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Q570C0

- TIR1_ARATH

UniProt

Q570C0 - TIR1_ARATH

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Protein
Protein TRANSPORT INHIBITOR RESPONSE 1
Gene
TIR1, FBL1, WEI1, At3g62980, T20O10.80
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Auxin receptor that mediates Aux/IAA proteins proteasomal degradation and auxin-regulated transcription. The SCF(TIR1) E3 ubiquitin ligase complex is involved in auxin-mediated signaling pathway that regulate root and hypocotyl growth, lateral root formation, cell elongation, and gravitropism. Appears to allow pericycle cells to overcome G2 arrest prior to lateral root development. Plays a role in ethylene signaling in roots. Confers sensitivity to the virulent bacterial pathogen P.syringae.8 Publications

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei74 – 741Myo-inositol hexakisphosphate
Sitei139 – 1391Interaction with auxin-responsive proteins
Sitei165 – 1651Interaction with auxin-responsive proteins
Binding sitei344 – 3441Myo-inositol hexakisphosphate
Sitei380 – 3801Interaction with auxin-responsive proteins
Binding sitei436 – 4361Myo-inositol hexakisphosphate
Sitei489 – 4891Interaction with auxin-responsive proteins
Binding sitei509 – 5091Myo-inositol hexakisphosphate

GO - Molecular functioni

  1. auxin binding Source: UniProtKB
  2. auxin receptor activity Source: UniProtKB
  3. inositol hexakisphosphate binding Source: UniProtKB
  4. protein binding Source: UniProtKB
  5. ubiquitin-protein transferase activity Source: TAIR

GO - Biological processi

  1. auxin-activated signaling pathway Source: UniProtKB
  2. cell cycle Source: UniProtKB-KW
  3. cellular response to phosphate starvation Source: TAIR
  4. defense response Source: UniProtKB-KW
  5. ethylene-activated signaling pathway Source: UniProtKB-KW
  6. lateral root formation Source: TAIR
  7. pollen maturation Source: TAIR
  8. response to auxin Source: TAIR
  9. response to molecule of bacterial origin Source: TAIR
  10. stamen development Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Auxin signaling pathway, Cell cycle, Ethylene signaling pathway, Plant defense, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein TRANSPORT INHIBITOR RESPONSE 1
Alternative name(s):
Weak ethylene-insensitive protein 1
Gene namesi
Name:TIR1
Synonyms:FBL1, WEI1
Ordered Locus Names:At3g62980
ORF Names:T20O10.80
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G62980.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. SCF ubiquitin ligase complex Source: TAIR
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Plant are deficient in a variety of auxin-regulated growth processes including lateral root formation, and hypocotyl and cell elongation.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi10 – 101P → A: Abolishes SCF(TIR1) complex formation, altered auxin-mediated response and reduced affinity for auxin. 2 Publications
Mutagenesisi33 – 331V → A: No affinity for auxin. 1 Publication
Mutagenesisi35 – 351K → A: No affinity for auxin. 1 Publication
Mutagenesisi147 – 1471G → D in tir1-1; insensitive to auxin ubiquitously and to ethylene in roots only. 1 Publication
Mutagenesisi441 – 4411G → D in tir1-2; insensitive to auxin. 1 Publication
Mutagenesisi574 – 59421Missing in tir1-101/wei1; insensitive to auxin ubiquitously and to ethylene in roots only. 1 Publication
Add
BLAST

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 594594Protein TRANSPORT INHIBITOR RESPONSE 1
PRO_0000119965Add
BLAST

Proteomic databases

PaxDbiQ570C0.
PRIDEiQ570C0.

Expressioni

Tissue specificityi

Expressed in roots, stems, leaves and flowers. In adult plants, mostly expressed in floral stigma, anther filaments, abscission zones and vascular tissues.2 Publications

Developmental stagei

Abundant expression in developing embryos. In young seedlings, expressed in root apical meristem, and expanding cotyledons and hypocotyls. In older seedlings, still expressed in root apical meristems, but also in lateral root primordia, stipules, shoot apical meristem and vascular tissues.1 Publication

Inductioni

Repressed by miR393a (microRNA) in response to flg-22 (flagellin-derived peptide 22).1 Publication

Gene expression databases

ArrayExpressiQ570C0.
GenevestigatoriQ570C0.

