Reviewed, UniProtKB/Swiss-Prot Q570C0 (TIR1_ARATH)

Names and origin

Protein names

Recommended name:
    Protein TRANSPORT INHIBITOR RESPONSE 1
Alternative name(s):
    Weak ethylene-insensitive protein 1

Gene names

Name:	TIR1
Synonyms:	FBL1, WEI1
Ordered Locus Names:	At3g62980
ORF Names:	T20O10.80

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	594 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Auxin receptor that mediates Aux/IAA proteins proteasomal degradation and auxin-regulated transcription. The SCF(TIR1) E3 ubiquitin ligase complex is involved in auxin-mediated signaling pathway that regulate root and hypocotyl growth, lateral root formation, cell elongation, and gravitropism. Appears to allow pericycle cells to overcome G2 arrest prior to lateral root development. Plays a role in ethylene signaling in roots. Confers sensitivity to the virulent bacterial pathogen P.syringae. Ref.1 Ref.7 Ref.13 Ref.14 Ref.15 Ref.16 Ref.17 Ref.19
Pathway	Protein modification; protein ubiquitination.
Subunit structure	Interacts with auxin. Part of a SCF E3 ubiquitin ligase complex SCF(TIR1) composed of SKP1, CUL1, RBX1 and TIR1. SCF(TIR1) interacts with the COP9 signalosome (CSN) complex. Interacts with Aux/IAA proteins (IAA3, IAA7, IAA12 and IAA17) in an auxin-dependent manner. The interaction with IAA3, a negative regulator of auxin responses, is promoted by auxin, but repressed by juglon (5-hydroxy-1,4-naphthoquinone). Interactions with auxin-responsive proteins is inactivated by auxin antagonists. Ref.7 Ref.14 Ref.15 Ref.16 Ref.9 Ref.10 Ref.11 Ref.12
Subcellular location	Nucleus. Ref.14
Tissue specificity	Expressed in roots, stems, leaves and flowers. In adult plants, mostly expressed in floral stigma, anther filaments, abscission zones and vascular tissues. Ref.1 Ref.7
Developmental stage	Abundant expression in developing embryos. In young seedlings, expressed in root apical meristem, and expanding cotyledons and hypocotyls. In older seedlings, still expressed in root apical meristems, but also in lateral root primordia, stipules, shoot apical meristem and vascular tissues. Ref.7
Induction	Repressed by miR393a (microRNA) in response to flg-22 (flagellin-derived peptide 22). Ref.17
Domain	The F-box is necessary for the interaction with SKP1. Ref.7
Disruption phenotype	Plant are deficient in a variety of auxin-regulated growth processes including lateral root formation, and hypocotyl and cell elongation. Ref.1
Miscellaneous	The myo-inositol hexakisphosphate acts as a structural cofactor.
Sequence similarities	Contains 1 F-box domain.

Ontologies

Keywords
Biological process	Auxin signaling pathway Cell cycle Ethylene signaling pathway Plant defense Ubl conjugation pathway
Cellular component	Nucleus
Molecular function	Developmental protein
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	auxin mediated signaling pathway Ref.19 Inferred from mutant phenotype. Source: UniProtKB cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cellular response to phosphate starvation Inferred from expression pattern. Source: TAIR defense response Inferred from electronic annotation. Source: UniProtKB-KW ethylene mediated signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW lateral root formation Ref.1 Inferred from mutant phenotype. Source: TAIR modification-dependent protein catabolic process Inferred from electronic annotation. Source: UniProtKB-KW pollen maturation Inferred from genetic interaction. Source: TAIR response to molecule of bacterial origin Ref.17 Inferred from expression pattern. Source: TAIR stamen development Inferred from genetic interaction. Source: TAIR
Cellular component	SCF ubiquitin ligase complex Ref.7 Inferred from direct assay. Source: TAIR nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	auxin binding Ref.15 Ref.18 Ref.19 Inferred from direct assay. Source: UniProtKB protein binding Ref.7 Ref.9 Ref.11 Ref.12 Ref.14 Ref.16 Ref.18 Inferred from physical interaction. Source: UniProtKB ubiquitin-protein ligase activity Ref.7 Inferred by curator. Source: TAIR
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
IAA1	P49677	1	EBI-307183,EBI-630505
IAA12	Q38830	1	EBI-307183,EBI-617608
IAA17	P93830	2	EBI-307183,EBI-632243
IAA3	Q38822	1	EBI-307183,EBI-307174
IAA7	Q38825	3	EBI-307183,EBI-602959
RBX1A	Q940X7	1	EBI-307183,EBI-532404
RCE1	Q9SDY5	1	EBI-307183,EBI-595116
SKP1A	Q39255	4	EBI-307183,EBI-532357
SKP1B	Q9FHW7	4	EBI-307183,EBI-604076

