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Protein

Mitogen-activated protein kinase kinase kinase 19

Gene

MAP3K19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1089 – 10891ATPPROSITE-ProRule annotation
Active sitei1186 – 11861Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1067 – 10759ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ56UN5.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase kinase kinase 19 (EC:2.7.11.1)
Alternative name(s):
Regulated in COPD, protein kinase
SPS1/STE20-related protein kinase YSK4
Gene namesi
Name:MAP3K19
Synonyms:RCK, YSK4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:26249. MAP3K19.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670554.

Chemistry

ChEMBLiCHEMBL6191.
GuidetoPHARMACOLOGYi2076.

Polymorphism and mutation databases

BioMutaiMAP3K19.
DMDMi74755104.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13281328Mitogen-activated protein kinase kinase kinase 19PRO_0000232640Add
BLAST

Proteomic databases

MaxQBiQ56UN5.
PaxDbiQ56UN5.
PRIDEiQ56UN5.

PTM databases

iPTMnetiQ56UN5.
PhosphoSiteiQ56UN5.

Expressioni

Gene expression databases

BgeeiQ56UN5.
CleanExiHS_YSK4.
ExpressionAtlasiQ56UN5. baseline and differential.
GenevisibleiQ56UN5. HS.

Organism-specific databases

HPAiHPA011388.

Interactioni

Protein-protein interaction databases

BioGridi123124. 1 interaction.
STRINGi9606.ENSP00000365005.

Chemistry

BindingDBiQ56UN5.

Structurei

3D structure databases

ProteinModelPortaliQ56UN5.
SMRiQ56UN5. Positions 988-1325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1061 – 1324264Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0198. Eukaryota.
ENOG410XQGS. LUCA.
GeneTreeiENSGT00800000124036.
HOVERGENiHBG094170.
InParanoidiQ56UN5.
KOiK17533.
OMAiVTKNQNI.
PhylomeDBiQ56UN5.
TreeFamiTF332735.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q56UN5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSMPKPERH AESLLDICHD TNSSPTDLMT VTKNQNIILQ SISRSEEFDQ
60 70 80 90 100
DGDCSHSTLV NEEEDPSGGR QDWQPRTEGV EITVTFPRDV SPPQEMSQED
110 120 130 140 150
LKEKNLINSS LQEWAQAHAV SHPNEIETVE LRKKKLTMRP LVLQKEESSR
160 170 180 190 200
ELCNVNLGFL LPRSCLELNI SKSVTREDAP HFLKEQQRKS EEFSTSHMKY
210 220 230 240 250
SGRSIKFLLP PLSLLPTRSG VLTIPQNHKF PKEKERNIPS LTSFVPKLSV
260 270 280 290 300
SVRQSDELSP SNEPPGALVK SLMDPTLRSS DGFIWSRNMC SFPKTNHHRQ
310 320 330 340 350
CLEKEENWKS KEIEECNKIE ITHFEKGQSL VSFENLKEGN IPAVREEDID
360 370 380 390 400
CHGSKTRKPE EENSQYLSSR KNESSVAKNY EQDPEIVCTI PSKFQETQHS
410 420 430 440 450
EITPSQDEEM RNNKAASKRV SLHKNEAMEP NNILEECTVL KSLSSVVFDD
460 470 480 490 500
PIDKLPEGCS SMETNIKISI AERAKPEMSR MVPLIHITFP VDGSPKEPVI
510 520 530 540 550
AKPSLQTRKG TIHNNHSVNI PVHQENDKHK MNSHRSKLDS KTKTSKKTPQ
560 570 580 590 600
NFVISTEGPI KPTMHKTSIK TQIFPALGLV DPRPWQLPRF QKKMPQIAKK
610 620 630 640 650
QSTHRTQKPK KQSFPCICKN PGTQKSCVPL SVQPTEPRLN YLDLKYSDMF
660 670 680 690 700
KEINSTANGP GIYEMFGTPV YCHVRETERD ENTYYREICS APSGRRITNK
710 720 730 740 750
CRSSHSERKS NIRTRLSQKK THMKCPKTSF GIKQEHKVLI SKEKSSKAVH
760 770 780 790 800
SNLHDIENGD GISEPDWQIK SSGNEFLSSK DEIHPMNLAQ TPEQSMKQNE
810 820 830 840 850
FPPVSDLSIV EEVSMEESTG DRDISNNQIL TTSLRDLQEL EELHHQIPFI
860 870 880 890 900
PSEDSWAVPS EKNSNKYVQQ EKQNTASLSK VNASRILTND LEFDSVSDHS
910 920 930 940 950
KTLTNFSFQA KQESASSQTY QYWVHYLDHD SLANKSITYQ MFGKTLSGTN
960 970 980 990 1000
SISQEIMDSV NNEELTDELL GCLAAELLAL DEKDNNSCQK MANETDPENL
1010 1020 1030 1040 1050
NLVLRWRGST PKEMGRETTK VKIQRHSSGL RIYDREEKFL ISNEKKIFSE
1060 1070 1080 1090 1100
NSLKSEEPIL WTKGEILGKG AYGTVYCGLT SQGQLIAVKQ VALDTSNKLA
1110 1120 1130 1140 1150
AEKEYRKLQE EVDLLKALKH VNIVAYLGTC LQENTVSIFM EFVPGGSISS
1160 1170 1180 1190 1200
IINRFGPLPE MVFCKYTKQI LQGVAYLHEN CVVHRDIKGN NVMLMPTGII
1210 1220 1230 1240 1250
KLIDFGCARR LAWAGLNGTH SDMLKSMHGT PYWMAPEVIN ESGYGRKSDI
1260 1270 1280 1290 1300
WSIGCTVFEM ATGKPPLASM DRMAAMFYIG AHRGLMPPLP DHFSENAADF
1310 1320
VRMCLTRDQH ERPSALQLLK HSFLERSH
Length:1,328
Mass (Da):150,537
Last modified:May 10, 2005 - v1
Checksum:i10E225EDB1EF4FA3
GO
Isoform 2 (identifier: Q56UN5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1122-1127: NIVAYL → PDQGPA
     1128-1328: Missing.

