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Q57168

- T1MH_HAEIN

UniProt

Q57168 - T1MH_HAEIN

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Protein
Putative type I restriction enzyme HindVIIP M protein
Gene
HI_1287
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Methylation of specific adenine residues; required for both restriction and modification activities By similarity.

Catalytic activityi

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei173 – 1731S-adenosyl-L-methionine By similarity

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. N-methyltransferase activity Source: InterPro
  3. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Restriction system

Keywords - Ligandi

S-adenosyl-L-methionine

Protein family/group databases

REBASEi3426. M.HindI.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative type I restriction enzyme HindVIIP M protein (EC:2.1.1.72)
Short name:
M.HindVIIP
Gene namesi
Ordered Locus Names:HI_1287
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Putative type I restriction enzyme HindVIIP M protein
PRO_0000088027Add
BLAST

Interactioni

Subunit structurei

The type I restriction/modification system is composed of three polypeptides R, M and S.

Protein-protein interaction databases

STRINGi71421.HI1287.

Structurei

3D structure databases

ProteinModelPortaliQ57168.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni117 – 1226S-adenosyl-L-methionine binding By similarity
Regioni146 – 1483S-adenosyl-L-methionine binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0286.
KOiK03427.
OMAiDIAGFCK.
OrthoDBiEOG6VQPSK.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR003356. DNA_methylase_A-5.
IPR002296. N12N6_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF02384. N6_Mtase. 1 hit.
[Graphical view]
PRINTSiPR00507. N12N6MTFRASE.
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

Q57168-1 [UniParc]FASTAAdd to Basket

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MPASARWQAL QEVSILNTGA ELPWGGKFSG VAKLIDDAFD AIEKDNEKLK    50
GVLQRISGYA VNEDTLRGLI ILFSDTHFTR PTYNGEPVHL GAKDILGHVY 100
EYFLSRFAQA EGKRSGQYFT PKSIVSLIVE MLEPYSGRVY DPAMGSGGFF 150
VQTERFITAH QGNINNVSIY GQEFNPTTWK LAAMNMAIRG IDYDFGKYNA 200
DSFTQPQHID KKMDFIMANP HFNDKEWWNE SLADDPRWAY GTPPKGNANF 250
AWLQHMIYHL SPNGKIALLL ANGSMSSQTN NEGEIRKAII NADLVECMVA 300
LPGQLFTNTK IPACIWFLNR NKKRKGEVLF IDARQIGYMK DRVLRDFTAD 350
DIAKIADTLH AWQTSDGYED QAAFCKSATL EEIKNNDFVL TPGRYVGTAE 400
QEDDGVPFAE KMQNLTALLK EQFAKSAELE AEIKKNLGGL GYE 443
Length:443
Mass (Da):49,732
Last modified:November 1, 1996 - v1
Checksum:i70573FBFFA78594C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22936.1.
PIRiG64114.
RefSeqiNP_439439.2. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22936; AAC22936; HI_1287.
GeneIDi950217.
KEGGihin:HI1287.
PATRICi20191257. VBIHaeInf48452_1339.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC22936.1 .
PIRi G64114.
RefSeqi NP_439439.2. NC_000907.1.

3D structure databases

ProteinModelPortali Q57168.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI1287.

Protein family/group databases

REBASEi 3426. M.HindI.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22936 ; AAC22936 ; HI_1287 .
GeneIDi 950217.
KEGGi hin:HI1287.
PATRICi 20191257. VBIHaeInf48452_1339.

Phylogenomic databases

eggNOGi COG0286.
KOi K03427.
OMAi DIAGFCK.
OrthoDBi EOG6VQPSK.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR003356. DNA_methylase_A-5.
IPR002296. N12N6_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF02384. N6_Mtase. 1 hit.
[Graphical view ]
PRINTSi PR00507. N12N6MTFRASE.
SUPFAMi SSF53335. SSF53335. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiT1MH_HAEIN
AccessioniPrimary (citable) accession number: Q57168
Secondary accession number(s): O05053
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi