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Protein

Coiled-coil domain-containing protein 40

Gene

ccdc40

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with ccdc39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella.By similarity

GO - Biological processi

  • axonemal dynein complex assembly Source: UniProtKB
  • axoneme assembly Source: ZFIN
  • cilium assembly Source: ZFIN
  • cilium movement Source: UniProtKB
  • determination of left/right symmetry Source: ZFIN
  • embryonic heart tube morphogenesis Source: ZFIN
  • epithelial cilium movement Source: ZFIN
  • epithelial cilium movement involved in determination of left/right asymmetry Source: UniProtKB
  • heart jogging Source: ZFIN
  • heart looping Source: ZFIN
  • pronephros development Source: ZFIN

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 40Curated
Alternative name(s):
Protein locke1 Publication
Gene namesi
Name:ccdc40
Synonyms:lok1 Publication
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 6

Organism-specific databases

ZFINiZDB-GENE-060503-723. ccdc40.

Subcellular locationi

  • Cytoplasm By similarity
  • Cell projectioncilium By similarity

  • Note: Localizes to cytoplasm and motile cilium.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Defects are the cause of the lok phenotype, a phenotype related to primary ciliary dyskinesia (PCD). PCD is characterized by curly-tail down phenotype, laterality defects and pronephric cysts, but without defects in sensory cilia and without the presence of hydrocephalus.1 Publication

Keywords - Diseasei

Ciliopathy, Primary ciliary dyskinesia

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004058211 – 941Coiled-coil domain-containing protein 40Add BLAST941

Proteomic databases

PaxDbiQ56A40.
PRIDEiQ56A40.

Expressioni

Tissue specificityi

Expressed in tissues that contain motile cilia, including Kupffer's vesicle, the floorplate, the pronephric tubules and the otic vesicle.1 Publication

Gene expression databases

BgeeiENSDARG00000100584.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000121686.

Structurei

3D structure databases

SMRiQ56A40.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili130 – 154Sequence analysisAdd BLAST25
Coiled coili210 – 430Sequence analysisAdd BLAST221
Coiled coili548 – 572Sequence analysisAdd BLAST25
Coiled coili609 – 765Sequence analysisAdd BLAST157
Coiled coili814 – 856Sequence analysisAdd BLAST43
Coiled coili895 – 915Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the CCDC40 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEY4. Eukaryota.
ENOG410XTIY. LUCA.
GeneTreeiENSGT00440000035688.
HOGENOMiHOG000111411.
InParanoidiQ56A40.
OMAiFHHKQLE.
OrthoDBiEOG091G0271.
PhylomeDBiQ56A40.
TreeFamiTF325559.

Family and domain databases

InterProiView protein in InterPro
IPR013956. E3_ubiquit_lig_BRE1.
PfamiView protein in Pfam
PF08647. BRE1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q56A40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGRQEDQMN RQEEVEQSNN YDRSVDHART GRSSWIDNSE INSKWIPQHS
60 70 80 90 100
LQLEMNNIEG EGSVRENDEE EEEIVVLDPE HPLMKRFQTA LKNNFTNQLE
110 120 130 140 150
RLNLDLCEKV VVEKAEAQRR HDLAEEVYMV QEMLARLQAS LEVCQETNSE
160 170 180 190 200
AAAQHRQAED HLYVVKNQYQ DTASQTNVQR LQVLELQSKV DNLALKLLYM
210 220 230 240 250
QEAKSDLCSD IKAIINASNK AQKERTQTEE QKHQQDIYVE RLTNRVEKLL
260 270 280 290 300
EQISLYDLQL ISQTEQTRAA KDSLSEAQLE LDSVIVEHRQ LLQQWKSSLL
310 320 330 340 350
MMKRRDEAYT AMQEELRQAN DQMLSLDTEI ESYKKSITQE EEQNECLTLR
360 370 380 390 400
LNRGQTDCTT SRKLITHSQN LQEVLQAQLS TYTRILQETE NTLSTLHGNL
410 420 430 440 450
EMHQSALKAL RKQMEKVSAV RLDLESQIMN KLQEQLTHNN AAKYSRRMND
460 470 480 490 500
KTAVYRREKE AQLIKFENDF NTVTLEGQEL ATHLDSLLAF QAELEQKSTQ
510 520 530 540 550
RHLLLSSREE EIVKQITDIE RKQATISIYN KKIKDIVSST GHEDLGPLEI
560 570 580 590 600
HAATLSKELE EVGAKIKECQ QLWLWQQGEL VRFTQEKQAH SSSVQILQTQ
610 620 630 640 650
LTILQQGKIR RESEMEQDQS ELADLDKQIK VLMADMVKLN SLLNKNSDLN
660 670 680 690 700
HALQQSSNLM ETEFRQRLKE AEKDSAETQL KLERLNEEKE RLINSLVEAE
710 720 730 740 750
RQVMLWGKRT QLMQETCSAI DSDIGQGDIR TMRAEIHRME VRYAQLMKQQ
760 770 780 790 800
ERLLRDMESV VAKSKTIAVW SEAQARTQAH KQPTHNDYHN TIQSLRRKIL
810 820 830 840 850
QTKKQTEECD GVIAQLEERL GSMTSRLQDK QMHLNNIQNT EAFLSQDLRR
860 870 880 890 900
LQEIKERNLY RLPVLQTRAK HLHAVKEGRY TPMATGVTAL ELGTHKQEER
910 920 930 940
LKMVSLTLQR LAQEYPQHHS TLHRMNSILA EHLHGECPNS Q
Length:941
Mass (Da):109,492
Last modified:March 8, 2011 - v2
Checksum:i197773239C344FEC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti337I → G in AAH92181 (Ref. 2) Curated1
Sequence conflicti466F → L in AAH92181 (Ref. 2) Curated1
Sequence conflicti730R → Q in AAH92181 (Ref. 2) Curated1
Sequence conflicti765K → E in AAH92181 (Ref. 2) Curated1
Sequence conflicti780H → Q in AAH92181 (Ref. 2) Curated1
Sequence conflicti854I → T in AAH92181 (Ref. 2) Curated1
Sequence conflicti882P → A in AAH92181 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX005286 Genomic DNA. No translation available.
CR854963 Genomic DNA. No translation available.
BC092181 mRNA. Translation: AAH92181.1.
RefSeqiNP_001258742.1. NM_001271813.1.
UniGeneiDr.157455.
Dr.25001.

Genome annotation databases

EnsembliENSDART00000169752; ENSDARP00000139124; ENSDARG00000100584.
GeneIDi568590.
KEGGidre:568590.

Entry informationi

Entry nameiCCD40_DANRE
AccessioniPrimary (citable) accession number: Q56A40
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 8, 2011
Last modified: August 30, 2017
This is version 66 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families