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Q56VN0

- Q56VN0_MOUSE

UniProt

Q56VN0 - Q56VN0_MOUSE

Protein
Submitted name:

Inward rectifying potassium channel Kir4.1

Gene

Kcnj10

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. inward rectifier potassium channel activity Source: MGI
    2. potassium channel activity Source: MGI
    3. protein binding Source: MGI

    GO - Biological processi

    1. adult walking behavior Source: MGI
    2. central nervous system myelination Source: MGI
    3. inflammatory response Source: Ensembl
    4. L-glutamate uptake involved in synaptic transmission Source: MGI
    5. membrane hyperpolarization Source: Ensembl
    6. oligodendrocyte development Source: MGI
    7. optic nerve development Source: Ensembl
    8. potassium ion homeostasis Source: MGI
    9. potassium ion import Source: Ensembl
    10. potassium ion transmembrane transport Source: MGI
    11. potassium ion transport Source: MGI
    12. protein homotetramerization Source: Ensembl
    13. regulation of long-term neuronal synaptic plasticity Source: MGI
    14. regulation of membrane potential Source: MGI
    15. regulation of resting membrane potential Source: MGI
    16. regulation of sensory perception of pain Source: Ensembl
    17. response to blue light Source: Ensembl
    18. response to glucocorticoid Source: Ensembl
    19. response to mineralocorticoid Source: Ensembl
    20. visual perception Source: MGI

    Keywords - Molecular functioni

    Ion channel, Voltage-gated channelUniRule annotationSAAS annotation

    Keywords - Biological processi

    Ion transport, Potassium transportUniRule annotationSAAS annotation, Transport

    Keywords - Ligandi

    Potassium

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Inward rectifying potassium channel Kir4.1Imported
    Gene namesi
    Name:Kcnj10Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:1194504. Kcnj10.

    Subcellular locationi

    Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. basolateral plasma membrane Source: MGI
    3. dystrophin-associated glycoprotein complex Source: Ensembl
    4. integral component of plasma membrane Source: MGI
    5. microvillus Source: Ensembl
    6. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    Expressioni

    Gene expression databases

    GenevestigatoriQ56VN0.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the inward rectifier-type potassium channel family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG006178.
    InParanoidiQ56VN0.
    KOiK05003.
    OMAiFYHVVDD.

    Family and domain databases

    Gene3Di2.60.40.1400. 1 hit.
    InterProiIPR014756. Ig_E-set.
    IPR016449. K_chnl_inward-rec_Kir.
    IPR003269. K_chnl_inward-rec_Kir1.2.
    IPR013518. K_chnl_inward-rec_Kir_cyto.
    [Graphical view]
    PANTHERiPTHR11767. PTHR11767. 1 hit.
    PTHR11767:SF21. PTHR11767:SF21. 1 hit.
    PfamiPF01007. IRK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005465. GIRK_kir. 1 hit.
    PRINTSiPR01322. KIR12CHANNEL.
    PR01320. KIRCHANNEL.
    SUPFAMiSSF81296. SSF81296. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q56VN0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSVAKVYYS QTTQTESRPL VAPGIRRRRV LTKDGRSNVR MEHIADKRFL    50
    YLKDLWTTFI DMQWRYKLLL FSATFAGTWF LFGVVWYLVA VAHGDLLELG 100
    PPANHTPCVV QVHTLTGAFL FSLESQTTIG YGFRYISEEC PLAIVLLIAQ 150
    LVLTTILEIF ITGTFLAKIA RPKKRAETIR FSQHAVVASH NGKPCLMIRV 200
    ANMRKSLLIG CQVTGKLLQT HQTKEGENIR LNQVNVTFQV DTASDSPFLI 250
    LPLTFYHVVD ETSPLKDLPL RSGEGDFELV LILSGTVEST SATCQVRTSY 300
    LPEEILWGYE FTPAISLSAS GKYIADFSLF DQVVKVASPS GLRDSTVRYG 350
    DPEKLKLEES LREQAEKEGS ALSVRISNV 379
    Length:379
    Mass (Da):42,432
    Last modified:May 10, 2005 - v1
    Checksum:i7FF08446B7F43453
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY374423 mRNA. Translation: AAQ82707.1.
    AK044640 mRNA. Translation: BAC32016.1.
    RefSeqiNP_001034573.1. NM_001039484.1.
    UniGeneiMm.254563.

    Genome annotation databases

    GeneIDi16513.
    KEGGimmu:16513.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY374423 mRNA. Translation: AAQ82707.1 .
    AK044640 mRNA. Translation: BAC32016.1 .
    RefSeqi NP_001034573.1. NM_001039484.1.
    UniGenei Mm.254563.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 16513.
    KEGGi mmu:16513.

    Organism-specific databases

    CTDi 3766.
    MGIi MGI:1194504. Kcnj10.

    Phylogenomic databases

    HOVERGENi HBG006178.
    InParanoidi Q56VN0.
    KOi K05003.
    OMAi FYHVVDD.

    Miscellaneous databases

    ChiTaRSi KCNJ10. mouse.
    NextBioi 289861.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q56VN0.

    Family and domain databases

    Gene3Di 2.60.40.1400. 1 hit.
    InterProi IPR014756. Ig_E-set.
    IPR016449. K_chnl_inward-rec_Kir.
    IPR003269. K_chnl_inward-rec_Kir1.2.
    IPR013518. K_chnl_inward-rec_Kir_cyto.
    [Graphical view ]
    PANTHERi PTHR11767. PTHR11767. 1 hit.
    PTHR11767:SF21. PTHR11767:SF21. 1 hit.
    Pfami PF01007. IRK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005465. GIRK_kir. 1 hit.
    PRINTSi PR01322. KIR12CHANNEL.
    PR01320. KIRCHANNEL.
    SUPFAMi SSF81296. SSF81296. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: RetinaImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: RetinaImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: RetinaImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: RetinaImported.
    5. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: RetinaImported.
    6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: RetinaImported.
    7. "Functional consequences of polyamine synthesis inhibition by L-alpha-difluoromethylornithine (DFMO): cellular mechanisms for DFMO-mediated ototoxicity."
      Nie L., Feng W., Diaz R., Gratton M.A., Doyle K.J., Yamoah E.N.
      J. Biol. Chem. 280:15097-15102(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BLImported.
      Tissue: CochleaImported.
    8. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: RetinaImported.
    9. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: RetinaImported.

    Entry informationi

    Entry nameiQ56VN0_MOUSE
    AccessioniPrimary (citable) accession number: Q56VN0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 10, 2005
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)