ID   Y107_HAEIN              Reviewed;         420 AA.
AC   Q57017; P96330;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-1998, sequence version 2.
DT   27-MAR-2024, entry version 143.
DE   RecName: Full=UPF0053 protein HI_0107;
GN   OrderedLocusNames=HI_0107;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0053 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC21785.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; L42023; AAC21785.1; ALT_INIT; Genomic_DNA.
DR   PIR; H64142; H64142.
DR   RefSeq; NP_438281.1; NC_000907.1.
DR   PDB; 3LAE; X-ray; 1.45 A; A=343-420.
DR   PDBsum; 3LAE; -.
DR   AlphaFoldDB; Q57017; -.
DR   SMR; Q57017; -.
DR   STRING; 71421.HI_0107; -.
DR   EnsemblBacteria; AAC21785; AAC21785; HI_0107.
DR   KEGG; hin:HI_0107; -.
DR   PATRIC; fig|71421.8.peg.111; -.
DR   eggNOG; COG4536; Bacteria.
DR   HOGENOM; CLU_015237_4_1_6; -.
DR   OrthoDB; 9797674at2; -.
DR   PhylomeDB; Q57017; -.
DR   EvolutionaryTrace; Q57017; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR   Gene3D; 3.30.465.10; -; 1.
DR   Gene3D; 3.10.580.10; CBS-domain; 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR002550; CNNM.
DR   InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR   InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR   InterPro; IPR044751; Ion_transp-like_CBS.
DR   InterPro; IPR005170; Transptr-assoc_dom.
DR   PANTHER; PTHR22777; HEMOLYSIN-RELATED; 1.
DR   PANTHER; PTHR22777:SF17; UPF0053 INNER MEMBRANE PROTEIN YFJD; 1.
DR   Pfam; PF00571; CBS; 1.
DR   Pfam; PF01595; CNNM; 1.
DR   Pfam; PF03471; CorC_HlyC; 1.
DR   SMART; SM01091; CorC_HlyC; 1.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR   PROSITE; PS51371; CBS; 2.
DR   PROSITE; PS51846; CNNM; 1.
PE   1: Evidence at protein level;
KW   3D-structure; CBS domain; Cell membrane; Membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix.
FT   CHAIN           1..420
FT                   /note="UPF0053 protein HI_0107"
FT                   /id="PRO_0000088358"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          2..190
FT                   /note="CNNM transmembrane"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01193"
FT   DOMAIN          208..268
FT                   /note="CBS 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT   DOMAIN          273..333
FT                   /note="CBS 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT   STRAND          350..353
FT                   /evidence="ECO:0007829|PDB:3LAE"
FT   HELIX           358..365
FT                   /evidence="ECO:0007829|PDB:3LAE"
FT   HELIX           377..384
FT                   /evidence="ECO:0007829|PDB:3LAE"
FT   STRAND          394..397
FT                   /evidence="ECO:0007829|PDB:3LAE"
FT   STRAND          400..408
FT                   /evidence="ECO:0007829|PDB:3LAE"
FT   STRAND          411..419
FT                   /evidence="ECO:0007829|PDB:3LAE"
SQ   SEQUENCE   420 AA;  46960 MW;  7CFFD76A12937231 CRC64;
     MDSIPLSTLF IILIICLVLS AYFSGSETGL LSLNKYRLRF LSEQGNKGAK KAEKLLEKPD
     TLLSFILIFN NLVNISASAI ATVIGMRLYG DAGVAIATGL LTFVMLVFSE IFPKTVAAMH
     AEKVSFFSSH ILTSLLKIFY PLVWLMNIFT KSLMQIVGLK LDMQKQVISS EELRSIVSEA
     GEATPNEQHP QMLLSILDME TVTVDDIMVP RNEIGGINID DDWRAIMRQL NHAAHNRVVL
     YKGSLDEQVL GILRVREAFR LLLEKNEFTK ETLIRAADEV YFIPESTPLK TQLANFRTNK
     ERIGLVVDEY GDIKGLVTLE DILEEIVGDF TTSTAPSIDK EVIQQSDGSM IIDGSANLRD
     LNKMFNWELD TEDARTFNGL ILEHLEEIPD EGTICEIDGL LITILEVGDN MIKQAKVVKL
//