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Q56VN0 (Q56VN0_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Kcnj10 MGI 1194504
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length379 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein By similarity RuleBase RU003822.

Sequence similarities

Belongs to the inward rectifier-type potassium channel family. RuleBase RU003822

Ontologies

Keywords
   Biological processIon transport
Potassium transport SAAS SAAS013518 RuleBase RU003822
Transport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix SAAS SAAS013518
   LigandPotassium
   Molecular functionIon channel
Voltage-gated channel SAAS SAAS013518 RuleBase RU003822
Gene Ontology (GO)
   Biological_processL-glutamate uptake involved in synaptic transmission

Inferred from mutant phenotype PubMed 17942730. Source: MGI

adult walking behavior

Inferred from mutant phenotype PubMed 10908613PubMed 17942730. Source: MGI

central nervous system myelination

Inferred from mutant phenotype PubMed 17942730. Source: MGI

inflammatory response

Inferred from electronic annotation. Source: Ensembl

membrane hyperpolarization

Inferred from electronic annotation. Source: Ensembl

oligodendrocyte development

Inferred from mutant phenotype PubMed 17942730. Source: MGI

optic nerve development

Inferred from electronic annotation. Source: Ensembl

potassium ion homeostasis

Inferred from mutant phenotype PubMed 16306174PubMed 17942730. Source: MGI

potassium ion import

Inferred from electronic annotation. Source: Ensembl

potassium ion transmembrane transport

Inferred from mutant phenotype PubMed 10908613PubMed 17869537PubMed 19515915PubMed 20074622. Source: MGI

potassium ion transport

Inferred from direct assay PubMed 9647694. Source: MGI

protein homotetramerization

Inferred from electronic annotation. Source: Ensembl

regulation of long-term neuronal synaptic plasticity

Inferred from mutant phenotype PubMed 17942730. Source: MGI

regulation of membrane potential

Inferred from mutant phenotype PubMed 19515915PubMed 20074622. Source: MGI

regulation of resting membrane potential

Inferred from mutant phenotype PubMed 10908613PubMed 16306174PubMed 17942730. Source: MGI

regulation of sensory perception of pain

Inferred from electronic annotation. Source: Ensembl

response to blue light

Inferred from electronic annotation. Source: Ensembl

response to glucocorticoid

Inferred from electronic annotation. Source: Ensembl

response to mineralocorticoid

Inferred from electronic annotation. Source: Ensembl

visual perception

Inferred from mutant phenotype PubMed 10908613PubMed 15359216. Source: MGI

   Cellular_componentapical plasma membrane

Inferred from electronic annotation. Source: Ensembl

basolateral plasma membrane

Inferred from direct assay PubMed 20651251. Source: MGI

dystrophin-associated glycoprotein complex

Inferred from electronic annotation. Source: Ensembl

integral component of plasma membrane

Inferred by curator PubMed 9647694. Source: MGI

microvillus

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from direct assay PubMed 15310750. Source: MGI

   Molecular_functioninward rectifier potassium channel activity

Inferred from mutant phenotype PubMed 19515915PubMed 20074622. Source: MGI

potassium channel activity

Inferred from direct assay PubMed 9647694. Source: MGI

protein binding

Inferred from physical interaction PubMed 15310750PubMed 9647694. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q56VN0 [UniParc].

Last modified May 10, 2005. Version 1.
Checksum: 7FF08446B7F43453

FASTA37942,432
        10         20         30         40         50         60 
MTSVAKVYYS QTTQTESRPL VAPGIRRRRV LTKDGRSNVR MEHIADKRFL YLKDLWTTFI 

        70         80         90        100        110        120 
DMQWRYKLLL FSATFAGTWF LFGVVWYLVA VAHGDLLELG PPANHTPCVV QVHTLTGAFL 

       130        140        150        160        170        180 
FSLESQTTIG YGFRYISEEC PLAIVLLIAQ LVLTTILEIF ITGTFLAKIA RPKKRAETIR 

       190        200        210        220        230        240 
FSQHAVVASH NGKPCLMIRV ANMRKSLLIG CQVTGKLLQT HQTKEGENIR LNQVNVTFQV 

       250        260        270        280        290        300 
DTASDSPFLI LPLTFYHVVD ETSPLKDLPL RSGEGDFELV LILSGTVEST SATCQVRTSY 

       310        320        330        340        350        360 
LPEEILWGYE FTPAISLSAS GKYIADFSLF DQVVKVASPS GLRDSTVRYG DPEKLKLEES 

       370 
LREQAEKEGS ALSVRISNV 

« Hide

References

[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC32016.1.
Tissue: Retina EMBL BAC32016.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC32016.1.
Tissue: Retina EMBL BAC32016.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC32016.1.
Tissue: Retina EMBL BAC32016.1.
[4]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC32016.1.
Tissue: Retina EMBL BAC32016.1.
[5]Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K. expand/collapse author list , Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC32016.1.
Tissue: Retina EMBL BAC32016.1.
[6]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC32016.1.
Tissue: Retina EMBL BAC32016.1.
[7]"Functional consequences of polyamine synthesis inhibition by L-alpha-difluoromethylornithine (DFMO): cellular mechanisms for DFMO-mediated ototoxicity."
Nie L., Feng W., Diaz R., Gratton M.A., Doyle K.J., Yamoah E.N.
J. Biol. Chem. 280:15097-15102(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL EMBL AAQ82707.1.
Tissue: Cochlea EMBL AAQ82707.1.
[8]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC32016.1.
Tissue: Retina EMBL BAC32016.1.
[9]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC32016.1.
Tissue: Retina EMBL BAC32016.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY374423 mRNA. Translation: AAQ82707.1.
AK044640 mRNA. Translation: BAC32016.1.
RefSeqNP_001034573.1. NM_001039484.1.
UniGeneMm.254563.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID16513.
KEGGmmu:16513.

Organism-specific databases

CTD3766.
MGIMGI:1194504. Kcnj10.

Phylogenomic databases

HOVERGENHBG006178.
InParanoidQ56VN0.
KOK05003.
OMAFYHVVDD.

Gene expression databases

GenevestigatorQ56VN0.

Family and domain databases

Gene3D2.60.40.1400. 1 hit.
InterProIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003269. K_chnl_inward-rec_Kir1.2.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERPTHR11767. PTHR11767. 1 hit.
PTHR11767:SF21. PTHR11767:SF21. 1 hit.
PfamPF01007. IRK. 1 hit.
[Graphical view]
PIRSFPIRSF005465. GIRK_kir. 1 hit.
PRINTSPR01322. KIR12CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMSSF81296. SSF81296. 1 hit.
ProtoNetSearch...

Other

ChiTaRSKCNJ10. mouse.
NextBio289861.
SOURCESearch...

Entry information

Entry nameQ56VN0_MOUSE
AccessionPrimary (citable) accession number: Q56VN0
Entry history
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: June 11, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)