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Protein

Adenine phosphoribosyltransferase

Gene

APRT

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.By similarity

Catalytic activityi

AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate.

Pathwayi: AMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes AMP from adenine.
Proteins known to be involved in this subpathway in this organism are:
  1. Adenine phosphoribosyltransferase (APRT)
This subpathway is part of the pathway AMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from adenine, the pathway AMP biosynthesis via salvage pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processPurine salvage

Enzyme and pathway databases

ReactomeiR-BTA-6798695 Neutrophil degranulation
R-BTA-74217 Purine salvage
UniPathwayiUPA00588; UER00646

Names & Taxonomyi

Protein namesi
Recommended name:
Adenine phosphoribosyltransferase (EC:2.4.2.7)
Short name:
APRT
Gene namesi
Name:APRT
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Organism-specific databases

VGNCiVGNC:26042 APRT

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002403442 – 180Adenine phosphoribosyltransferaseAdd BLAST179

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei15PhosphoserineBy similarity1
Modified residuei30PhosphoserineBy similarity1
Modified residuei60PhosphotyrosineBy similarity1
Modified residuei66PhosphoserineBy similarity1
Modified residuei135PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ56JW4
PeptideAtlasiQ56JW4
PRIDEiQ56JW4

Expressioni

Gene expression databases

BgeeiENSBTAG00000000639

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000841

Structurei

3D structure databases

ProteinModelPortaliQ56JW4
SMRiQ56JW4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1712 Eukaryota
COG0503 LUCA
GeneTreeiENSGT00390000017259
HOGENOMiHOG000036776
HOVERGENiHBG003144
InParanoidiQ56JW4
KOiK00759
OMAiCAPIRKK
OrthoDBiEOG091G0XZC
TreeFamiTF300227

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_00004 Aden_phosphoribosyltr, 1 hit
InterProiView protein in InterPro
IPR005764 Ade_phspho_trans
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
PfamiView protein in Pfam
PF00156 Pribosyltran, 1 hit
SUPFAMiSSF53271 SSF53271, 1 hit
TIGRFAMsiTIGR01090 apt, 1 hit
PROSITEiView protein in PROSITE
PS00103 PUR_PYR_PR_TRANSFER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q56JW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADPELQLVA RRIRSFPNFP IPGVLFRDIS PVLKDPTSFR ASINLLANHL
60 70 80 90 100
KKAHGGRIDY IAGLDSRGFL FGPSLAQELG LGCILIRKRG KLPGPTVCAS
110 120 130 140 150
YALEYGKGEL EIQRDALEPG QKVVVVDDLL ATGGTMCAAC ELLGQLRAEV
160 170 180
LECVSLVELT SLKGREKLGA VPFFSLLQYE
Length:180
Mass (Da):19,537
Last modified:May 10, 2005 - v1
Checksum:i12594AF43DAFBCD4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY911367 mRNA Translation: AAW82131.1
BC102283 mRNA Translation: AAI02284.1
RefSeqiNP_001020505.1, NM_001025334.2
UniGeneiBt.6947

Genome annotation databases

EnsembliENSBTAT00000000841; ENSBTAP00000000841; ENSBTAG00000000639
GeneIDi519017
KEGGibta:519017

Similar proteinsi

Entry informationi

Entry nameiAPT_BOVIN
AccessioniPrimary (citable) accession number: Q56JW4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: May 10, 2005
Last modified: March 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health