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Protein

G patch domain and KOW motifs-containing protein

Gene

Gpkow

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
G patch domain and KOW motifs-containing protein
Alternative name(s):
Protein MOS2 homolog
Gene namesi
Name:Gpkow
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1859610. Gpkow.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 488487G patch domain and KOW motifs-containing proteinPRO_0000280563Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei115 – 1151PhosphoserineBy similarity
Modified residuei485 – 4851PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ56A08.
MaxQBiQ56A08.
PaxDbiQ56A08.
PeptideAtlasiQ56A08.
PRIDEiQ56A08.

PTM databases

iPTMnetiQ56A08.
PhosphoSiteiQ56A08.

Expressioni

Gene expression databases

BgeeiQ56A08.
CleanExiMM_GPKOW.
ExpressionAtlasiQ56A08. baseline and differential.
GenevisibleiQ56A08. MM.

Interactioni

Subunit structurei

Interacts with PRKX.By similarity

Protein-protein interaction databases

BioGridi229077. 13 interactions.
IntActiQ56A08. 13 interactions.
STRINGi10090.ENSMUSP00000076178.

Structurei

3D structure databases

ProteinModelPortaliQ56A08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini164 – 21047G-patchPROSITE-ProRule annotationAdd
BLAST
Domaini231 – 25828KOW 1Add
BLAST
Domaini401 – 42828KOW 2Add
BLAST

Sequence similaritiesi

Belongs to the MOS2 family.Curated
Contains 1 G-patch domain.PROSITE-ProRule annotation
Contains 2 KOW domains.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4315. Eukaryota.
ENOG410YYBE. LUCA.
GeneTreeiENSGT00390000015154.
HOGENOMiHOG000231362.
HOVERGENiHBG080241.
InParanoidiQ56A08.
KOiK13101.
OMAiCIPEREG.
OrthoDBiEOG7FV3Q7.
PhylomeDBiQ56A08.
TreeFamiTF316786.

Family and domain databases

InterProiIPR000467. G_patch_dom.
IPR005824. KOW.
IPR026822. Spp2/MOS2_G-patch.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PfamiPF12656. G-patch_2. 1 hit.
PF00467. KOW. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
SM00739. KOW. 2 hits.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
PROSITEiPS50174. G_PATCH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q56A08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRESPPPS APSMAPISFG FTRTSVRRRL ADLGDSERQA PEEKDFLATV
60 70 80 90 100
EGRKLQSVNP PEAPKELVIP LIQNGSRRQP LSKNPKPSSE TSTVLMSDGV
110 120 130 140 150
LSQAVKELIE ESKKSLEERE NAGVDPTLTI PMIQKGCTPI EEGSDSEPQA
160 170 180 190 200
ETVPEEADYE AVPVEAYGLA MLRGMGWKPG KGIGNTFSQV VKPRVNSIRP
210 220 230 240 250
KGLGLGANRM EAQDLASVGS HHPPRPDGDR ENDKEGQPQG LMHGRAVVVL
260 270 280 290 300
SGPYRGLYGK VEGLDPDNVR AMVRLAVGNR IVTVSEYCLR PVSQQEFDSH
310 320 330 340 350
TSKPGHVSQT STEQQNRATG TASSLKAAQN QEDSKRRQKG SEKKRKHSPD
360 370 380 390 400
RQDGPVPKTE KAAPRNKHWL HRDLRVRFID KLHKSGRYYN TKMTIEDVLS
410 420 430 440 450
PDTCVCRTDE GRVLEDVRED MLETLIPKGE GHRVMVVLGP HAGKVGLLRS
460 470 480
RDRAQSHALV QLRRENQVVE LHYNAICQYM GPGDSDED
Length:488
Mass (Da):53,832
Last modified:March 20, 2007 - v2
Checksum:iBCF1E648CA7CDD4B
GO

Sequence cautioni

The sequence AAH92224.2 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI20680.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI25336.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC25949.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028433 mRNA. Translation: BAC25949.1. Different initiation.
AL671995 Genomic DNA. Translation: CAM13581.1.
BC062646 mRNA. Translation: AAH62646.1.
BC092224 mRNA. Translation: AAH92224.2. Different initiation.
BC120679 mRNA. Translation: AAI20680.1. Different initiation.
BC125335 mRNA. Translation: AAI25336.1. Different initiation.
CCDSiCCDS29969.2.
RefSeqiNP_776108.2. NM_173747.3.
UniGeneiMm.148753.

Genome annotation databases

EnsembliENSMUST00000049896; ENSMUSP00000076178; ENSMUSG00000031148.
GeneIDi209416.
KEGGimmu:209416.
UCSCiuc009sma.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028433 mRNA. Translation: BAC25949.1. Different initiation.
AL671995 Genomic DNA. Translation: CAM13581.1.
BC062646 mRNA. Translation: AAH62646.1.
BC092224 mRNA. Translation: AAH92224.2. Different initiation.
BC120679 mRNA. Translation: AAI20680.1. Different initiation.
BC125335 mRNA. Translation: AAI25336.1. Different initiation.
CCDSiCCDS29969.2.
RefSeqiNP_776108.2. NM_173747.3.
UniGeneiMm.148753.

3D structure databases

ProteinModelPortaliQ56A08.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229077. 13 interactions.
IntActiQ56A08. 13 interactions.
STRINGi10090.ENSMUSP00000076178.

PTM databases

iPTMnetiQ56A08.
PhosphoSiteiQ56A08.

Proteomic databases

EPDiQ56A08.
MaxQBiQ56A08.
PaxDbiQ56A08.
PeptideAtlasiQ56A08.
PRIDEiQ56A08.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049896; ENSMUSP00000076178; ENSMUSG00000031148.
GeneIDi209416.
KEGGimmu:209416.
UCSCiuc009sma.1. mouse.

Organism-specific databases

CTDi27238.
MGIiMGI:1859610. Gpkow.

Phylogenomic databases

eggNOGiKOG4315. Eukaryota.
ENOG410YYBE. LUCA.
GeneTreeiENSGT00390000015154.
HOGENOMiHOG000231362.
HOVERGENiHBG080241.
InParanoidiQ56A08.
KOiK13101.
OMAiCIPEREG.
OrthoDBiEOG7FV3Q7.
PhylomeDBiQ56A08.
TreeFamiTF316786.

Enzyme and pathway databases

ReactomeiR-MMU-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

PROiQ56A08.
SOURCEiSearch...

Gene expression databases

BgeeiQ56A08.
CleanExiMM_GPKOW.
ExpressionAtlasiQ56A08. baseline and differential.
GenevisibleiQ56A08. MM.

Family and domain databases

InterProiIPR000467. G_patch_dom.
IPR005824. KOW.
IPR026822. Spp2/MOS2_G-patch.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PfamiPF12656. G-patch_2. 1 hit.
PF00467. KOW. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
SM00739. KOW. 2 hits.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
PROSITEiPS50174. G_PATCH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Liver.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-488.
    Strain: C57BL/6J.
    Tissue: Brain.
  4. "MOS2, a protein containing G-patch and KOW motifs, is essential for innate immunity in Arabidopsis thaliana."
    Zhang Y., Cheng Y.T., Bi D., Palma K., Li X.
    Curr. Biol. 15:1936-1942(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-485, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney and Liver.

Entry informationi

Entry nameiGPKOW_MOUSE
AccessioniPrimary (citable) accession number: Q56A08
Secondary accession number(s): A0JLW7
, A2AEU7, Q6P5V0, Q8C1C3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: July 6, 2016
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.