Q570C0 (TIR1_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein TRANSPORT INHIBITOR RESPONSE 1

Alternative name(s):
Weak ethylene-insensitive protein 1

Gene names

Name:	TIR1
Synonyms:	FBL1, WEI1
Ordered Locus Names:	At3g62980
ORF Names:	T20O10.80

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	594 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Auxin receptor that mediates Aux/IAA proteins proteasomal degradation and auxin-regulated transcription. The SCF(TIR1) E3 ubiquitin ligase complex is involved in auxin-mediated signaling pathway that regulate root and hypocotyl growth, lateral root formation, cell elongation, and gravitropism. Appears to allow pericycle cells to overcome G2 arrest prior to lateral root development. Plays a role in ethylene signaling in roots. Confers sensitivity to the virulent bacterial pathogen P.syringae. Ref.1 Ref.8 Ref.14 Ref.15 Ref.16 Ref.17 Ref.18 Ref.20
Pathway	Protein modification; protein ubiquitination.
Subunit structure	Interacts with auxin. Part of a SCF E3 ubiquitin ligase complex SCF(TIR1) composed of SKP1, CUL1, RBX1 and TIR1. SCF(TIR1) interacts with the COP9 signalosome (CSN) complex. Interacts with Aux/IAA proteins (IAA3, IAA7, IAA12 and IAA17) in an auxin-dependent manner. The interaction with IAA3, a negative regulator of auxin responses, is promoted by auxin, but repressed by juglon (5-hydroxy-1,4-naphthoquinone). Interactions with auxin-responsive proteins is inactivated by auxin antagonists. Ref.8 Ref.10 Ref.11 Ref.12 Ref.13 Ref.15 Ref.16 Ref.17
Subcellular location	Nucleus Ref.15.
Tissue specificity	Expressed in roots, stems, leaves and flowers. In adult plants, mostly expressed in floral stigma, anther filaments, abscission zones and vascular tissues. Ref.1 Ref.8
Developmental stage	Abundant expression in developing embryos. In young seedlings, expressed in root apical meristem, and expanding cotyledons and hypocotyls. In older seedlings, still expressed in root apical meristems, but also in lateral root primordia, stipules, shoot apical meristem and vascular tissues. Ref.8
Induction	Repressed by miR393a (microRNA) in response to flg-22 (flagellin-derived peptide 22). Ref.18
Domain	The F-box is necessary for the interaction with SKP1. Ref.8
Disruption phenotype	Plant are deficient in a variety of auxin-regulated growth processes including lateral root formation, and hypocotyl and cell elongation. Ref.1
Miscellaneous	The myo-inositol hexakisphosphate acts as a structural cofactor.
Sequence similarities	Contains 1 F-box domain.
Sequence caution	The sequence BAD94031.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Auxin signaling pathway Cell cycle Ethylene signaling pathway Plant defense Ubl conjugation pathway
Cellular component	Nucleus
Molecular function	Developmental protein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	auxin mediated signaling pathway Inferred from mutant phenotype Ref.20. Source: UniProtKB cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cellular response to phosphate starvation Inferred from expression pattern PubMed 19106375. Source: TAIR defense response Inferred from electronic annotation. Source: UniProtKB-KW ethylene mediated signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW lateral root formation Inferred from mutant phenotype Ref.1. Source: TAIR pollen maturation Inferred from genetic interaction PubMed 18628351. Source: TAIR response to molecule of bacterial origin Inferred from expression pattern Ref.18. Source: TAIR stamen development Inferred from genetic interaction PubMed 18628351. Source: TAIR
Cellular_component	SCF ubiquitin ligase complex Inferred from direct assay Ref.8. Source: TAIR nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	auxin binding Inferred from direct assay Ref.19Ref.20. Source: UniProtKB inositol hexakisphosphate binding Inferred from direct assay Ref.19. Source: UniProtKB ubiquitin-protein ligase activity Inferred by curator Ref.8. Source: TAIR
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
IAA17	P93830	2	EBI-307183,EBI-632243
IAA7	Q38825	4	EBI-307183,EBI-602959
SKP1A	Q39255	4	EBI-307183,EBI-532357
SKP1B	Q9FHW7	4	EBI-307183,EBI-604076

