Q56VN0 (Q56VN0_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Inward rectifying potassium channel Kir4.1 EMBL AAQ82707.1

Gene names

Name:

Kcnj10 MGI 1194504

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	379 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein By similarity RuleBase RU003822.
Sequence similarities	Belongs to the inward rectifier-type potassium channel family. RuleBase RU003822

Ontologies

Keywords
Biological process	Ion transport Potassium transport SAAS SAAS013518 RuleBase RU003822 Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix SAAS SAAS013518
Ligand	Potassium
Molecular function	Ion channel Voltage-gated channel SAAS SAAS013518 RuleBase RU003822
Gene Ontology (GO)
Biological_process	L-glutamate uptake involved in synaptic transmission Inferred from mutant phenotype PubMed 17942730. Source: MGI adult walking behavior Inferred from mutant phenotype PubMed 10908613PubMed 17942730. Source: MGI central nervous system myelination Inferred from mutant phenotype PubMed 17942730. Source: MGI inflammatory response Inferred from electronic annotation. Source: Compara membrane hyperpolarization Inferred from electronic annotation. Source: Compara optic nerve development Inferred from electronic annotation. Source: Compara potassium ion homeostasis Inferred from mutant phenotype PubMed 16306174PubMed 17942730. Source: MGI potassium ion import Inferred from electronic annotation. Source: Compara protein homotetramerization Inferred from electronic annotation. Source: Compara regulation of long-term neuronal synaptic plasticity Inferred from mutant phenotype PubMed 17942730. Source: MGI regulation of resting membrane potential Inferred from mutant phenotype PubMed 10908613PubMed 16306174PubMed 17942730. Source: MGI regulation of sensory perception of pain Inferred from electronic annotation. Source: Compara response to blue light Inferred from electronic annotation. Source: Compara response to glucocorticoid stimulus Inferred from electronic annotation. Source: Compara response to mineralocorticoid stimulus Inferred from electronic annotation. Source: Compara visual perception Inferred from mutant phenotype PubMed 10908613PubMed 15359216. Source: MGI
Cellular_component	apical plasma membrane Inferred from electronic annotation. Source: Compara basolateral plasma membrane Inferred from direct assay PubMed 20651251. Source: MGI dystrophin-associated glycoprotein complex Inferred from electronic annotation. Source: Compara integral to plasma membrane Inferred by curator PubMed 9647694. Source: MGI microvillus Inferred from electronic annotation. Source: Compara
Molecular_function	inward rectifier potassium channel activity Inferred from mutant phenotype PubMed 19515915PubMed 20074622. Source: MGI
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q56VN0 [UniParc]. Last modified May 10, 2005. Version 1. Checksum: 7FF08446B7F43453	FASTA	379	42,432
	10 20 30 40 50 60 MTSVAKVYYS QTTQTESRPL VAPGIRRRRV LTKDGRSNVR MEHIADKRFL YLKDLWTTFI 70 80 90 100 110 120 DMQWRYKLLL FSATFAGTWF LFGVVWYLVA VAHGDLLELG PPANHTPCVV QVHTLTGAFL 130 140 150 160 170 180 FSLESQTTIG YGFRYISEEC PLAIVLLIAQ LVLTTILEIF ITGTFLAKIA RPKKRAETIR 190 200 210 220 230 240 FSQHAVVASH NGKPCLMIRV ANMRKSLLIG CQVTGKLLQT HQTKEGENIR LNQVNVTFQV 250 260 270 280 290 300 DTASDSPFLI LPLTFYHVVD ETSPLKDLPL RSGEGDFELV LILSGTVEST SATCQVRTSY 310 320 330 340 350 360 LPEEILWGYE FTPAISLSAS GKYIADFSLF DQVVKVASPS GLRDSTVRYG DPEKLKLEES 370 LREQAEKEGS ALSVRISNV

References

[1]	"High-efficiency full-length cDNA cloning." Carninci P., Hayashizaki Y. Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC32016.1. Tissue: Retina EMBL BAC32016.1.
[2]	"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes." Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y. Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC32016.1. Tissue: Retina EMBL BAC32016.1.
[3]	"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer." Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y. Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC32016.1. Tissue: Retina EMBL BAC32016.1.
[4]	"Functional annotation of a full-length mouse cDNA collection." The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium Nature 409:685-690(2001) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC32016.1. Tissue: Retina EMBL BAC32016.1.
[5]	Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K. , Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC32016.1. Tissue: Retina EMBL BAC32016.1.
[6]	"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs." The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team Nature 420:563-573(2002) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC32016.1. Tissue: Retina EMBL BAC32016.1.
[7]	"Functional consequences of polyamine synthesis inhibition by L-alpha-difluoromethylornithine (DFMO): cellular mechanisms for DFMO-mediated ototoxicity." Nie L., Feng W., Diaz R., Gratton M.A., Doyle K.J., Yamoah E.N. J. Biol. Chem. 280:15097-15102(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL EMBL AAQ82707.1. Tissue: Cochlea EMBL AAQ82707.1.
[8]	"The Transcriptional Landscape of the Mammalian Genome." The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) Science 309:1559-1563(2005) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC32016.1. Tissue: Retina EMBL BAC32016.1.
[9]	"Antisense Transcription in the Mammalian Transcriptome." RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC32016.1. Tissue: Retina EMBL BAC32016.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY374423 mRNA. Translation: AAQ82707.1. AK044640 mRNA. Translation: BAC32016.1.
IPI	IPI00124792.
RefSeq	NP_001034573.1. NM_001039484.1.
UniGene	Mm.254563.
3D structure databases
SMR	Q56VN0. Positions 27-339.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	16513.
KEGG	mmu:16513.
UCSC	uc007dqj.1. mouse.
Organism-specific databases
CTD	3766.
MGI	MGI:1194504. Kcnj10.
Phylogenomic databases
HOVERGEN	HBG006178.
InParanoid	Q56VN0.
KO	K05003.
OMA	LGPPANH.
Gene expression databases
Genevestigator	Q56VN0.
Family and domain databases
Gene3D	2.60.40.1400. 1 hit.
InterPro	IPR014756. Ig_E-set. IPR016449. K_chnl_inward-rec_Kir. IPR003269. K_chnl_inward-rec_Kir1.2. IPR013518. K_chnl_inward-rec_Kir_cyto. [Graphical view]
PANTHER	PTHR11767. PTHR11767. 1 hit. PTHR11767:SF21. PTHR11767:SF21. 1 hit.
Pfam	PF01007. IRK. 1 hit. [Graphical view]
PIRSF	PIRSF005465. GIRK_kir. 1 hit.
PRINTS	PR01322. KIR12CHANNEL. PR01320. KIRCHANNEL.
SUPFAM	SSF81296. Ig_E-set. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	KCNJ10. mouse.
NextBio	289861.
SOURCE	Search...

Entry information

Entry name

Q56VN0_MOUSE

Accession

Primary (citable) accession number: Q56VN0

Entry history

Integrated into UniProtKB/TrEMBL:	May 10, 2005
Last sequence update:	May 10, 2005
Last modified:	May 1, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)