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Q56JV6

- TWF1_BOVIN

UniProt

Q56JV6 - TWF1_BOVIN

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Protein

Twinfilin-1

Gene

TWF1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles (By similarity).By similarity

GO - Molecular functioni

  1. ATP binding Source: Ensembl
  2. phosphatidylinositol-4,5-bisphosphate binding Source: Ensembl
  3. protein tyrosine kinase activity Source: Ensembl

GO - Biological processi

  1. barbed-end actin filament capping Source: Ensembl
  2. regulation of actin phosphorylation Source: Ensembl
  3. sequestering of actin monomers Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Twinfilin-1
Gene namesi
Name:TWF1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 5

Subcellular locationi

Cytoplasm. Cytoplasmcytoskeleton By similarity
Note: Diffuse cytoplasmic localization with perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts (By similarity).By similarity

GO - Cellular componenti

  1. actin cytoskeleton Source: Ensembl
  2. cell-cell junction Source: Ensembl
  3. filopodium Source: Ensembl
  4. myofibril Source: Ensembl
  5. perinuclear region of cytoplasm Source: Ensembl
  6. ruffle membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 350349Twinfilin-1PRO_0000232404Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei143 – 1431PhosphoserineBy similarity
Modified residuei309 – 3091PhosphotyrosineBy similarity
Modified residuei349 – 3491PhosphothreonineBy similarity

Post-translational modificationi

Phosphorylated on serine and threonine residues.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ56JV6.

Interactioni

Subunit structurei

Interacts with G-actin; ADP-actin form and capping protein (CP). May also be able to interact with TWF2 and phosphoinositides, PI(4,5)P2. When bound to PI(4,5)P2, it is down-regulated (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027889.

Structurei

3D structure databases

ProteinModelPortaliQ56JV6.
SMRiQ56JV6. Positions 7-139, 161-313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 139138ADF-H 1PROSITE-ProRule annotationAdd
BLAST
Domaini177 – 313137ADF-H 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ADF-H domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG263290.
GeneTreeiENSGT00530000063868.
HOGENOMiHOG000168296.
HOVERGENiHBG000848.
InParanoidiQ56JV6.
KOiK08870.
OMAiTVFIYSM.
OrthoDBiEOG79GT6W.
TreeFamiTF352598.

Family and domain databases

Gene3Di3.40.20.10. 2 hits.
InterProiIPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR028458. Twinfilin.
[Graphical view]
PANTHERiPTHR13759. PTHR13759. 1 hit.
PfamiPF00241. Cofilin_ADF. 2 hits.
[Graphical view]
SMARTiSM00102. ADF. 2 hits.
[Graphical view]
PROSITEiPS51263. ADF_H. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q56JV6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSHQTGIQAS EDVKDIFARA RNGKYRLLKI SIENEKLVIG SCRKPSDSWD
60 70 80 90 100
QDYDSFVLPL LEDKQPCYVL FRLDSQNAQG YEWIFIAWSP DHSHVRQKML
110 120 130 140 150
YAATRATLKK EFGGGHIKDE MFGTVKEDVS LHGYKKYLLS QSSPAPLTAA
160 170 180 190 200
EEELRQIKIN EVQTDVSVDA KHQTLQGVAF PISQEAFQAL EKLNNRQLNY
210 220 230 240 250
VQLEIDIKNE IIILANTINT ELKDLPKRIP KDAARYHFFL YKHSHEGDYL
260 270 280 290 300
ESIVFIYSMP GYTCSIRERM LYSSCKSPLL EIVERQLQMD IIRKIEIDNG
310 320 330 340 350
DELTADFLYE EVHPKQHAHK QSFAKPKGPS GKRGIRRIIR GPAETEATTE
Length:350
Mass (Da):40,249
Last modified:May 10, 2005 - v1
Checksum:iEFEFC1E0DC21E7A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY911376 mRNA. Translation: AAW82139.1.
RefSeqiNP_001020491.1. NM_001025320.2.
UniGeneiBt.5944.

Genome annotation databases

EnsembliENSBTAT00000027889; ENSBTAP00000027889; ENSBTAG00000020938.
GeneIDi506683.
KEGGibta:506683.

Cross-referencesi

Web resourcesi

Protein Spotlight

Molecular embrace - Issue 73 of August 2006

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY911376 mRNA. Translation: AAW82139.1 .
RefSeqi NP_001020491.1. NM_001025320.2.
UniGenei Bt.5944.

3D structure databases

ProteinModelPortali Q56JV6.
SMRi Q56JV6. Positions 7-139, 161-313.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000027889.

Proteomic databases

PRIDEi Q56JV6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000027889 ; ENSBTAP00000027889 ; ENSBTAG00000020938 .
GeneIDi 506683.
KEGGi bta:506683.

Organism-specific databases

CTDi 5756.

Phylogenomic databases

eggNOGi NOG263290.
GeneTreei ENSGT00530000063868.
HOGENOMi HOG000168296.
HOVERGENi HBG000848.
InParanoidi Q56JV6.
KOi K08870.
OMAi TVFIYSM.
OrthoDBi EOG79GT6W.
TreeFami TF352598.

Miscellaneous databases

NextBioi 20867714.

Family and domain databases

Gene3Di 3.40.20.10. 2 hits.
InterProi IPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR028458. Twinfilin.
[Graphical view ]
PANTHERi PTHR13759. PTHR13759. 1 hit.
Pfami PF00241. Cofilin_ADF. 2 hits.
[Graphical view ]
SMARTi SM00102. ADF. 2 hits.
[Graphical view ]
PROSITEi PS51263. ADF_H. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Analysis of sequences obtained from constructed full-length bovine cDNA libraries."
    Yu J., Meng Y., Wang Z., Hansen C., Li C., Moore S.S.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymphoid epithelium.

Entry informationi

Entry nameiTWF1_BOVIN
AccessioniPrimary (citable) accession number: Q56JV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: May 10, 2005
Last modified: October 1, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3