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Protein

PRA1 family protein 3

Gene

ARL6IP5

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. May be involved in membrane traffic.By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-SSC-210500. Glutamate Neurotransmitter Release Cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
PRA1 family protein 3
Alternative name(s):
ADP-ribosylation factor-like protein 6-interacting protein 5
Short name:
ARL-6-interacting protein 5
Short name:
Aip-5
Gene namesi
Name:ARL6IP5
Synonyms:PRAF3
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 13

Subcellular locationi

  • Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein Sequence analysis
  • Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
  • Cytoplasm By similarity
  • Cytoplasmcytoskeleton By similarity

  • Note: Also exists as a soluble form in the cytoplasm. Associated with microtubules.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35CytoplasmicBy similarityAdd BLAST35
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Transmembranei57 – 77HelicalSequence analysisAdd BLAST21
Topological domaini78 – 93CytoplasmicBy similarityAdd BLAST16
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Topological domaini136 – 188CytoplasmicBy similarityAdd BLAST53

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002568491 – 188PRA1 family protein 3Add BLAST188

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ56P28.
PeptideAtlasiQ56P28.

Expressioni

Gene expression databases

BgeeiENSSSCG00000011507.
GenevisibleiQ56P28. SS.

Interactioni

Subunit structurei

Homodimer. Heterodimer with ARL6IP1. Forms multimers. Interacts with prenylated RAB1A, RAB3A and SLC1A1/EAAC1. Does not interact with VAMP1, VAMP2 or VAMP3. Interacts with ARL6. Interacts with SLC1A1/EAAC1.By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000012264.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni103 – 117Required for homodimer formation and heterodimer formation with ARL6IP1By similarityAdd BLAST15
Regioni136 – 188Targeting to endoplasmic reticulum membraneBy similarityAdd BLAST53

Sequence similaritiesi

Belongs to the PRA1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4050. Eukaryota.
ENOG4111MUC. LUCA.
GeneTreeiENSGT00390000008631.
HOGENOMiHOG000231363.
HOVERGENiHBG053661.
InParanoidiQ56P28.
KOiK20393.
OMAiAHNKDIL.
OrthoDBiEOG091G0QS5.
TreeFamiTF105479.

Family and domain databases

InterProiView protein in InterPro
IPR004895. Prenylated_rab_accept_PRA1.
PfamiView protein in Pfam
PF03208. PRA1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q56P28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVNIAPLRA WDDFFPGSDR FARPDFRDIS KWNNRVVSNL LYYQTNYLVV
60 70 80 90 100
AAMMISVVGF LSPFNMILGG IVVVLVFTGF VWAAHNKDIL RRLKKQYPTV
110 120 130 140 150
FVMVVMLASY FLISMFGGVM VFVFGITFPL LLMFIHASLR LRNLKNKLEN
160 170 180
KIEGIGLKRT PMGIVLDALE QQEENISKFA DYISKVNE
Length:188
Mass (Da):21,541
Last modified:May 10, 2005 - v1
Checksum:iC7C1A312F73DA58E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY864608 mRNA. Translation: AAX77004.1.
RefSeqiNP_001041538.1. NM_001048073.1.
UniGeneiSsc.83950.

Genome annotation databases

EnsembliENSSSCT00000012593; ENSSSCP00000012264; ENSSSCG00000011507.
GeneIDi595127.
KEGGissc:595127.

Similar proteinsi

Entry informationi

Entry nameiPRAF3_PIG
AccessioniPrimary (citable) accession number: Q56P28
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 10, 2005
Last modified: June 7, 2017
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families