Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Aldehyde dehydrogenase family 2 member C4

Gene

ALDH2C4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in ferulic acid and sinapic acid biosynthesis by oxidation of conyferylaldehyde and sinapaldehyde, respectively. Can oxidize L-lactaldehyde. Possesses activity on acetaldehyde and glycolaldehyde in vitro.2 Publications

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei169Transition state stabilizerBy similarity1
Active sitei268Proton acceptorPROSITE-ProRule annotation1
Active sitei302NucleophilePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi245 – 250NADBy similarity6

GO - Molecular functioni

  • aldehyde dehydrogenase (NAD) activity Source: TAIR
  • coniferyl-aldehyde dehydrogenase activity Source: TAIR

GO - Biological processi

  • phenylpropanoid biosynthetic process Source: TAIR

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

ReactomeiR-ATH-380612 Metabolism of serotonin
R-ATH-5365859 RA biosynthesis pathway
R-ATH-70350 Fructose catabolism
R-ATH-71384 Ethanol oxidation

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase family 2 member C4 (EC:1.2.1.3)
Alternative name(s):
ALDH1a
Protein REDUCED EPIDERMAL FLUORESCENCE 1
Gene namesi
Name:ALDH2C4
Synonyms:REF1
Ordered Locus Names:At3g24503
ORF Names:MOB24.3
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G24503
TAIRilocus:505006369 AT3G24503

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi152G → E in ref1-7; reduced activity on sinapaldehyde. 1 Publication1
Mutagenesisi416G → R in ref1-6; reduced activity on sinapaldehyde. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002560581 – 501Aldehyde dehydrogenase family 2 member C4Add BLAST501

Proteomic databases

PaxDbiQ56YU0
PRIDEiQ56YU0

PTM databases

iPTMnetiQ56YU0

Expressioni

Gene expression databases

ExpressionAtlasiQ56YU0 baseline and differential
GenevisibleiQ56YU0 AT

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

BioGridi7373, 3 interactors
IntActiQ56YU0, 1 interactor
STRINGi3702.AT3G24503.1

Structurei

3D structure databases

ProteinModelPortaliQ56YU0
SMRiQ56YU0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiKOG2450 Eukaryota
COG1012 LUCA
HOGENOMiHOG000271505
InParanoidiQ56YU0
KOiK12355
OMAiPMNQVTL
OrthoDBiEOG0936084C
PhylomeDBiQ56YU0

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

Q56YU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENGKCNGAT TVKLPEIKFT KLFINGQFID AASGKTFETI DPRNGEVIAT
60 70 80 90 100
IAEGDKEDVD LAVNAARYAF DHGPWPRMTG FERAKLINKF ADLIEENIEE
110 120 130 140 150
LAKLDAVDGG KLFQLGKYAD IPATAGHFRY NAGAADKIHG ETLKMTRQSL
160 170 180 190 200
FGYTLKEPIG VVGNIIPWNF PSIMFATKVA PAMAAGCTMV VKPAEQTSLS
210 220 230 240 250
ALFYAHLSKE AGIPDGVLNI VTGFGSTAGA AIASHMDVDK VSFTGSTDVG
260 270 280 290 300
RKIMQAAAAS NLKKVSLELG GKSPLLIFND ADIDKAADLA LLGCFYNKGE
310 320 330 340 350
ICVASSRVFV QEGIYDKVVE KLVEKAKDWT VGDPFDSTAR QGPQVDKRQF
360 370 380 390 400
EKILSYIEHG KNEGATLLTG GKAIGDKGYF IQPTIFADVT EDMKIYQDEI
410 420 430 440 450
FGPVMSLMKF KTVEEGIKCA NNTKYGLAAG ILSQDIDLIN TVSRSIKAGI
460 470 480 490 500
IWVNCYFGFD LDCPYGGYKM SGNCRESGMD ALDNYLQTKS VVMPLHNSPW

M
Length:501
Mass (Da):54,360
Last modified:October 31, 2006 - v2
Checksum:i3E93A166B1D3ECF6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF349448 mRNA Translation: AAM27004.1
AB020746 Genomic DNA Translation: BAB01998.1
CP002686 Genomic DNA Translation: AEE76907.1
AY056398 mRNA Translation: AAL08254.1
AK221230 mRNA Translation: BAD93825.1
RefSeqiNP_566749.1, NM_113359.4
UniGeneiAt.22894

Genome annotation databases

EnsemblPlantsiAT3G24503.1; AT3G24503.1; AT3G24503
GeneIDi822042
GrameneiAT3G24503.1; AT3G24503.1; AT3G24503
KEGGiath:AT3G24503

Similar proteinsi

Entry informationi

Entry nameiAL2C4_ARATH
AccessioniPrimary (citable) accession number: Q56YU0
Secondary accession number(s): Q9LV57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: April 25, 2018
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health