Q57083 (PERR_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
HTH-type transcriptional regulator PerR

Alternative name(s):
Peroxide resistance protein PerR

Gene names

Name:	perR
Ordered Locus Names:	b0254, JW0244

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	297 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Function	Apparent regulatory gene involved in peroxide resistance in stationary phase.
Sequence similarities	Contains 1 HTH lysR-type DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 297	297	HTH-type transcriptional regulator PerR		PRO_0000105743
Regions
	Domain	7 – 64	58	HTH lysR-type
	DNA binding	24 – 44	21	H-T-H motif Potential

Sequences

	Sequence		Length	Mass (Da)
	Q57083 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: E197CE2334B7420E	FASTA	297	33,639
	10 20 30 40 50 60 MKLLAKAPLN LLRAFEAAGR TGAFALAASE LELSPSAISH AIRKLENLLD VRLFQRSTRE 70 80 90 100 110 120 ITLTKEGEIL LEHIQRGFNE LQQGLALVTA DESRPLRLHT APSFAHQWLL PRLGKFIREN 130 140 150 160 170 180 PSIDLRLSAS TEYARFEQDD FDLDIVYGEP RPSPYEKIPL AVEELTPLCS PQLAERLKKP 190 200 210 220 230 240 EDLYALTLIQ CDVQLYQWKG WFEANKMTPP NNYGLRFDRS FMAIAAAVDG LGVVLESKLL 250 260 270 280 290 AEREIASGKL VCPLVNSTSE IHYIGHYLVF PQHQHMHSAL DVFKTWLLNE LNLGKIR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Loewen P.C., Switala J., Volkert M.R. Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12.
[2]	"Systematic sequencing of the Escherichia coli genome: analysis of the 4.0 - 6.0 min (189,987 - 281,416bp) region." Takemoto K., Mori H., Murayama N., Kataoka K., Yano M., Itoh T., Yamamoto Y., Inokuchi H., Miki T., Hatada E., Fukuda R., Ichihara S., Mizuno T., Makino K., Nakata A., Yura T., Sampei G., Mizobuchi K. Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]	"Sequence of minutes 4-25 of Escherichia coli." Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W. Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[5]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U57080 Genomic DNA. Translation: AAB01994.1. U70214 Genomic DNA. Translation: AAB08673.1. U00096 Genomic DNA. Translation: AAC73357.1. AP009048 Genomic DNA. Translation: BAA77924.1.
PIR	F64750.
RefSeq	NP_414788.1. NC_000913.2. YP_488549.1. NC_007779.1.
3D structure databases
ProteinModelPortal	Q57083.
SMR	Q57083. Positions 9-283.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-10463N.
IntAct	Q57083. 6 interactions.
MINT	MINT-1292741.
STRING	511145.b0254.
Proteomic databases
PRIDE	Q57083.
Protocols and materials databases
DNASU	945417.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC73357; AAC73357; b0254. BAA77924; BAA77924; BAA77924.
GeneID	12930780. 945417.
KEGG	ecj:Y75_p0245. eco:b0254.
PATRIC	32115627. VBIEscCol129921_0257.
Organism-specific databases
EchoBASE	EB3124.
EcoGene	EG13340. perR.
Phylogenomic databases
eggNOG	COG0583.
HOGENOM	HOG000233528.
OMA	AGENLMR.
ProtClustDB	CLSK891706.
Enzyme and pathway databases
BioCyc	EcoCyc:G6129-MONOMER. ECOL316407:JW0244-MONOMER.
Gene expression databases
Genevestigator	Q57083.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR005119. LysR_subst-bd. IPR000847. Tscrpt_reg_HTH_LysR. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00126. HTH_1. 1 hit. PF03466. LysR_substrate. 1 hit. [Graphical view]
PRINTS	PR00039. HTHLYSR.
PROSITE	PS50931. HTH_LYSR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PERR_ECOLI

Accession

Primary (citable) accession number: Q57083

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program