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 594

594

Protein TRANSPORT INHIBITOR RESPONSE 1

PRO_0000119965

Regions

Domain

3 – 50

48

F-box

Region

81 – 82

2

Interaction with auxin-responsive proteins

Region

113 – 114

2

Myo-inositol hexakisphosphate binding

Region

347 – 352

6

Interaction with auxin-responsive proteins

Region

401 – 403

3

Myo-inositol hexakisphosphate binding

Region

403 – 404

2

Auxin binding

Region

405 – 409

5

Interaction with auxin-responsive proteins

Region

438 – 439

2

Auxin binding

Region

464 – 465

2

Interaction with auxin-responsive proteins

Region

484 – 485

2

Myo-inositol hexakisphosphate binding

Sites

Binding site

74

1

Myo-inositol hexakisphosphate

Binding site

344

1

Myo-inositol hexakisphosphate

Binding site

436

1

Myo-inositol hexakisphosphate

Binding site

509

1

Myo-inositol hexakisphosphate

Site

139

1

Interaction with auxin-responsive proteins

Site

165

1

Interaction with auxin-responsive proteins

Site

380

1

Interaction with auxin-responsive proteins

Site

489

1

Interaction with auxin-responsive proteins

Experimental info

Mutagenesis

10

1

P → A: Abolishes SCF(TIR1) complex formation, altered auxin-mediated response and reduced affinity for auxin. Ref.7 Ref.16

Mutagenesis

33

1

V → A: No affinity for auxin. Ref.16

Mutagenesis

35

1

K → A: No affinity for auxin. Ref.16

Mutagenesis

147

1

G → D in tir1-1; insensitive to auxin ubiquitously and to ethylene in roots only. Ref.1

Mutagenesis

441

1

G → D in tir1-2; insensitive to auxin. Ref.1

Mutagenesis

574 – 594

21

Missing in tir1-101/wei1; insensitive to auxin ubiquitously and to ethylene in roots only. Ref.13

Sequence conflict

490

1

D → E in BAD94031. Ref.5

Sequence conflict

568

1

D → G in BAD94031. Ref.5

Secondary structure

1

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594

Helix Strand Turn

Details...

