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Q57168 (T1MH_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative type I restriction enzyme HindVIIP M protein

Short name=M.HindVIIP
EC=2.1.1.72
Gene names
Ordered Locus Names:HI_1287
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length443 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Methylation of specific adenine residues; required for both restriction and modification activities By similarity.

Catalytic activity

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

Subunit structure

The type I restriction/modification system is composed of three polypeptides R, M and S.

Sequence similarities

Belongs to the N(4)/N(6)-methyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 443443Putative type I restriction enzyme HindVIIP M protein
PRO_0000088027

Regions

Region117 – 1226S-adenosyl-L-methionine binding By similarity
Region146 – 1483S-adenosyl-L-methionine binding By similarity

Sites

Binding site1731S-adenosyl-L-methionine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q57168 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 70573FBFFA78594C

FASTA44349,732
        10         20         30         40         50         60 
MPASARWQAL QEVSILNTGA ELPWGGKFSG VAKLIDDAFD AIEKDNEKLK GVLQRISGYA 

        70         80         90        100        110        120 
VNEDTLRGLI ILFSDTHFTR PTYNGEPVHL GAKDILGHVY EYFLSRFAQA EGKRSGQYFT 

       130        140        150        160        170        180 
PKSIVSLIVE MLEPYSGRVY DPAMGSGGFF VQTERFITAH QGNINNVSIY GQEFNPTTWK 

       190        200        210        220        230        240 
LAAMNMAIRG IDYDFGKYNA DSFTQPQHID KKMDFIMANP HFNDKEWWNE SLADDPRWAY 

       250        260        270        280        290        300 
GTPPKGNANF AWLQHMIYHL SPNGKIALLL ANGSMSSQTN NEGEIRKAII NADLVECMVA 

       310        320        330        340        350        360 
LPGQLFTNTK IPACIWFLNR NKKRKGEVLF IDARQIGYMK DRVLRDFTAD DIAKIADTLH 

       370        380        390        400        410        420 
AWQTSDGYED QAAFCKSATL EEIKNNDFVL TPGRYVGTAE QEDDGVPFAE KMQNLTALLK 

       430        440 
EQFAKSAELE AEIKKNLGGL GYE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC22936.1.
PIRG64114.
RefSeqNP_439439.2. NC_000907.1.

3D structure databases

ProteinModelPortalQ57168.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI1287.

Protein family/group databases

REBASE3426. M.HindI.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC22936; AAC22936; HI_1287.
GeneID950217.
KEGGhin:HI1287.
PATRIC20191257. VBIHaeInf48452_1339.

Phylogenomic databases

eggNOGCOG0286.
KOK03427.
OMADIAGFCK.
OrthoDBEOG6VQPSK.

Family and domain databases

Gene3D3.40.50.150. 1 hit.
InterProIPR003356. DNA_methylase_A-5.
IPR002296. N12N6_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamPF02384. N6_Mtase. 1 hit.
[Graphical view]
PRINTSPR00507. N12N6MTFRASE.
SUPFAMSSF53335. SSF53335. 1 hit.
ProtoNetSearch...

Entry information

Entry nameT1MH_HAEIN
AccessionPrimary (citable) accession number: Q57168
Secondary accession number(s): O05053
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names