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Protein

E2F-associated phosphoprotein

Gene

EAPP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression.1 Publication

GO - Biological processi

  • negative regulation of transcription elongation from RNA polymerase II promoter Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of transcription elongation from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
E2F-associated phosphoprotein
Short name:
EAPP
Gene namesi
Name:EAPP
Synonyms:C14orf11
ORF Names:BM-036
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19312. EAPP.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000129518.
PharmGKBiPA162384208.

Polymorphism and mutation databases

BioMutaiEAPP.
DMDMi296439474.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000869041 – 285E2F-associated phosphoproteinAdd BLAST285

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei17PhosphoserineCombined sources1
Modified residuei37PhosphothreonineCombined sources1
Modified residuei109PhosphoserineCombined sources1
Modified residuei111PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ56P03.
MaxQBiQ56P03.
PaxDbiQ56P03.
PeptideAtlasiQ56P03.
PRIDEiQ56P03.

PTM databases

iPTMnetiQ56P03.
PhosphoSitePlusiQ56P03.

Expressioni

Tissue specificityi

Ubiquitously expressed. Highest levels in heart, placenta, skeletal muscle and pancreas. Lower levels in brain, lung and kidney. In the brain, expressed in all regions with high levels in the cerebellum and cerebral cortex. Expressed in COS1 and transformed skin fibroblasts.2 Publications

Developmental stagei

During the cell cycle, expression disappears during mitosis.

Gene expression databases

BgeeiENSG00000129518.
CleanExiHS_EAPP.
ExpressionAtlasiQ56P03. baseline and differential.
GenevisibleiQ56P03. HS.

Organism-specific databases

HPAiHPA002916.

Interactioni

Subunit structurei

Interacts with E2F1. The C-terminal half binds the N-terminal of E2F1. Also interacts with E2F2 and E2F3, but not E2F4.1 Publication

Protein-protein interaction databases

BioGridi120941. 24 interactors.
IntActiQ56P03. 5 interactors.
MINTiMINT-2874613.
STRINGi9606.ENSP00000250454.

Structurei

3D structure databases

ProteinModelPortaliQ56P03.
SMRiQ56P03.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi122 – 127Poly-Lys6

Phylogenomic databases

eggNOGiKOG3395. Eukaryota.
ENOG4110B8Q. LUCA.
GeneTreeiENSGT00390000001332.
HOGENOMiHOG000068005.
HOVERGENiHBG054593.
InParanoidiQ56P03.
OMAiRGHKKMR.
OrthoDBiEOG091G0BO0.
PhylomeDBiQ56P03.
TreeFamiTF328497.

Family and domain databases

InterProiIPR019370. E2F-assoc_phosphoprotein.
[Graphical view]
PfamiPF10238. Eapp_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q56P03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRLPDDYDP YAVEEPSDEE PALSSSEDEV DVLLHGTPDQ KRKLIRECLT
60 70 80 90 100
GESESSSEDE FEKEMEAELN STMKTMEDKL SSLGTGSSSG NGKVATAPTR
110 120 130 140 150
YYDDIYFDSD SEDEDRAVQV TKKKKKKQHK IPTNDELLYD PEKDNRDQAW
160 170 180 190 200
VDAQRRGYHG LGPQRSRQQQ PVPNSDAVLN CPACMTTLCL DCQRHESYKT
210 220 230 240 250
QYRAMFVMNC SINKEEVLRY KASENRKKRR VHKKMRSNRE DAAEKAETDV
260 270 280
EEIYHPVMCT ECSTEVAVYD KDEVFHFFNV LASHS
Length:285
Mass (Da):32,762
Last modified:May 18, 2010 - v4
Checksum:i1C0691602FFB516A
GO

