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Protein

HTH-type transcriptional regulator PerR

Gene

perR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Apparent regulatory gene involved in peroxide resistance in stationary phase.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi24 – 44H-T-H motifPROSITE-ProRule annotationAdd BLAST21

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:G6129-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator PerR
Alternative name(s):
Peroxide resistance protein PerR
Gene namesi
Name:perR
Ordered Locus Names:b0254, JW0244
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13340 perR

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001057431 – 297HTH-type transcriptional regulator PerRAdd BLAST297

Proteomic databases

PaxDbiQ57083
PRIDEiQ57083

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-541993,EBI-541993

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi4259774, 3 interactors
DIPiDIP-10463N
IntActiQ57083, 6 interactors
STRINGi316385.ECDH10B_0239

Structurei

3D structure databases

ProteinModelPortaliQ57083
SMRiQ57083
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 64HTH lysR-typePROSITE-ProRule annotationAdd BLAST58

Phylogenomic databases

eggNOGiENOG4108PZW Bacteria
ENOG410Z3XZ LUCA
HOGENOMiHOG000233528
InParanoidiQ57083
OMAiAQWLTPR
PhylomeDBiQ57083

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR005119 LysR_subst-bd
IPR000847 Tscrpt_reg_HTH_LysR
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00126 HTH_1, 1 hit
PF03466 LysR_substrate, 1 hit
PRINTSiPR00039 HTHLYSR
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50931 HTH_LYSR, 1 hit

Sequencei

Sequence statusi: Complete.

Q57083-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLAKAPLN LLRAFEAAGR TGAFALAASE LELSPSAISH AIRKLENLLD
60 70 80 90 100
VRLFQRSTRE ITLTKEGEIL LEHIQRGFNE LQQGLALVTA DESRPLRLHT
110 120 130 140 150
APSFAHQWLL PRLGKFIREN PSIDLRLSAS TEYARFEQDD FDLDIVYGEP
160 170 180 190 200
RPSPYEKIPL AVEELTPLCS PQLAERLKKP EDLYALTLIQ CDVQLYQWKG
210 220 230 240 250
WFEANKMTPP NNYGLRFDRS FMAIAAAVDG LGVVLESKLL AEREIASGKL
260 270 280 290
VCPLVNSTSE IHYIGHYLVF PQHQHMHSAL DVFKTWLLNE LNLGKIR
Length:297
Mass (Da):33,639
Last modified:November 1, 1996 - v1
Checksum:iE197CE2334B7420E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57080 Genomic DNA Translation: AAB01994.1
U70214 Genomic DNA Translation: AAB08673.1
U00096 Genomic DNA Translation: AAC73357.1
AP009048 Genomic DNA Translation: BAA77924.1
PIRiF64750
RefSeqiNP_414788.1, NC_000913.3
WP_000770246.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73357; AAC73357; b0254
BAA77924; BAA77924; BAA77924
GeneIDi945417
KEGGiecj:JW0244
eco:b0254
PATRICifig|1411691.4.peg.2028

Similar proteinsi

Entry informationi

Entry nameiPERR_ECOLI
AccessioniPrimary (citable) accession number: Q57083
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health