Show »
Length:1,127
Mass (Da):127,941
Checksum:iB031EFB739B3B28B
GO
Isoform 3 (identifier: Q56UN5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-191: Missing.

Show »
Length:1,215
Mass (Da):137,548
Checksum:iF0197C84572ED393
GO
Isoform 4 (identifier: Q56UN5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     207-1024: Missing.
     1064-1111: Missing.

Show »
Length:462
Mass (Da):52,504
Checksum:i123177F7965C4C64
GO
Isoform 5 (identifier: Q56UN5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     207-1024: Missing.

Show »
Length:510
Mass (Da):57,659
Checksum:i27E67C237A50AD36
GO
Isoform 6 (identifier: Q56UN5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1139: Missing.
     1308-1328: Missing.

Show »
Length:168
Mass (Da):18,702
Checksum:iA9B594F15FE13CA9
GO
Isoform 7 (identifier: Q56UN5-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     207-1074: Missing.

Note: No experimental confirmation available.
Show »
Length:460
Mass (Da):51,920
Checksum:i2B40C5FC91E2D11B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1235 – 12351A → V in BAB15538 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti438 – 4381T → I.
Corresponds to variant rs16831235 [ dbSNP | Ensembl ].
VAR_051687
Natural varianti500 – 5001I → M in a breast pleomorphic lobular carcinoma sample; somatic mutation. 1 Publication
VAR_041334
Natural varianti676 – 6761E → Q.
Corresponds to variant rs1112542 [ dbSNP | Ensembl ].
VAR_051688
Natural varianti812 – 8121E → G.
Corresponds to variant rs3905317 [ dbSNP | Ensembl ].
VAR_051689

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11391139Missing in isoform 6. 2 PublicationsVSP_017922Add
BLAST
Alternative sequencei79 – 191113Missing in isoform 3. 1 PublicationVSP_017924Add
BLAST
Alternative sequencei207 – 1074868Missing in isoform 7. 1 PublicationVSP_055367Add
BLAST
Alternative sequencei207 – 1024818Missing in isoform 4 and isoform 5. 1 PublicationVSP_017925Add
BLAST
Alternative sequencei1064 – 111148Missing in isoform 4. 1 PublicationVSP_017926Add
BLAST
Alternative sequencei1122 – 11276NIVAYL → PDQGPA in isoform 2. 1 PublicationVSP_017927
Alternative sequencei1128 – 1328201Missing in isoform 2. 1 PublicationVSP_017928Add
BLAST
Alternative sequencei1308 – 132821Missing in isoform 6. 2 PublicationsVSP_017923Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY574901 mRNA. Translation: AAT81410.1.
AY574902 mRNA. Translation: AAT81411.1.
AY574903 mRNA. Translation: AAT81412.1.
AY574904 mRNA. Translation: AAT81413.1.
AY574905 mRNA. Translation: AAT81414.1.
AK026727 mRNA. Translation: BAB15538.1.
AC016725 Genomic DNA. Translation: AAY14999.1.
AC020602 Genomic DNA. No translation available.
BC034417 mRNA. Translation: AAH34417.1.
BC137276 mRNA. Translation: AAI37277.1.
BC137277 mRNA. Translation: AAI37278.1.
BC144555 mRNA. Translation: AAI44556.1.
CCDSiCCDS2176.2. [Q56UN5-1]
CCDS33293.1. [Q56UN5-5]
CCDS63020.1. [Q56UN5-3]
CCDS63021.1. [Q56UN5-7]
CCDS63022.1. [Q56UN5-4]
RefSeqiNP_001018054.1. NM_001018044.2. [Q56UN5-3]
NP_001018056.1. NM_001018046.2. [Q56UN5-5]
NP_001018057.1. NM_001018047.2. [Q56UN5-4]
NP_001269812.1. NM_001282883.1. [Q56UN5-7]
NP_079328.3. NM_025052.4.
XP_006712837.1. XM_006712774.2. [Q56UN5-1]
XP_011510194.1. XM_011511892.1. [Q56UN5-1]
XP_011510195.1. XM_011511893.1. [Q56UN5-1]
XP_011510201.1. XM_011511899.1. [Q56UN5-1]
UniGeneiHs.659395.

