Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Spindlin-4

Gene

SPIN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Spindlin-4
Gene namesi
Name:SPIN4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:27040. SPIN4.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162404539.

Polymorphism and mutation databases

BioMutaiSPIN4.
DMDMi74735974.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 249249Spindlin-4PRO_0000313794Add
BLAST

Proteomic databases

EPDiQ56A73.
MaxQBiQ56A73.
PaxDbiQ56A73.
PRIDEiQ56A73.

PTM databases

iPTMnetiQ56A73.
PhosphoSiteiQ56A73.

Expressioni

Gene expression databases

BgeeiQ56A73.
CleanExiHS_SPIN4.
ExpressionAtlasiQ56A73. baseline and differential.
GenevisibleiQ56A73. HS.

Organism-specific databases

HPAiHPA044559.

Interactioni

Protein-protein interaction databases

BioGridi126590. 4 interactions.

Structurei

Secondary structure

1
249
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi44 – 496Combined sources
Beta strandi57 – 6610Combined sources
Beta strandi74 – 785Combined sources
Beta strandi85 – 873Combined sources
Turni89 – 913Combined sources
Beta strandi95 – 1017Combined sources
Helixi112 – 1187Combined sources
Beta strandi122 – 1276Combined sources
Turni130 – 1323Combined sources
Beta strandi135 – 14410Combined sources
Beta strandi146 – 1483Combined sources
Beta strandi151 – 1566Combined sources
Beta strandi159 – 1657Combined sources
Helixi168 – 1725Combined sources
Beta strandi176 – 1816Combined sources
Beta strandi204 – 2085Combined sources
Beta strandi214 – 2229Combined sources
Beta strandi224 – 2263Combined sources
Beta strandi229 – 2346Combined sources
Beta strandi241 – 2455Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4UY4X-ray1.86A/B36-249[»]
ProteinModelPortaliQ56A73.
SMRiQ56A73. Positions 35-246.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SPIN/STSY family.Curated

Phylogenomic databases

eggNOGiENOG410JB46. Eukaryota.
ENOG41113VC. LUCA.
GeneTreeiENSGT00760000119261.
HOGENOMiHOG000293367.
HOVERGENiHBG000686.
InParanoidiQ56A73.
OMAiHGRKDEW.
OrthoDBiEOG7CK37K.
PhylomeDBiQ56A73.
TreeFamiTF332665.

Family and domain databases

InterProiIPR003671. SPIN/Ssty.
IPR029578. Spindlin-4.
[Graphical view]
PANTHERiPTHR10405. PTHR10405. 1 hit.
PTHR10405:SF9. PTHR10405:SF9. 1 hit.
PfamiPF02513. Spin-Ssty. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q56A73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPPTVPPMG VDGVSAYLMK KRHTHRKQRR KPTFLTRRNI VGCRIQHGWK
60 70 80 90 100
EGNEPVEQWK GTVLEQVSVK PTLYIIKYDG KDSVYGLELH RDKRVLALEI
110 120 130 140 150
LPERVPTPRI DSRLADSLIG KAVEHVFEGE HGTKDEWKGM VLARAPVMDT
160 170 180 190 200
WFYITYEKDP VLYMYTLLDD YKDGDLRIIP DSNYYFPTAE QEPGEVVDSL
210 220 230 240
VGKQVEHAKD DGSKRTGIFI HQVVAKPSVY FIKFDDDIHI YVYGLVKTP
Length:249
Mass (Da):28,660
Last modified:May 10, 2005 - v1
Checksum:iFF0CB0229107D8D4
GO

Sequence cautioni

The sequence CAI41371.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti227 – 2271P → S in BAG54402 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126931 mRNA. Translation: BAG54402.1.
AL158203 Genomic DNA. Translation: CAI41371.1. Different initiation.
BC043412 mRNA. Translation: AAH43412.1.
BC112360 mRNA. Translation: AAI12361.1.
CCDSiCCDS43964.1.
RefSeqiNP_001012986.2. NM_001012968.2.
UniGeneiHs.612782.

Genome annotation databases

EnsembliENST00000335144; ENSP00000334163; ENSG00000186767.
GeneIDi139886.
KEGGihsa:139886.
UCSCiuc004dvf.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126931 mRNA. Translation: BAG54402.1.
AL158203 Genomic DNA. Translation: CAI41371.1. Different initiation.
BC043412 mRNA. Translation: AAH43412.1.
BC112360 mRNA. Translation: AAI12361.1.
CCDSiCCDS43964.1.
RefSeqiNP_001012986.2. NM_001012968.2.
UniGeneiHs.612782.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4UY4X-ray1.86A/B36-249[»]
ProteinModelPortaliQ56A73.
SMRiQ56A73. Positions 35-246.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126590. 4 interactions.

PTM databases

iPTMnetiQ56A73.
PhosphoSiteiQ56A73.

Polymorphism and mutation databases

BioMutaiSPIN4.
DMDMi74735974.

Proteomic databases

EPDiQ56A73.
MaxQBiQ56A73.
PaxDbiQ56A73.
PRIDEiQ56A73.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335144; ENSP00000334163; ENSG00000186767.
GeneIDi139886.
KEGGihsa:139886.
UCSCiuc004dvf.3. human.

Organism-specific databases

CTDi139886.
GeneCardsiSPIN4.
HGNCiHGNC:27040. SPIN4.
HPAiHPA044559.
neXtProtiNX_Q56A73.
PharmGKBiPA162404539.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JB46. Eukaryota.
ENOG41113VC. LUCA.
GeneTreeiENSGT00760000119261.
HOGENOMiHOG000293367.
HOVERGENiHBG000686.
InParanoidiQ56A73.
OMAiHGRKDEW.
OrthoDBiEOG7CK37K.
PhylomeDBiQ56A73.
TreeFamiTF332665.

Miscellaneous databases

GenomeRNAii139886.
NextBioi35470554.
PROiQ56A73.

Gene expression databases

BgeeiQ56A73.
CleanExiHS_SPIN4.
ExpressionAtlasiQ56A73. baseline and differential.
GenevisibleiQ56A73. HS.

Family and domain databases

InterProiIPR003671. SPIN/Ssty.
IPR029578. Spindlin-4.
[Graphical view]
PANTHERiPTHR10405. PTHR10405. 1 hit.
PTHR10405:SF9. PTHR10405:SF9. 1 hit.
PfamiPF02513. Spin-Ssty. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.

Entry informationi

Entry nameiSPIN4_HUMAN
AccessioniPrimary (citable) accession number: Q56A73
Secondary accession number(s): B3KX90, Q5JUL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 10, 2005
Last modified: March 16, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.