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Protein

Neuropeptides B/W receptor type 1

Gene

Npbwr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptides B/W receptor type 1
Alternative name(s):
G-protein coupled receptor 7
Gene namesi
Name:Npbwr1
Synonyms:Gpr7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1305917. Npbwr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3939ExtracellularSequence analysisAdd
BLAST
Transmembranei40 – 6324Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini64 – 7411CytoplasmicSequence analysisAdd
BLAST
Transmembranei75 – 9925Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini100 – 11415ExtracellularSequence analysisAdd
BLAST
Transmembranei115 – 13420Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini135 – 15925CytoplasmicSequence analysisAdd
BLAST
Transmembranei160 – 17920Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini180 – 20425ExtracellularSequence analysisAdd
BLAST
Transmembranei205 – 22622Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini227 – 25024CytoplasmicSequence analysisAdd
BLAST
Transmembranei251 – 27525Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini276 – 28510ExtracellularSequence analysis
Transmembranei286 – 30015Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini301 – 32929CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

GuidetoPHARMACOLOGYi303.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329Neuropeptides B/W receptor type 1PRO_0000069520Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence analysis
Glycosylationi13 – 131N-linked (GlcNAc...)Sequence analysis
Glycosylationi25 – 251N-linked (GlcNAc...)Sequence analysis
Disulfide bondi111 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ56UD9.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010032.

Structurei

3D structure databases

ProteinModelPortaliQ56UD9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000230485.
HOVERGENiHBG106919.
InParanoidiQ56UD9.
KOiK05268.
OMAiLGCPNAS.
OrthoDBiEOG7BKCVQ.
PhylomeDBiQ56UD9.
TreeFamiTF315737.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009150. Neuropept_B/W_rcpt.
IPR027348. NPBW1.
[Graphical view]
PANTHERiPTHR24229:SF47. PTHR24229:SF47. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01855. NRPEPTIDEWR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q56UD9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHNLSLFEPG RGNVSCGGPF LGCPNESNPA PLPLPQPLAV AVPVVYGVIC
60 70 80 90 100
AVGLAGNSAV LYVLLRTPRM KTVTNVFILN LAIADELFTL VLPINIADFL
110 120 130 140 150
LRRWPFGEVM CKLIVAVDQY NTFSSLYFLA VMSADRYLVV LATAESRRVS
160 170 180 190 200
GRTYGAARAV SLAVWALVTL VVLPFAVFAR LDEEQGRRQC VLVFPQPEAF
210 220 230 240 250
WWRASRLYTL VLGFAIPVST ICALYITLLC RLRAIQLDSH AKALDRAKKR
260 270 280 290 300
VTLLVVAILA VCLLCWTPYH LSTIVALTTD LPQTPLVIGI SYFITSLSYA
310 320
NSCLNPFLYA FLDDSFRRSL RQLVSCRTA
Length:329
Mass (Da):36,306
Last modified:May 10, 2005 - v1
Checksum:iD93B017240F570D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY577901 mRNA. Translation: AAT72915.1.
RefSeqiNP_001014784.1. NM_001014784.1.
UniGeneiRn.140960.

Genome annotation databases

EnsembliENSRNOT00000010032; ENSRNOP00000010032; ENSRNOG00000007640.
GeneIDi297795.
KEGGirno:297795.
UCSCiRGD:1305917. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY577901 mRNA. Translation: AAT72915.1.
RefSeqiNP_001014784.1. NM_001014784.1.
UniGeneiRn.140960.

3D structure databases

ProteinModelPortaliQ56UD9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010032.

Chemistry

GuidetoPHARMACOLOGYi303.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ56UD9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010032; ENSRNOP00000010032; ENSRNOG00000007640.
GeneIDi297795.
KEGGirno:297795.
UCSCiRGD:1305917. rat.

Organism-specific databases

CTDi2831.
RGDi1305917. Npbwr1.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000230485.
HOVERGENiHBG106919.
InParanoidiQ56UD9.
KOiK05268.
OMAiLGCPNAS.
OrthoDBiEOG7BKCVQ.
PhylomeDBiQ56UD9.
TreeFamiTF315737.

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiQ56UD9.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009150. Neuropept_B/W_rcpt.
IPR027348. NPBW1.
[Graphical view]
PANTHERiPTHR24229:SF47. PTHR24229:SF47. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01855. NRPEPTIDEWR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Pharmacological characterization of rat GPR7."
    Nothacker H.-P., Wang Z., Civelli O.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiNPBW1_RAT
AccessioniPrimary (citable) accession number: Q56UD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: May 10, 2005
Last modified: June 8, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.