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Protein

Protein TRANSPORT INHIBITOR RESPONSE 1

Gene

TIR1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Auxin receptor that mediates Aux/IAA proteins proteasomal degradation and auxin-regulated transcription. The SCF(TIR1) E3 ubiquitin ligase complex is involved in auxin-mediated signaling pathway that regulate root and hypocotyl growth, lateral root formation, cell elongation, and gravitropism. Appears to allow pericycle cells to overcome G2 arrest prior to lateral root development. Plays a role in ethylene signaling in roots. Confers sensitivity to the virulent bacterial pathogen P.syringae.8 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei74Myo-inositol hexakisphosphate2 Publications1
Binding sitei344Myo-inositol hexakisphosphate2 Publications1
Binding sitei436Myo-inositol hexakisphosphate2 Publications1
Binding sitei509Myo-inositol hexakisphosphate2 Publications1

GO - Molecular functioni

  • auxin binding Source: UniProtKB
  • auxin receptor activity Source: UniProtKB
  • inositol hexakisphosphate binding Source: UniProtKB
  • ubiquitin-protein transferase activity Source: TAIR

GO - Biological processi

  • auxin-activated signaling pathway Source: UniProtKB
  • cell cycle Source: UniProtKB-KW
  • cellular response to phosphate starvation Source: TAIR
  • defense response Source: UniProtKB-KW
  • ethylene-activated signaling pathway Source: UniProtKB-KW
  • lateral root formation Source: TAIR
  • pollen maturation Source: TAIR
  • response to auxin Source: TAIR
  • stamen development Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Auxin signaling pathway, Cell cycle, Ethylene signaling pathway, Plant defense, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein TRANSPORT INHIBITOR RESPONSE 1
Alternative name(s):
Weak ethylene-insensitive protein 1
Gene namesi
Name:TIR1
Synonyms:FBL1, WEI1
Ordered Locus Names:At3g62980
ORF Names:T20O10.80
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G62980.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB-SubCell
  • SCF ubiquitin ligase complex Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Plant are deficient in a variety of auxin-regulated growth processes including lateral root formation, and hypocotyl and cell elongation.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi10P → A: Abolishes SCF(TIR1) complex formation, altered auxin-mediated response and reduced affinity for auxin. 2 Publications1
Mutagenesisi33V → A: No affinity for auxin. 1 Publication1
Mutagenesisi35K → A: No affinity for auxin. 1 Publication1
Mutagenesisi147G → D in tir1-1; insensitive to auxin ubiquitously and to ethylene in roots only. 1 Publication1
Mutagenesisi441G → D in tir1-2; insensitive to auxin. 1 Publication1
Mutagenesisi574 – 594Missing in tir1-101/wei1; insensitive to auxin ubiquitously and to ethylene in roots only. 1 PublicationAdd BLAST21

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001199651 – 594Protein TRANSPORT INHIBITOR RESPONSE 1Add BLAST594

Proteomic databases

PaxDbiQ570C0.
PRIDEiQ570C0.

PTM databases

iPTMnetiQ570C0.

Expressioni

Tissue specificityi

Expressed in roots, stems, leaves and flowers. In adult plants, mostly expressed in floral stigma, anther filaments, abscission zones and vascular tissues.2 Publications

Developmental stagei

Abundant expression in developing embryos. In young seedlings, expressed in root apical meristem, and expanding cotyledons and hypocotyls. In older seedlings, still expressed in root apical meristems, but also in lateral root primordia, stipules, shoot apical meristem and vascular tissues.1 Publication

Inductioni

Repressed by miR393a (microRNA) in response to flg-22 (flagellin-derived peptide 22).1 Publication

Gene expression databases

GenevisibleiQ570C0. AT.