Helix

11 – 19

9

Helix

24 – 31

8

Helix

35 – 44

10

Beta strand

47 – 52

6

Helix

58 – 64

7

Beta strand

70 – 74

5

Helix

78 – 82

5

Helix

94 – 103

10

Beta strand

109 – 114

6

Helix

119 – 128

10

Beta strand

134 – 139

6

Beta strand

141 – 144

4

Helix

145 – 154

10

Beta strand

160 – 162

3

Beta strand

167 – 169

3

Helix

173 – 178

6

Beta strand

188 – 190

3

Helix

200 – 209

10

Beta strand

215 – 217

3

Helix

224 – 233

10

Beta strand

238 – 241

4

Helix

251 – 262

12

Beta strand

269 – 271

3

Helix

278 – 284

7

Helix

285 – 288

4

Beta strand

293 – 295

3

Helix

303 – 310

8

Beta strand

318 – 322

5

Helix

323 – 325

3

Helix

326 – 336

11

Beta strand

342 – 346

5

Helix

361 – 370

10

Beta strand

376 – 382

7

Helix

386 – 395

10

Beta strand

401 – 408

8

Turn

414 – 416

3

Helix

421 – 430

10

Beta strand

436 – 438

3

Helix

445 – 454

10

Beta strand

460 – 465

6

Helix

470 – 479

10

Beta strand

485 – 490

6

Helix

495 – 500

6

Helix

502 – 507

6

Beta strand

508 – 516

9

Helix

520 – 529

10

Beta strand

533 – 538

6

Beta strand

540 – 542

3

Helix

544 – 546

3

Beta strand

554 – 560

7

Beta strand

573 – 575

3

Sequences

	Sequence		Length	Mass (Da)
	Q570C0-1 [UniParc]. Last modified June 21, 2005. Version 2. Checksum: 9E19ED5DABF40D07	FASTA	594	66,799
	10 20 30 40 50 60 MQKRIALSFP EEVLEHVFSF IQLDKDRNSV SLVCKSWYEI ERWCRRKVFI GNCYAVSPAT 70 80 90 100 110 120 VIRRFPKVRS VELKGKPHFA DFNLVPDGWG GYVYPWIEAM SSSYTWLEEI RLKRMVVTDD 130 140 150 160 170 180 CLELIAKSFK NFKVLVLSSC EGFSTDGLAA IAATCRNLKE LDLRESDVDD VSGHWLSHFP 190 200 210 220 230 240 DTYTSLVSLN ISCLASEVSF SALERLVTRC PNLKSLKLNR AVPLEKLATL LQRAPQLEEL 250 260 270 280 290 300 GTGGYTAEVR PDVYSGLSVA LSGCKELRCL SGFWDAVPAY LPAVYSVCSR LTTLNLSYAT 310 320 330 340 350 360 VQSYDLVKLL CQCPKLQRLW VLDYIEDAGL EVLASTCKDL RELRVFPSEP FVMEPNVALT 370 380 390 400 410 420 EQGLVSVSMG CPKLESVLYF CRQMTNAALI TIARNRPNMT RFRLCIIEPK APDYLTLEPL 430 440 450 460 470 480 DIGFGAIVEH CKDLRRLSLS GLLTDKVFEY IGTYAKKMEM LSVAFAGDSD LGMHHVLSGC 490 500 510 520 530 540 DSLRKLEIRD CPFGDKALLA NASKLETMRS LWMSSCSVSF GACKLLGQKM PKLNVEVIDE 550 560 570 580 590 RGAPDSRPES CPVERVFIYR TVAGPRFDMP GFVWNMDQDS TMRFSRQIIT TNGL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The TIR1 protein of Arabidopsis functions in auxin response and is related to human SKP2 and yeast grr1p." Ruegger M., Dewey E., Gray W.M., Hobbie L., Turner J., Estelle M. Genes Dev. 12:198-207(1998) [PubMed: 9436980] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, MUTAGENESIS OF GLY-147 AND GLY-441.
[2]	"Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana." Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F. , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. Nature 408:820-822(2000) [PubMed: 11130713] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[3]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R. Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[4]	"The genetic architecture of shoot branching in Arabidopsis thaliana: a comparative assessment of candidate gene associations vs. quantitative trait locus mapping." Ehrenreich I.M., Stafford P.A., Purugganan M.D. Genetics 176:1223-1236(2007) [PubMed: 17435248] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 172-380. Strain: cv. Ag-0, cv. An-1, cv. Br-0, cv. C24, cv. Ct-1, cv. Cvi-1, cv. Edi-0, cv. Ga-0, cv. Kas-2, cv. Kin-0, cv. Landsberg erecta, cv. Ll-0, cv. Lz-0, cv. Ms-0, cv. Mt-0, cv. Nd-1, cv. Nok-3, cv. Oy-0, cv. Se-0, cv. Sorbo, cv. Tsu-1, cv. Van-0, cv. Wa-1 and cv. Wassilewskija.
[5]	"Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs." Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K. , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 359-594. Strain: cv. Columbia.
