMAiIYYLPRE.
OrthoDBiEOG6VQPSK.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR003356. DNA_methylase_A-5.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF02384. N6_Mtase. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

Q57168-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPASARWQAL QEVSILNTGA ELPWGGKFSG VAKLIDDAFD AIEKDNEKLK
60 70 80 90 100
GVLQRISGYA VNEDTLRGLI ILFSDTHFTR PTYNGEPVHL GAKDILGHVY
110 120 130 140 150
EYFLSRFAQA EGKRSGQYFT PKSIVSLIVE MLEPYSGRVY DPAMGSGGFF
160 170 180 190 200
VQTERFITAH QGNINNVSIY GQEFNPTTWK LAAMNMAIRG IDYDFGKYNA
210 220 230 240 250
DSFTQPQHID KKMDFIMANP HFNDKEWWNE SLADDPRWAY GTPPKGNANF
260 270 280 290 300
AWLQHMIYHL SPNGKIALLL ANGSMSSQTN NEGEIRKAII NADLVECMVA
310 320 330 340 350
LPGQLFTNTK IPACIWFLNR NKKRKGEVLF IDARQIGYMK DRVLRDFTAD
360 370 380 390 400
DIAKIADTLH AWQTSDGYED QAAFCKSATL EEIKNNDFVL TPGRYVGTAE
410 420 430 440
QEDDGVPFAE KMQNLTALLK EQFAKSAELE AEIKKNLGGL GYE
Length:443
Mass (Da):49,732
Last modified:November 1, 1996 - v1
Checksum:i70573FBFFA78594C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22936.1.
PIRiG64114.
RefSeqiNP_439439.2. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22936; AAC22936; HI_1287.
GeneIDi950217.
KEGGihin:HI1287.
PATRICi20191257. VBIHaeInf48452_1339.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22936.1.
PIRiG64114.
RefSeqiNP_439439.2. NC_000907.1.

3D structure databases

ProteinModelPortaliQ57168.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI1287.

Protein family/group databases

REBASEi3426. M.HindI.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22936; AAC22936; HI_1287.
GeneIDi950217.
KEGGihin:HI1287.
PATRICi20191257. VBIHaeInf48452_1339.

Phylogenomic databases

eggNOGiCOG0286.
KOiK03427.
OMAiIYYLPRE.
OrthoDBiEOG6VQPSK.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR003356. DNA_methylase_A-5.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF02384. N6_Mtase. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiT1MH_HAEIN
AccessioniPrimary (citable) accession number: Q57168
Secondary accession number(s): O05053
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: April 29, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.