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Q56XE8

- HXK4_ARATH

UniProt

Q56XE8 - HXK4_ARATH

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Protein
Hexokinase-4
Gene
At3g20040, MAL21.4
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Fructose and glucose phosphorylating enzyme. May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol By similarity.

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi101 – 1066ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hexokinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT3G20040-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Hexokinase-4 (EC:2.7.1.1)
Gene namesi
Ordered Locus Names:At3g20040
ORF Names:MAL21.4
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G20040.

Subcellular locationi

Mitochondrion outer membrane; Single-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of mitochondrial outer membrane Source: TAIR
  2. mitochondrion Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 502502Hexokinase-4
PRO_0000259632Add
BLAST

Proteomic databases

PaxDbiQ56XE8.
PRIDEiQ56XE8.

Expressioni

Gene expression databases

GenevestigatoriQ56XE8.

Interactioni

Protein-protein interaction databases

BioGridi6875. 1 interaction.
STRINGi3702.AT3G20040.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ56XE8.
SMRiQ56XE8. Positions 62-491.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 235195Hexokinase type-1
Add
BLAST
Domaini248 – 491244Hexokinase type-2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni171 – 19727Glucose-binding Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the hexokinase family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5026.
HOGENOMiHOG000162670.
InParanoidiQ56XE8.
KOiK00844.
OMAiGFNCAGV.
PhylomeDBiQ56XE8.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.

Sequencei

Sequence statusi: Complete.

Q56XE8-1 [UniParc]FASTAAdd to Basket

« Hide

MGKVLVMLTA AAAVVACSVA TVMVRRRMKG RRKWRRVVGL LKDLEEACET    50
PLGRLRQMVD AIAVEMQAGL VSEGGSKLKM LLTFVDDLPN GSETGTYYAL 100
HLGGSYFRII KVHLGGQRSS LEVQDVERHS IPTSLMNSTS EVLFDFLASS 150
LQRFIEKEGN DFSLSQPLKR ELAFTFSFPV KQTSISSGVL IKWTKGFAIS 200
EMAGEDIAEC LQGALNKRGL DIRVAALVND TVGALSFGHF HDPDTIAAVV 250
FGTGSNACYL ERTDAIIKCQ NPRTTSGSMV VNMEWGNFWS SRLPRTSYDL 300
ELDAESMNSN DMGFEKMIGG MYLGDIVRRV ILRMSQESDI FGPISSILST 350
PFVLRTNSVS AMHEDDTSEL QEVARILKDL GVSEVPMKVR KLVVKICDVV 400
TRRAARLAAA GIAGILKKVG RDGSGGGRRS DKQIMRRTVV AVEGGLYLNY 450
RMFREYMDEA LRDILGEDVA QHVVVKAMED GSSIGSALLL ASSQSVQTIP 500
SV 502
Length:502
Mass (Da):54,955
Last modified:October 31, 2006 - v2
Checksum:i354D46773BA91199
GO

Sequence cautioni

The sequence BAD93730.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti502 – 5021V → I in BAD93730. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP000383 Genomic DNA. Translation: BAB01861.1.
CP002686 Genomic DNA. Translation: AEE76323.1.
AK221726 mRNA. Translation: BAD93730.1. Different initiation.
RefSeqiNP_188639.2. NM_112895.2.
UniGeneiAt.50841.

Genome annotation databases

EnsemblPlantsiAT3G20040.1; AT3G20040.1; AT3G20040.
GeneIDi821543.
KEGGiath:AT3G20040.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP000383 Genomic DNA. Translation: BAB01861.1 .
CP002686 Genomic DNA. Translation: AEE76323.1 .
AK221726 mRNA. Translation: BAD93730.1 . Different initiation.
RefSeqi NP_188639.2. NM_112895.2.
UniGenei At.50841.

3D structure databases

ProteinModelPortali Q56XE8.
SMRi Q56XE8. Positions 62-491.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 6875. 1 interaction.
STRINGi 3702.AT3G20040.1-P.

Proteomic databases

PaxDbi Q56XE8.
PRIDEi Q56XE8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G20040.1 ; AT3G20040.1 ; AT3G20040 .
GeneIDi 821543.
KEGGi ath:AT3G20040.

Organism-specific databases

GeneFarmi 4272. 430.
TAIRi AT3G20040.

Phylogenomic databases

eggNOGi COG5026.
HOGENOMi HOG000162670.
InParanoidi Q56XE8.
KOi K00844.
OMAi GFNCAGV.
PhylomeDBi Q56XE8.

Enzyme and pathway databases

BioCyci ARA:AT3G20040-MONOMER.

Gene expression databases

Genevestigatori Q56XE8.

Family and domain databases

InterProi IPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view ]
PANTHERi PTHR19443. PTHR19443. 1 hit.
Pfami PF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view ]
PRINTSi PR00475. HEXOKINASE.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC clones."
    Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.
    DNA Res. 7:217-221(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 18-502.
    Strain: cv. Columbia.
  4. "Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins."
    Heazlewood J.L., Tonti-Filippini J.S., Gout A.M., Day D.A., Whelan J., Millar A.H.
    Plant Cell 16:241-256(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Strain: cv. Landsberg erecta.

Entry informationi

Entry nameiHXK4_ARATH
AccessioniPrimary (citable) accession number: Q56XE8
Secondary accession number(s): Q9LJZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: June 11, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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