Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

HTH-type transcriptional regulator PerR

Gene

perR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Apparent regulatory gene involved in peroxide resistance in stationary phase.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi24 – 4421H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:G6129-MONOMER.
ECOL316407:JW0244-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator PerR
Alternative name(s):
Peroxide resistance protein PerR
Gene namesi
Name:perR
Ordered Locus Names:b0254, JW0244
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13340. perR.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297HTH-type transcriptional regulator PerRPRO_0000105743Add
BLAST

Proteomic databases

PaxDbiQ57083.
PRIDEiQ57083.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-541993,EBI-541993

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi4259774. 3 interactions.
DIPiDIP-10463N.
IntActiQ57083. 6 interactions.
MINTiMINT-1292741.
STRINGi511145.b0254.

Structurei

3D structure databases

ProteinModelPortaliQ57083.
SMRiQ57083. Positions 9-283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 6458HTH lysR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH lysR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108PZW. Bacteria.
ENOG410Z3XZ. LUCA.
HOGENOMiHOG000233528.
InParanoidiQ57083.
OMAiSTDYARF.
OrthoDBiEOG6G4VSC.
PhylomeDBiQ57083.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005119. LysR_subst-bd.
IPR000847. Tscrpt_reg_HTH_LysR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00126. HTH_1. 1 hit.
PF03466. LysR_substrate. 1 hit.
[Graphical view]
PRINTSiPR00039. HTHLYSR.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50931. HTH_LYSR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57083-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLAKAPLN LLRAFEAAGR TGAFALAASE LELSPSAISH AIRKLENLLD
60 70 80 90 100
VRLFQRSTRE ITLTKEGEIL LEHIQRGFNE LQQGLALVTA DESRPLRLHT
110 120 130 140 150
APSFAHQWLL PRLGKFIREN PSIDLRLSAS TEYARFEQDD FDLDIVYGEP
160 170 180 190 200
RPSPYEKIPL AVEELTPLCS PQLAERLKKP EDLYALTLIQ CDVQLYQWKG
210 220 230 240 250
WFEANKMTPP NNYGLRFDRS FMAIAAAVDG LGVVLESKLL AEREIASGKL
260 270 280 290
VCPLVNSTSE IHYIGHYLVF PQHQHMHSAL DVFKTWLLNE LNLGKIR
Length:297
Mass (Da):33,639
Last modified:November 1, 1996 - v1
Checksum:iE197CE2334B7420E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57080 Genomic DNA. Translation: AAB01994.1.
U70214 Genomic DNA. Translation: AAB08673.1.
U00096 Genomic DNA. Translation: AAC73357.1.
AP009048 Genomic DNA. Translation: BAA77924.1.
PIRiF64750.
RefSeqiNP_414788.1. NC_000913.3.
WP_000770246.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73357; AAC73357; b0254.
BAA77924; BAA77924; BAA77924.
GeneIDi945417.
KEGGiecj:JW0244.
eco:b0254.
PATRICi32115627. VBIEscCol129921_0257.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57080 Genomic DNA. Translation: AAB01994.1.
U70214 Genomic DNA. Translation: AAB08673.1.
U00096 Genomic DNA. Translation: AAC73357.1.
AP009048 Genomic DNA. Translation: BAA77924.1.
PIRiF64750.
RefSeqiNP_414788.1. NC_000913.3.
WP_000770246.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliQ57083.
SMRiQ57083. Positions 9-283.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259774. 3 interactions.
DIPiDIP-10463N.
IntActiQ57083. 6 interactions.
MINTiMINT-1292741.
STRINGi511145.b0254.

Proteomic databases

PaxDbiQ57083.
PRIDEiQ57083.

Protocols and materials databases

DNASUi945417.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73357; AAC73357; b0254.
BAA77924; BAA77924; BAA77924.
GeneIDi945417.
KEGGiecj:JW0244.
eco:b0254.
PATRICi32115627. VBIEscCol129921_0257.

Organism-specific databases

EchoBASEiEB3124.
EcoGeneiEG13340. perR.

Phylogenomic databases

eggNOGiENOG4108PZW. Bacteria.
ENOG410Z3XZ. LUCA.
HOGENOMiHOG000233528.
InParanoidiQ57083.
OMAiSTDYARF.
OrthoDBiEOG6G4VSC.
PhylomeDBiQ57083.

Enzyme and pathway databases

BioCyciEcoCyc:G6129-MONOMER.
ECOL316407:JW0244-MONOMER.

Miscellaneous databases

PROiQ57083.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005119. LysR_subst-bd.
IPR000847. Tscrpt_reg_HTH_LysR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00126. HTH_1. 1 hit.
PF03466. LysR_substrate. 1 hit.
[Graphical view]
PRINTSiPR00039. HTHLYSR.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50931. HTH_LYSR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Loewen P.C., Switala J., Volkert M.R.
    Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. "Systematic sequencing of the Escherichia coli genome: analysis of the 4.0 - 6.0 min (189,987 - 281,416bp) region."
    Takemoto K., Mori H., Murayama N., Kataoka K., Yano M., Itoh T., Yamamoto Y., Inokuchi H., Miki T., Hatada E., Fukuda R., Ichihara S., Mizuno T., Makino K., Nakata A., Yura T., Sampei G., Mizobuchi K.
    Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. "Sequence of minutes 4-25 of Escherichia coli."
    Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  5. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiPERR_ECOLI
AccessioniPrimary (citable) accession number: Q57083
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: January 20, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.