Sequence cautioni

The sequence AAF67623 differs from that shown. Reason: Frameshift at positions 178, 189, 198 and 226.Curated
The sequence AAO17041 differs from that shown. Reason: Frameshift at positions 178, 189, 198 and 226.Curated
The sequence AAO17042 differs from that shown. Reason: Frameshift at positions 178, 189, 198 and 226.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3R → L in AAX63200 (PubMed:15716352).Curated1
Sequence conflicti52E → G in BAA91271 (PubMed:14702039).Curated1
Sequence conflicti239R → Q in AAX63200 (PubMed:15716352).Curated1
Sequence conflicti239R → Q in AAH01245 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031915168Q → E.2 PublicationsCorresponds to variant rs17352411dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY157300 mRNA. Translation: AAO17041.1. Frameshift.
AY157301 mRNA. Translation: AAO17042.1. Frameshift.
AY869694 mRNA. Translation: AAX63200.1.
AF217512 mRNA. Translation: AAF67623.1. Frameshift.
AK000585 mRNA. Translation: BAA91271.1.
AL445363 Genomic DNA. No translation available.
BC001245 mRNA. Translation: AAH01245.1.
CCDSiCCDS41941.1.
RefSeqiNP_001305845.1. NM_001318916.1.
NP_060923.2. NM_018453.3.
UniGeneiHs.433269.

Genome annotation databases

EnsembliENST00000250454; ENSP00000250454; ENSG00000129518.
GeneIDi55837.
KEGGihsa:55837.
UCSCiuc001wsd.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY157300 mRNA. Translation: AAO17041.1. Frameshift.
AY157301 mRNA. Translation: AAO17042.1. Frameshift.
AY869694 mRNA. Translation: AAX63200.1.
AF217512 mRNA. Translation: AAF67623.1. Frameshift.
AK000585 mRNA. Translation: BAA91271.1.
AL445363 Genomic DNA. No translation available.
BC001245 mRNA. Translation: AAH01245.1.
CCDSiCCDS41941.1.
RefSeqiNP_001305845.1. NM_001318916.1.
NP_060923.2. NM_018453.3.
UniGeneiHs.433269.

3D structure databases

ProteinModelPortaliQ56P03.
SMRiQ56P03.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120941. 24 interactors.
IntActiQ56P03. 5 interactors.
MINTiMINT-2874613.
STRINGi9606.ENSP00000250454.

PTM databases

iPTMnetiQ56P03.
PhosphoSitePlusiQ56P03.

Polymorphism and mutation databases

BioMutaiEAPP.
DMDMi296439474.

Proteomic databases

EPDiQ56P03.
MaxQBiQ56P03.
PaxDbiQ56P03.
PeptideAtlasiQ56P03.
PRIDEiQ56P03.

Protocols and materials databases

DNASUi55837.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000250454; ENSP00000250454; ENSG00000129518.
GeneIDi55837.
KEGGihsa:55837.
UCSCiuc001wsd.2. human.

Organism-specific databases

CTDi55837.
GeneCardsiEAPP.
HGNCiHGNC:19312. EAPP.
HPAiHPA002916.
MIMi609486. gene.
neXtProtiNX_Q56P03.
OpenTargetsiENSG00000129518.
PharmGKBiPA162384208.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3395. Eukaryota.
ENOG4110B8Q. LUCA.
GeneTreeiENSGT00390000001332.
HOGENOMiHOG000068005.
HOVERGENiHBG054593.
InParanoidiQ56P03.
OMAiRGHKKMR.
OrthoDBiEOG091G0BO0.
PhylomeDBiQ56P03.
TreeFamiTF328497.

Miscellaneous databases

ChiTaRSiEAPP. human.
GeneWikiiEAPP.
GenomeRNAii55837.
PROiQ56P03.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000129518.
CleanExiHS_EAPP.
ExpressionAtlasiQ56P03. baseline and differential.
GenevisibleiQ56P03. HS.

Family and domain databases

InterProiIPR019370. E2F-assoc_phosphoprotein.
[Graphical view]
PfamiPF10238. Eapp_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEAPP_HUMAN
AccessioniPrimary (citable) accession number: Q56P03
Secondary accession number(s): Q9BVF4, Q9NWV5, Q9NZ86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 107 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.