Interactioni

Subunit structurei

Interacts with auxin. Part of a SCF E3 ubiquitin ligase complex SCF(TIR1) composed of SKP1, CUL1, RBX1 and TIR1. SCF(TIR1) interacts with the COP9 signalosome (CSN) complex. Interacts with Aux/IAA proteins (IAA3, IAA7, IAA12 and IAA17) in an auxin-dependent manner. The interaction with IAA3, a negative regulator of auxin responses, is promoted by auxin, but repressed by juglon (5-hydroxy-1,4-naphthoquinone). Interactions with auxin-responsive proteins is inactivated by auxin antagonists.8 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
IAA17P938302EBI-307183,EBI-632243
IAA7Q388254EBI-307183,EBI-602959
SKP1AQ392554EBI-307183,EBI-532357
SKP1BQ9FHW74EBI-307183,EBI-604076

Protein-protein interaction databases

BioGridi10787. 18 interactions.
DIPiDIP-31740N.
IntActiQ570C0. 16 interactions.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi11 – 199
Helixi24 – 318
Helixi35 – 4410
Beta strandi47 – 526
Helixi53 – 553
Helixi58 – 647
Beta strandi70 – 745
Helixi78 – 825
Helixi94 – 10310
Beta strandi109 – 1146
Helixi119 – 12810
Beta strandi134 – 1396
Beta strandi141 – 1444
Helixi145 – 15410
Beta strandi160 – 1623
Beta strandi167 – 1693
Helixi173 – 1786
Beta strandi188 – 1903
Helixi200 – 20910
Beta strandi215 – 2173
Helixi224 – 23310
Beta strandi238 – 2414
Helixi251 – 26212
Beta strandi269 – 2713
Helixi278 – 2847
Helixi285 – 2884
Beta strandi293 – 2953
Helixi303 – 3108
Beta strandi318 – 3225
Helixi323 – 3253
Helixi326 – 33611
Beta strandi342 – 3465
Beta strandi350 – 3523
Helixi361 – 37010
Beta strandi376 – 3827
Helixi386 – 39510
Beta strandi401 – 4088
Turni414 – 4163
Helixi421 – 43010
Beta strandi436 – 4383
Helixi445 – 45410
Beta strandi460 – 4656
Helixi470 – 47910
Beta strandi485 – 4906
Helixi495 – 5006
Helixi502 – 5076
Beta strandi508 – 5169
Helixi520 – 52910
Beta strandi533 – 5386
Beta strandi540 – 5423
Helixi544 – 5463
Beta strandi554 – 5607
Beta strandi573 – 5753

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2P1MX-ray1.80B1-594[»]
2P1NX-ray2.50B/E1-594[»]
2P1OX-ray1.90B1-594[»]
2P1PX-ray2.21B1-594[»]
2P1QX-ray1.91B1-594[»]
3C6NX-ray2.60B1-594[»]
3C6OX-ray2.70B1-594[»]
3C6PX-ray2.70B1-594[»]
ProteinModelPortaliQ570C0.
SMRiQ570C0. Positions 10-576.

Miscellaneous databases

EvolutionaryTraceiQ570C0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 5048F-box
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni81 – 822Interaction with auxin-responsive proteins
Regioni113 – 1142Myo-inositol hexakisphosphate binding
Regioni347 – 3526Interaction with auxin-responsive proteins
Regioni401 – 4033Myo-inositol hexakisphosphate binding
Regioni403 – 4042Auxin binding
Regioni405 – 4095Interaction with auxin-responsive proteins
Regioni438 – 4392Auxin binding
Regioni464 – 4652Interaction with auxin-responsive proteins
Regioni484 – 4852Myo-inositol hexakisphosphate binding

Domaini

The F-box is necessary for the interaction with SKP1.1 Publication

Sequence similaritiesi

Contains 1 F-box domain.

Phylogenomic databases

eggNOGiNOG267823.
HOGENOMiHOG000239805.
InParanoidiQ570C0.
KOiK14485.
OMAiCEGLTSL.
PhylomeDBiQ570C0.