Interactioni

Subunit structurei

Interacts with auxin. Part of a SCF E3 ubiquitin ligase complex SCF(TIR1) composed of SKP1, CUL1, RBX1 and TIR1. SCF(TIR1) interacts with the COP9 signalosome (CSN) complex. Interacts with Aux/IAA proteins (IAA3, IAA7, IAA12 and IAA17) in an auxin-dependent manner. The interaction with IAA3, a negative regulator of auxin responses, is promoted by auxin, but repressed by juglon (5-hydroxy-1,4-naphthoquinone). Interactions with auxin-responsive proteins is inactivated by auxin antagonists.10 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei139Interaction with auxin-responsive proteins1
Sitei165Interaction with auxin-responsive proteins1
Sitei380Interaction with auxin-responsive proteins1
Sitei489Interaction with auxin-responsive proteins1

Binary interactionsi

WithEntry#Exp.IntActNotes
IAA17P938302EBI-307183,EBI-632243
IAA7Q388254EBI-307183,EBI-602959
SKP1AQ392554EBI-307183,EBI-532357
SKP1BQ9FHW74EBI-307183,EBI-604076

Protein-protein interaction databases

BioGridi10787. 20 interactors.
DIPiDIP-31740N.
IntActiQ570C0. 16 interactors.
STRINGi3702.AT3G62980.1.

Structurei

Secondary structure

1594
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 19Combined sources9
Helixi24 – 31Combined sources8
Helixi35 – 44Combined sources10
Beta strandi47 – 52Combined sources6
Helixi53 – 55Combined sources3
Helixi58 – 64Combined sources7
Beta strandi70 – 74Combined sources5
Helixi78 – 82Combined sources5
Helixi94 – 103Combined sources10
Beta strandi109 – 114Combined sources6
Helixi119 – 128Combined sources10
Beta strandi134 – 139Combined sources6
Beta strandi141 – 144Combined sources4
Helixi145 – 154Combined sources10
Beta strandi160 – 162Combined sources3
Beta strandi167 – 169Combined sources3
Helixi173 – 178Combined sources6
Beta strandi188 – 190Combined sources3
Helixi200 – 209Combined sources10
Beta strandi215 – 217Combined sources3
Helixi224 – 233Combined sources10
Beta strandi238 – 241Combined sources4
Helixi251 – 262Combined sources12
Beta strandi269 – 271Combined sources3
Helixi278 – 284Combined sources7
Helixi285 – 288Combined sources4
Beta strandi293 – 295Combined sources3
Helixi303 – 310Combined sources8
Beta strandi318 – 322Combined sources5
Helixi323 – 325Combined sources3
Helixi326 – 336Combined sources11
Beta strandi342 – 346Combined sources5
Beta strandi350 – 352Combined sources3
Helixi361 – 370Combined sources10
Beta strandi376 – 382Combined sources7
Helixi386 – 395Combined sources10
Beta strandi401 – 408Combined sources8
Turni414 – 416Combined sources3
Helixi421 – 430Combined sources10
Beta strandi436 – 438Combined sources3
Helixi445 – 454Combined sources10
Beta strandi460 – 465Combined sources6
Helixi470 – 479Combined sources10
Beta strandi485 – 490Combined sources6
Helixi495 – 500Combined sources6
Helixi502 – 507Combined sources6
Beta strandi508 – 516Combined sources9
Helixi520 – 529Combined sources10
Beta strandi533 – 538Combined sources6
Beta strandi540 – 542Combined sources3
Helixi544 – 546Combined sources3
Beta strandi554 – 560Combined sources7
Beta strandi573 – 575Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2P1MX-ray1.80B1-594[»]
2P1NX-ray2.50B/E1-594[»]
2P1OX-ray1.90B1-594[»]
2P1PX-ray2.21B1-594[»]
2P1QX-ray1.91B1-594[»]
3C6NX-ray2.60B1-594[»]
3C6OX-ray2.70B1-594[»]
3C6PX-ray2.70B1-594[»]
ProteinModelPortaliQ570C0.
SMRiQ570C0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ570C0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 50F-boxAdd BLAST48

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni81 – 82Interaction with auxin-responsive proteins2
Regioni113 – 114Myo-inositol hexakisphosphate binding2
Regioni347 – 352Interaction with auxin-responsive proteins6
Regioni401 – 403Myo-inositol hexakisphosphate binding3
Regioni403 – 404Auxin binding2
Regioni405 – 409Interaction with auxin-responsive proteins5
Regioni438 – 439Auxin binding2
Regioni464 – 465Interaction with auxin-responsive proteins2
Regioni484 – 485Myo-inositol hexakisphosphate binding2

