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Q56YT0

- LAC3_ARATH

UniProt

Q56YT0 - LAC3_ARATH

Protein

Laccase-3

Gene

LAC3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 2 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Lignin degradation and detoxification of lignin-derived products.By similarity

    Catalytic activityi

    4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

    Cofactori

    Binds 4 copper ions per monomer.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi83 – 831Copper 1; type 2By similarity
    Metal bindingi85 – 851Copper 2; type 3By similarity
    Metal bindingi128 – 1281Copper 2; type 3By similarity
    Metal bindingi130 – 1301Copper 3; type 3By similarity
    Metal bindingi471 – 4711Copper 4; type 1By similarity
    Metal bindingi474 – 4741Copper 1; type 2By similarity
    Metal bindingi476 – 4761Copper 3; type 3By similarity
    Metal bindingi533 – 5331Copper 3; type 3By similarity
    Metal bindingi534 – 5341Copper 4; type 1By similarity
    Metal bindingi535 – 5351Copper 2; type 3By similarity
    Metal bindingi539 – 5391Copper 4; type 1By similarity

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lignin catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Lignin degradation

    Keywords - Ligandi

    Copper, Metal-binding

    Enzyme and pathway databases

    BioCyciARA:AT2G30210-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Laccase-3 (EC:1.10.3.2)
    Alternative name(s):
    Benzenediol:oxygen oxidoreductase 3
    Diphenol oxidase 3
    Urishiol oxidase 3
    Gene namesi
    Name:LAC3
    Ordered Locus Names:At2g30210
    ORF Names:T9D9.2
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 2

    Organism-specific databases

    TAIRiAT2G30210.

    Subcellular locationi

    GO - Cellular componenti

    1. apoplast Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Apoplast, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 570545Laccase-3PRO_0000283631Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi298 – 2981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi332 – 3321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi383 – 3831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi393 – 3931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ56YT0.
    PRIDEiQ56YT0.

    Expressioni

    Tissue specificityi

    Mostly expressed in roots and siliques.2 Publications

    Gene expression databases

    GenevestigatoriQ56YT0.

    Structurei

    3D structure databases

    ProteinModelPortaliQ56YT0.
    SMRiQ56YT0. Positions 43-549.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini33 – 149117Plastocyanin-like 1Add
    BLAST
    Domaini159 – 310152Plastocyanin-like 2Add
    BLAST
    Domaini419 – 554136Plastocyanin-like 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the multicopper oxidase family.Curated
    Contains 3 plastocyanin-like domains.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG2132.
    HOGENOMiHOG000241916.
    InParanoidiQ56YT0.
    OMAiRYNISIH.
    PhylomeDBiQ56YT0.

    Family and domain databases

    Gene3Di2.60.40.420. 3 hits.
    InterProiIPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    IPR017761. Laccase.
    [Graphical view]
    PfamiPF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 3 hits.
    TIGRFAMsiTIGR03389. laccase. 1 hit.
    PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
    PS00080. MULTICOPPER_OXIDASE2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q56YT0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESFRRFSLL SFIALLAYFA FLASAEHHVH QFVITPTPVK RLCRTHQSIT    50
    VNGQYPGPTL VVRNGDSLAI TVINRARYNI SIHWHGIRQL RNPWADGPEY 100
    ITQCPIRPGQ TYTYRFKIED QEGTLWWHAH SRWLRATVYG ALIIYPRLGS 150
    PYPFSMPKRD IPILLGEWWD RNPMDVLKQA QFTGAAANVS DAYTINGQPG 200
    DLYRCSRAGT IRFPIFPGET VQLRVINAGM NQELFFSVAN HQFTVVETDS 250
    AYTKPFTTNV IMIGPGQTTN VLLTANQRPG RYYMAARAYN SANAPFDNTT 300
    TTAILQYVNA PTRRGRGRGQ IAPVFPVLPG FNDTATATAF TNRLRYWKRA 350
    PVPQQVDENL FFTVGLGLIN CANPNSPRCQ GPNGTRFAAS MNNMSFVLPR 400
    SNSVMQAYYQ GTPGIFTTDF PPVPPVQFDY TGNVSRGLWQ PIKGTKAYKL 450
    KYKSNVQIVL QDTSIVTPEN HPMHLHGYQF YVVGSGFGNF NPRTDPARFN 500
    LFDPPERNTI GTPPGGWVAI RFVADNPGAW FMHCHIDSHL GWGLAMVFLV 550
    ENGRGQLQSV QAPPLDLPRC 570
    Length:570
    Mass (Da):64,027
    Last modified:April 3, 2007 - v2
    Checksum:i48520C684D7B2DA3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC002338 Genomic DNA. Translation: AAC16927.1.
    AC004165 Genomic DNA. Translation: AAM14916.1.
    CP002685 Genomic DNA. Translation: AEC08358.1.
    AK221241 mRNA. Translation: BAD93858.1.
    PIRiT00579.
    RefSeqiNP_180580.1. NM_128574.3.
    UniGeneiAt.27864.

    Genome annotation databases

    EnsemblPlantsiAT2G30210.1; AT2G30210.1; AT2G30210.
    GeneIDi817571.
    KEGGiath:AT2G30210.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC002338 Genomic DNA. Translation: AAC16927.1 .
    AC004165 Genomic DNA. Translation: AAM14916.1 .
    CP002685 Genomic DNA. Translation: AEC08358.1 .
    AK221241 mRNA. Translation: BAD93858.1 .
    PIRi T00579.
    RefSeqi NP_180580.1. NM_128574.3.
    UniGenei At.27864.

    3D structure databases

    ProteinModelPortali Q56YT0.
    SMRi Q56YT0. Positions 43-549.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q56YT0.
    PRIDEi Q56YT0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT2G30210.1 ; AT2G30210.1 ; AT2G30210 .
    GeneIDi 817571.
    KEGGi ath:AT2G30210.

    Organism-specific databases

    TAIRi AT2G30210.

    Phylogenomic databases

    eggNOGi COG2132.
    HOGENOMi HOG000241916.
    InParanoidi Q56YT0.
    OMAi RYNISIH.
    PhylomeDBi Q56YT0.

    Enzyme and pathway databases

    BioCyci ARA:AT2G30210-MONOMER.

    Gene expression databases

    Genevestigatori Q56YT0.

    Family and domain databases

    Gene3Di 2.60.40.420. 3 hits.
    InterProi IPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    IPR017761. Laccase.
    [Graphical view ]
    Pfami PF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 3 hits.
    TIGRFAMsi TIGR03389. laccase. 1 hit.
    PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
    PS00080. MULTICOPPER_OXIDASE2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
      Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
      , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 391-570.
      Strain: cv. Columbia.
    4. "Gene structure and molecular analysis of the laccase-like multicopper oxidase (LMCO) gene family in Arabidopsis thaliana."
      McCaig B.C., Meagher R.B., Dean J.F.D.
      Planta 221:619-636(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    5. "Mutant identification and characterization of the laccase gene family in Arabidopsis."
      Cai X., Davis E.J., Ballif J., Liang M., Bushman E., Haroldsen V., Torabinejad J., Wu Y.
      J. Exp. Bot. 57:2563-2569(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiLAC3_ARATH
    AccessioniPrimary (citable) accession number: Q56YT0
    Secondary accession number(s): O22917
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 76 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3