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 594

594

Protein TRANSPORT INHIBITOR RESPONSE 1

PRO_0000119965

Regions

Domain

3 – 50

48

F-box

Region

81 – 82

2

Interaction with auxin-responsive proteins

Region

113 – 114

2

Myo-inositol hexakisphosphate binding

Region

347 – 352

6

Interaction with auxin-responsive proteins

Region

401 – 403

3

Myo-inositol hexakisphosphate binding

Region

403 – 404

2

Auxin binding

Region

405 – 409

5

Interaction with auxin-responsive proteins

Region

438 – 439

2

Auxin binding

Region

464 – 465

2

Interaction with auxin-responsive proteins

Region

484 – 485

2

Myo-inositol hexakisphosphate binding

Sites

Binding site

74

1

Myo-inositol hexakisphosphate

Binding site

344

1

Myo-inositol hexakisphosphate

Binding site

436

1

Myo-inositol hexakisphosphate

Binding site

509

1

Myo-inositol hexakisphosphate

Site

139

1

Interaction with auxin-responsive proteins

Site

165

1

Interaction with auxin-responsive proteins

Site

380

1

Interaction with auxin-responsive proteins

Site

489

1

Interaction with auxin-responsive proteins

Experimental info

Mutagenesis

10

1

P → A: Abolishes SCF(TIR1) complex formation, altered auxin-mediated response and reduced affinity for auxin. Ref.8 Ref.17

Mutagenesis

33

1

V → A: No affinity for auxin. Ref.17

Mutagenesis

35

1

K → A: No affinity for auxin. Ref.17

Mutagenesis

147

1

G → D in tir1-1; insensitive to auxin ubiquitously and to ethylene in roots only. Ref.1

Mutagenesis

441

1

G → D in tir1-2; insensitive to auxin. Ref.1

Mutagenesis

574 – 594

21

Missing in tir1-101/wei1; insensitive to auxin ubiquitously and to ethylene in roots only. Ref.14

Sequence conflict

490

1

D → E in BAD94031. Ref.6

Sequence conflict

568

1

D → G in BAD94031. Ref.6

Secondary structure

1

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594

Helix Strand Turn

Details...