Domaini

The F-box is necessary for the interaction with SKP1.1 Publication

Sequence similaritiesi

Contains 1 F-box domain.Curated

Phylogenomic databases

eggNOGiKOG1947. Eukaryota.
ENOG410XQ54. LUCA.
HOGENOMiHOG000239805.
InParanoidiQ570C0.
KOiK14485.
OMAiCLSGFWD.
OrthoDBiEOG093606S7.
PhylomeDBiQ570C0.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00367. LRR_CC. 6 hits.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q570C0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKRIALSFP EEVLEHVFSF IQLDKDRNSV SLVCKSWYEI ERWCRRKVFI
60 70 80 90 100
GNCYAVSPAT VIRRFPKVRS VELKGKPHFA DFNLVPDGWG GYVYPWIEAM
110 120 130 140 150
SSSYTWLEEI RLKRMVVTDD CLELIAKSFK NFKVLVLSSC EGFSTDGLAA
160 170 180 190 200
IAATCRNLKE LDLRESDVDD VSGHWLSHFP DTYTSLVSLN ISCLASEVSF
210 220 230 240 250
SALERLVTRC PNLKSLKLNR AVPLEKLATL LQRAPQLEEL GTGGYTAEVR
260 270 280 290 300
PDVYSGLSVA LSGCKELRCL SGFWDAVPAY LPAVYSVCSR LTTLNLSYAT
310 320 330 340 350
VQSYDLVKLL CQCPKLQRLW VLDYIEDAGL EVLASTCKDL RELRVFPSEP
360 370 380 390 400
FVMEPNVALT EQGLVSVSMG CPKLESVLYF CRQMTNAALI TIARNRPNMT
410 420 430 440 450
RFRLCIIEPK APDYLTLEPL DIGFGAIVEH CKDLRRLSLS GLLTDKVFEY
460 470 480 490 500
IGTYAKKMEM LSVAFAGDSD LGMHHVLSGC DSLRKLEIRD CPFGDKALLA
510 520 530 540 550
NASKLETMRS LWMSSCSVSF GACKLLGQKM PKLNVEVIDE RGAPDSRPES
560 570 580 590
CPVERVFIYR TVAGPRFDMP GFVWNMDQDS TMRFSRQIIT TNGL
Length:594
Mass (Da):66,799
Last modified:June 21, 2005 - v2
Checksum:i9E19ED5DABF40D07
GO

