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Protein

Hexokinase-4

Gene

At3g20040

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Fructose and glucose phosphorylating enzyme. May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol (By similarity).By similarity

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi101 – 106ATPSequence analysis6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT3G20040-MONOMER
ReactomeiR-ATH-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-ATH-6798695 Neutrophil degranulation
R-ATH-70171 Glycolysis

Names & Taxonomyi

Protein namesi
Recommended name:
Hexokinase-4 (EC:2.7.1.1)
Gene namesi
Ordered Locus Names:At3g20040
ORF Names:MAL21.4
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G20040
TAIRilocus:2087590 AT3G20040

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002596321 – 502Hexokinase-4Add BLAST502

Proteomic databases

PaxDbiQ56XE8
PRIDEiQ56XE8

Expressioni

Gene expression databases

ExpressionAtlasiQ56XE8 baseline and differential
GenevisibleiQ56XE8 AT

Interactioni

Protein-protein interaction databases

BioGridi6875, 1 interactor
STRINGi3702.AT3G20040.1

Structurei

3D structure databases

ProteinModelPortaliQ56XE8
SMRiQ56XE8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 491HexokinasePROSITE-ProRule annotationAdd BLAST457

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni90 – 228Hexokinase small subdomainPROSITE-ProRule annotationAdd BLAST139
Regioni171 – 197Glucose-bindingSequence analysisAdd BLAST27
Regioni229 – 480Hexokinase large subdomainPROSITE-ProRule annotationAdd BLAST252

Sequence similaritiesi

Belongs to the hexokinase family.PROSITE-ProRule annotationCurated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1369 Eukaryota
COG5026 LUCA
HOGENOMiHOG000162670
InParanoidiQ56XE8
KOiK00844
OMAiRMFREYM
OrthoDBiEOG09360B3Y
PhylomeDBiQ56XE8

Family and domain databases

InterProiView protein in InterPro
IPR001312 Hexokinase
IPR022673 Hexokinase_C
IPR022672 Hexokinase_N
PANTHERiPTHR19443 PTHR19443, 1 hit
PfamiView protein in Pfam
PF00349 Hexokinase_1, 1 hit
PF03727 Hexokinase_2, 1 hit
PROSITEiView protein in PROSITE
PS51748 HEXOKINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q56XE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKVLVMLTA AAAVVACSVA TVMVRRRMKG RRKWRRVVGL LKDLEEACET
60 70 80 90 100
PLGRLRQMVD AIAVEMQAGL VSEGGSKLKM LLTFVDDLPN GSETGTYYAL
110 120 130 140 150
HLGGSYFRII KVHLGGQRSS LEVQDVERHS IPTSLMNSTS EVLFDFLASS
160 170 180 190 200
LQRFIEKEGN DFSLSQPLKR ELAFTFSFPV KQTSISSGVL IKWTKGFAIS
210 220 230 240 250
EMAGEDIAEC LQGALNKRGL DIRVAALVND TVGALSFGHF HDPDTIAAVV
260 270 280 290 300
FGTGSNACYL ERTDAIIKCQ NPRTTSGSMV VNMEWGNFWS SRLPRTSYDL
310 320 330 340 350
ELDAESMNSN DMGFEKMIGG MYLGDIVRRV ILRMSQESDI FGPISSILST
360 370 380 390 400
PFVLRTNSVS AMHEDDTSEL QEVARILKDL GVSEVPMKVR KLVVKICDVV
410 420 430 440 450
TRRAARLAAA GIAGILKKVG RDGSGGGRRS DKQIMRRTVV AVEGGLYLNY
460 470 480 490 500
RMFREYMDEA LRDILGEDVA QHVVVKAMED GSSIGSALLL ASSQSVQTIP

SV
Length:502
Mass (Da):54,955
Last modified:October 31, 2006 - v2
Checksum:i354D46773BA91199
GO

Sequence cautioni

The sequence BAD93730 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti502V → I in BAD93730 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000383 Genomic DNA Translation: BAB01861.1
CP002686 Genomic DNA Translation: AEE76323.1
AK221726 mRNA Translation: BAD93730.1 Different initiation.
RefSeqiNP_188639.2, NM_112895.3
UniGeneiAt.50841

Genome annotation databases

EnsemblPlantsiAT3G20040.1; AT3G20040.1; AT3G20040
GeneIDi821543
GrameneiAT3G20040.1; AT3G20040.1; AT3G20040
KEGGiath:AT3G20040

Similar proteinsi

Entry informationi

Entry nameiHXK4_ARATH
AccessioniPrimary (citable) accession number: Q56XE8
Secondary accession number(s): Q9LJZ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: April 25, 2018
This is version 88 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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