Q56UN5 (YSK4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SPS1/STE20-related protein kinase YSK4
EC=2.7.11.1

Alternative name(s):
Regulated in COPD, protein kinase

Gene names

Name:	YSK4
Synonyms:	RCK

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1328 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Sequence similarities	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q56UN5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q56UN5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1122-1127: NIVAYL → PDQGPA
     1128-1328: Missing.

Isoform 3 (identifier: Q56UN5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     79-191: Missing.

Isoform 4 (identifier: Q56UN5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     207-1024: Missing.
     1064-1111: Missing.

Isoform 5 (identifier: Q56UN5-5)

The sequence of this isoform differs from the canonical sequence as follows:
     207-1024: Missing.

Isoform 6 (identifier: Q56UN5-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1139: Missing.
     1308-1328: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1328	1328	SPS1/STE20-related protein kinase YSK4		PRO_0000232640
Regions
	Domain	1061 – 1324	264	Protein kinase
	Nucleotide binding	1067 – 1075	9	ATP By similarity
Sites
	Active site	1186	1	Proton acceptor By similarity
	Binding site	1089	1	ATP By similarity
Amino acid modifications
	Modified residue	417	1	Phosphoserine Ref.5
Natural variations
	Alternative sequence	1 – 1139	1139	Missing in isoform 6.		VSP_017922
	Alternative sequence	79 – 191	113	Missing in isoform 3.		VSP_017924
	Alternative sequence	207 – 1024	818	Missing in isoform 4 and isoform 5.		VSP_017925
	Alternative sequence	1064 – 1111	48	Missing in isoform 4.		VSP_017926
	Alternative sequence	1122 – 1127	6	NIVAYL → PDQGPA in isoform 2.		VSP_017927
	Alternative sequence	1128 – 1328	201	Missing in isoform 2.		VSP_017928
	Alternative sequence	1308 – 1328	21	Missing in isoform 6.		VSP_017923
	Natural variant	438	1	T → I. Corresponds to variant rs16831235 [ dbSNP | Ensembl ].		VAR_051687
	Natural variant	500	1	I → M in a breast pleomorphic lobular carcinoma sample; somatic mutation. Ref.6		VAR_041334
	Natural variant	676	1	E → Q. Corresponds to variant rs1112542 [ dbSNP | Ensembl ].		VAR_051688
	Natural variant	812	1	E → G. Corresponds to variant rs3905317 [ dbSNP | Ensembl ].		VAR_051689
Experimental info
	Sequence conflict	1235	1	A → V in BAB15538. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 10, 2005. Version 1. Checksum: 10E225EDB1EF4FA3	FASTA	1,328	150,537