Sequence cautioni

The sequence BAD94031 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti490D → E in BAD94031 (Ref. 6) Curated1
Sequence conflicti568D → G in BAD94031 (Ref. 6) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005047 Genomic DNA. Translation: AAB69175.1.
AF005048 mRNA. Translation: AAB69176.1.
AL163816 Genomic DNA. Translation: CAB87743.1.
CP002686 Genomic DNA. Translation: AEE80419.1.
BT001946 mRNA. Translation: AAN71945.1.
EF598824 Genomic DNA. Translation: ABR04117.1.
EF598825 Genomic DNA. Translation: ABR04118.1.
EF598826 Genomic DNA. Translation: ABR04119.1.
EF598827 Genomic DNA. Translation: ABR04120.1.
EF598828 Genomic DNA. Translation: ABR04121.1.
EF598829 Genomic DNA. Translation: ABR04122.1.
EF598830 Genomic DNA. Translation: ABR04123.1.
EF598831 Genomic DNA. Translation: ABR04124.1.
EF598832 Genomic DNA. Translation: ABR04125.1.
EF598833 Genomic DNA. Translation: ABR04126.1.
EF598834 Genomic DNA. Translation: ABR04127.1.
EF598835 Genomic DNA. Translation: ABR04128.1.
EF598836 Genomic DNA. Translation: ABR04129.1.
EF598837 Genomic DNA. Translation: ABR04130.1.
EF598838 Genomic DNA. Translation: ABR04131.1.
EF598839 Genomic DNA. Translation: ABR04132.1.
EF598840 Genomic DNA. Translation: ABR04133.1.
EF598841 Genomic DNA. Translation: ABR04134.1.
EF598842 Genomic DNA. Translation: ABR04135.1.
EF598843 Genomic DNA. Translation: ABR04136.1.
EF598844 Genomic DNA. Translation: ABR04137.1.
EF598845 Genomic DNA. Translation: ABR04138.1.
EF598846 Genomic DNA. Translation: ABR04139.1.
EF598847 Genomic DNA. Translation: ABR04140.1.
AK220790 mRNA. Translation: BAD94031.1. Different initiation.
EU550991 Genomic DNA. Translation: ACB31753.1.
EU550992 Genomic DNA. Translation: ACB31754.1.
EU550993 Genomic DNA. Translation: ACB31755.1.
EU550994 Genomic DNA. Translation: ACB31756.1.
EU550995 Genomic DNA. Translation: ACB31757.1.
EU550996 Genomic DNA. Translation: ACB31758.1.
EU550997 Genomic DNA. Translation: ACB31759.1.
EU550998 Genomic DNA. Translation: ACB31760.1.
EU550999 Genomic DNA. Translation: ACB31761.1.
EU551000 Genomic DNA. Translation: ACB31762.1.
EU551001 Genomic DNA. Translation: ACB31763.1.
EU551002 Genomic DNA. Translation: ACB31764.1.
EU551003 Genomic DNA. Translation: ACB31765.1.
EU551004 Genomic DNA. Translation: ACB31766.1.
EU551005 Genomic DNA. Translation: ACB31767.1.
EU551006 Genomic DNA. Translation: ACB31768.1.
EU551007 Genomic DNA. Translation: ACB31769.1.
EU551008 Genomic DNA. Translation: ACB31770.1.
EU551009 Genomic DNA. Translation: ACB31771.1.
EU551010 Genomic DNA. Translation: ACB31772.1.
EU551011 Genomic DNA. Translation: ACB31773.1.
EU551012 Genomic DNA. Translation: ACB31774.1.
EU551013 Genomic DNA. Translation: ACB31775.1.
EU551014 Genomic DNA. Translation: ACB31776.1.
PIRiT48087.
RefSeqiNP_567135.1. NM_116163.4.
UniGeneiAt.25594.

Genome annotation databases

EnsemblPlantsiAT3G62980.1; AT3G62980.1; AT3G62980.
GeneIDi825473.
GrameneiAT3G62980.1; AT3G62980.1; AT3G62980.
KEGGiath:AT3G62980.

