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Protein

Mitogen-activated protein kinase

Gene

Mapk14

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: Ensembl

GO - Biological processi

  1. angiogenesis Source: Ensembl
  2. cartilage condensation Source: Ensembl
  3. cell morphogenesis Source: Ensembl
  4. cellular response to ionizing radiation Source: Ensembl
  5. cellular response to vascular endothelial growth factor stimulus Source: Ensembl
  6. chondrocyte differentiation Source: Ensembl
  7. DNA damage checkpoint Source: Ensembl
  8. fatty acid oxidation Source: Ensembl
  9. glucose metabolic process Source: Ensembl
  10. lipopolysaccharide-mediated signaling pathway Source: Ensembl
  11. myoblast differentiation involved in skeletal muscle regeneration Source: Ensembl
  12. negative regulation of canonical Wnt signaling pathway Source: Ensembl
  13. osteoclast differentiation Source: Ensembl
  14. p38MAPK cascade Source: Ensembl
  15. peptidyl-serine phosphorylation Source: Ensembl
  16. positive regulation of brown fat cell differentiation Source: Ensembl
  17. positive regulation of erythrocyte differentiation Source: Ensembl
  18. positive regulation of myoblast differentiation Source: Ensembl
  19. positive regulation of myoblast fusion Source: Ensembl
  20. positive regulation of protein import into nucleus Source: Ensembl
  21. positive regulation of reactive oxygen species metabolic process Source: Ensembl
  22. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  23. response to muramyl dipeptide Source: Ensembl
  24. signal transduction in response to DNA damage Source: Ensembl
  25. skeletal muscle tissue development Source: Ensembl
  26. stress-induced premature senescence Source: Ensembl
  27. striated muscle cell differentiation Source: Ensembl
  28. transmembrane receptor protein serine/threonine kinase signaling pathway Source: Ensembl
  29. vascular endothelial growth factor receptor signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_287155. CDO in myogenesis.
REACT_297490. ERK/MAPK targets.
REACT_300308. Activation of the AP-1 family of transcription factors.
REACT_301330. VEGFA-VEGFR2 Pathway.
REACT_302239. Oxidative Stress Induced Senescence.
REACT_303984. NOD1/2 Signaling Pathway.
REACT_309327. Platelet sensitization by LDL.
REACT_312904. p38MAPK events.
REACT_318757. ADP signalling through P2Y purinoceptor 1.
REACT_324879. Activation of PPARGC1A (PGC-1alpha) by phosphorylation.
REACT_332847. KSRP destabilizes mRNA.
REACT_335299. DSCAM interactions.
REACT_347906. activated TAK1 mediates p38 MAPK activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinaseSAAS annotation (EC:2.7.11.24SAAS annotation)
Gene namesi
Name:Mapk14Imported
ORF Names:rCG_61074Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi70496. Mapk14.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. extracellular vesicular exosome Source: Ensembl
  3. mitochondrion Source: Ensembl
  4. nucleus Source: Ensembl
  5. spindle pole Source: Ensembl
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

PhosphoproteinSAAS annotation

Expressioni

Gene expression databases

GenevestigatoriQ56A33.

Family & Domainsi

Sequence similaritiesi

Contains protein kinase domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00550000074271.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
KOiK04441.
OMAiFETTERY.
OrthoDBiEOG7PCJGV.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008352. MAPK_p38.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01773. P38MAPKINASE.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q56A33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQERPTFYR QELNKTVWEV PERYQNLSPV GSGAYGSVCA AFDTKTGHRV
60 70 80 90 100
AVKKLSRPFQ SIIHAKRTYR ELRLLKHMKH ENVIGLLDVF TPARSLEEFN
110 120 130 140 150
DVYLVTHLMG ADLNNIVKCQ KLTDDHVQFL IYQILRGLKY IHSADIIHRD
160 170 180 190 200
LKPSNLAVNE DCELKILDFG LARHTDDEMT GYVATRWYRA PEIMLNWMHY
210 220 230 240 250
NQTVDIWSVG CIMAELLTGR TLFPGTDHIN QLQQIMRLTG TPPAYLINRM
260 270 280 290 300
PSHEARNYIQ SLAQMPKMNF ANVFIGANPL AVDLLEKMLV LDSDKRITAA
310 320 330 340 350
QALAHAYFAQ YHDPDDEPVA DPYDQSFESR DLLIDEWKSL TYDEVISFVP
360
PPLDQEEMES
Length:360
Mass (Da):41,473
Last modified:May 10, 2005 - v1
Checksum:i96FCD91227264A6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06099918 Genomic DNA. No translation available.
AABR06099919 Genomic DNA. No translation available.
AABR06099920 Genomic DNA. No translation available.
BC092193 mRNA. Translation: AAH92193.1.
AB000783 mRNA. Translation: BAF80890.1.
CH473988 Genomic DNA. Translation: EDL96935.1.
CH473988 Genomic DNA. Translation: EDL96937.1.
RefSeqiNP_112282.2. NM_031020.2.
UniGeneiRn.88085.

Genome annotation databases

EnsembliENSRNOT00000000617; ENSRNOP00000000617; ENSRNOG00000000513.
GeneIDi81649.
KEGGirno:81649.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06099918 Genomic DNA. No translation available.
AABR06099919 Genomic DNA. No translation available.
AABR06099920 Genomic DNA. No translation available.
BC092193 mRNA. Translation: AAH92193.1.
AB000783 mRNA. Translation: BAF80890.1.
CH473988 Genomic DNA. Translation: EDL96935.1.
CH473988 Genomic DNA. Translation: EDL96937.1.
RefSeqiNP_112282.2. NM_031020.2.
UniGeneiRn.88085.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000000617; ENSRNOP00000000617; ENSRNOG00000000513.
GeneIDi81649.
KEGGirno:81649.

Organism-specific databases

CTDi1432.
RGDi70496. Mapk14.

Phylogenomic databases

GeneTreeiENSGT00550000074271.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
KOiK04441.
OMAiFETTERY.
OrthoDBiEOG7PCJGV.

Enzyme and pathway databases

ReactomeiREACT_287155. CDO in myogenesis.
REACT_297490. ERK/MAPK targets.
REACT_300308. Activation of the AP-1 family of transcription factors.
REACT_301330. VEGFA-VEGFR2 Pathway.
REACT_302239. Oxidative Stress Induced Senescence.
REACT_303984. NOD1/2 Signaling Pathway.
REACT_309327. Platelet sensitization by LDL.
REACT_312904. p38MAPK events.
REACT_318757. ADP signalling through P2Y purinoceptor 1.
REACT_324879. Activation of PPARGC1A (PGC-1alpha) by phosphorylation.
REACT_332847. KSRP destabilizes mRNA.
REACT_335299. DSCAM interactions.
REACT_347906. activated TAK1 mediates p38 MAPK activation.

Miscellaneous databases

NextBioi615178.

Gene expression databases

GenevestigatoriQ56A33.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008352. MAPK_p38.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01773. P38MAPKINASE.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of rat P38 mitogen-activated protein kinase and it's osmotic regulation in rat kidney."
    Yoshida T., Sone M., Ogawa T., Nihei H., Ozasa H., Tsukada K., Horikawa S.
    IUBMB Life 43:63-72(1997)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: WistarImported.
    Tissue: KidneyImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.
  3. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  6. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ56A33_RAT
AccessioniPrimary (citable) accession number: Q56A33
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: April 29, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.