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Q56YU0

- AL2C4_ARATH

UniProt

Q56YU0 - AL2C4_ARATH

Protein

Aldehyde dehydrogenase family 2 member C4

Gene

ALDH2C4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 2 (31 Oct 2006)
      Previous versions | rss
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    Functioni

    Involved in ferulic acid and sinapic acid biosynthesis by oxidation of conyferylaldehyde and sinapaldehyde, respectively. Can oxidize L-lactaldehyde. Possesses activity on acetaldehyde and glycolaldehyde in vitro.2 Publications

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei169 – 1691Transition state stabilizerBy similarity
    Active sitei268 – 2681Proton acceptorPROSITE-ProRule annotation
    Active sitei302 – 3021NucleophilePROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi245 – 2506NADBy similarity

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: TAIR
    2. coniferyl-aldehyde dehydrogenase activity Source: TAIR

    GO - Biological processi

    1. phenylpropanoid biosynthetic process Source: TAIR

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciRETL1328306-WGS:GSTH-1757-MONOMER.
    RETL1328306-WGS:GSTH-6623-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldehyde dehydrogenase family 2 member C4 (EC:1.2.1.3)
    Alternative name(s):
    ALDH1a
    Protein REDUCED EPIDERMAL FLUORESCENCE 1
    Gene namesi
    Name:ALDH2C4
    Synonyms:REF1
    Ordered Locus Names:At3g24503
    ORF Names:MOB24.3
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 3

    Organism-specific databases

    TAIRiAT3G24503.

    Subcellular locationi

    Cytoplasmcytosol Curated

    GO - Cellular componenti

    1. cytosol Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi152 – 1521G → E in ref1-7; reduced activity on sinapaldehyde. 1 Publication
    Mutagenesisi416 – 4161G → R in ref1-6; reduced activity on sinapaldehyde. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 501501Aldehyde dehydrogenase family 2 member C4PRO_0000256058Add
    BLAST

    Post-translational modificationi

    Ubiquitinated.1 Publication

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    PaxDbiQ56YU0.
    PRIDEiQ56YU0.

    Expressioni

    Gene expression databases

    GenevestigatoriQ56YU0.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    BioGridi7373. 3 interactions.
    IntActiQ56YU0. 1 interaction.
    STRINGi3702.AT3G24503.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ56YU0.
    SMRiQ56YU0. Positions 15-485.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271505.
    InParanoidiQ56YU0.
    KOiK12355.
    OMAiIANHTDI.
    PhylomeDBiQ56YU0.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q56YU0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENGKCNGAT TVKLPEIKFT KLFINGQFID AASGKTFETI DPRNGEVIAT    50
    IAEGDKEDVD LAVNAARYAF DHGPWPRMTG FERAKLINKF ADLIEENIEE 100
    LAKLDAVDGG KLFQLGKYAD IPATAGHFRY NAGAADKIHG ETLKMTRQSL 150
    FGYTLKEPIG VVGNIIPWNF PSIMFATKVA PAMAAGCTMV VKPAEQTSLS 200
    ALFYAHLSKE AGIPDGVLNI VTGFGSTAGA AIASHMDVDK VSFTGSTDVG 250
    RKIMQAAAAS NLKKVSLELG GKSPLLIFND ADIDKAADLA LLGCFYNKGE 300
    ICVASSRVFV QEGIYDKVVE KLVEKAKDWT VGDPFDSTAR QGPQVDKRQF 350
    EKILSYIEHG KNEGATLLTG GKAIGDKGYF IQPTIFADVT EDMKIYQDEI 400
    FGPVMSLMKF KTVEEGIKCA NNTKYGLAAG ILSQDIDLIN TVSRSIKAGI 450
    IWVNCYFGFD LDCPYGGYKM SGNCRESGMD ALDNYLQTKS VVMPLHNSPW 500
    M 501
    Length:501
    Mass (Da):54,360
    Last modified:October 31, 2006 - v2
    Checksum:i3E93A166B1D3ECF6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF349448 mRNA. Translation: AAM27004.1.
    AB020746 Genomic DNA. Translation: BAB01998.1.
    CP002686 Genomic DNA. Translation: AEE76907.1.
    AY056398 mRNA. Translation: AAL08254.1.
    AK221230 mRNA. Translation: BAD93825.1.
    RefSeqiNP_566749.1. NM_113359.3.
    UniGeneiAt.22894.

    Genome annotation databases

    EnsemblPlantsiAT3G24503.1; AT3G24503.1; AT3G24503.
    GeneIDi822042.
    KEGGiath:AT3G24503.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF349448 mRNA. Translation: AAM27004.1 .
    AB020746 Genomic DNA. Translation: BAB01998.1 .
    CP002686 Genomic DNA. Translation: AEE76907.1 .
    AY056398 mRNA. Translation: AAL08254.1 .
    AK221230 mRNA. Translation: BAD93825.1 .
    RefSeqi NP_566749.1. NM_113359.3.
    UniGenei At.22894.

    3D structure databases

    ProteinModelPortali Q56YU0.
    SMRi Q56YU0. Positions 15-485.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 7373. 3 interactions.
    IntActi Q56YU0. 1 interaction.
    STRINGi 3702.AT3G24503.1-P.

    Proteomic databases

    PaxDbi Q56YU0.
    PRIDEi Q56YU0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT3G24503.1 ; AT3G24503.1 ; AT3G24503 .
    GeneIDi 822042.
    KEGGi ath:AT3G24503.

    Organism-specific databases

    TAIRi AT3G24503.

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271505.
    InParanoidi Q56YU0.
    KOi K12355.
    OMAi IANHTDI.
    PhylomeDBi Q56YU0.

    Enzyme and pathway databases

    BioCyci RETL1328306-WGS:GSTH-1757-MONOMER.
    RETL1328306-WGS:GSTH-6623-MONOMER.

    Gene expression databases

    Genevestigatori Q56YU0.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the aldehyde dehydrogenase gene families of Zea mays and Arabidopsis."
      Skibbe D.S., Liu F., Wen T.-J., Yandeau M.D., Cui X., Cao J., Simmons C.R., Schnable P.S.
      Plant Mol. Biol. 48:751-764(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    2. "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC clones."
      Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.
      DNA Res. 7:217-221(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
      Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
      , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 322-501.
      Strain: cv. Columbia.
    6. "The Arabidopsis thaliana REDUCED EPIDERMAL FLUORESCENCE1 gene encodes an aldehyde dehydrogenase involved in ferulic acid and sinapic acid biosynthesis."
      Nair R.B., Bastress K.L., Ruegger M.O., Denault J.W., Chapple C.
      Plant Cell 16:544-554(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MUTAGENESIS OF GLY-152 AND GLY-416.
    7. Cited for: NOMENCLATURE.
    8. "Tandem affinity purification and mass spectrometric analysis of ubiquitylated proteins in Arabidopsis."
      Saracco S.A., Hansson M., Scalf M., Walker J.M., Smith L.M., Vierstra R.D.
      Plant J. 59:344-358(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiAL2C4_ARATH
    AccessioniPrimary (citable) accession number: Q56YU0
    Secondary accession number(s): Q9LV57
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: October 31, 2006
    Last modified: October 1, 2014
    This is version 69 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3