Helix

11 – 19

9

Helix

24 – 31

8

Helix

35 – 44

10

Beta strand

47 – 52

6

Helix

53 – 55

3

Helix

58 – 64

7

Beta strand

70 – 74

5

Helix

78 – 82

5

Helix

94 – 103

10

Beta strand

109 – 114

6

Helix

119 – 128

10

Beta strand

134 – 139

6

Beta strand

141 – 144

4

Helix

145 – 154

10

Beta strand

160 – 162

3

Beta strand

167 – 169

3

Helix

173 – 178

6

Beta strand

188 – 190

3

Helix

200 – 209

10

Beta strand

215 – 217

3

Helix

224 – 233

10

Beta strand

238 – 241

4

Helix

251 – 262

12

Beta strand

269 – 271

3

Helix

278 – 284

7

Helix

285 – 288

4

Beta strand

293 – 295

3

Helix

303 – 310

8

Beta strand

318 – 322

5

Helix

323 – 325

3

Helix

326 – 336

11

Beta strand

342 – 346

5

Beta strand

350 – 352

3

Helix

361 – 370

10

Beta strand

376 – 382

7

Helix

386 – 395

10

Beta strand

401 – 408

8

Turn

414 – 416

3

Helix

421 – 430

10

Beta strand

436 – 438

3

Helix

445 – 454

10

Beta strand

460 – 465

6

Helix

470 – 479

10

Beta strand

485 – 490

6

Helix

495 – 500

6

Helix

502 – 507

6

Beta strand

508 – 516

9

Helix

520 – 529

10

Beta strand

533 – 538

6

Beta strand

540 – 542

3

Helix

544 – 546

3

Beta strand

554 – 560

7

Beta strand

573 – 575

3

Sequences

	Sequence		Length	Mass (Da)
	Q570C0 [UniParc]. Last modified June 21, 2005. Version 2. Checksum: 9E19ED5DABF40D07	FASTA	594	66,799
	10 20 30 40 50 60 MQKRIALSFP EEVLEHVFSF IQLDKDRNSV SLVCKSWYEI ERWCRRKVFI GNCYAVSPAT 70 80 90 100 110 120 VIRRFPKVRS VELKGKPHFA DFNLVPDGWG GYVYPWIEAM SSSYTWLEEI RLKRMVVTDD 130 140 150 160 170 180 CLELIAKSFK NFKVLVLSSC EGFSTDGLAA IAATCRNLKE LDLRESDVDD VSGHWLSHFP 190 200 210 220 230 240 DTYTSLVSLN ISCLASEVSF SALERLVTRC PNLKSLKLNR AVPLEKLATL LQRAPQLEEL 250 260 270 280 290 300 GTGGYTAEVR PDVYSGLSVA LSGCKELRCL SGFWDAVPAY LPAVYSVCSR LTTLNLSYAT 310 320 330 340 350 360 VQSYDLVKLL CQCPKLQRLW VLDYIEDAGL EVLASTCKDL RELRVFPSEP FVMEPNVALT 370 380 390 400 410 420 EQGLVSVSMG CPKLESVLYF CRQMTNAALI TIARNRPNMT RFRLCIIEPK APDYLTLEPL 430 440 450 460 470 480 DIGFGAIVEH CKDLRRLSLS GLLTDKVFEY IGTYAKKMEM LSVAFAGDSD LGMHHVLSGC 490 500 510 520 530 540 DSLRKLEIRD CPFGDKALLA NASKLETMRS LWMSSCSVSF GACKLLGQKM PKLNVEVIDE 550 560 570 580 590 RGAPDSRPES CPVERVFIYR TVAGPRFDMP GFVWNMDQDS TMRFSRQIIT TNGL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The TIR1 protein of Arabidopsis functions in auxin response and is related to human SKP2 and yeast grr1p." Ruegger M., Dewey E., Gray W.M., Hobbie L., Turner J., Estelle M. Genes Dev. 12:198-207(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, MUTAGENESIS OF GLY-147 AND GLY-441.
[2]	"Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana." Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F. , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[3]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[4]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R. Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[5]	"The genetic architecture of shoot branching in Arabidopsis thaliana: a comparative assessment of candidate gene associations vs. quantitative trait locus mapping." Ehrenreich I.M., Stafford P.A., Purugganan M.D. Genetics 176:1223-1236(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 172-380. Strain: cv. Ag-0, cv. An-1, cv. Br-0, cv. C24, cv. Ct-1, cv. Cvi-1, cv. Edi-0, cv. Ga-0, cv. Kas-2, cv. Kin-0, cv. Landsberg erecta, cv. Ll-0, cv. Lz-0, cv. Ms-0, cv. Mt-0, cv. Nd-1, cv. Nok-3, cv. Oy-0, cv. Se-0, cv. Sorbo, cv. Tsu-1, cv. Van-0, cv. Wa-1 and cv. Wassilewskija.
[6]	"Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs." Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K. , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 359-594. Strain: cv. Columbia.
