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Protein

Pyrin domain-containing protein 2

Gene

PYDC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in innate immunity by disrupting the interaction between PYCARD and NLRP3, thereby regulating the NLRP3 inflammasome (PubMed:17339483, PubMed:17178784). May also inhibit NF-kappa-B signaling distally by affecting the nuclear accumulation of RELA (PubMed:17339483, PubMed:24871464).3 Publications

GO - Biological processi

  • inflammatory response Source: UniProtKB-KW
  • innate immune response Source: UniProtKB-KW
  • negative regulation of inflammatory response Source: UniProtKB
  • negative regulation of interleukin-1 beta secretion Source: UniProtKB
  • negative regulation of NF-kappaB import into nucleus Source: UniProtKB
  • negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
  • negative regulation of NLRP3 inflammasome complex assembly Source: UniProtKB
  • negative regulation of tumor necrosis factor-mediated signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrin domain-containing protein 2Curated
Alternative name(s):
Pyrin-only protein 21 Publication
cellular POP21 Publication
Short name:
cPOP21 Publication
Gene namesi
Name:PYDC2Imported
Synonyms:POP21 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:33512. PYDC2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162400524.

Polymorphism and mutation databases

BioMutaiPYDC2.
DMDMi74721597.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9797Pyrin domain-containing protein 2PRO_0000348427Add
BLAST

Proteomic databases

PaxDbiQ56P42.
PRIDEiQ56P42.

Expressioni

Tissue specificityi

Predominantly expressed in peripheral blood. Weakly expressed in testis.1 Publication

Gene expression databases

CleanExiHS_PYDC2.

Organism-specific databases

HPAiHPA055895.

Interactioni

Subunit structurei

Interacts with PYCARD/ASC (via pyrin domain) (PubMed:17339483, PubMed:17178784). Interacts with NLRP2 (via pyrin domain) (PubMed:17178784).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NLRP2Q9NX026EBI-6374418,EBI-6374482
PYCARDQ9ULZ34EBI-6374418,EBI-751215

Protein-protein interaction databases

IntActiQ56P42. 5 interactions.
STRINGi9606.ENSP00000428325.

Structurei

3D structure databases

ProteinModelPortaliQ56P42.
SMRiQ56P42. Positions 3-88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 9494PyrinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 pyrin domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410ITCB. Eukaryota.
ENOG4110PZ0. LUCA.
GeneTreeiENSGT00390000008721.
HOGENOMiHOG000115808.
InParanoidiQ56P42.
OMAiETHLSER.
OrthoDBiEOG7P5T07.
PhylomeDBiQ56P42.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR004020. DAPIN.
IPR011029. DEATH-like_dom.
[Graphical view]
PfamiPF02758. PYRIN. 1 hit.
[Graphical view]
SMARTiSM01289. PYRIN. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50824. DAPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q56P42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSAELDFN LQALLEQLSQ DELSKFKSLI RTISLGKELQ TVPQTEVDKA
60 70 80 90
NGKQLVEIFT SHSCSYWAGM AAIQVFEKMN QTHLSGRADE HCVMPPP
Length:97
Mass (Da):10,795
Last modified:May 10, 2005 - v1
Checksum:iE2EE7A27FB90E586
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti81 – 811Q → R.
Corresponds to variant rs293833 [ dbSNP | Ensembl ].
VAR_046150

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY858112 mRNA. Translation: AAX54598.1.
RefSeqiNP_001076777.1. NM_001083308.1.
UniGeneiHs.690618.

Genome annotation databases

EnsembliENST00000518817; ENSP00000428325; ENSG00000253548.
GeneIDi152138.
KEGGihsa:152138.
UCSCiuc011bso.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY858112 mRNA. Translation: AAX54598.1.
RefSeqiNP_001076777.1. NM_001083308.1.
UniGeneiHs.690618.

3D structure databases

ProteinModelPortaliQ56P42.
SMRiQ56P42. Positions 3-88.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ56P42. 5 interactions.
STRINGi9606.ENSP00000428325.

Polymorphism and mutation databases

BioMutaiPYDC2.
DMDMi74721597.

Proteomic databases

PaxDbiQ56P42.
PRIDEiQ56P42.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000518817; ENSP00000428325; ENSG00000253548.
GeneIDi152138.
KEGGihsa:152138.
UCSCiuc011bso.2. human.

Organism-specific databases

CTDi152138.
GeneCardsiPYDC2.
HGNCiHGNC:33512. PYDC2.
HPAiHPA055895.
MIMi615701. gene.
neXtProtiNX_Q56P42.
PharmGKBiPA162400524.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITCB. Eukaryota.
ENOG4110PZ0. LUCA.
GeneTreeiENSGT00390000008721.
HOGENOMiHOG000115808.
InParanoidiQ56P42.
OMAiETHLSER.
OrthoDBiEOG7P5T07.
PhylomeDBiQ56P42.

Miscellaneous databases

GenomeRNAii152138.
NextBioi86910.
PROiQ56P42.
SOURCEiSearch...

Gene expression databases

CleanExiHS_PYDC2.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR004020. DAPIN.
IPR011029. DEATH-like_dom.
[Graphical view]
PfamiPF02758. PYRIN. 1 hit.
[Graphical view]
SMARTiSM01289. PYRIN. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50824. DAPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Pyrin-only protein 2 modulates NF-kappaB and disrupts ASC:CLR interactions."
    Bedoya F., Sandler L.L., Harton J.A.
    J. Immunol. 178:3837-3845(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH PYCARD, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation."
    Dorfleutner A., Bryan N.B., Talbott S.J., Funya K.N., Rellick S.L., Reed J.C., Shi X., Rojanasakul Y., Flynn D.C., Stehlik C.
    Infect. Immun. 75:1484-1492(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH NLRP2 AND PYCARD, SUBCELLULAR LOCATION.
  3. "Recent evolution of the NF-kappaB and inflammasome regulating protein POP2 in primates."
    Atianand M.K., Fuchs T., Harton J.A.
    BMC Evol. Biol. 11:56-56(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: CAUTION.
  4. "The CLRX.1/NOD24 (NLRP2P) pseudogene codes a functional negative regulator of NF-kappaB, pyrin-only protein 4."
    Porter K.A., Duffy E.B., Nyland P., Atianand M.K., Sharifi H., Harton J.A.
    Genes Immun. 15:392-403(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiPYDC2_HUMAN
AccessioniPrimary (citable) accession number: Q56P42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: May 10, 2005
Last modified: May 11, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Absent from the genome of domestic mammals and New World monkeys it is found in the genome of hominids and Old World monkeys. Likely derived from retrogene insertion of an NLRP2/NLRP7-like gene, it has probably arisen recently in the mammalian genomes where it is under purifying selection.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.