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Protein

Ornithine decarboxylase antizyme 1

Gene

OAZ1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome. Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC. Stabilizes AZIN2 by interfering with its ubiquitination. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processPolyamine biosynthesis, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine decarboxylase antizyme 1
Short name:
ODC-Az
Gene namesi
Name:OAZ1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002403422 – 227Ornithine decarboxylase antizyme 1Add BLAST226

Proteomic databases

PaxDbiQ56K12.

Interactioni

Subunit structurei

Interacts with ODC1 and thereby sterically blocks ODC homodimerization. Forms a ternary complex with PSMB4 and OAZ1 before PSMB4 is incorporated into the 20S proteasome. Interacts with AZIN2; this interaction disrupts the interaction between the antizyme and ODC1.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024656.

Structurei

3D structure databases

ProteinModelPortaliQ56K12.
SMRiQ56K12.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ODC antizyme family.Curated

Phylogenomic databases

eggNOGiKOG4387. Eukaryota.
ENOG4112791. LUCA.
HOGENOMiHOG000115253.
HOVERGENiHBG007857.
InParanoidiQ56K12.

Family and domain databases

InterProiView protein in InterPro
IPR016181. Acyl_CoA_acyltransferase.
IPR029914. ODC-AZ_1.
IPR002993. ODC_AZ.
PANTHERiPTHR10279. PTHR10279. 1 hit.
PTHR10279:SF15. PTHR10279:SF15. 1 hit.
PfamiView protein in Pfam
PF02100. ODC_AZ. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiView protein in PROSITE
PS01337. ODC_AZ. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by ribosomal frameshifting. AlignAdd to basket

Note: A ribosomal frameshift occurs between the codons for Ser-68 and Asp-69. An autoregulatory mechanism enables modulation of frameshifting according to the cellular concentration of polyamines.
Isoform 1 (identifier: Q56K12-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVKSSLQRIL NSHCFAREKE GDKPSATVHA TRTMPLLSLH SRGGRSSESS
60 70 80 90 100
RVSINCCSNL GPGPRWCSDV PHPPLKIPGG RGNSQRDHNL SANLFYSDNR
110 120 130 140 150
LNVTEELTSN NKTRIFNVQS RLTEAKHINW RAVLSNSCLY VEIPGGALPE
160 170 180 190 200
GSKDSFAVLL EFAEEQLHVD HVFICFHKNR DDRAALLRTF SFLGFEIVRP
210 220
GHPLVPKRPD ACFMAYTFER ESSGEEE
Length:227
Mass (Da):25,448
Last modified:January 23, 2007 - v3
Checksum:i9AD48078032FE66A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY911315 mRNA. Translation: AAW82083.1. Sequence problems.
UniGeneiBt.3694.

Keywords - Coding sequence diversityi

Ribosomal frameshifting

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiOAZ1_BOVIN
AccessioniPrimary (citable) accession number: Q56K12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: January 23, 2007
Last modified: March 15, 2017
This is version 63 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families