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Protein

Mitogen-activated protein kinase

Gene

Mapk14

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

Cofactori

Mg2+SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseSAAS annotation, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-168638 NOD1/2 Signaling Pathway
R-RNO-171007 p38MAPK events
R-RNO-198753 ERK/MAPK targets
R-RNO-2559580 Oxidative Stress Induced Senescence
R-RNO-375170 CDO in myogenesis
R-RNO-376172 DSCAM interactions
R-RNO-418592 ADP signalling through P2Y purinoceptor 1
R-RNO-432142 Platelet sensitization by LDL
R-RNO-4420097 VEGFA-VEGFR2 Pathway
R-RNO-450302 activated TAK1 mediates p38 MAPK activation
R-RNO-450341 Activation of the AP-1 family of transcription factors
R-RNO-6798695 Neutrophil degranulation
R-RNO-6804756 Regulation of TP53 Activity through Phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinaseSAAS annotation (EC:2.7.11.24SAAS annotation)
Gene namesi
Name:Mapk14Imported
ORF Names:rCG_61074Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi70496 Mapk14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiQ56A33

Expressioni

Gene expression databases

BgeeiENSRNOG00000000513
ExpressionAtlasiQ56A33 baseline and differential

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 308Protein kinaseInterPro annotationAdd BLAST285

Phylogenomic databases

eggNOGiKOG0660 Eukaryota
ENOG410XNY0 LUCA
GeneTreeiENSGT00550000074271
HOGENOMiHOG000233024
HOVERGENiHBG014652
KOiK04441
OMAiDVIDTIC

Family and domain databases

CDDicd07877 STKc_p38alpha, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR003527 MAP_kinase_CS
IPR008352 MAPK_p38-like
IPR038784 p38alpha
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PRINTSiPR01773 P38MAPKINASE
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS01351 MAPK, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

Q56A33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQERPTFYR QELNKTVWEV PERYQNLSPV GSGAYGSVCA AFDTKTGHRV
60 70 80 90 100
AVKKLSRPFQ SIIHAKRTYR ELRLLKHMKH ENVIGLLDVF TPARSLEEFN
110 120 130 140 150
DVYLVTHLMG ADLNNIVKCQ KLTDDHVQFL IYQILRGLKY IHSADIIHRD
160 170 180 190 200
LKPSNLAVNE DCELKILDFG LARHTDDEMT GYVATRWYRA PEIMLNWMHY
210 220 230 240 250
NQTVDIWSVG CIMAELLTGR TLFPGTDHIN QLQQIMRLTG TPPAYLINRM
260 270 280 290 300
PSHEARNYIQ SLAQMPKMNF ANVFIGANPL AVDLLEKMLV LDSDKRITAA
310 320 330 340 350
QALAHAYFAQ YHDPDDEPVA DPYDQSFESR DLLIDEWKSL TYDEVISFVP
360
PPLDQEEMES
Length:360
Mass (Da):41,473
Last modified:May 10, 2005 - v1
Checksum:i96FCD91227264A6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07044432 Genomic DNA No translation available.
AABR07044433 Genomic DNA No translation available.
AABR07044434 Genomic DNA No translation available.
BC092193 mRNA Translation: AAH92193.1
AB000783 mRNA Translation: BAF80890.1
CH473988 Genomic DNA Translation: EDL96935.1
CH473988 Genomic DNA Translation: EDL96937.1
RefSeqiNP_112282.2, NM_031020.2
UniGeneiRn.88085

Genome annotation databases

EnsembliENSRNOT00000000617; ENSRNOP00000000617; ENSRNOG00000000513
GeneIDi81649
KEGGirno:81649

Similar proteinsi

Entry informationi

Entry nameiQ56A33_RAT
AccessioniPrimary (citable) accession number: Q56A33
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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