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Q56XE8

- HXK4_ARATH

UniProt

Q56XE8 - HXK4_ARATH

Protein

Hexokinase-4

Gene

At3g20040

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 2 (31 Oct 2006)
      Previous versions | rss
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    Functioni

    Fructose and glucose phosphorylating enzyme. May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol By similarity.By similarity

    Catalytic activityi

    ATP + D-hexose = ADP + D-hexose 6-phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi101 – 1066ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. hexokinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciARA:AT3G20040-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hexokinase-4 (EC:2.7.1.1)
    Gene namesi
    Ordered Locus Names:At3g20040
    ORF Names:MAL21.4
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 3

    Organism-specific databases

    TAIRiAT3G20040.

    Subcellular locationi

    Mitochondrion outer membrane 1 Publication; Single-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of mitochondrial outer membrane Source: TAIR
    2. mitochondrion Source: TAIR

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 502502Hexokinase-4PRO_0000259632Add
    BLAST

    Proteomic databases

    PaxDbiQ56XE8.
    PRIDEiQ56XE8.

    Expressioni

    Gene expression databases

    GenevestigatoriQ56XE8.

    Interactioni

    Protein-protein interaction databases

    BioGridi6875. 1 interaction.
    STRINGi3702.AT3G20040.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ56XE8.
    SMRiQ56XE8. Positions 62-491.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 2421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini41 – 235195Hexokinase type-1Add
    BLAST
    Domaini248 – 491244Hexokinase type-2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni171 – 19727Glucose-bindingSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the hexokinase family.Curated
    Contains 1 hexokinase type-1 domain.Curated
    Contains 1 hexokinase type-2 domain.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5026.
    HOGENOMiHOG000162670.
    InParanoidiQ56XE8.
    KOiK00844.
    OMAiGFNCAGV.
    PhylomeDBiQ56XE8.

    Family and domain databases

    InterProiIPR001312. Hexokinase.
    IPR022673. Hexokinase_C.
    IPR022672. Hexokinase_N.
    [Graphical view]
    PANTHERiPTHR19443. PTHR19443. 1 hit.
    PfamiPF00349. Hexokinase_1. 1 hit.
    PF03727. Hexokinase_2. 1 hit.
    [Graphical view]
    PRINTSiPR00475. HEXOKINASE.

    Sequencei

    Sequence statusi: Complete.

    Q56XE8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKVLVMLTA AAAVVACSVA TVMVRRRMKG RRKWRRVVGL LKDLEEACET    50
    PLGRLRQMVD AIAVEMQAGL VSEGGSKLKM LLTFVDDLPN GSETGTYYAL 100
    HLGGSYFRII KVHLGGQRSS LEVQDVERHS IPTSLMNSTS EVLFDFLASS 150
    LQRFIEKEGN DFSLSQPLKR ELAFTFSFPV KQTSISSGVL IKWTKGFAIS 200
    EMAGEDIAEC LQGALNKRGL DIRVAALVND TVGALSFGHF HDPDTIAAVV 250
    FGTGSNACYL ERTDAIIKCQ NPRTTSGSMV VNMEWGNFWS SRLPRTSYDL 300
    ELDAESMNSN DMGFEKMIGG MYLGDIVRRV ILRMSQESDI FGPISSILST 350
    PFVLRTNSVS AMHEDDTSEL QEVARILKDL GVSEVPMKVR KLVVKICDVV 400
    TRRAARLAAA GIAGILKKVG RDGSGGGRRS DKQIMRRTVV AVEGGLYLNY 450
    RMFREYMDEA LRDILGEDVA QHVVVKAMED GSSIGSALLL ASSQSVQTIP 500
    SV 502
    Length:502
    Mass (Da):54,955
    Last modified:October 31, 2006 - v2
    Checksum:i354D46773BA91199
    GO

    Sequence cautioni

    The sequence BAD93730.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti502 – 5021V → I in BAD93730. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP000383 Genomic DNA. Translation: BAB01861.1.
    CP002686 Genomic DNA. Translation: AEE76323.1.
    AK221726 mRNA. Translation: BAD93730.1. Different initiation.
    RefSeqiNP_188639.2. NM_112895.2.
    UniGeneiAt.50841.

    Genome annotation databases

    EnsemblPlantsiAT3G20040.1; AT3G20040.1; AT3G20040.
    GeneIDi821543.
    KEGGiath:AT3G20040.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP000383 Genomic DNA. Translation: BAB01861.1 .
    CP002686 Genomic DNA. Translation: AEE76323.1 .
    AK221726 mRNA. Translation: BAD93730.1 . Different initiation.
    RefSeqi NP_188639.2. NM_112895.2.
    UniGenei At.50841.

    3D structure databases

    ProteinModelPortali Q56XE8.
    SMRi Q56XE8. Positions 62-491.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 6875. 1 interaction.
    STRINGi 3702.AT3G20040.1-P.

    Proteomic databases

    PaxDbi Q56XE8.
    PRIDEi Q56XE8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT3G20040.1 ; AT3G20040.1 ; AT3G20040 .
    GeneIDi 821543.
    KEGGi ath:AT3G20040.

    Organism-specific databases

    GeneFarmi 4272. 430.
    TAIRi AT3G20040.

    Phylogenomic databases

    eggNOGi COG5026.
    HOGENOMi HOG000162670.
    InParanoidi Q56XE8.
    KOi K00844.
    OMAi GFNCAGV.
    PhylomeDBi Q56XE8.

    Enzyme and pathway databases

    BioCyci ARA:AT3G20040-MONOMER.

    Gene expression databases

    Genevestigatori Q56XE8.

    Family and domain databases

    InterProi IPR001312. Hexokinase.
    IPR022673. Hexokinase_C.
    IPR022672. Hexokinase_N.
    [Graphical view ]
    PANTHERi PTHR19443. PTHR19443. 1 hit.
    Pfami PF00349. Hexokinase_1. 1 hit.
    PF03727. Hexokinase_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00475. HEXOKINASE.
    ProtoNeti Search...

    Publicationsi

    1. "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC clones."
      Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.
      DNA Res. 7:217-221(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
      Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
      , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 18-502.
      Strain: cv. Columbia.
    4. "Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins."
      Heazlewood J.L., Tonti-Filippini J.S., Gout A.M., Day D.A., Whelan J., Millar A.H.
      Plant Cell 16:241-256(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Strain: cv. Landsberg erecta.

    Entry informationi

    Entry nameiHXK4_ARATH
    AccessioniPrimary (citable) accession number: Q56XE8
    Secondary accession number(s): Q9LJZ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: October 31, 2006
    Last modified: October 1, 2014
    This is version 69 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3