	10 20 30 40 50 60 MSSMPKPERH AESLLDICHD TNSSPTDLMT VTKNQNIILQ SISRSEEFDQ DGDCSHSTLV 70 80 90 100 110 120 NEEEDPSGGR QDWQPRTEGV EITVTFPRDV SPPQEMSQED LKEKNLINSS LQEWAQAHAV 130 140 150 160 170 180 SHPNEIETVE LRKKKLTMRP LVLQKEESSR ELCNVNLGFL LPRSCLELNI SKSVTREDAP 190 200 210 220 230 240 HFLKEQQRKS EEFSTSHMKY SGRSIKFLLP PLSLLPTRSG VLTIPQNHKF PKEKERNIPS 250 260 270 280 290 300 LTSFVPKLSV SVRQSDELSP SNEPPGALVK SLMDPTLRSS DGFIWSRNMC SFPKTNHHRQ 310 320 330 340 350 360 CLEKEENWKS KEIEECNKIE ITHFEKGQSL VSFENLKEGN IPAVREEDID CHGSKTRKPE 370 380 390 400 410 420 EENSQYLSSR KNESSVAKNY EQDPEIVCTI PSKFQETQHS EITPSQDEEM RNNKAASKRV 430 440 450 460 470 480 SLHKNEAMEP NNILEECTVL KSLSSVVFDD PIDKLPEGCS SMETNIKISI AERAKPEMSR 490 500 510 520 530 540 MVPLIHITFP VDGSPKEPVI AKPSLQTRKG TIHNNHSVNI PVHQENDKHK MNSHRSKLDS 550 560 570 580 590 600 KTKTSKKTPQ NFVISTEGPI KPTMHKTSIK TQIFPALGLV DPRPWQLPRF QKKMPQIAKK 610 620 630 640 650 660 QSTHRTQKPK KQSFPCICKN PGTQKSCVPL SVQPTEPRLN YLDLKYSDMF KEINSTANGP 670 680 690 700 710 720 GIYEMFGTPV YCHVRETERD ENTYYREICS APSGRRITNK CRSSHSERKS NIRTRLSQKK 730 740 750 760 770 780 THMKCPKTSF GIKQEHKVLI SKEKSSKAVH SNLHDIENGD GISEPDWQIK SSGNEFLSSK 790 800 810 820 830 840 DEIHPMNLAQ TPEQSMKQNE FPPVSDLSIV EEVSMEESTG DRDISNNQIL TTSLRDLQEL 850 860 870 880 890 900 EELHHQIPFI PSEDSWAVPS EKNSNKYVQQ EKQNTASLSK VNASRILTND LEFDSVSDHS 910 920 930 940 950 960 KTLTNFSFQA KQESASSQTY QYWVHYLDHD SLANKSITYQ MFGKTLSGTN SISQEIMDSV 970 980 990 1000 1010 1020 NNEELTDELL GCLAAELLAL DEKDNNSCQK MANETDPENL NLVLRWRGST PKEMGRETTK 1030 1040 1050 1060 1070 1080 VKIQRHSSGL RIYDREEKFL ISNEKKIFSE NSLKSEEPIL WTKGEILGKG AYGTVYCGLT 1090 1100 1110 1120 1130 1140 SQGQLIAVKQ VALDTSNKLA AEKEYRKLQE EVDLLKALKH VNIVAYLGTC LQENTVSIFM 1150 1160 1170 1180 1190 1200 EFVPGGSISS IINRFGPLPE MVFCKYTKQI LQGVAYLHEN CVVHRDIKGN NVMLMPTGII 1210 1220 1230 1240 1250 1260 KLIDFGCARR LAWAGLNGTH SDMLKSMHGT PYWMAPEVIN ESGYGRKSDI WSIGCTVFEM 1270 1280 1290 1300 1310 1320 ATGKPPLASM DRMAAMFYIG AHRGLMPPLP DHFSENAADF VRMCLTRDQH ERPSALQLLK HSFLERSH
	Isoform 2 [UniParc]. Checksum: B031EFB739B3B28B	FASTA	1,127	127,941
	10 20 30 40 50 60 MSSMPKPERH AESLLDICHD TNSSPTDLMT VTKNQNIILQ SISRSEEFDQ DGDCSHSTLV 70 80 90 100 110 120 NEEEDPSGGR QDWQPRTEGV EITVTFPRDV SPPQEMSQED LKEKNLINSS LQEWAQAHAV 130 140 150 160 170 180 SHPNEIETVE LRKKKLTMRP LVLQKEESSR ELCNVNLGFL LPRSCLELNI SKSVTREDAP 190 200 210 220 230 240 HFLKEQQRKS EEFSTSHMKY SGRSIKFLLP PLSLLPTRSG VLTIPQNHKF PKEKERNIPS 250 260 270 280 290 300 LTSFVPKLSV SVRQSDELSP SNEPPGALVK SLMDPTLRSS DGFIWSRNMC SFPKTNHHRQ 310 320 330 340 350 360 CLEKEENWKS KEIEECNKIE