[6]	"Sequence variation of microRNAs and their binding sites in Arabidopsis." Ehrenreich I.M., Purugganan M.D. Plant Physiol. 146:1974-1982(2008) [PubMed: 18305205] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 429-579. Strain: cv. Ag-0, cv. An-1, cv. Bay-0, cv. Br-0, cv. C24, cv. Ct-1, cv. Cvi-0, cv. Edi-0, cv. Ei-2, cv. Ga-0, cv. Gy-0, cv. Kas-2, cv. Ll-0, cv. Mrk-0, cv. Ms-0, cv. Mt-0, cv. Nd-1, cv. Nok-3, cv. Oy-0, cv. Sorbo, cv. Wa-1, cv. Wassilewskija, cv. Wei-0 and cv. Wt-5.
[7]	"Identification of an SCF ubiquitin-ligase complex required for auxin response in Arabidopsis thaliana." Gray W.M., del Pozo J.C., Walker L., Hobbie L., Risseeuw E., Banks T., Crosby W.L., Yang M., Ma H., Estelle M. Genes Dev. 13:1678-1691(1999) [PubMed: 10398681] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INTERACTION WITH SKP1A; SKP1B AND CUL1, DOMAIN, MUTAGENESIS OF PRO-10.
[8]	"F-box proteins in Arabidopsis." Xiao W., Jang J.-C. Trends Plant Sci. 5:454-457(2000) [PubMed: 11077244] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.
[9]	"Auxin regulates SCF(TIR1)-dependent degradation of AUX/IAA proteins." Gray W.M., Kepinski S., Rouse D., Leyser O., Estelle M. Nature 414:271-276(2001) [PubMed: 11713520] [Abstract] Cited for: INTERACTION WITH IAA7 AND IAA17.
[10]	"Interactions of the COP9 signalosome with the E3 ubiquitin ligase SCF(TIR1) in mediating auxin response." Schwechheimer C., Serino G., Callis J., Crosby W.L., Lyapina S., Deshaies R.J., Gray W.M., Estelle M., Deng X.-W. Science 292:1379-1382(2001) [PubMed: 11337587] [Abstract] Cited for: INTERACTION WITH THE CSN COMPLEX.
[11]	"Role of the Arabidopsis RING-H2 protein RBX1 in RUB modification and SCF function." Gray W.M., Hellmann H., Dharmasiri S., Estelle M. Plant Cell 14:2137-2144(2002) [PubMed: 12215511] [Abstract] Cited for: INTERACTION WITH RBX1.
[12]	"Regulation of Arabidopsis SHY2/IAA3 protein turnover." Tian Q., Nagpal P., Reed J.W. Plant J. 36:643-651(2003) [PubMed: 14617065] [Abstract] Cited for: INTERACTION WITH IAA3.
[13]	"Five components of the ethylene-response pathway identified in a screen for weak ethylene-insensitive mutants in Arabidopsis." Alonso J.M., Stepanova A.N., Solano R., Wisman E., Ferrari S., Ausubel F.M., Ecker J.R. Proc. Natl. Acad. Sci. U.S.A. 100:2992-2997(2003) [PubMed: 12606727] [Abstract] Cited for: FUNCTION, MUTAGENESIS OF 574-TRP--LEU-594.
[14]	"Plant development is regulated by a family of auxin receptor F box proteins." Dharmasiri N., Dharmasiri S., Weijers D., Lechner E., Yamada M., Hobbie L., Ehrismann J.S., Juergens G., Estelle M. Dev. Cell 9:109-119(2005) [PubMed: 15992545] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH IAA12; IAA7 AND SKP1A/ASK1.
[15]	"The F-box protein TIR1 is an auxin receptor." Dharmasiri N., Dharmasiri S., Estelle M. Nature 435:441-445(2005) [PubMed: 15917797] [Abstract] Cited for: FUNCTION, INTERACTION WITH AUX/IAA PROTEINS AND AUXIN.
[16]	"The Arabidopsis F-box protein TIR1 is an auxin receptor." Kepinski S., Leyser O. Nature 435:446-451(2005) [PubMed: 15917798] [Abstract] Cited for: FUNCTION, INTERACTION WITH AUX/IAA PROTEINS AND AUXIN, MUTAGENESIS OF PRO-10; VAL-33 AND LYS-35.
[17]	"A plant miRNA contributes to antibacterial resistance by repressing auxin signaling." Navarro L., Dunoyer P., Jay F., Arnold B., Dharmasiri N., Estelle M., Voinnet O., Jones J.D.G. Science 312:436-439(2006) [PubMed: 16627744] [Abstract] Cited for: FUNCTION, INDUCTION.
[18]	"Mechanism of auxin perception by the TIR1 ubiquitin ligase." Tan X., Calderon-Villalobos L.I.A., Sharon M., Zheng C., Robinson C.V., Estelle M., Zheng N. Nature 446:640-645(2007) [PubMed: 17410169] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) IN COMPLEX WITH SKP1A; AUXIN; AUX/IAA POLYPEPTIDE SUBSTRATE; AUXIN ANALOGS AND MYO-INOSITOL HEXAKISPHOSPHATE.
[19]	"Small-molecule agonists and antagonists of F-box protein-substrate interactions in auxin perception and signaling." Hayashi K., Tan X., Zheng N., Hatate T., Kimura Y., Kepinski S., Nozaki H. Proc. Natl. Acad. Sci. U.S.A. 105:5632-5637(2008) [PubMed: 18391211] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) IN COMPLEX WITH SKP1A; AUX/IAA POLYPEPTIDE; AUXIN; AUXIN AGONISTS; AUXIN ANTAGONISTS AND MYO-INOSITOL HEXAKISPHOSPHATE, FUNCTION.