Family and domain databases

InterProiIPR001810. F-box_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q570C0-1 [UniParc]FASTAAdd to Basket

« Hide

MQKRIALSFP EEVLEHVFSF IQLDKDRNSV SLVCKSWYEI ERWCRRKVFI    50
GNCYAVSPAT VIRRFPKVRS VELKGKPHFA DFNLVPDGWG GYVYPWIEAM 100
SSSYTWLEEI RLKRMVVTDD CLELIAKSFK NFKVLVLSSC EGFSTDGLAA 150
IAATCRNLKE LDLRESDVDD VSGHWLSHFP DTYTSLVSLN ISCLASEVSF 200
SALERLVTRC PNLKSLKLNR AVPLEKLATL LQRAPQLEEL GTGGYTAEVR 250
PDVYSGLSVA LSGCKELRCL SGFWDAVPAY LPAVYSVCSR LTTLNLSYAT 300
VQSYDLVKLL CQCPKLQRLW VLDYIEDAGL EVLASTCKDL RELRVFPSEP 350
FVMEPNVALT EQGLVSVSMG CPKLESVLYF CRQMTNAALI TIARNRPNMT 400
RFRLCIIEPK APDYLTLEPL DIGFGAIVEH CKDLRRLSLS GLLTDKVFEY 450
IGTYAKKMEM LSVAFAGDSD LGMHHVLSGC DSLRKLEIRD CPFGDKALLA 500
NASKLETMRS LWMSSCSVSF GACKLLGQKM PKLNVEVIDE RGAPDSRPES 550
CPVERVFIYR TVAGPRFDMP GFVWNMDQDS TMRFSRQIIT TNGL 594
Length:594
Mass (Da):66,799
Last modified:June 21, 2005 - v2
Checksum:i9E19ED5DABF40D07
GO

Sequence cautioni

The sequence BAD94031.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti490 – 4901D → E in BAD94031. 1 Publication
Sequence conflicti568 – 5681D → G in BAD94031. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF005047 Genomic DNA. Translation: AAB69175.1.
AF005048 mRNA. Translation: AAB69176.1.
AL163816 Genomic DNA. Translation: CAB87743.1.
CP002686 Genomic DNA. Translation: AEE80419.1.
BT001946 mRNA. Translation: AAN71945.1.
EF598824 Genomic DNA. Translation: ABR04117.1.
EF598825 Genomic DNA. Translation: ABR04118.1.
EF598826 Genomic DNA. Translation: ABR04119.1.
EF598827 Genomic DNA. Translation: ABR04120.1.
EF598828 Genomic DNA. Translation: ABR04121.1.
EF598829 Genomic DNA. Translation: ABR04122.1.
EF598830 Genomic DNA. Translation: ABR04123.1.
EF598831 Genomic DNA. Translation: ABR04124.1.
EF598832 Genomic DNA. Translation: ABR04125.1.
EF598833 Genomic DNA. Translation: ABR04126.1.
EF598834 Genomic DNA. Translation: ABR04127.1.
EF598835 Genomic DNA. Translation: ABR04128.1.
EF598836 Genomic DNA. Translation: ABR04129.1.
EF598837 Genomic DNA. Translation: ABR04130.1.
EF598838 Genomic DNA. Translation: ABR04131.1.
EF598839 Genomic DNA. Translation: ABR04132.1.
EF598840 Genomic DNA. Translation: ABR04133.1.
EF598841 Genomic DNA. Translation: ABR04134.1.
EF598842 Genomic DNA. Translation: ABR04135.1.
EF598843 Genomic DNA. Translation: ABR04136.1.
EF598844 Genomic DNA. Translation: ABR04137.1.
EF598845 Genomic DNA. Translation: ABR04138.1.
EF598846 Genomic DNA. Translation: ABR04139.1.
EF598847 Genomic DNA. Translation: ABR04140.1.
AK220790 mRNA. Translation: BAD94031.1. Different initiation.
EU550991 Genomic DNA. Translation: ACB31753.1.
EU550992 Genomic DNA. Translation: ACB31754.1.
EU550993 Genomic DNA. Translation: ACB31755.1.
EU550994 Genomic DNA. Translation: ACB31756.1.
EU550995 Genomic DNA. Translation: ACB31757.1.
EU550996 Genomic DNA. Translation: ACB31758.1.
EU550997 Genomic DNA. Translation: ACB31759.1.
EU550998 Genomic DNA. Translation: ACB31760.1.
EU550999 Genomic DNA. Translation: ACB31761.1.
EU551000 Genomic DNA. Translation: ACB31762.1.
EU551001 Genomic DNA. Translation: ACB31763.1.
EU551002 Genomic DNA. Translation: ACB31764.1.
EU551003 Genomic DNA. Translation: ACB31765.1.
EU551004 Genomic DNA. Translation: ACB31766.1.
EU551005 Genomic DNA. Translation: ACB31767.1.
EU551006 Genomic DNA. Translation: ACB31768.1.
EU551007 Genomic DNA. Translation: ACB31769.1.
EU551008 Genomic DNA. Translation: ACB31770.1.
EU551009 Genomic DNA. Translation: ACB31771.1.
EU551010 Genomic DNA. Translation: ACB31772.1.
EU551011 Genomic DNA. Translation: ACB31773.1.
EU551012 Genomic DNA. Translation: ACB31774.1.
EU551013 Genomic DNA. Translation: ACB31775.1.
EU551014 Genomic DNA. Translation: ACB31776.1.
PIRiT48087.
RefSeqiNP_567135.1. NM_116163.3.
UniGeneiAt.25594.

