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Protein

Laccase-3

Gene

LAC3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi83Copper 1; type 2By similarity1
Metal bindingi85Copper 2; type 3By similarity1
Metal bindingi128Copper 2; type 3By similarity1
Metal bindingi130Copper 3; type 3By similarity1
Metal bindingi471Copper 4; type 1By similarity1
Metal bindingi474Copper 1; type 2By similarity1
Metal bindingi476Copper 3; type 3By similarity1
Metal bindingi533Copper 3; type 3By similarity1
Metal bindingi534Copper 4; type 1By similarity1
Metal bindingi535Copper 2; type 3By similarity1
Metal bindingi539Copper 4; type 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processLignin degradation
LigandCopper, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT2G30210-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-3 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 3
Diphenol oxidase 3
Urishiol oxidase 3
Gene namesi
Name:LAC3
Ordered Locus Names:At2g30210
ORF Names:T9D9.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G30210
TAIRilocus:2060879 AT2G30210

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000028363126 – 570Laccase-3Add BLAST545

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi298N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi332N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi383N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi393N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi433N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ56YT0

Expressioni

Tissue specificityi

Mostly expressed in roots and siliques.2 Publications

Gene expression databases

ExpressionAtlasiQ56YT0 baseline and differential
GenevisibleiQ56YT0 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G30210.1

Structurei

3D structure databases

ProteinModelPortaliQ56YT0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 149Plastocyanin-like 1Add BLAST117
Domaini159 – 310Plastocyanin-like 2Add BLAST152
Domaini419 – 554Plastocyanin-like 3Add BLAST136

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1263 Eukaryota
COG2132 LUCA
HOGENOMiHOG000241916
InParanoidiQ56YT0
KOiK05909
OMAiDGVDKWP
OrthoDBiEOG093605O6
PhylomeDBiQ56YT0

Family and domain databases

CDDicd13849 CuRO_1_LCC_plant, 1 hit
cd13875 CuRO_2_LCC_plant, 1 hit
cd13897 CuRO_3_LCC_plant, 1 hit
Gene3Di2.60.40.420, 3 hits
InterProiView protein in InterPro
IPR001117 Cu-oxidase
IPR011706 Cu-oxidase_2
IPR011707 Cu-oxidase_3
IPR033138 Cu_oxidase_CS
IPR002355 Cu_oxidase_Cu_BS
IPR008972 Cupredoxin
IPR034288 CuRO_1_LCC
IPR034285 CuRO_2_LCC
IPR034289 CuRO_3_LCC
IPR017761 Laccase
PfamiView protein in Pfam
PF00394 Cu-oxidase, 1 hit
PF07731 Cu-oxidase_2, 1 hit
PF07732 Cu-oxidase_3, 1 hit
SUPFAMiSSF49503 SSF49503, 3 hits
TIGRFAMsiTIGR03389 laccase, 1 hit
PROSITEiView protein in PROSITE
PS00079 MULTICOPPER_OXIDASE1, 1 hit
PS00080 MULTICOPPER_OXIDASE2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q56YT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESFRRFSLL SFIALLAYFA FLASAEHHVH QFVITPTPVK RLCRTHQSIT
60 70 80 90 100
VNGQYPGPTL VVRNGDSLAI TVINRARYNI SIHWHGIRQL RNPWADGPEY
110 120 130 140 150
ITQCPIRPGQ TYTYRFKIED QEGTLWWHAH SRWLRATVYG ALIIYPRLGS
160 170 180 190 200
PYPFSMPKRD IPILLGEWWD RNPMDVLKQA QFTGAAANVS DAYTINGQPG
210 220 230 240 250
DLYRCSRAGT IRFPIFPGET VQLRVINAGM NQELFFSVAN HQFTVVETDS
260 270 280 290 300
AYTKPFTTNV IMIGPGQTTN VLLTANQRPG RYYMAARAYN SANAPFDNTT
310 320 330 340 350
TTAILQYVNA PTRRGRGRGQ IAPVFPVLPG FNDTATATAF TNRLRYWKRA
360 370 380 390 400
PVPQQVDENL FFTVGLGLIN CANPNSPRCQ GPNGTRFAAS MNNMSFVLPR
410 420 430 440 450
SNSVMQAYYQ GTPGIFTTDF PPVPPVQFDY TGNVSRGLWQ PIKGTKAYKL
460 470 480 490 500
KYKSNVQIVL QDTSIVTPEN HPMHLHGYQF YVVGSGFGNF NPRTDPARFN
510 520 530 540 550
LFDPPERNTI GTPPGGWVAI RFVADNPGAW FMHCHIDSHL GWGLAMVFLV
560 570
ENGRGQLQSV QAPPLDLPRC
Length:570
Mass (Da):64,027
Last modified:April 3, 2007 - v2
Checksum:i48520C684D7B2DA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002338 Genomic DNA Translation: AAC16927.1
AC004165 Genomic DNA Translation: AAM14916.1
CP002685 Genomic DNA Translation: AEC08358.1
AK221241 mRNA Translation: BAD93858.1
PIRiT00579
RefSeqiNP_180580.1, NM_128574.4
UniGeneiAt.27864

Genome annotation databases

EnsemblPlantsiAT2G30210.1; AT2G30210.1; AT2G30210
GeneIDi817571
GrameneiAT2G30210.1; AT2G30210.1; AT2G30210
KEGGiath:AT2G30210

Similar proteinsi

Entry informationi

Entry nameiLAC3_ARATH
AccessioniPrimary (citable) accession number: Q56YT0
Secondary accession number(s): O22917
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: April 25, 2018
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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