ITHFEKGQSL VSFENLKEGN IPAVREEDID CHGSKTRKPE 370 380 390 400 410 420 EENSQYLSSR KNESSVAKNY EQDPEIVCTI PSKFQETQHS EITPSQDEEM RNNKAASKRV 430 440 450 460 470 480 SLHKNEAMEP NNILEECTVL KSLSSVVFDD PIDKLPEGCS SMETNIKISI AERAKPEMSR 490 500 510 520 530 540 MVPLIHITFP VDGSPKEPVI AKPSLQTRKG TIHNNHSVNI PVHQENDKHK MNSHRSKLDS 550 560 570 580 590 600 KTKTSKKTPQ NFVISTEGPI KPTMHKTSIK TQIFPALGLV DPRPWQLPRF QKKMPQIAKK 610 620 630 640 650 660 QSTHRTQKPK KQSFPCICKN PGTQKSCVPL SVQPTEPRLN YLDLKYSDMF KEINSTANGP 670 680 690 700 710 720 GIYEMFGTPV YCHVRETERD ENTYYREICS APSGRRITNK CRSSHSERKS NIRTRLSQKK 730 740 750 760 770 780 THMKCPKTSF GIKQEHKVLI SKEKSSKAVH SNLHDIENGD GISEPDWQIK SSGNEFLSSK 790 800 810 820 830 840 DEIHPMNLAQ TPEQSMKQNE FPPVSDLSIV EEVSMEESTG DRDISNNQIL TTSLRDLQEL 850 860 870 880 890 900 EELHHQIPFI PSEDSWAVPS EKNSNKYVQQ EKQNTASLSK VNASRILTND LEFDSVSDHS 910 920 930 940 950 960 KTLTNFSFQA KQESASSQTY QYWVHYLDHD SLANKSITYQ MFGKTLSGTN SISQEIMDSV 970 980 990 1000 1010 1020 NNEELTDELL GCLAAELLAL DEKDNNSCQK MANETDPENL NLVLRWRGST PKEMGRETTK 1030 1040 1050 1060 1070 1080 VKIQRHSSGL RIYDREEKFL ISNEKKIFSE NSLKSEEPIL WTKGEILGKG AYGTVYCGLT 1090 1100 1110 1120 SQGQLIAVKQ VALDTSNKLA AEKEYRKLQE EVDLLKALKH VPDQGPA
	Isoform 3 [UniParc]. Checksum: F0197C84572ED393	FASTA	1,215	137,548
	10 20 30 40 50 60 MSSMPKPERH AESLLDICHD TNSSPTDLMT VTKNQNIILQ SISRSEEFDQ DGDCSHSTLV 70 80 90 100 110 120 NEEEDPSGGR QDWQPRTEEF STSHMKYSGR SIKFLLPPLS LLPTRSGVLT IPQNHKFPKE 130 140 150 160 170 180 KERNIPSLTS FVPKLSVSVR QSDELSPSNE PPGALVKSLM DPTLRSSDGF IWSRNMCSFP 190 200 210 220 230 240 KTNHHRQCLE KEENWKSKEI EECNKIEITH FEKGQSLVSF ENLKEGNIPA VREEDIDCHG 250 260 270 280 290 300 SKTRKPEEEN SQYLSSRKNE SSVAKNYEQD PEIVCTIPSK FQETQHSEIT PSQDEEMRNN 310 320 330 340 350 360 KAASKRVSLH KNEAMEPNNI LEECTVLKSL SSVVFDDPID KLPEGCSSME TNIKISIAER 370 380 390 400 410 420 AKPEMSRMVP LIHITFPVDG SPKEPVIAKP SLQTRKGTIH NNHSVNIPVH QENDKHKMNS 430 440 450 460 470 480 HRSKLDSKTK TSKKTPQNFV ISTEGPIKPT MHKTSIKTQI FPALGLVDPR PWQLPRFQKK 490 500 510 520 530 540 MPQIAKKQST HRTQKPKKQS FPCICKNPGT QKSCVPLSVQ PTEPRLNYLD LKYSDMFKEI 550 560 570 580 590 600 NSTANGPGIY EMFGTPVYCH VRETERDENT YYREICSAPS GRRITNKCRS SHSERKSNIR 610 620 630 640 650 660 TRLSQKKTHM KCPKTSFGIK QEHKVLISKE KSSKAVHSNL HDIENGDGIS EPDWQIKSSG 670 680 690 700 710 720 NEFLSSKDEI HPMNLAQTPE QSMKQNEFPP VSDLSIVEEV SMEESTGDRD ISNNQILTTS 730 740 750 760 770 780 LRDLQELEEL HHQIPFIPSE DSWAVPSEKN SNKYVQQEKQ NTASLSKVNA SRILTNDLEF 790 800 810 820 830 840 DSVSDHSKTL TNFSFQAKQE SASSQTYQYW VHYLDHDSLA NKSITYQMFG KTLSGTNSIS 850 860 870 880 890 900 QEIMDSVNNE