Q56JW4 (APT_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenine phosphoribosyltransferase
Short name=APRT
EC=2.4.2.7

Gene names

Name:

APRT

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	180 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis By similarity.
Catalytic activity	AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate.
Pathway	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Ontologies

Keywords
Biological process	Purine salvage
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside salvage Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	adenine phosphoribosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 180	180	Adenine phosphoribosyltransferase		PRO_0000240344
Amino acid modifications
	Modified residue	15	1	Phosphoserine By similarity
	Modified residue	30	1	Phosphoserine By similarity
	Modified residue	60	1	Phosphotyrosine By similarity
	Modified residue	66	1	Phosphoserine By similarity
	Modified residue	100	1	Phosphoserine By similarity
	Modified residue	135	1	Phosphothreonine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q56JW4 [UniParc]. Last modified May 10, 2005. Version 1. Checksum: 12594AF43DAFBCD4	FASTA	180	19,537
	10 20 30 40 50 60 MADPELQLVA RRIRSFPNFP IPGVLFRDIS PVLKDPTSFR ASINLLANHL KKAHGGRIDY 70 80 90 100 110 120 IAGLDSRGFL FGPSLAQELG LGCILIRKRG KLPGPTVCAS YALEYGKGEL EIQRDALEPG 130 140 150 160 170 180 QKVVVVDDLL ATGGTMCAAC ELLGQLRAEV LECVSLVELT SLKGREKLGA VPFFSLLQYE

References

[1]	"Analysis of sequences obtained from constructed full-length bovine cDNA libraries." Yu J., Meng Y., Wang Z., Hansen C., Li C., Moore S.S. Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lymphoid epithelium.
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY911367 mRNA. Translation: AAW82131.1. BC102283 mRNA. Translation: AAI02284.1.
IPI	IPI00686658.
RefSeq	NP_001020505.1. NM_001025334.2.
UniGene	Bt.6947.
3D structure databases
ProteinModelPortal	Q56JW4.
SMR	Q56JW4. Positions 2-180.
ModBase	Search...
Protein-protein interaction databases
STRING	Q56JW4.
Proteomic databases
PRIDE	Q56JW4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000000841; ENSBTAP00000000841; ENSBTAG00000000639.
GeneID	519017.
KEGG	bta:519017.
Organism-specific databases
CTD	353.
Phylogenomic databases
eggNOG	maNOG17492.
GeneTree	ENSGT00390000017259.
HOVERGEN	HBG003144.
InParanoid	Q56JW4.
OMA	MNAACEL.
OrthoDB	EOG48KRCC.
PhylomeDB	Q56JW4.
Family and domain databases
InterPro	IPR005764. Ade_phspho_trans. IPR000836. PRibTrfase. [Graphical view]
KO	K00759.
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR01090. Apt. 1 hit.
PROSITE	PS00103. PUR_PYR_PR_TRANSFER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

APT_BOVIN

Accession

Primary (citable) accession number: Q56JW4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	May 10, 2005
Last modified:	November 16, 2011
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program