Q56VL3 (OCAD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
OCIA domain-containing protein 2

Alternative name(s):
Ovarian carcinoma immunoreactive antigen-like protein

Gene names

Name:

OCIAD2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	154 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Endosome Probable.
Sequence similarities	Contains 1 OCIA domain.

Ontologies

Keywords
Cellular component	Endosome
Coding sequence diversity	Alternative splicing Polymorphism
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	endosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q56VL3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q56VL3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     89-154: LAGLLGFGLG...EKGDSQPSAS → RTASLPVRNAK

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 154	154	OCIA domain-containing protein 2		PRO_0000299392
Regions
	Domain	1 – 120	120	OCIA
Amino acid modifications
	Modified residue	41	1	N6-acetyllysine Ref.6
Natural variations
	Alternative sequence	89 – 154	66	LAGLL…QPSAS → RTASLPVRNAK in isoform 2.		VSP_027626
	Natural variant	44	1	R → Q. Corresponds to variant rs7676916 [ dbSNP | Ensembl ].		VAR_053950

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 10, 2005. Version 1. Checksum: B2278F751BA03A3E	FASTA	154	16,954
	10 20 30 40 50 60 MASASARGNQ DKDAHFPPPS KQSLLFCPKS KLHIHRAEIS KIMRECQEES FWKRALPFSL 70 80 90 100 110 120 VSMLVTQGLV YQGYLAANSR FGSLPKVALA GLLGFGLGKV SYIGVCQSKF HFFEDQLRGA 130 140 150 GFGPQHNRHC LLTCEECKIK HGLSEKGDSQ PSAS
	Isoform 2 [UniParc]. Checksum: 7DC87F06B4F35084	FASTA	99	11,030
	10 20 30 40 50 60 MASASARGNQ DKDAHFPPPS KQSLLFCPKS KLHIHRAEIS KIMRECQEES FWKRALPFSL 70 80 90 VSMLVTQGLV YQGYLAANSR FGSLPKVART ASLPVRNAK

References

[1]	Zhang J., Wu M., Mao Y., Xie Y. Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Kidney.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Uterine endothelium.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Kidney.
[6]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-41, MASS SPECTROMETRY.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY472117 mRNA. Translation: AAS47684.1. AK298305 mRNA. Translation: BAG60559.1. CR749310 mRNA. Translation: CAH18165.1. CH471069 Genomic DNA. Translation: EAW93077.1. CH471069 Genomic DNA. Translation: EAW93075.1. BC032808 mRNA. Translation: AAH32808.1.
IPI	IPI00181546. IPI00555902.
RefSeq	NP_001014446.1. NM_001014446.1. NP_689611.1. NM_152398.2.
UniGene	Hs.95835.
3D structure databases
ProteinModelPortal	Q56VL3.
ModBase	Search...
Protein-protein interaction databases
STRING	Q56VL3.
PTM databases
PhosphoSite	Q56VL3.
Polymorphism databases
DMDM	74741044.
Proteomic databases
PeptideAtlas	Q56VL3.
PRIDE	Q56VL3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000381464; ENSP00000370873; ENSG00000145247.
GeneID	132299.
KEGG	hsa:132299.
UCSC	uc003gyt.1. human. uc003gyu.1. human.
Organism-specific databases
CTD	132299.
GeneCards	GC04M048887.
H-InvDB	HIX0004203.
HGNC	HGNC:28685. OCIAD2.
HPA	HPA040979. HPA041090.
neXtProt	NX_Q56VL3.
PharmGKB	PA128394755.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG07148.
GeneTree	ENSGT00530000063690.
HOGENOM	HBG714580.
HOVERGEN	HBG054610.
InParanoid	Q56VL3.
OMA	PKSKLHI.
OrthoDB	EOG4BCDP6.
PhylomeDB	Q56VL3.
Gene expression databases
ArrayExpress	Q56VL3.
Bgee	Q56VL3.
CleanEx	HS_OCIAD2.
Genevestigator	Q56VL3.
Family and domain databases
InterPro	IPR009764. OCIA. [Graphical view]
PANTHER	PTHR13336. OCIA. 1 hit.
Pfam	PF07051. OCIA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	83073.

Entry information

Entry name

OCAD2_HUMAN

Accession

Primary (citable) accession number: Q56VL3
Secondary accession number(s): B4DPE7, Q8N544

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	May 10, 2005
Last modified:	January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.