Cross-referencesi

Web resourcesi

PlantsUBQ

A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005047 Genomic DNA. Translation: AAB69175.1.
AF005048 mRNA. Translation: AAB69176.1.
AL163816 Genomic DNA. Translation: CAB87743.1.
CP002686 Genomic DNA. Translation: AEE80419.1.
BT001946 mRNA. Translation: AAN71945.1.
EF598824 Genomic DNA. Translation: ABR04117.1.
EF598825 Genomic DNA. Translation: ABR04118.1.
EF598826 Genomic DNA. Translation: ABR04119.1.
EF598827 Genomic DNA. Translation: ABR04120.1.
EF598828 Genomic DNA. Translation: ABR04121.1.
EF598829 Genomic DNA. Translation: ABR04122.1.
EF598830 Genomic DNA. Translation: ABR04123.1.
EF598831 Genomic DNA. Translation: ABR04124.1.
EF598832 Genomic DNA. Translation: ABR04125.1.
EF598833 Genomic DNA. Translation: ABR04126.1.
EF598834 Genomic DNA. Translation: ABR04127.1.
EF598835 Genomic DNA. Translation: ABR04128.1.
EF598836 Genomic DNA. Translation: ABR04129.1.
EF598837 Genomic DNA. Translation: ABR04130.1.
EF598838 Genomic DNA. Translation: ABR04131.1.
EF598839 Genomic DNA. Translation: ABR04132.1.
EF598840 Genomic DNA. Translation: ABR04133.1.
EF598841 Genomic DNA. Translation: ABR04134.1.
EF598842 Genomic DNA. Translation: ABR04135.1.
EF598843 Genomic DNA. Translation: ABR04136.1.
EF598844 Genomic DNA. Translation: ABR04137.1.
EF598845 Genomic DNA. Translation: ABR04138.1.
EF598846 Genomic DNA. Translation: ABR04139.1.
EF598847 Genomic DNA. Translation: ABR04140.1.
AK220790 mRNA. Translation: BAD94031.1. Different initiation.
EU550991 Genomic DNA. Translation: ACB31753.1.
EU550992 Genomic DNA. Translation: ACB31754.1.
EU550993 Genomic DNA. Translation: ACB31755.1.
EU550994 Genomic DNA. Translation: ACB31756.1.
EU550995 Genomic DNA. Translation: ACB31757.1.
EU550996 Genomic DNA. Translation: ACB31758.1.
EU550997 Genomic DNA. Translation: ACB31759.1.
EU550998 Genomic DNA. Translation: ACB31760.1.
EU550999 Genomic DNA. Translation: ACB31761.1.
EU551000 Genomic DNA. Translation: ACB31762.1.
EU551001 Genomic DNA. Translation: ACB31763.1.
EU551002 Genomic DNA. Translation: ACB31764.1.
EU551003 Genomic DNA. Translation: ACB31765.1.
EU551004 Genomic DNA. Translation: ACB31766.1.
EU551005 Genomic DNA. Translation: ACB31767.1.
EU551006 Genomic DNA. Translation: ACB31768.1.
EU551007 Genomic DNA. Translation: ACB31769.1.
EU551008 Genomic DNA. Translation: ACB31770.1.
EU551009 Genomic DNA. Translation: ACB31771.1.
EU551010 Genomic DNA. Translation: ACB31772.1.
EU551011 Genomic DNA. Translation: ACB31773.1.
EU551012 Genomic DNA. Translation: ACB31774.1.
EU551013 Genomic DNA. Translation: ACB31775.1.
EU551014 Genomic DNA. Translation: ACB31776.1.
PIRiT48087.
RefSeqiNP_567135.1. NM_116163.4.
UniGeneiAt.25594.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2P1MX-ray1.80B1-594[»]
2P1NX-ray2.50B/E1-594[»]
2P1OX-ray1.90B1-594[»]
2P1PX-ray2.21B1-594[»]
2P1QX-ray1.91B1-594[»]
3C6NX-ray2.60B1-594[»]
3C6OX-ray2.70B1-594[»]
3C6PX-ray2.70B1-594[»]
ProteinModelPortaliQ570C0.
SMRiQ570C0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi10787. 20 interactors.
DIPiDIP-31740N.
IntActiQ570C0. 16 interactors.
STRINGi3702.AT3G62980.1.

PTM databases

iPTMnetiQ570C0.

Proteomic databases

PaxDbiQ570C0.
PRIDEiQ570C0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G62980.1; AT3G62980.1; AT3G62980.
GeneIDi825473.
GrameneiAT3G62980.1; AT3G62980.1; AT3G62980.
KEGGiath:AT3G62980.

Organism-specific databases

TAIRiAT3G62980.

Phylogenomic databases

eggNOGiKOG1947. Eukaryota.
ENOG410XQ54. LUCA.
HOGENOMiHOG000239805.
InParanoidiQ570C0.
KOiK14485.
OMAiCLSGFWD.
OrthoDBiEOG093606S7.
PhylomeDBiQ570C0.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

EvolutionaryTraceiQ570C0.
PROiQ570C0.

Gene expression databases

GenevisibleiQ570C0. AT.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00367. LRR_CC. 6 hits.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTIR1_ARATH
AccessioniPrimary (citable) accession number: Q570C0
Secondary accession number(s): A5YZP2, B2CVU0, O24660
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: November 30, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

The myo-inositol hexakisphosphate acts as a structural cofactor.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.