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Q56XE8 (HXK4_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hexokinase-4

EC=2.7.1.1
Gene names
Ordered Locus Names:At3g20040
ORF Names:MAL21.4
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length502 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Fructose and glucose phosphorylating enzyme. May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol By similarity.

Catalytic activity

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Subcellular location

Mitochondrion outer membrane; Single-pass membrane protein Ref.4.

Sequence similarities

Belongs to the hexokinase family.

Contains 1 hexokinase type-1 domain.

Contains 1 hexokinase type-2 domain.

Sequence caution

The sequence BAD93730.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 502502Hexokinase-4
PRO_0000259632

Regions

Transmembrane4 – 2421Helical; Potential
Domain41 – 235195Hexokinase type-1
Domain248 – 491244Hexokinase type-2
Nucleotide binding101 – 1066ATP Potential
Region171 – 19727Glucose-binding Potential

Experimental info

Sequence conflict5021V → I in BAD93730. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q56XE8 [UniParc].

Last modified October 31, 2006. Version 2.
Checksum: 354D46773BA91199

FASTA50254,955
        10         20         30         40         50         60 
MGKVLVMLTA AAAVVACSVA TVMVRRRMKG RRKWRRVVGL LKDLEEACET PLGRLRQMVD 

        70         80         90        100        110        120 
AIAVEMQAGL VSEGGSKLKM LLTFVDDLPN GSETGTYYAL HLGGSYFRII KVHLGGQRSS 

       130        140        150        160        170        180 
LEVQDVERHS IPTSLMNSTS EVLFDFLASS LQRFIEKEGN DFSLSQPLKR ELAFTFSFPV 

       190        200        210        220        230        240 
KQTSISSGVL IKWTKGFAIS EMAGEDIAEC LQGALNKRGL DIRVAALVND TVGALSFGHF 

       250        260        270        280        290        300 
HDPDTIAAVV FGTGSNACYL ERTDAIIKCQ NPRTTSGSMV VNMEWGNFWS SRLPRTSYDL 

       310        320        330        340        350        360 
ELDAESMNSN DMGFEKMIGG MYLGDIVRRV ILRMSQESDI FGPISSILST PFVLRTNSVS 

       370        380        390        400        410        420 
AMHEDDTSEL QEVARILKDL GVSEVPMKVR KLVVKICDVV TRRAARLAAA GIAGILKKVG 

       430        440        450        460        470        480 
RDGSGGGRRS DKQIMRRTVV AVEGGLYLNY RMFREYMDEA LRDILGEDVA QHVVVKAMED 

       490        500 
GSSIGSALLL ASSQSVQTIP SV 

« Hide

References

« Hide 'large scale' references
[1]"Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC clones."
Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.
DNA Res. 7:217-221(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K. expand/collapse author list , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 18-502.
Strain: cv. Columbia.
[4]"Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins."
Heazlewood J.L., Tonti-Filippini J.S., Gout A.M., Day D.A., Whelan J., Millar A.H.
Plant Cell 16:241-256(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
Strain: cv. Landsberg erecta.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP000383 Genomic DNA. Translation: BAB01861.1.
CP002686 Genomic DNA. Translation: AEE76323.1.
AK221726 mRNA. Translation: BAD93730.1. Different initiation.
RefSeqNP_188639.2. NM_112895.2.
UniGeneAt.50841.

3D structure databases

ProteinModelPortalQ56XE8.
SMRQ56XE8. Positions 62-491.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid6875. 1 interaction.
STRING3702.AT3G20040.1-P.

Proteomic databases

PaxDbQ56XE8.
PRIDEQ56XE8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT3G20040.1; AT3G20040.1; AT3G20040.
GeneID821543.
KEGGath:AT3G20040.

Organism-specific databases

GeneFarm4272. 430.
TAIRAT3G20040.

Phylogenomic databases

eggNOGCOG5026.
HOGENOMHOG000162670.
InParanoidQ56XE8.
KOK00844.
OMAQIMDELG.
PhylomeDBQ56XE8.
ProtClustDBPLN02362.

Enzyme and pathway databases

BioCycARA:AT3G20040-MONOMER.

Gene expression databases

GenevestigatorQ56XE8.

Family and domain databases

InterProIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERPTHR19443. PTHR19443. 1 hit.
PfamPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSPR00475. HEXOKINASE.
ProtoNetSearch...

Entry information

Entry nameHXK4_ARATH
AccessionPrimary (citable) accession number: Q56XE8
Secondary accession number(s): Q9LJZ7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: April 16, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names