Web resources

PlantsUBQ

A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

Cross-references

Sequence databases

EMBLGenBankDDBJ

AF005047 Genomic DNA. Translation: AAB69175.1.
AF005048 mRNA. Translation: AAB69176.1.
AL163816 Genomic DNA. Translation: CAB87743.1.
BT001946 mRNA. Translation: AAN71945.1.
EF598824 Genomic DNA. Translation: ABR04117.1.
EF598825 Genomic DNA. Translation: ABR04118.1.
EF598826 Genomic DNA. Translation: ABR04119.1.
EF598827 Genomic DNA. Translation: ABR04120.1.
EF598828 Genomic DNA. Translation: ABR04121.1.
EF598829 Genomic DNA. Translation: ABR04122.1.
EF598830 Genomic DNA. Translation: ABR04123.1.
EF598831 Genomic DNA. Translation: ABR04124.1.
EF598832 Genomic DNA. Translation: ABR04125.1.
EF598833 Genomic DNA. Translation: ABR04126.1.
EF598834 Genomic DNA. Translation: ABR04127.1.
EF598835 Genomic DNA. Translation: ABR04128.1.
EF598836 Genomic DNA. Translation: ABR04129.1.
EF598837 Genomic DNA. Translation: ABR04130.1.
EF598838 Genomic DNA. Translation: ABR04131.1.
EF598839 Genomic DNA. Translation: ABR04132.1.
EF598840 Genomic DNA. Translation: ABR04133.1.
EF598841 Genomic DNA. Translation: ABR04134.1.
EF598842 Genomic DNA. Translation: ABR04135.1.
EF598843 Genomic DNA. Translation: ABR04136.1.
EF598844 Genomic DNA. Translation: ABR04137.1.
EF598845 Genomic DNA. Translation: ABR04138.1.
EF598846 Genomic DNA. Translation: ABR04139.1.
EF598847 Genomic DNA. Translation: ABR04140.1.
AK220790 mRNA. Translation: BAD94031.1. Different initiation.
EU550991 Genomic DNA. Translation: ACB31753.1.
EU550992 Genomic DNA. Translation: ACB31754.1.
EU550993 Genomic DNA. Translation: ACB31755.1.
EU550994 Genomic DNA. Translation: ACB31756.1.
EU550995 Genomic DNA. Translation: ACB31757.1.
EU550996 Genomic DNA. Translation: ACB31758.1.
EU550997 Genomic DNA. Translation: ACB31759.1.
EU550998 Genomic DNA. Translation: ACB31760.1.
EU550999 Genomic DNA. Translation: ACB31761.1.
EU551000 Genomic DNA. Translation: ACB31762.1.
EU551001 Genomic DNA. Translation: ACB31763.1.
EU551002 Genomic DNA. Translation: ACB31764.1.
EU551003 Genomic DNA. Translation: ACB31765.1.
EU551004 Genomic DNA. Translation: ACB31766.1.
EU551005 Genomic DNA. Translation: ACB31767.1.
EU551006 Genomic DNA. Translation: ACB31768.1.
EU551007 Genomic DNA. Translation: ACB31769.1.
EU551008 Genomic DNA. Translation: ACB31770.1.
EU551009 Genomic DNA. Translation: ACB31771.1.
EU551010 Genomic DNA. Translation: ACB31772.1.
EU551011 Genomic DNA. Translation: ACB31773.1.
EU551012 Genomic DNA. Translation: ACB31774.1.
EU551013 Genomic DNA. Translation: ACB31775.1.
EU551014 Genomic DNA. Translation: ACB31776.1.

IPI

IPI00531280.

PIR

T48087.

RefSeq

NP_567135.1.

UniGene

At.25594

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2P1M	X-ray	1.80	B	1-594	[»]
2P1N	X-ray	2.50	B/E	1-594	[»]
2P1O	X-ray	1.90	B	1-594	[»]
2P1P	X-ray	2.21	B	1-594	[»]
2P1Q	X-ray	1.91	B	1-594	[»]
3C6N	X-ray	2.60	B	1-594	[»]
3C6O	X-ray	2.70	B	1-594	[»]
3C6P	X-ray	2.70	B	1-594	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

Q570C0. 17 interactions.

Proteomic databases

PRIDE

Q570C0.

Genome annotation databases

GeneID

825473.

GenomeReviews

Gene locus AT3G62980 in contig BA000014_GR.

KEGG

ath:AT3G62980.

NMPDR

fig|3702.1.peg.17686.

Organism-specific databases

GeneFarm

4958.

TAIR

At3g62980.

Phylogenomic databases

OMA

Q570C0. ERLVTRC.

Gene expression databases

GermOnline

AT3G62980. Arabidopsis thaliana.

Family and domain databases

InterPro

IPR001810. F-box.
[Graphical view]

Pfam

PF00646. F-box. 1 hit.
[Graphical view]

SMART

SM00256. FBOX. 1 hit.
[Graphical view]

PROSITE

PS50181. FBOX. False negative.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

TIR1_ARATH

Accession

Primary (citable) accession number: Q570C0
Secondary accession number(s): A5YZP2, B2CVU0, O24660

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
Last sequence update:	June 21, 2005
Last modified:	June 16, 2009
This is version 49 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)