Genome annotation databases

EnsemblPlantsiAT3G62980.1; AT3G62980.1; AT3G62980.
GeneIDi825473.
KEGGiath:AT3G62980.

Cross-referencesi

Web resourcesi

PlantsUBQ

A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF005047 Genomic DNA. Translation: AAB69175.1 .
AF005048 mRNA. Translation: AAB69176.1 .
AL163816 Genomic DNA. Translation: CAB87743.1 .
CP002686 Genomic DNA. Translation: AEE80419.1 .
BT001946 mRNA. Translation: AAN71945.1 .
EF598824 Genomic DNA. Translation: ABR04117.1 .
EF598825 Genomic DNA. Translation: ABR04118.1 .
EF598826 Genomic DNA. Translation: ABR04119.1 .
EF598827 Genomic DNA. Translation: ABR04120.1 .
EF598828 Genomic DNA. Translation: ABR04121.1 .
EF598829 Genomic DNA. Translation: ABR04122.1 .
EF598830 Genomic DNA. Translation: ABR04123.1 .
EF598831 Genomic DNA. Translation: ABR04124.1 .
EF598832 Genomic DNA. Translation: ABR04125.1 .
EF598833 Genomic DNA. Translation: ABR04126.1 .
EF598834 Genomic DNA. Translation: ABR04127.1 .
EF598835 Genomic DNA. Translation: ABR04128.1 .
EF598836 Genomic DNA. Translation: ABR04129.1 .
EF598837 Genomic DNA. Translation: ABR04130.1 .
EF598838 Genomic DNA. Translation: ABR04131.1 .
EF598839 Genomic DNA. Translation: ABR04132.1 .
EF598840 Genomic DNA. Translation: ABR04133.1 .
EF598841 Genomic DNA. Translation: ABR04134.1 .
EF598842 Genomic DNA. Translation: ABR04135.1 .
EF598843 Genomic DNA. Translation: ABR04136.1 .
EF598844 Genomic DNA. Translation: ABR04137.1 .
EF598845 Genomic DNA. Translation: ABR04138.1 .
EF598846 Genomic DNA. Translation: ABR04139.1 .
EF598847 Genomic DNA. Translation: ABR04140.1 .
AK220790 mRNA. Translation: BAD94031.1 . Different initiation.
EU550991 Genomic DNA. Translation: ACB31753.1 .
EU550992 Genomic DNA. Translation: ACB31754.1 .
EU550993 Genomic DNA. Translation: ACB31755.1 .
EU550994 Genomic DNA. Translation: ACB31756.1 .
EU550995 Genomic DNA. Translation: ACB31757.1 .
EU550996 Genomic DNA. Translation: ACB31758.1 .
EU550997 Genomic DNA. Translation: ACB31759.1 .
EU550998 Genomic DNA. Translation: ACB31760.1 .
EU550999 Genomic DNA. Translation: ACB31761.1 .
EU551000 Genomic DNA. Translation: ACB31762.1 .
EU551001 Genomic DNA. Translation: ACB31763.1 .
EU551002 Genomic DNA. Translation: ACB31764.1 .
EU551003 Genomic DNA. Translation: ACB31765.1 .
EU551004 Genomic DNA. Translation: ACB31766.1 .
EU551005 Genomic DNA. Translation: ACB31767.1 .
EU551006 Genomic DNA. Translation: ACB31768.1 .
EU551007 Genomic DNA. Translation: ACB31769.1 .
EU551008 Genomic DNA. Translation: ACB31770.1 .
EU551009 Genomic DNA. Translation: ACB31771.1 .
EU551010 Genomic DNA. Translation: ACB31772.1 .
EU551011 Genomic DNA. Translation: ACB31773.1 .
EU551012 Genomic DNA. Translation: ACB31774.1 .
EU551013 Genomic DNA. Translation: ACB31775.1 .
EU551014 Genomic DNA. Translation: ACB31776.1 .
PIRi T48087.
RefSeqi NP_567135.1. NM_116163.3.
UniGenei At.25594.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2P1M X-ray 1.80 B 1-594 [» ]
2P1N X-ray 2.50 B/E 1-594 [» ]
2P1O X-ray 1.90 B 1-594 [» ]
2P1P X-ray 2.21 B 1-594 [» ]
2P1Q X-ray 1.91 B 1-594 [» ]
3C6N X-ray 2.60 B 1-594 [» ]
3C6O X-ray 2.70 B 1-594 [» ]
3C6P X-ray 2.70 B 1-594 [» ]
ProteinModelPortali Q570C0.
SMRi Q570C0. Positions 10-576.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 10787. 18 interactions.
DIPi DIP-31740N.
IntActi Q570C0. 16 interactions.

