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Protein

Phosphoinositide phospholipase C 3

Gene

PLC3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.1 Publication

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei121PROSITE-ProRule annotation1
Active sitei167PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Transducer
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

BioCyciARA:AT4G38530-MONOMER
BRENDAi3.1.4.11 399
ReactomeiR-ATH-112043 PLC beta mediated events
R-ATH-114604 GPVI-mediated activation cascade
R-ATH-1855204 Synthesis of IP3 and IP4 in the cytosol
R-ATH-202433 Generation of second messenger molecules
R-ATH-399997 Acetylcholine regulates insulin secretion
R-ATH-416476 G alpha (q) signalling events
R-ATH-434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
R-ATH-5607764 CLEC7A (Dectin-1) signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide phospholipase C 3 (EC:3.1.4.11)
Alternative name(s):
Phosphoinositide phospholipase PLC3
Short name:
AtPLC1F
Short name:
AtPLC3
Short name:
PI-PLC3
Gene namesi
Name:PLC3
Synonyms:ATPLC1
Ordered Locus Names:At4g38530
ORF Names:F20M13.90
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G38530
TAIRilocus:2121239 AT4G38530

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003241281 – 564Phosphoinositide phospholipase C 3Add BLAST564

Proteomic databases

PaxDbiQ56W08
PRIDEiQ56W08

Expressioni

Tissue specificityi

Expressed in leaves, roots and siliques, but not in flowers.1 Publication

Inductioni

Not induced by environmental stresses such as dehydration, salinity and low temperature.

Gene expression databases

ExpressionAtlasiQ56W08 differential
GenevisibleiQ56W08 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G38530.1

Structurei

3D structure databases

ProteinModelPortaliQ56W08
SMRiQ56W08
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 54EF-handAdd BLAST36
Domaini106 – 250PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST145
Domaini296 – 412PI-PLC Y-boxPROSITE-ProRule annotationAdd BLAST117
Domaini415 – 523C2PROSITE-ProRule annotationAdd BLAST109

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi67 – 82His-richAdd BLAST16

Phylogenomic databases

eggNOGiKOG0169 Eukaryota
ENOG410XPSW LUCA
HOGENOMiHOG000244119
InParanoidiQ56W08
KOiK05857
OMAiNDTQNDF
OrthoDBiEOG0936050V
PhylomeDBiQ56W08

Family and domain databases

Gene3Di2.60.40.150, 1 hit
3.20.20.190, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011992 EF-hand-dom_pair
IPR001192 PI-PLC_fam
IPR017946 PLC-like_Pdiesterase_TIM-brl
IPR000909 PLipase_C_PInositol-sp_X_dom
IPR001711 PLipase_C_Pinositol-sp_Y
PANTHERiPTHR10336 PTHR10336, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF00388 PI-PLC-X, 1 hit
PF00387 PI-PLC-Y, 1 hit
PRINTSiPR00390 PHPHLIPASEC
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00148 PLCXc, 1 hit
SM00149 PLCYc, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF51695 SSF51695, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS50007 PIPLC_X_DOMAIN, 1 hit
PS50008 PIPLC_Y_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q56W08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSESFKVCFC CSRSFKEKTR QPPVSIKRLF EAYSRNGKMS FDELLRFVSE
60 70 80 90 100
VQGERHAGLD YVQDIFHSVK HHNVFHHHGL VHLNAFYRYL FSDTNSPLPM
110 120 130 140 150
SGQVHHDMKA PLSHYFVYTG HNSYLTGNQV NSRSSVEPIV QALRKGVKVI
160 170 180 190 200
ELDLWPNPSG NAAEVRHGRT LTSHEDLQKC LTAIKDNAFH VSDYPVIITL
210 220 230 240 250
EDHLPPKLQA QVAKMLTKTY RGMLFRRVSE SFKHFPSPEE LKGKILISTK
260 270 280 290 300
PPKEYLESKT VHTTRTPTVK ETSWNRVANK ILEEYKDMES EAVGYRDLIA
310 320 330 340 350
IHAANCKDPS KDCLSDDPEK PIRVSMDEQW LDTMVRTRGT DLVRFTQRNL
360 370 380 390 400
VRIYPKGTRV DSSNYDPHVG WTHGAQMVAF NMQGHGKQLW IMQGMFRGNG
410 420 430 440 450
GCGYVKKPRI LLDEHTLFDP CKRFPIKTTL KVKIYTGEGW DLDFHHTHFD
460 470 480 490 500
QYSPPDFFVK IGIAGVPRDT VSYRTETAVD QWFPIWGNDE FLFQLSVPEL
510 520 530 540 550
ALLWFKVQDY DNDTQNDFAG QTCLPLPELK SGVRAVRLHD RTGKAYKNTR
560
LLVSFALDPP YTFR
Length:564
Mass (Da):64,944
Last modified:May 10, 2005 - v1
Checksum:i6EA1067C8864345A
GO

Sequence cautioni

The sequence AAC48991 differs from that shown. Reason: Frameshift at positions 535 and 543.Curated
The sequence AAC48991 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAB37509 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB80517 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti526L → R in AAC48991 (PubMed:7716237).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035540 Genomic DNA Translation: CAB37509.1 Sequence problems.
AL161593 Genomic DNA Translation: CAB80517.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE86943.1
AK222239 mRNA Translation: BAD95426.1
U13203 mRNA Translation: AAC48991.1 Sequence problems.
PIRiT05681
RefSeqiNP_195565.2, NM_120014.5
UniGeneiAt.2775

Genome annotation databases

EnsemblPlantsiAT4G38530.1; AT4G38530.1; AT4G38530
GeneIDi830010
GrameneiAT4G38530.1; AT4G38530.1; AT4G38530
KEGGiath:AT4G38530

Similar proteinsi

Entry informationi

Entry nameiPLCD3_ARATH
AccessioniPrimary (citable) accession number: Q56W08
Secondary accession number(s): Q38811, Q9SZN3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 10, 2005
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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