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Protein

Adenine phosphoribosyltransferase

Gene

APRT

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.By similarity

Catalytic activityi

AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate.

Pathwayi: AMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes AMP from adenine.
Proteins known to be involved in this subpathway in this organism are:
  1. Adenine phosphoribosyltransferase (APRT)
This subpathway is part of the pathway AMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from adenine, the pathway AMP biosynthesis via salvage pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

ReactomeiR-BTA-74217. Purine salvage.
UniPathwayiUPA00588; UER00646.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenine phosphoribosyltransferase (EC:2.4.2.7)
Short name:
APRT
Gene namesi
Name:APRT
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 180179Adenine phosphoribosyltransferasePRO_0000240344Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei15 – 151PhosphoserineBy similarity
Modified residuei30 – 301PhosphoserineBy similarity
Modified residuei60 – 601PhosphotyrosineBy similarity
Modified residuei66 – 661PhosphoserineBy similarity
Modified residuei135 – 1351PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ56JW4.
PeptideAtlasiQ56JW4.
PRIDEiQ56JW4.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000841.

Structurei

3D structure databases

ProteinModelPortaliQ56JW4.
SMRiQ56JW4. Positions 2-180.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1712. Eukaryota.
COG0503. LUCA.
GeneTreeiENSGT00390000017259.
HOGENOMiHOG000036776.
HOVERGENiHBG003144.
InParanoidiQ56JW4.
KOiK00759.
OMAiATVEIHA.
OrthoDBiEOG7FFMT9.
TreeFamiTF300227.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_00004. Aden_phosphoribosyltr.
InterProiIPR005764. Ade_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01090. apt. 1 hit.
PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q56JW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADPELQLVA RRIRSFPNFP IPGVLFRDIS PVLKDPTSFR ASINLLANHL
60 70 80 90 100
KKAHGGRIDY IAGLDSRGFL FGPSLAQELG LGCILIRKRG KLPGPTVCAS
110 120 130 140 150
YALEYGKGEL EIQRDALEPG QKVVVVDDLL ATGGTMCAAC ELLGQLRAEV
160 170 180
LECVSLVELT SLKGREKLGA VPFFSLLQYE
Length:180
Mass (Da):19,537
Last modified:May 10, 2005 - v1
Checksum:i12594AF43DAFBCD4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY911367 mRNA. Translation: AAW82131.1.
BC102283 mRNA. Translation: AAI02284.1.
RefSeqiNP_001020505.1. NM_001025334.2.
UniGeneiBt.6947.

Genome annotation databases

EnsembliENSBTAT00000000841; ENSBTAP00000000841; ENSBTAG00000000639.
GeneIDi519017.
KEGGibta:519017.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY911367 mRNA. Translation: AAW82131.1.
BC102283 mRNA. Translation: AAI02284.1.
RefSeqiNP_001020505.1. NM_001025334.2.
UniGeneiBt.6947.

3D structure databases

ProteinModelPortaliQ56JW4.
SMRiQ56JW4. Positions 2-180.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000841.

Proteomic databases

PaxDbiQ56JW4.
PeptideAtlasiQ56JW4.
PRIDEiQ56JW4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000000841; ENSBTAP00000000841; ENSBTAG00000000639.
GeneIDi519017.
KEGGibta:519017.

Organism-specific databases

CTDi353.

Phylogenomic databases

eggNOGiKOG1712. Eukaryota.
COG0503. LUCA.
GeneTreeiENSGT00390000017259.
HOGENOMiHOG000036776.
HOVERGENiHBG003144.
InParanoidiQ56JW4.
KOiK00759.
OMAiATVEIHA.
OrthoDBiEOG7FFMT9.
TreeFamiTF300227.

Enzyme and pathway databases

UniPathwayiUPA00588; UER00646.
ReactomeiR-BTA-74217. Purine salvage.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_00004. Aden_phosphoribosyltr.
InterProiIPR005764. Ade_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01090. apt. 1 hit.
PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Analysis of sequences obtained from constructed full-length bovine cDNA libraries."
    Yu J., Meng Y., Wang Z., Hansen C., Li C., Moore S.S.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymphoid epithelium.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiAPT_BOVIN
AccessioniPrimary (citable) accession number: Q56JW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: May 10, 2005
Last modified: July 6, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.