Proteomic databases

PaxDbi Q570C0.
PRIDEi Q570C0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G62980.1 ; AT3G62980.1 ; AT3G62980 .
GeneIDi 825473.
KEGGi ath:AT3G62980.

Organism-specific databases

GeneFarmi 4958.
TAIRi AT3G62980.

Phylogenomic databases

eggNOGi NOG267823.
HOGENOMi HOG000239805.
InParanoidi Q570C0.
KOi K14485.
OMAi CEGLTSL.
PhylomeDBi Q570C0.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

EvolutionaryTracei Q570C0.
PROi Q570C0.

Gene expression databases

ArrayExpressi Q570C0.
Genevestigatori Q570C0.

Family and domain databases

InterProi IPR001810. F-box_dom.
[Graphical view ]
Pfami PF12937. F-box-like. 1 hit.
[Graphical view ]
SMARTi SM00256. FBOX. 1 hit.
[Graphical view ]
SUPFAMi SSF81383. SSF81383. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The TIR1 protein of Arabidopsis functions in auxin response and is related to human SKP2 and yeast grr1p."
    Ruegger M., Dewey E., Gray W.M., Hobbie L., Turner J., Estelle M.
    Genes Dev. 12:198-207(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, MUTAGENESIS OF GLY-147 AND GLY-441.
  2. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "The genetic architecture of shoot branching in Arabidopsis thaliana: a comparative assessment of candidate gene associations vs. quantitative trait locus mapping."
    Ehrenreich I.M., Stafford P.A., Purugganan M.D.
    Genetics 176:1223-1236(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 172-380.
    Strain: cv. Ag-0, cv. An-1, cv. Br-0, cv. C24, cv. Ct-1, cv. Cvi-1, cv. Edi-0, cv. Ga-0, cv. Kas-2, cv. Kin-0, cv. Landsberg erecta, cv. Ll-0, cv. Lz-0, cv. Ms-0, cv. Mt-0, cv. Nd-1, cv. Nok-3, cv. Oy-0, cv. Se-0, cv. Sorbo, cv. Tsu-1, cv. Van-0, cv. Wa-1 and cv. Wassilewskija.
  6. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 359-594.
    Strain: cv. Columbia.
  7. "Sequence variation of microRNAs and their binding sites in Arabidopsis."
    Ehrenreich I.M., Purugganan M.D.
    Plant Physiol. 146:1974-1982(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 429-579.
    Strain: cv. Ag-0, cv. An-1, cv. Bay-0, cv. Br-0, cv. C24, cv. Ct-1, cv. Cvi-0, cv. Edi-0, cv. Ei-2, cv. Ga-0, cv. Gy-0, cv. Kas-2, cv. Ll-0, cv. Mrk-0, cv. Ms-0, cv. Mt-0, cv. Nd-1, cv. Nok-3, cv. Oy-0, cv. Sorbo, cv. Wa-1, cv. Wassilewskija, cv. Wei-0 and cv. Wt-5.
  8. "Identification of an SCF ubiquitin-ligase complex required for auxin response in Arabidopsis thaliana."
    Gray W.M., del Pozo J.C., Walker L., Hobbie L., Risseeuw E., Banks T., Crosby W.L., Yang M., Ma H., Estelle M.
    Genes Dev. 13:1678-1691(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INTERACTION WITH SKP1A; SKP1B AND CUL1, DOMAIN, MUTAGENESIS OF PRO-10.
  9. Cited for: GENE FAMILY, NOMENCLATURE.
  10. "Auxin regulates SCF(TIR1)-dependent degradation of AUX/IAA proteins."
    Gray W.M., Kepinski S., Rouse D., Leyser O., Estelle M.
    Nature 414:271-276(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH IAA7 AND IAA17.
  11. "Interactions of the COP9 signalosome with the E3 ubiquitin ligase SCF(TIR1) in mediating auxin response."