ELTDELLGCL AAELLALDEK DNNSCQKMAN ETDPENLNLV LRWRGSTPKE 910 920 930 940 950 960 MGRETTKVKI QRHSSGLRIY DREEKFLISN EKKIFSENSL KSEEPILWTK GEILGKGAYG 970 980 990 1000 1010 1020 TVYCGLTSQG QLIAVKQVAL DTSNKLAAEK EYRKLQEEVD LLKALKHVNI VAYLGTCLQE 1030 1040 1050 1060 1070 1080 NTVSIFMEFV PGGSISSIIN RFGPLPEMVF CKYTKQILQG VAYLHENCVV HRDIKGNNVM 1090 1100 1110 1120 1130 1140 LMPTGIIKLI DFGCARRLAW AGLNGTHSDM LKSMHGTPYW MAPEVINESG YGRKSDIWSI 1150 1160 1170 1180 1190 1200 GCTVFEMATG KPPLASMDRM AAMFYIGAHR GLMPPLPDHF SENAADFVRM CLTRDQHERP 1210 SALQLLKHSF LERSH
	Isoform 4 [UniParc]. Checksum: 123177F7965C4C64	FASTA	462	52,504
	10 20 30 40 50 60 MSSMPKPERH AESLLDICHD TNSSPTDLMT VTKNQNIILQ SISRSEEFDQ DGDCSHSTLV 70 80 90 100 110 120 NEEEDPSGGR QDWQPRTEGV EITVTFPRDV SPPQEMSQED LKEKNLINSS LQEWAQAHAV 130 140 150 160 170 180 SHPNEIETVE LRKKKLTMRP LVLQKEESSR ELCNVNLGFL LPRSCLELNI SKSVTREDAP 190 200 210 220 230 240 HFLKEQQRKS EEFSTSHMKY SGRSIKRHSS GLRIYDREEK FLISNEKKIF SENSLKSEEP 250 260 270 280 290 300 ILWTKVDLLK ALKHVNIVAY LGTCLQENTV SIFMEFVPGG SISSIINRFG PLPEMVFCKY 310 320 330 340 350 360 TKQILQGVAY LHENCVVHRD IKGNNVMLMP TGIIKLIDFG CARRLAWAGL NGTHSDMLKS 370 380 390 400 410 420 MHGTPYWMAP EVINESGYGR KSDIWSIGCT VFEMATGKPP LASMDRMAAM FYIGAHRGLM 430 440 450 460 PPLPDHFSEN AADFVRMCLT RDQHERPSAL QLLKHSFLER SH
	Isoform 5 [UniParc]. Checksum: 27E67C237A50AD36	FASTA	510	57,659
	10 20 30 40 50 60 MSSMPKPERH AESLLDICHD TNSSPTDLMT VTKNQNIILQ SISRSEEFDQ DGDCSHSTLV 70 80 90 100 110 120 NEEEDPSGGR QDWQPRTEGV EITVTFPRDV SPPQEMSQED LKEKNLINSS LQEWAQAHAV 130 140 150 160 170 180 SHPNEIETVE LRKKKLTMRP LVLQKEESSR ELCNVNLGFL LPRSCLELNI SKSVTREDAP 190 200 210 220 230 240 HFLKEQQRKS EEFSTSHMKY SGRSIKRHSS GLRIYDREEK FLISNEKKIF SENSLKSEEP 250 260 270 280 290 300 ILWTKGEILG KGAYGTVYCG LTSQGQLIAV KQVALDTSNK LAAEKEYRKL QEEVDLLKAL 310 320 330 340 350 360 KHVNIVAYLG TCLQENTVSI FMEFVPGGSI SSIINRFGPL PEMVFCKYTK QILQGVAYLH 370 380 390 400 410 420 ENCVVHRDIK GNNVMLMPTG IIKLIDFGCA RRLAWAGLNG THSDMLKSMH GTPYWMAPEV 430 440 450 460 470 480 INESGYGRKS DIWSIGCTVF EMATGKPPLA SMDRMAAMFY IGAHRGLMPP LPDHFSENAA 490 500 510 DFVRMCLTRD QHERPSALQL LKHSFLERSH
	Isoform 6 [UniParc]. Checksum: A9B594F15FE13CA9	FASTA	168	18,702
	10 20 30 40 50 60 MEFVPGGSIS SIINRFGPLP EMVFCKYTKQ ILQGVAYLHE NCVVHRDIKG NNVMLMPTGI 70 80 90 100 110 120 IKLIDFGCAR RLAWAGLNGT HSDMLKSMHG TPYWMAPEVI NESGYGRKSD IWSIGCTVFE 130 140 150 160 MATGKPPLAS MDRMAAMFYI GAHRGLMPPL PDHFSENAAD FVRMCLTR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of RCK, a MAPK kinase kinase that specifically phosphorylates MKK4." Watanabe S., Kondo S., Tanabe E., Takao E., Bacon K.B., Encinas J.A. Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4 AND 5).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6). Tissue: Lung.
