Reviewed, UniProtKB/Swiss-Prot Q56E62 (NDK1_TOBAC)

Names and origin

Protein names	Recommended name:     Nucleoside diphosphate kinase 1     EC=2.7.4.6 Alternative name(s):     Nucleoside diphosphate kinase I       Short name=NDP kinase I       Short name=NDPK I       Short name=NDK I
Organism	Nicotiana tabacum (Common tobacco)
Taxonomic identifier	4097 [NCBI]
Taxonomic lineage	Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Solanales › Solanaceae › Nicotianoideae › Nicotianeae › Nicotiana

Protein attributes

Sequence length	148 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate By similarity.
Catalytic activity	ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
Cofactor	Magnesium By similarity. UniProtKB P08879
Sequence similarities	Belongs to the NDK family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	CTP biosynthetic process Inferred from electronic annotation. Source: InterPro GTP biosynthetic process Inferred from electronic annotation. Source: InterPro UTP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside diphosphate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 148	148	Nucleoside diphosphate kinase 1		PRO_0000257977
Sites
	Active site	115	1	Pros-phosphohistidine intermediate By similarity UniProtKB P08879
	Binding site	9	1	ATP By similarity UniProtKB P08879
	Binding site	57	1	ATP By similarity UniProtKB P08879
	Binding site	85	1	ATP By similarity UniProtKB P08879
	Binding site	91	1	ATP By similarity UniProtKB P08879
	Binding site	102	1	ATP By similarity UniProtKB P08879
	Binding site	112	1	ATP By similarity UniProtKB P08879

Sequences

	Sequence		Length	Mass (Da)
	Q56E62-1 [UniParc]. Last modified May 10, 2005. Version 1. Checksum: BABA6D30AE3D3BF7	FASTA	148	16,296
	10 20 30 40 50 60 MEQTFIMIKP DGVQRGLVGE IIGRFEKKGF SLKGLKLITV DRAFAEKHYS DLSAKPFFNG 70 80 90 100 110 120 LVDYIISGPV VAMVWEGKGV VTTGRKIIGA TNPLESAPGT IRGDYAIDIG RNVIHGSDAV 130 140 ESARKEIALW FPEGVAEWQS SLHSWIYE

References

[1]	"Nicotiana tabacum nucleoside diphosphate kinase." Zhou Q., Zhang J., Chen S. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY962601 mRNA. Translation: AAX63738.1.
3D structure databases
SMR	Q56E62. Positions 1-148.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.7.4.6. 298.
Family and domain databases
InterPro	IPR001564. Nuc_diP_kinase_core. [Graphical view]
Gene3D	G3DSA:3.30.70.141. NDK. 1 hit.
PANTHER	PTHR11349. Nuc_diP_kinase_core. 1 hit.
Pfam	PF00334. NDK. 1 hit. [Graphical view]
PRINTS	PR01243. NUCDPKINASE.
ProDom	PD001018. NDK. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00562. NDK. 1 hit. [Graphical view]
PROSITE	PS00469. NDP_KINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NDK1_TOBAC

Accession

Primary (citable) accession number: Q56E62

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	May 10, 2005
Last modified:	June 16, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)