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Protein

60S ribosomal protein L35a

Gene

RPL35A

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation (By similarity). The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, tRNA-binding

Enzyme and pathway databases

ReactomeiR-BTA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-BTA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-BTA-6791226. Major pathway of rRNA processing in the nucleolus.
R-BTA-72689. Formation of a pool of free 40S subunits.
R-BTA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-BTA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-BTA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L35a
Gene namesi
Name:RPL35A
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11011060S ribosomal protein L35aPRO_0000240151Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei8 – 81N6-acetyllysineBy similarity
Modified residuei63 – 631N6-acetyllysine; alternateBy similarity
Modified residuei63 – 631N6-succinyllysine; alternateBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ56JY1.
PeptideAtlasiQ56JY1.
PRIDEiQ56JY1.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018888.

Structurei

3D structure databases

ProteinModelPortaliQ56JY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L35Ae family.Curated

Phylogenomic databases

eggNOGiKOG0887. Eukaryota.
COG2451. LUCA.
GeneTreeiENSGT00390000016972.
HOGENOMiHOG000195636.
HOVERGENiHBG054581.
InParanoidiQ56JY1.
KOiK02917.
OMAiSTRLYSK.
OrthoDBiEOG741Z4R.
TreeFamiTF300104.

Family and domain databases

InterProiIPR001780. Ribosomal_L35A.
IPR018266. Ribosomal_L35Ae_CS.
IPR009000. Transl_B-barrel.
[Graphical view]
PANTHERiPTHR10902. PTHR10902. 1 hit.
PfamiPF01247. Ribosomal_L35Ae. 1 hit.
[Graphical view]
ProDomiPD012670. Ribosomal_L35Ae. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF50447. SSF50447. 1 hit.
PROSITEiPS01105. RIBOSOMAL_L35AE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q56JY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRLWSKAI FAGYKRGLRN QREHTALLKI EGVYARDETE FYLGKRCAYV
60 70 80 90 100
YKAKNNTVTP GGKPNKTRVI WGKITRAHGN SGMVRAKFRS NLPAKAIGHR
110
IRVMLYPSRI
Length:110
Mass (Da):12,552
Last modified:May 10, 2005 - v1
Checksum:iF32E4A26B1E64278
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY911347 mRNA. Translation: AAW82114.1.
BC111654 mRNA. Translation: AAI11655.1.
RefSeqiNP_001020492.1. NM_001025321.3.
XP_005201446.1. XM_005201389.1.
XP_005201447.1. XM_005201390.2.
UniGeneiBt.15384.
Bt.65591.

Genome annotation databases

EnsembliENSBTAT00000018888; ENSBTAP00000018888; ENSBTAG00000014208.
GeneIDi506768.
KEGGibta:506768.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY911347 mRNA. Translation: AAW82114.1.
BC111654 mRNA. Translation: AAI11655.1.
RefSeqiNP_001020492.1. NM_001025321.3.
XP_005201446.1. XM_005201389.1.
XP_005201447.1. XM_005201390.2.
UniGeneiBt.15384.
Bt.65591.

3D structure databases

ProteinModelPortaliQ56JY1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018888.

Proteomic databases

PaxDbiQ56JY1.
PeptideAtlasiQ56JY1.
PRIDEiQ56JY1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000018888; ENSBTAP00000018888; ENSBTAG00000014208.
GeneIDi506768.
KEGGibta:506768.

Organism-specific databases

CTDi6165.

Phylogenomic databases

eggNOGiKOG0887. Eukaryota.
COG2451. LUCA.
GeneTreeiENSGT00390000016972.
HOGENOMiHOG000195636.
HOVERGENiHBG054581.
InParanoidiQ56JY1.
KOiK02917.
OMAiSTRLYSK.
OrthoDBiEOG741Z4R.
TreeFamiTF300104.

Enzyme and pathway databases

ReactomeiR-BTA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-BTA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-BTA-6791226. Major pathway of rRNA processing in the nucleolus.
R-BTA-72689. Formation of a pool of free 40S subunits.
R-BTA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-BTA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-BTA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Family and domain databases

InterProiIPR001780. Ribosomal_L35A.
IPR018266. Ribosomal_L35Ae_CS.
IPR009000. Transl_B-barrel.
[Graphical view]
PANTHERiPTHR10902. PTHR10902. 1 hit.
PfamiPF01247. Ribosomal_L35Ae. 1 hit.
[Graphical view]
ProDomiPD012670. Ribosomal_L35Ae. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF50447. SSF50447. 1 hit.
PROSITEiPS01105. RIBOSOMAL_L35AE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Analysis of sequences obtained from constructed full-length bovine cDNA libraries."
    Yu J., Meng Y., Wang Z., Hansen C., Li C., Moore S.S.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymphoid epithelium.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Testis.

Entry informationi

Entry nameiRL35A_BOVIN
AccessioniPrimary (citable) accession number: Q56JY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: May 10, 2005
Last modified: July 6, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.