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Protein

40S ribosomal protein S3a

Gene

RPS3A

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role during erythropoiesis through regulation of transcription factor DDIT3.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Biological processi

Differentiation

Enzyme and pathway databases

ReactomeiR-BTA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-BTA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-BTA-72649. Translation initiation complex formation.
R-BTA-72689. Formation of a pool of free 40S subunits.
R-BTA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-BTA-72702. Ribosomal scanning and start codon recognition.
R-BTA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-BTA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-BTA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S3aUniRule annotation
Gene namesi
Name:RPS3AUniRule annotation
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 17

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Nucleus UniRule annotation

  • Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002307632 – 26440S ribosomal protein S3aAdd BLAST263

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34N6-acetyllysineBy similarity1
Modified residuei56N6-acetyllysineBy similarity1
Modified residuei236PhosphoserineBy similarity1
Modified residuei237PhosphoserineBy similarity1
Modified residuei249N6-acetyllysine; alternateBy similarity1
Cross-linki249Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei256PhosphotyrosineBy similarity1
Modified residuei263PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ56JV9.
PeptideAtlasiQ56JV9.
PRIDEiQ56JV9.

Expressioni

Gene expression databases

BgeeiENSBTAG00000009908.

Interactioni

Subunit structurei

Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.UniRule annotation

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013079.

Structurei

3D structure databases

ProteinModelPortaliQ56JV9.
SMRiQ56JV9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S3Ae family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1628. Eukaryota.
COG1890. LUCA.
GeneTreeiENSGT00390000018433.
HOGENOMiHOG000105220.
HOVERGENiHBG000783.
InParanoidiQ56JV9.
KOiK02984.
OMAiGQNAYTK.
OrthoDBiEOG091G0HTU.
TreeFamiTF300037.

Family and domain databases

HAMAPiMF_03122. Ribosomal_S3Ae_euk. 1 hit.
InterProiIPR027500. Ribosomal_S1/3_euk.
IPR001593. Ribosomal_S3Ae.
IPR018281. Ribosomal_S3Ae_CS.
[Graphical view]
PfamiPF01015. Ribosomal_S3Ae. 1 hit.
[Graphical view]
SMARTiSM01397. Ribosomal_S3Ae. 1 hit.
[Graphical view]
PROSITEiPS01191. RIBOSOMAL_S3AE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q56JV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVGKNKRLT KGGKKGAKKK VVDPFSKKDW YDVKAPAMFN IRNIGKTLVT
60 70 80 90 100
RTQGTKIASD GLKGRVFEVS LADLQNDEVA FRKFKLITED VQGKNCLTNF
110 120 130 140 150
HGMDLTRDKM CSMVKKWQTM IEAHVDVKTT DGYLLRLFCV GFTKKRNNQI
160 170 180 190 200
RKTSYAQHQQ VRQIRKKMME IMTREVQTND LKEVVNKLIP DSIGKDIEKA
210 220 230 240 250
CQSIYPLHDV FVRKVKMLKK PKFELGKLME LHGEGSSSGK ATGDETGAKV
260
ERADGYEPPV QESV
Length:264
Mass (Da):29,945
Last modified:January 23, 2007 - v3
Checksum:i000037AE195F7A9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY911372 mRNA. Translation: AAW82136.1.
BC151408 mRNA. Translation: AAI51409.1.
BC102789 mRNA. Translation: AAI02790.1.
RefSeqiNP_001029210.1. NM_001034038.1.
UniGeneiBt.14068.

Genome annotation databases

EnsembliENSBTAT00000013079; ENSBTAP00000013079; ENSBTAG00000009908.
GeneIDi282053.
KEGGibta:282053.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY911372 mRNA. Translation: AAW82136.1.
BC151408 mRNA. Translation: AAI51409.1.
BC102789 mRNA. Translation: AAI02790.1.
RefSeqiNP_001029210.1. NM_001034038.1.
UniGeneiBt.14068.

3D structure databases

ProteinModelPortaliQ56JV9.
SMRiQ56JV9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013079.

Proteomic databases

PaxDbiQ56JV9.
PeptideAtlasiQ56JV9.
PRIDEiQ56JV9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000013079; ENSBTAP00000013079; ENSBTAG00000009908.
GeneIDi282053.
KEGGibta:282053.

Organism-specific databases

CTDi6189.

Phylogenomic databases

eggNOGiKOG1628. Eukaryota.
COG1890. LUCA.
GeneTreeiENSGT00390000018433.
HOGENOMiHOG000105220.
HOVERGENiHBG000783.
InParanoidiQ56JV9.
KOiK02984.
OMAiGQNAYTK.
OrthoDBiEOG091G0HTU.
TreeFamiTF300037.

Enzyme and pathway databases

ReactomeiR-BTA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-BTA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-BTA-72649. Translation initiation complex formation.
R-BTA-72689. Formation of a pool of free 40S subunits.
R-BTA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-BTA-72702. Ribosomal scanning and start codon recognition.
R-BTA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-BTA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-BTA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Gene expression databases

BgeeiENSBTAG00000009908.

Family and domain databases

HAMAPiMF_03122. Ribosomal_S3Ae_euk. 1 hit.
InterProiIPR027500. Ribosomal_S1/3_euk.
IPR001593. Ribosomal_S3Ae.
IPR018281. Ribosomal_S3Ae_CS.
[Graphical view]
PfamiPF01015. Ribosomal_S3Ae. 1 hit.
[Graphical view]
SMARTiSM01397. Ribosomal_S3Ae. 1 hit.
[Graphical view]
PROSITEiPS01191. RIBOSOMAL_S3AE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRS3A_BOVIN
AccessioniPrimary (citable) accession number: Q56JV9
Secondary accession number(s): A2V9E4, B0JYM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 88 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.