    Schwechheimer C., Serino G., Callis J., Crosby W.L., Lyapina S., Deshaies R.J., Gray W.M., Estelle M., Deng X.-W.
    Science 292:1379-1382(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH THE CSN COMPLEX.
  12. "Role of the Arabidopsis RING-H2 protein RBX1 in RUB modification and SCF function."
    Gray W.M., Hellmann H., Dharmasiri S., Estelle M.
    Plant Cell 14:2137-2144(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RBX1.
  13. "Regulation of Arabidopsis SHY2/IAA3 protein turnover."
    Tian Q., Nagpal P., Reed J.W.
    Plant J. 36:643-651(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH IAA3.
  14. "Five components of the ethylene-response pathway identified in a screen for weak ethylene-insensitive mutants in Arabidopsis."
    Alonso J.M., Stepanova A.N., Solano R., Wisman E., Ferrari S., Ausubel F.M., Ecker J.R.
    Proc. Natl. Acad. Sci. U.S.A. 100:2992-2997(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF 574-TRP--LEU-594.
  15. "Plant development is regulated by a family of auxin receptor F box proteins."
    Dharmasiri N., Dharmasiri S., Weijers D., Lechner E., Yamada M., Hobbie L., Ehrismann J.S., Juergens G., Estelle M.
    Dev. Cell 9:109-119(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH IAA12; IAA7 AND SKP1A/ASK1.
  16. "The F-box protein TIR1 is an auxin receptor."
    Dharmasiri N., Dharmasiri S., Estelle M.
    Nature 435:441-445(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH AUX/IAA PROTEINS AND AUXIN.
  17. "The Arabidopsis F-box protein TIR1 is an auxin receptor."
    Kepinski S., Leyser O.
    Nature 435:446-451(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH AUX/IAA PROTEINS AND AUXIN, MUTAGENESIS OF PRO-10; VAL-33 AND LYS-35.
  18. "A plant miRNA contributes to antibacterial resistance by repressing auxin signaling."
    Navarro L., Dunoyer P., Jay F., Arnold B., Dharmasiri N., Estelle M., Voinnet O., Jones J.D.G.
    Science 312:436-439(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  19. Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) IN COMPLEX WITH SKP1A; AUXIN; AUX/IAA POLYPEPTIDE SUBSTRATE; AUXIN ANALOGS AND MYO-INOSITOL HEXAKISPHOSPHATE.
  20. "Small-molecule agonists and antagonists of F-box protein-substrate interactions in auxin perception and signaling."
    Hayashi K., Tan X., Zheng N., Hatate T., Kimura Y., Kepinski S., Nozaki H.
    Proc. Natl. Acad. Sci. U.S.A. 105:5632-5637(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) IN COMPLEX WITH SKP1A; AUX/IAA POLYPEPTIDE; AUXIN; AUXIN AGONISTS; AUXIN ANTAGONISTS AND MYO-INOSITOL HEXAKISPHOSPHATE, FUNCTION.

Entry informationi

Entry nameiTIR1_ARATH
AccessioniPrimary (citable) accession number: Q570C0
Secondary accession number(s): A5YZP2, B2CVU0, O24660
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: September 3, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

The myo-inositol hexakisphosphate acts as a structural cofactor.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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