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Protein

OCIA domain-containing protein 2

Gene

OCIAD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
OCIA domain-containing protein 2
Alternative name(s):
Ovarian carcinoma immunoreactive antigen-like protein
Gene namesi
Name:OCIAD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:28685. OCIAD2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394755.

Polymorphism and mutation databases

DMDMi74741044.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 154154OCIA domain-containing protein 2PRO_0000299392Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei41 – 411N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ56VL3.
MaxQBiQ56VL3.
PaxDbiQ56VL3.
PeptideAtlasiQ56VL3.
PRIDEiQ56VL3.

PTM databases

iPTMnetiQ56VL3.
PhosphoSiteiQ56VL3.
SwissPalmiQ56VL3.

Expressioni

Gene expression databases

BgeeiQ56VL3.
CleanExiHS_OCIAD2.
ExpressionAtlasiQ56VL3. baseline and differential.
GenevisibleiQ56VL3. HS.

Organism-specific databases

HPAiHPA040979.
HPA041090.

Interactioni

Protein-protein interaction databases

BioGridi126317. 4 interactions.
IntActiQ56VL3. 3 interactions.
STRINGi9606.ENSP00000423014.

Structurei

3D structure databases

ProteinModelPortaliQ56VL3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 120120OCIAAdd
BLAST

Sequence similaritiesi

Contains 1 OCIA domain.Curated

Phylogenomic databases

eggNOGiENOG410J13G. Eukaryota.
ENOG4111YF8. LUCA.
GeneTreeiENSGT00530000063690.
HOVERGENiHBG054610.
InParanoidiQ56VL3.
OMAiQSKFHSF.
OrthoDBiEOG78PVD4.
PhylomeDBiQ56VL3.
TreeFamiTF327106.

Family and domain databases

InterProiIPR009764. OCIA.
[Graphical view]
PANTHERiPTHR13336. PTHR13336. 1 hit.
PfamiPF07051. OCIA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q56VL3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASASARGNQ DKDAHFPPPS KQSLLFCPKS KLHIHRAEIS KIMRECQEES
60 70 80 90 100
FWKRALPFSL VSMLVTQGLV YQGYLAANSR FGSLPKVALA GLLGFGLGKV
110 120 130 140 150
SYIGVCQSKF HFFEDQLRGA GFGPQHNRHC LLTCEECKIK HGLSEKGDSQ

PSAS
Length:154
Mass (Da):16,954
Last modified:May 10, 2005 - v1
Checksum:iB2278F751BA03A3E
GO
Isoform 2 (identifier: Q56VL3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-154: LAGLLGFGLG...EKGDSQPSAS → RTASLPVRNAK

Show »
Length:99
Mass (Da):11,030
Checksum:i7DC87F06B4F35084
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti44 – 441R → Q.
Corresponds to variant rs7676916 [ dbSNP | Ensembl ].
VAR_053950

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei89 – 15466LAGLL…QPSAS → RTASLPVRNAK in isoform 2. 2 PublicationsVSP_027626Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY472117 mRNA. Translation: AAS47684.1.
AK298305 mRNA. Translation: BAG60559.1.
CR749310 mRNA. Translation: CAH18165.1.
CH471069 Genomic DNA. Translation: EAW93077.1.
CH471069 Genomic DNA. Translation: EAW93075.1.
BC032808 mRNA. Translation: AAH32808.1.
CCDSiCCDS33981.1. [Q56VL3-1]
CCDS3485.1. [Q56VL3-2]
RefSeqiNP_001014446.1. NM_001014446.2. [Q56VL3-1]
NP_001273702.1. NM_001286773.1. [Q56VL3-2]
NP_689611.1. NM_152398.3. [Q56VL3-2]
UniGeneiHs.95835.

Genome annotation databases

EnsembliENST00000273860; ENSP00000273860; ENSG00000145247. [Q56VL3-2]
ENST00000508632; ENSP00000423014; ENSG00000145247. [Q56VL3-1]
ENST00000620187; ENSP00000483997; ENSG00000145247. [Q56VL3-2]
GeneIDi132299.
KEGGihsa:132299.
UCSCiuc003gyt.5. human. [Q56VL3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY472117 mRNA. Translation: AAS47684.1.
AK298305 mRNA. Translation: BAG60559.1.
CR749310 mRNA. Translation: CAH18165.1.
CH471069 Genomic DNA. Translation: EAW93077.1.
CH471069 Genomic DNA. Translation: EAW93075.1.
BC032808 mRNA. Translation: AAH32808.1.
CCDSiCCDS33981.1. [Q56VL3-1]
CCDS3485.1. [Q56VL3-2]
RefSeqiNP_001014446.1. NM_001014446.2. [Q56VL3-1]
NP_001273702.1. NM_001286773.1. [Q56VL3-2]
NP_689611.1. NM_152398.3. [Q56VL3-2]
UniGeneiHs.95835.

3D structure databases

ProteinModelPortaliQ56VL3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126317. 4 interactions.
IntActiQ56VL3. 3 interactions.
STRINGi9606.ENSP00000423014.

PTM databases

iPTMnetiQ56VL3.
PhosphoSiteiQ56VL3.
SwissPalmiQ56VL3.

Polymorphism and mutation databases

DMDMi74741044.

Proteomic databases

EPDiQ56VL3.
MaxQBiQ56VL3.
PaxDbiQ56VL3.
PeptideAtlasiQ56VL3.
PRIDEiQ56VL3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273860; ENSP00000273860; ENSG00000145247. [Q56VL3-2]
ENST00000508632; ENSP00000423014; ENSG00000145247. [Q56VL3-1]
ENST00000620187; ENSP00000483997; ENSG00000145247. [Q56VL3-2]
GeneIDi132299.
KEGGihsa:132299.
UCSCiuc003gyt.5. human. [Q56VL3-1]

Organism-specific databases

CTDi132299.
GeneCardsiOCIAD2.
HGNCiHGNC:28685. OCIAD2.
HPAiHPA040979.
HPA041090.
neXtProtiNX_Q56VL3.
PharmGKBiPA128394755.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J13G. Eukaryota.
ENOG4111YF8. LUCA.
GeneTreeiENSGT00530000063690.
HOVERGENiHBG054610.
InParanoidiQ56VL3.
OMAiQSKFHSF.
OrthoDBiEOG78PVD4.
PhylomeDBiQ56VL3.
TreeFamiTF327106.

Miscellaneous databases

GenomeRNAii132299.
NextBioi83073.
PROiQ56VL3.

Gene expression databases

BgeeiQ56VL3.
CleanExiHS_OCIAD2.
ExpressionAtlasiQ56VL3. baseline and differential.
GenevisibleiQ56VL3. HS.

Family and domain databases

InterProiIPR009764. OCIA.
[Graphical view]
PANTHERiPTHR13336. PTHR13336. 1 hit.
PfamiPF07051. OCIA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Zhang J., Wu M., Mao Y., Xie Y.
    Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Uterine endothelium.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Kidney.
  6. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-41, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiOCAD2_HUMAN
AccessioniPrimary (citable) accession number: Q56VL3
Secondary accession number(s): B4DPE7, Q8N544
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 10, 2005
Last modified: March 16, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.