[7]	"Sequence variation of microRNAs and their binding sites in Arabidopsis." Ehrenreich I.M., Purugganan M.D. Plant Physiol. 146:1974-1982(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 429-579. Strain: cv. Ag-0, cv. An-1, cv. Bay-0, cv. Br-0, cv. C24, cv. Ct-1, cv. Cvi-0, cv. Edi-0, cv. Ei-2, cv. Ga-0, cv. Gy-0, cv. Kas-2, cv. Ll-0, cv. Mrk-0, cv. Ms-0, cv. Mt-0, cv. Nd-1, cv. Nok-3, cv. Oy-0, cv. Sorbo, cv. Wa-1, cv. Wassilewskija, cv. Wei-0 and cv. Wt-5.
[8]	"Identification of an SCF ubiquitin-ligase complex required for auxin response in Arabidopsis thaliana." Gray W.M., del Pozo J.C., Walker L., Hobbie L., Risseeuw E., Banks T., Crosby W.L., Yang M., Ma H., Estelle M. Genes Dev. 13:1678-1691(1999) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INTERACTION WITH SKP1A; SKP1B AND CUL1, DOMAIN, MUTAGENESIS OF PRO-10.
[9]	"F-box proteins in Arabidopsis." Xiao W., Jang J.-C. Trends Plant Sci. 5:454-457(2000) [PubMed] [Europe PMC] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.
[10]	"Auxin regulates SCF(TIR1)-dependent degradation of AUX/IAA proteins." Gray W.M., Kepinski S., Rouse D., Leyser O., Estelle M. Nature 414:271-276(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH IAA7 AND IAA17.
[11]	"Interactions of the COP9 signalosome with the E3 ubiquitin ligase SCF(TIR1) in mediating auxin response." Schwechheimer C., Serino G., Callis J., Crosby W.L., Lyapina S., Deshaies R.J., Gray W.M., Estelle M., Deng X.-W. Science 292:1379-1382(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH THE CSN COMPLEX.
[12]	"Role of the Arabidopsis RING-H2 protein RBX1 in RUB modification and SCF function." Gray W.M., Hellmann H., Dharmasiri S., Estelle M. Plant Cell 14:2137-2144(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH RBX1.
[13]	"Regulation of Arabidopsis SHY2/IAA3 protein turnover." Tian Q., Nagpal P., Reed J.W. Plant J. 36:643-651(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH IAA3.
[14]	"Five components of the ethylene-response pathway identified in a screen for weak ethylene-insensitive mutants in Arabidopsis." Alonso J.M., Stepanova A.N., Solano R., Wisman E., Ferrari S., Ausubel F.M., Ecker J.R. Proc. Natl. Acad. Sci. U.S.A. 100:2992-2997(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, MUTAGENESIS OF 574-TRP--LEU-594.
[15]	"Plant development is regulated by a family of auxin receptor F box proteins." Dharmasiri N., Dharmasiri S., Weijers D., Lechner E., Yamada M., Hobbie L., Ehrismann J.S., Juergens G., Estelle M. Dev. Cell 9:109-119(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH IAA12; IAA7 AND SKP1A/ASK1.
[16]	"The F-box protein TIR1 is an auxin receptor." Dharmasiri N., Dharmasiri S., Estelle M. Nature 435:441-445(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH AUX/IAA PROTEINS AND AUXIN.
[17]	"The Arabidopsis F-box protein TIR1 is an auxin receptor." Kepinski S., Leyser O. Nature 435:446-451(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH AUX/IAA PROTEINS AND AUXIN, MUTAGENESIS OF PRO-10; VAL-33 AND LYS-35.
[18]	"A plant miRNA contributes to antibacterial resistance by repressing auxin signaling." Navarro L., Dunoyer P., Jay F., Arnold B., Dharmasiri N., Estelle M., Voinnet O., Jones J.D.G. Science 312:436-439(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INDUCTION.
[19]	"Mechanism of auxin perception by the TIR1 ubiquitin ligase." Tan X., Calderon-Villalobos L.I.A., Sharon M., Zheng C., Robinson C.V., Estelle M., Zheng N. Nature 446:640-645(2007) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) IN COMPLEX WITH SKP1A; AUXIN; AUX/IAA POLYPEPTIDE SUBSTRATE; AUXIN ANALOGS AND MYO-INOSITOL HEXAKISPHOSPHATE.
[20]	"Small-molecule agonists and antagonists of F-box protein-substrate interactions in auxin perception and signaling." Hayashi K., Tan X., Zheng N., Hatate T., Kimura Y., Kepinski S., Nozaki H. Proc. Natl. Acad. Sci. U.S.A. 105:5632-5637(2008) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) IN COMPLEX WITH SKP1A; AUX/IAA POLYPEPTIDE; AUXIN; AUXIN AGONISTS; AUXIN ANTAGONISTS AND MYO-INOSITOL HEXAKISPHOSPHATE, FUNCTION.
+	Additional computationally mapped references.

