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Q56YT0

- LAC3_ARATH

UniProt

Q56YT0 - LAC3_ARATH

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Protein

Laccase-3

Gene

LAC3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi83 – 831Copper 1; type 2By similarity
Metal bindingi85 – 851Copper 2; type 3By similarity
Metal bindingi128 – 1281Copper 2; type 3By similarity
Metal bindingi130 – 1301Copper 3; type 3By similarity
Metal bindingi471 – 4711Copper 4; type 1By similarity
Metal bindingi474 – 4741Copper 1; type 2By similarity
Metal bindingi476 – 4761Copper 3; type 3By similarity
Metal bindingi533 – 5331Copper 3; type 3By similarity
Metal bindingi534 – 5341Copper 4; type 1By similarity
Metal bindingi535 – 5351Copper 2; type 3By similarity
Metal bindingi539 – 5391Copper 4; type 1By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

GO - Biological processi

  1. lignin catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT2G30210-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-3 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 3
Diphenol oxidase 3
Urishiol oxidase 3
Gene namesi
Name:LAC3
Ordered Locus Names:At2g30210
ORF Names:T9D9.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 2

Organism-specific databases

TAIRiAT2G30210.

Subcellular locationi

GO - Cellular componenti

  1. apoplast Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 570545Laccase-3PRO_0000283631Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi298 – 2981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi332 – 3321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi383 – 3831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi393 – 3931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ56YT0.
PRIDEiQ56YT0.

Expressioni

Tissue specificityi

Mostly expressed in roots and siliques.2 Publications

Gene expression databases

GenevestigatoriQ56YT0.

Structurei

3D structure databases

ProteinModelPortaliQ56YT0.
SMRiQ56YT0. Positions 43-549.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 149117Plastocyanin-like 1Add
BLAST
Domaini159 – 310152Plastocyanin-like 2Add
BLAST
Domaini419 – 554136Plastocyanin-like 3Add
BLAST

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated
Contains 3 plastocyanin-like domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG2132.
HOGENOMiHOG000241916.
InParanoidiQ56YT0.
OMAiRYNISIH.
PhylomeDBiQ56YT0.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q56YT0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESFRRFSLL SFIALLAYFA FLASAEHHVH QFVITPTPVK RLCRTHQSIT
60 70 80 90 100
VNGQYPGPTL VVRNGDSLAI TVINRARYNI SIHWHGIRQL RNPWADGPEY
110 120 130 140 150
ITQCPIRPGQ TYTYRFKIED QEGTLWWHAH SRWLRATVYG ALIIYPRLGS
160 170 180 190 200
PYPFSMPKRD IPILLGEWWD RNPMDVLKQA QFTGAAANVS DAYTINGQPG
210 220 230 240 250
DLYRCSRAGT IRFPIFPGET VQLRVINAGM NQELFFSVAN HQFTVVETDS
260 270 280 290 300
AYTKPFTTNV IMIGPGQTTN VLLTANQRPG RYYMAARAYN SANAPFDNTT
310 320 330 340 350
TTAILQYVNA PTRRGRGRGQ IAPVFPVLPG FNDTATATAF TNRLRYWKRA
360 370 380 390 400
PVPQQVDENL FFTVGLGLIN CANPNSPRCQ GPNGTRFAAS MNNMSFVLPR
410 420 430 440 450
SNSVMQAYYQ GTPGIFTTDF PPVPPVQFDY TGNVSRGLWQ PIKGTKAYKL
460 470 480 490 500
KYKSNVQIVL QDTSIVTPEN HPMHLHGYQF YVVGSGFGNF NPRTDPARFN
510 520 530 540 550
LFDPPERNTI GTPPGGWVAI RFVADNPGAW FMHCHIDSHL GWGLAMVFLV
560 570
ENGRGQLQSV QAPPLDLPRC
Length:570
Mass (Da):64,027
Last modified:April 3, 2007 - v2
Checksum:i48520C684D7B2DA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002338 Genomic DNA. Translation: AAC16927.1.
AC004165 Genomic DNA. Translation: AAM14916.1.
CP002685 Genomic DNA. Translation: AEC08358.1.
AK221241 mRNA. Translation: BAD93858.1.
PIRiT00579.
RefSeqiNP_180580.1. NM_128574.3.
UniGeneiAt.27864.

Genome annotation databases

EnsemblPlantsiAT2G30210.1; AT2G30210.1; AT2G30210.
GeneIDi817571.
KEGGiath:AT2G30210.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002338 Genomic DNA. Translation: AAC16927.1 .
AC004165 Genomic DNA. Translation: AAM14916.1 .
CP002685 Genomic DNA. Translation: AEC08358.1 .
AK221241 mRNA. Translation: BAD93858.1 .
PIRi T00579.
RefSeqi NP_180580.1. NM_128574.3.
UniGenei At.27864.

3D structure databases

ProteinModelPortali Q56YT0.
SMRi Q56YT0. Positions 43-549.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q56YT0.
PRIDEi Q56YT0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT2G30210.1 ; AT2G30210.1 ; AT2G30210 .
GeneIDi 817571.
KEGGi ath:AT2G30210.

Organism-specific databases

TAIRi AT2G30210.

Phylogenomic databases

eggNOGi COG2132.
HOGENOMi HOG000241916.
InParanoidi Q56YT0.
OMAi RYNISIH.
PhylomeDBi Q56YT0.

Enzyme and pathway databases

BioCyci ARA:AT2G30210-MONOMER.

Gene expression databases

Genevestigatori Q56YT0.

Family and domain databases

Gene3Di 2.60.40.420. 3 hits.
InterProi IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view ]
Pfami PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 3 hits.
TIGRFAMsi TIGR03389. laccase. 1 hit.
PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 391-570.
    Strain: cv. Columbia.
  4. "Gene structure and molecular analysis of the laccase-like multicopper oxidase (LMCO) gene family in Arabidopsis thaliana."
    McCaig B.C., Meagher R.B., Dean J.F.D.
    Planta 221:619-636(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. "Mutant identification and characterization of the laccase gene family in Arabidopsis."
    Cai X., Davis E.J., Ballif J., Liang M., Bushman E., Haroldsen V., Torabinejad J., Wu Y.
    J. Exp. Bot. 57:2563-2569(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiLAC3_ARATH
AccessioniPrimary (citable) accession number: Q56YT0
Secondary accession number(s): O22917
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: November 26, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3