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 6). Tissue: Brain.
[5]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed: 19369195] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-417, MASS SPECTROMETRY.
[6]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed: 17344846] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-500.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY574901 mRNA. Translation: AAT81410.1. AY574902 mRNA. Translation: AAT81411.1. AY574903 mRNA. Translation: AAT81412.1. AY574904 mRNA. Translation: AAT81413.1. AY574905 mRNA. Translation: AAT81414.1. AK026727 mRNA. Translation: BAB15538.1. AC016725 Genomic DNA. Translation: AAY14999.1. BC034417 mRNA. Translation: AAH34417.1. BC137276 mRNA. Translation: AAI37277.1. BC137277 mRNA. Translation: AAI37278.1.
IPI	IPI00074966. IPI00555896. IPI00604447. IPI00743362. IPI00743855. IPI00749020.
RefSeq	NP_001018056.1. NM_001018046.1. NP_079328.3. NM_025052.3.
UniGene	Hs.659395.
3D structure databases
ProteinModelPortal	Q56UN5.
SMR	Q56UN5. Positions 1061-1326.
ModBase	Search...
PTM databases
PhosphoSite	Q56UN5.
Polymorphism databases
DMDM	74755104.
Proteomic databases
PRIDE	Q56UN5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000375845; ENSP00000365005; ENSG00000176601.
GeneID	80122.
KEGG	hsa:80122.
UCSC	uc002tue.1. human. uc002tuf.1. human. uc002tuh.2. human. uc010fnc.1. human.
Organism-specific databases
CTD	80122.
GeneCards	GC02M135722.
H-InvDB	HIX0002473.
HGNC	HGNC:26249. YSK4.
HPA	HPA011388.
neXtProt	NX_Q56UN5.
PharmGKB	PA142670554.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG10517.
GeneTree	ENSGT00600000084293.
HOVERGEN	HBG094170.
InParanoid	Q56UN5.
OMA	DEKDNNS.
OrthoDB	EOG4MPHP8.
PhylomeDB	Q56UN5.
Gene expression databases
ArrayExpress	Q56UN5.
Bgee	Q56UN5.
CleanEx	HS_YSK4.
Genevestigator	Q56UN5.
GermOnline	ENSG00000176601. Homo sapiens.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_kinase-like_dom. IPR008271. Ser/Thr_kinase_AS. IPR002290. Ser/Thr_kinase_dom. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	70354.

Entry information

Entry name

YSK4_HUMAN

Accession

Primary (citable) accession number: Q56UN5
Secondary accession number(s): B2RP57 , Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 18, 2006
Last sequence update:	May 10, 2005
Last modified:	January 25, 2012
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.