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Q56YU0

- AL2C4_ARATH

UniProt

Q56YU0 - AL2C4_ARATH

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Protein
Aldehyde dehydrogenase family 2 member C4
Gene
ALDH2C4, REF1, At3g24503, MOB24.3
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in ferulic acid and sinapic acid biosynthesis by oxidation of conyferylaldehyde and sinapaldehyde, respectively. Can oxidize L-lactaldehyde. Possesses activity on acetaldehyde and glycolaldehyde in vitro.2 Publications

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei169 – 1691Transition state stabilizer By similarity
Active sitei268 – 2681Proton acceptor By similarity
Active sitei302 – 3021Nucleophile By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi245 – 2506NAD By similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: TAIR
  2. coniferyl-aldehyde dehydrogenase activity Source: TAIR

GO - Biological processi

  1. phenylpropanoid biosynthetic process Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-1757-MONOMER.
RETL1328306-WGS:GSTH-6623-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase family 2 member C4 (EC:1.2.1.3)
Alternative name(s):
ALDH1a
Protein REDUCED EPIDERMAL FLUORESCENCE 1
Gene namesi
Name:ALDH2C4
Synonyms:REF1
Ordered Locus Names:At3g24503
ORF Names:MOB24.3
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G24503.

Subcellular locationi

Cytoplasmcytosol Reviewed prediction

GO - Cellular componenti

  1. cytosol Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi152 – 1521G → E in ref1-7; reduced activity on sinapaldehyde. 1 Publication
Mutagenesisi416 – 4161G → R in ref1-6; reduced activity on sinapaldehyde. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 501501Aldehyde dehydrogenase family 2 member C4
PRO_0000256058Add
BLAST

Post-translational modificationi

Ubiquitinated.

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ56YU0.
PRIDEiQ56YU0.

Expressioni

Gene expression databases

GenevestigatoriQ56YU0.

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

BioGridi7373. 3 interactions.
IntActiQ56YU0. 1 interaction.
STRINGi3702.AT3G24503.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ56YU0.
SMRiQ56YU0. Positions 15-485.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
InParanoidiQ56YU0.
KOiK12355.
OMAiIANHTDI.
PhylomeDBiQ56YU0.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q56YU0-1 [UniParc]FASTAAdd to Basket

« Hide

MENGKCNGAT TVKLPEIKFT KLFINGQFID AASGKTFETI DPRNGEVIAT    50
IAEGDKEDVD LAVNAARYAF DHGPWPRMTG FERAKLINKF ADLIEENIEE 100
LAKLDAVDGG KLFQLGKYAD IPATAGHFRY NAGAADKIHG ETLKMTRQSL 150
FGYTLKEPIG VVGNIIPWNF PSIMFATKVA PAMAAGCTMV VKPAEQTSLS 200
ALFYAHLSKE AGIPDGVLNI VTGFGSTAGA AIASHMDVDK VSFTGSTDVG 250
RKIMQAAAAS NLKKVSLELG GKSPLLIFND ADIDKAADLA LLGCFYNKGE 300
ICVASSRVFV QEGIYDKVVE KLVEKAKDWT VGDPFDSTAR QGPQVDKRQF 350
EKILSYIEHG KNEGATLLTG GKAIGDKGYF IQPTIFADVT EDMKIYQDEI 400
FGPVMSLMKF KTVEEGIKCA NNTKYGLAAG ILSQDIDLIN TVSRSIKAGI 450
IWVNCYFGFD LDCPYGGYKM SGNCRESGMD ALDNYLQTKS VVMPLHNSPW 500
M 501
Length:501
Mass (Da):54,360
Last modified:October 31, 2006 - v2
Checksum:i3E93A166B1D3ECF6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF349448 mRNA. Translation: AAM27004.1.
AB020746 Genomic DNA. Translation: BAB01998.1.
CP002686 Genomic DNA. Translation: AEE76907.1.
AY056398 mRNA. Translation: AAL08254.1.
AK221230 mRNA. Translation: BAD93825.1.
RefSeqiNP_566749.1. NM_113359.3.
UniGeneiAt.22894.

Genome annotation databases

EnsemblPlantsiAT3G24503.1; AT3G24503.1; AT3G24503.
GeneIDi822042.
KEGGiath:AT3G24503.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF349448 mRNA. Translation: AAM27004.1 .
AB020746 Genomic DNA. Translation: BAB01998.1 .
CP002686 Genomic DNA. Translation: AEE76907.1 .
AY056398 mRNA. Translation: AAL08254.1 .
AK221230 mRNA. Translation: BAD93825.1 .
RefSeqi NP_566749.1. NM_113359.3.
UniGenei At.22894.

3D structure databases

ProteinModelPortali Q56YU0.
SMRi Q56YU0. Positions 15-485.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 7373. 3 interactions.
IntActi Q56YU0. 1 interaction.
STRINGi 3702.AT3G24503.1-P.

Proteomic databases

PaxDbi Q56YU0.
PRIDEi Q56YU0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G24503.1 ; AT3G24503.1 ; AT3G24503 .
GeneIDi 822042.
KEGGi ath:AT3G24503.

Organism-specific databases

TAIRi AT3G24503.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271505.
InParanoidi Q56YU0.
KOi K12355.
OMAi IANHTDI.
PhylomeDBi Q56YU0.

Enzyme and pathway databases

BioCyci RETL1328306-WGS:GSTH-1757-MONOMER.
RETL1328306-WGS:GSTH-6623-MONOMER.

Gene expression databases

Genevestigatori Q56YU0.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the aldehyde dehydrogenase gene families of Zea mays and Arabidopsis."
    Skibbe D.S., Liu F., Wen T.-J., Yandeau M.D., Cui X., Cao J., Simmons C.R., Schnable P.S.
    Plant Mol. Biol. 48:751-764(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
  2. "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC clones."
    Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.
    DNA Res. 7:217-221(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 322-501.
    Strain: cv. Columbia.
  6. "The Arabidopsis thaliana REDUCED EPIDERMAL FLUORESCENCE1 gene encodes an aldehyde dehydrogenase involved in ferulic acid and sinapic acid biosynthesis."
    Nair R.B., Bastress K.L., Ruegger M.O., Denault J.W., Chapple C.
    Plant Cell 16:544-554(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF GLY-152 AND GLY-416.
  7. Cited for: NOMENCLATURE.
  8. "Tandem affinity purification and mass spectrometric analysis of ubiquitylated proteins in Arabidopsis."
    Saracco S.A., Hansson M., Scalf M., Walker J.M., Smith L.M., Vierstra R.D.
    Plant J. 59:344-358(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiAL2C4_ARATH
AccessioniPrimary (citable) accession number: Q56YU0
Secondary accession number(s): Q9LV57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: July 9, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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