Web resources

PlantsUBQ

A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF005047 Genomic DNA. Translation: AAB69175.1.
AF005048 mRNA. Translation: AAB69176.1.
AL163816 Genomic DNA. Translation: CAB87743.1.
CP002686 Genomic DNA. Translation: AEE80419.1.
BT001946 mRNA. Translation: AAN71945.1.
EF598824 Genomic DNA. Translation: ABR04117.1.
EF598825 Genomic DNA. Translation: ABR04118.1.
EF598826 Genomic DNA. Translation: ABR04119.1.
EF598827 Genomic DNA. Translation: ABR04120.1.
EF598828 Genomic DNA. Translation: ABR04121.1.
EF598829 Genomic DNA. Translation: ABR04122.1.
EF598830 Genomic DNA. Translation: ABR04123.1.
EF598831 Genomic DNA. Translation: ABR04124.1.
EF598832 Genomic DNA. Translation: ABR04125.1.
EF598833 Genomic DNA. Translation: ABR04126.1.
EF598834 Genomic DNA. Translation: ABR04127.1.
EF598835 Genomic DNA. Translation: ABR04128.1.
EF598836 Genomic DNA. Translation: ABR04129.1.
EF598837 Genomic DNA. Translation: ABR04130.1.
EF598838 Genomic DNA. Translation: ABR04131.1.
EF598839 Genomic DNA. Translation: ABR04132.1.
EF598840 Genomic DNA. Translation: ABR04133.1.
EF598841 Genomic DNA. Translation: ABR04134.1.
EF598842 Genomic DNA. Translation: ABR04135.1.
EF598843 Genomic DNA. Translation: ABR04136.1.
EF598844 Genomic DNA. Translation: ABR04137.1.
EF598845 Genomic DNA. Translation: ABR04138.1.
EF598846 Genomic DNA. Translation: ABR04139.1.
EF598847 Genomic DNA. Translation: ABR04140.1.
AK220790 mRNA. Translation: BAD94031.1. Different initiation.
EU550991 Genomic DNA. Translation: ACB31753.1.
EU550992 Genomic DNA. Translation: ACB31754.1.
EU550993 Genomic DNA. Translation: ACB31755.1.
EU550994 Genomic DNA. Translation: ACB31756.1.
EU550995 Genomic DNA. Translation: ACB31757.1.
EU550996 Genomic DNA. Translation: ACB31758.1.
EU550997 Genomic DNA. Translation: ACB31759.1.
EU550998 Genomic DNA. Translation: ACB31760.1.
EU550999 Genomic DNA. Translation: ACB31761.1.
EU551000 Genomic DNA. Translation: ACB31762.1.
EU551001 Genomic DNA. Translation: ACB31763.1.
EU551002 Genomic DNA. Translation: ACB31764.1.
EU551003 Genomic DNA. Translation: ACB31765.1.
EU551004 Genomic DNA. Translation: ACB31766.1.
EU551005 Genomic DNA. Translation: ACB31767.1.
EU551006 Genomic DNA. Translation: ACB31768.1.
EU551007 Genomic DNA. Translation: ACB31769.1.
EU551008 Genomic DNA. Translation: ACB31770.1.
EU551009 Genomic DNA. Translation: ACB31771.1.
EU551010 Genomic DNA. Translation: ACB31772.1.
EU551011 Genomic DNA. Translation: ACB31773.1.
EU551012 Genomic DNA. Translation: ACB31774.1.
EU551013 Genomic DNA. Translation: ACB31775.1.
EU551014 Genomic DNA. Translation: ACB31776.1.

IPI

IPI00531280.

PIR

T48087.

RefSeq

NP_567135.1. NM_116163.3.

UniGene

At.25594.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2P1M	X-ray	1.80	B	1-594	[»]
2P1N	X-ray	2.50	B/E	1-594	[»]
2P1O	X-ray	1.90	B	1-594	[»]
2P1P	X-ray	2.21	B	1-594	[»]
2P1Q	X-ray	1.91	B	1-594	[»]
3C6N	X-ray	2.60	B	1-594	[»]
3C6O	X-ray	2.70	B	1-594	[»]
3C6P	X-ray	2.70	B	1-594	[»]

ProteinModelPortal

Q570C0.

SMR

Q570C0. Positions 10-576.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-31740N.

IntAct

Q570C0. 16 interactions.

Proteomic databases

PaxDb

Q570C0.

PRIDE

Q570C0.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblPlants

AT3G62980.1; AT3G62980.1; AT3G62980.

GeneID

825473.

KEGG

ath:AT3G62980.

Organism-specific databases

GeneFarm

4958.

TAIR

At3g62980.

Phylogenomic databases

eggNOG

NOG267823.

HOGENOM

HOG000239805.

InParanoid

Q570C0.

KO

K14485.

OMA

PNMTRFR.

PhylomeDB

Q570C0.

ProtClustDB

CLSN2689313.

Enzyme and pathway databases

UniPathway

UPA00143.

Gene expression databases

ArrayExpress

Q570C0.

Genevestigator

Q570C0.

GermOnline

AT3G62980. Arabidopsis thaliana.

Family and domain databases

InterPro

IPR001810. F-box_dom_cyclin-like.
[Graphical view]

SMART

SM00256. FBOX. 1 hit.
[Graphical view]

PROSITE

PS50181. FBOX. False negative.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q570C0.

Entry information

Entry name

TIR1_ARATH

Accession

Primary (citable) accession number: Q570C0
Secondary accession number(s): A5YZP2, B2CVU0, O24660

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
Last sequence update:	June 21, 2005
Last modified:	May 1, 2013
This is version 82 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program