Genome annotation databases

EnsembliENST00000358371; ENSP00000351140; ENSG00000176601. [Q56UN5-3]
ENST00000375844; ENSP00000365004; ENSG00000176601. [Q56UN5-5]
ENST00000375845; ENSP00000365005; ENSG00000176601. [Q56UN5-1]
ENST00000392917; ENSP00000376649; ENSG00000176601. [Q56UN5-7]
ENST00000392918; ENSP00000376650; ENSG00000176601. [Q56UN5-4]
GeneIDi80122.
KEGGihsa:80122.
UCSCiuc002tue.2. human. [Q56UN5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY574901 mRNA. Translation: AAT81410.1.
AY574902 mRNA. Translation: AAT81411.1.
AY574903 mRNA. Translation: AAT81412.1.
AY574904 mRNA. Translation: AAT81413.1.
AY574905 mRNA. Translation: AAT81414.1.
AK026727 mRNA. Translation: BAB15538.1.
AC016725 Genomic DNA. Translation: AAY14999.1.
AC020602 Genomic DNA. No translation available.
BC034417 mRNA. Translation: AAH34417.1.
BC137276 mRNA. Translation: AAI37277.1.
BC137277 mRNA. Translation: AAI37278.1.
BC144555 mRNA. Translation: AAI44556.1.
CCDSiCCDS2176.2. [Q56UN5-1]
CCDS33293.1. [Q56UN5-5]
CCDS63020.1. [Q56UN5-3]
CCDS63021.1. [Q56UN5-7]
CCDS63022.1. [Q56UN5-4]
RefSeqiNP_001018054.1. NM_001018044.2. [Q56UN5-3]
NP_001018056.1. NM_001018046.2. [Q56UN5-5]
NP_001018057.1. NM_001018047.2. [Q56UN5-4]
NP_001269812.1. NM_001282883.1. [Q56UN5-7]
NP_079328.3. NM_025052.4.
XP_006712837.1. XM_006712774.2. [Q56UN5-1]
XP_011510194.1. XM_011511892.1. [Q56UN5-1]
XP_011510195.1. XM_011511893.1. [Q56UN5-1]
XP_011510201.1. XM_011511899.1. [Q56UN5-1]
UniGeneiHs.659395.

3D structure databases

ProteinModelPortaliQ56UN5.
SMRiQ56UN5. Positions 988-1325.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123124. 1 interaction.
STRINGi9606.ENSP00000365005.

Chemistry

BindingDBiQ56UN5.
ChEMBLiCHEMBL6191.
GuidetoPHARMACOLOGYi2076.

PTM databases

iPTMnetiQ56UN5.
PhosphoSiteiQ56UN5.

Polymorphism and mutation databases

BioMutaiMAP3K19.
DMDMi74755104.

Proteomic databases

MaxQBiQ56UN5.
PaxDbiQ56UN5.
PRIDEiQ56UN5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358371; ENSP00000351140; ENSG00000176601. [Q56UN5-3]
ENST00000375844; ENSP00000365004; ENSG00000176601. [Q56UN5-5]
ENST00000375845; ENSP00000365005; ENSG00000176601. [Q56UN5-1]
ENST00000392917; ENSP00000376649; ENSG00000176601. [Q56UN5-7]
ENST00000392918; ENSP00000376650; ENSG00000176601. [Q56UN5-4]
GeneIDi80122.
KEGGihsa:80122.
UCSCiuc002tue.2. human. [Q56UN5-1]

Organism-specific databases

CTDi80122.
GeneCardsiMAP3K19.
H-InvDBHIX0002473.
HGNCiHGNC:26249. MAP3K19.
HPAiHPA011388.
neXtProtiNX_Q56UN5.
PharmGKBiPA142670554.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0198. Eukaryota.
ENOG410XQGS. LUCA.
GeneTreeiENSGT00800000124036.
HOVERGENiHBG094170.
InParanoidiQ56UN5.
KOiK17533.
OMAiVTKNQNI.
PhylomeDBiQ56UN5.
TreeFamiTF332735.

Enzyme and pathway databases

SignaLinkiQ56UN5.

Miscellaneous databases

GenomeRNAii80122.
NextBioi35481435.
PROiQ56UN5.

Gene expression databases

BgeeiQ56UN5.
CleanExiHS_YSK4.
ExpressionAtlasiQ56UN5. baseline and differential.
GenevisibleiQ56UN5. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of RCK, a MAPK kinase kinase that specifically phosphorylates MKK4."
    Watanabe S., Kondo S., Tanabe E., Takao E., Bacon K.B., Encinas J.A.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4 AND 5).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
    Tissue: Lung.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 6 AND 7).
    Tissue: Brain.
  5. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-500.

Entry informationi

Entry nameiM3K19_HUMAN
AccessioniPrimary (citable) accession number: Q56UN5
Secondary accession number(s): B2RP57
, B7ZMH9, E2QRE3, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: May 10, 2005
Last modified: May 11, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.